Background: With a reduction in the weight of telescopic boom crane and an increase in its lifting capacity, the contradiction between its speed, stability and safety becomes more prominent. The telescopic arm also has flexible deformation during operation, which will cause vibration of the whole vehicle system. Therefore, in order to ensure safety, accuracy, and efficiency in the working process, it is necessary to accurately predict the dynamic characteristics of the telescopic boom load in the working process. Objective: The purpose of this study is to establish a rigid-flexible coupling dynamic model of the crane, which can accurately reflect the dynamic characteristics of the telescopic boom during its operation in the simulation test. Methods: In theory, this study analyzes the characteristics of a truck crane and simplifies it as a cantilever beam. Based on the Euler-Bernoulli beam theory, the vibration differential equation of the mobile masscantilever beam system is established. In the aspect of simulation, the three-dimensional modeling software Solidworks is used to establish the solid model of the truck telescopic boom, the finite element analysis software is used to establish the finite element model of the telescopic boom, and the modal neutral file is generated and imported into ADAMS to establish the dynamic model of the truck crane multi-level flexible telescopic boom. The dynamic simulation of the virtual prototype model of the truck telescopic boom crane is carried out in ADAMS software to obtain the dynamic characteristics of the key components of crane under specific working conditions. Results: The vibration differential equation derived in theory can be used to solve the dynamic response of the crane jib under specific conditions by MATLAB programming. In the aspect of simulation, the error fluctuation and its causes in the key components of the crane in the working state are analyzed, and the rationality of the virtual prototype model is verified. Finally, through the trajectory planning of the crane under typical working conditions, the purpose of stable control of the telescopic boom system of the truck crane is realized. Conclusion: The derived equation is universal for solving the vibration of crane jib in general cases. The rigid-flexible coupling model also provides a reference for the dynamic modeling, analysis, design, and manufacture of a multi-stage flexible telescopic boom. The findings of this study can provide a reference for related patent research and development.