As the most excellent indicator for hydrological cycle and a central link to water-balance calculations, the reference evapotranspiration (ET0) is of increasing importance in assessing the potential impacts of climate change on hydrology and water resources systems since the climate change has been becoming more pronounced. In this study, we conduct an investigation on the spatial and temporal changes in ET0 of the Haihe River Basin in present and future stages. The ET0 in the past five decades (1961–2010) are calculated by the Penman–Monteith method with historical climatic variables in 40 sites while the ET0 estimation for the future period of 2011–2099 is based on the related climatic variables projected by Coupled General Circulation Model (CGCM) multimodel ensemble projections in Phase 3 of the Coupled Model Intercomparison Project (CMIP3) using the Bayesian Model Average (BMA) approach. Results can be summarized for the present and future as follows. (1) No coherent spatial patterns in ET0 changes are seen in the whole basin. Half of the stations distributed mainly in the eastern and southeastern plain regions present significant negative trends, while only 3 stations in the western mountainous and plateau basin show significant positive trends. Radiation is mainly responsible for the ET0 change in the southern and eastern basin, whereas relative humidity and wind speed are the leading factors in the eastern coastal and north parts. (2) BMA ensemble method is competent to produce lower bias in comparison with other common methods in this basin. Future spatiotemporal ET0 pattern analysis by means of the BMA method based on the ensembles of four CGCMs suggested that although the spatial patterns under three scenarios are different in the forthcoming two decades, generally increasing trends can be found in the 21st century, which is mainly attributed to the significant increasing temperature. In addition, the implication of future ET0 change in agriculture and local water resources is discussed as an extension of this work. The results can provide beneficial reference and comprehensive information to understand the impact of climate change on the future water balance and improve the regional strategy for water resource and eco-environment management in the Haihe River Basin.