Heat dissipation from a segmental heat source confined in a vented cavity with a moving lid is investigated numerically. The left wall is made flexible with an opening to force the cooling fluid with Rein. The fluid is discharged out from another opening located in the opposite right wall. The lid of the cavity is driven by a speed four times greater than the inlet velocity, ReLid = 4Rein. The κ -ε turbulent model together with the interaction of the fluid with the flexible wall (FSI) are solved numerically using the method of finite element. The impacts of Reynolds, Richardson Ri and Prandtl Pr numbers, elasticity of the flexible wall and the location of the inlet ports are scrutinized. It is found that the location of the inlet port and the Prandtl number play crucial roles in improving the overall performance. It is found that the lower position of the inlet port gives better performance than the higher position, where the performance criterion is 1.69 at Ri = 100. Results reveal that the lower Prandtl number (0.71) gives higher Nusselt number, where at Ri = 100, setting Pr at 0.71 the Nusselt number increases by 125% more than Pr = 6.5. It is concluded that the flexible wall either promotes the Nusselt number or alleviates the pressure drop.