It is necessary for students to have a deep understanding of knowledge and intelligence. We have been teaching Knowledge and Intelligence course to the students majoring in computer science and artificial intelligence at Northeastern University since 2018. This paper is about the instructional design of the introductory part of the knowledge and intelligence course. We use a question to draw out the significance of the Knowledge and Intelligence course: "When did humans part ways with other animals?" We organize students to debate whether "walking upright" or "using tools" can better distinguish humans from animals. Through the teacher's comments on the debate, students will find that both "walking upright is a sign that distinguishes humans from other animals" or "using tools is a sign that distinguishes humans from other animals" are correct. Their essence is that "knowledge is the mark that distinguishes humans from other animals." Through the exploration and inheritance of knowledge, humans gradually parted ways with other animals. Students will understand the great significance of the Knowledge and Intelligence course by this way.