In the process of seepage, the internally unstable fine particles of sandy soil are easy to be lost and form suffusion, which has a negative effect on the geotechnical building or foundation. The loss rate of fine particles is a key parameter for soil mechanical property degradation and stability analysis. In order to predict the loss rate of fine particles in sandy soil under suffusion, the internal stability evaluation criteria for determining whether soil will undergo suffusion is discussed first. Second this paper gives critical hydraulic gradient for erosion initiation and introduces the stress reduction factor. And then considering the difference of soil particles' forces, the stress reduction factor is modified, meanwhile the “erosion initiation probability of fine particles” is introduced to quantify the erosion initiation of fine particles. Next the migration process of fine particles in the pore network of soil is analyzed, and the probability of fine particles through constriction and the migration distance are given. Finally, the law of fine particle erosion and deposition are given according to the law of fine particle erosion initiation and migration, and the prediction method of fine particle loss rate was formed based on the law of mass conservation. The calculated results of fine particle loss by this prediction method are in good agreement with the numerical results, and the error is basically within 15%.