University students may be particularly vulnerable to develop mental disorders, including depression, due to sudden and unexpected changes in their daily life during the COVID-19 pandemic. The present study aimed to assess depression among male smokers and non-smokers university students during the first wave of COVID-19 in Bangladesh. A web-based cross-sectional survey was conducted among 444 university male students using convenient and snowball sampling with a 1:1 ratio of male smokers and non-smokers from July to October, 2020. The prevalence estimates of moderate to severe depression were 53.6 % and 22.1 %, respectively among male smokers and non-smokers with an overall prevalence rate of 37.9 %. The participants who smoked cigarette were 4.05 times more likely to have depression compared to those who did not smoke (AOR = 4.05; 95 % CI = 2.60–6.30, p < 0.001). The following factors were found to be associated with depression: being smokers, having family members who lost jobs due to the impact of COVID-19, and having food scarcity due to COVID-19. The findings suggest mental health awareness and psychosocial support programs with a special focus on quitting smoking behavior among university students.
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