Thin-walled structure is widely used as energy absorber in automotive industries due to its superior crashworthiness characteristics. In these recent years, many studies had been performed to design the new shapes of thin-walled tube that are inspired by a biological component, especially from animals and plants. This research aims to conduct a parametric study of bio-inspired thin-walled tubes to enhance the energy absorption characteristics. Two designs of bio-inspired thin-walled tubes had been proposed in this study. The tubes were impacted under axial and oblique loadings by using a finite element analysis software. The results show that the proposed designs provide better energy absorption capacity and specific energy absorption compared to the conventional tube at different thicknesses and diameters. The trend of the results obtained from this study can be used to improve the design of bio-inspired thin-walled structure in the future.