Stockholm County Research Articles

Acculturation and 4-year caries increment among children of foreign-born mothers in Sweden: a register-based cohort study

BackgroundTo study the association of maternal age upon arrival and length of residence in Sweden with the 4-year caries increment in their children between ages 3 and 7 years in relation to the human development index (HDI) of the maternal country of origin.MethodThis registry-based cohort study included all children born in 2000–2003 who resided in Stockholm County, Sweden, at age 3 years and who were followed up at age 7 (n = 63,931). Negative binomial regressions were used to analyze different models adjusted for sociodemographic factors.ResultsChildren of foreign-born mothers, regardless of the HDI of the maternal country of origin, had a higher risk of caries increment between ages 3 and 7 years than children of Swedish-born mothers. Furthermore, children of mothers who had arrived from a low or medium HDI country had a lower caries increment if their mothers arrived before age 7 compared with after age 7. Nearly half (44%) of the children whose mothers arrived in Sweden at age ≥ 20 years from a low HDI country had a caries increment compared to 22% of the children whose mothers had arrived in Sweden before 7 years of age. Furthermore, children whose mothers were born in a low HDI country and had resided in Sweden ≤ 19 years had approximately 1.5 times higher risk of caries increment compared to children of mothers who had resided in Sweden for more than 20 years.ConclusionsCaries increment in the children of foreign-born mothers was associated with the age of their mother when she arrived in Sweden and was lower when the mother had arrived before age 7 years. This indicates an intergenerational effect that carries over to the children and is greater the longer the mother has participated in Swedish dental healthcare.

Influence of work ability and smoking on the prognosis of long-duration activity-limiting neck/back pain: a cohort study of a Swedish working population

ObjectivesLong-duration activity-limiting neck/back pain is common, but the knowledge of what work and lifestyle factors that influence the prognosis is sparse. The objective was therefore to evaluate if two factors,...

Association of maternal polycystic ovary syndrome and diabetes with preterm birth and offspring birth size: a population-based cohort study.

Association of maternal polycystic ovary syndrome and diabetes with preterm birth and offspring birth size: a population-based cohort study.

Unravelling individual mobility temporal patterns using longitudinal smart card data

The increasing availability of longitudinal individual human mobility traces enables the disaggregate analysis of temporal properties of mobility patterns. The objective of this study is to identify distinctive market segments in terms of habitual temporal travel patterns of public transport users. First, travel patterns are clustered using a K-means approach followed by grouping the resulting patterns into a small number of profiles using a hierarchical clustering method. Second, we construct user-week vectors that are then clustered using a Gaussian Mixture Model approach.We apply our clustering analysis to the multi-modal public transport system of Stockholm County, Sweden, using data from more than 3 million smart card-holders. Our clustering analysis resulted in 10 day-of-the-week patterns with their composition varying across the county. In addition, we identify the following hour-by-hour weekly profiles:’Weekly commuters', ‘Lower peaks',’Late travellers', ‘Early birds' and ’Flat curve’. The behavior represented by ’Weekday commuters' and ‘Lower peaks' is most persistent over weeks. We demonstrate how a better understanding of user travel patterns offers policy makers, service planners and providers with enhanced opportunities to understand and cater for diverse market segments, for example by means of tailored fare products.

Bladder Cancer (NMIBC) in a population-based cohort from Stockholm County with long-term follow-up; A comparative analysis of prediction models for recurrence and progression, including external validation of the updated 2021 E.A.U. model

Non muscle invasive bladder cancer (NMIBC) has recurrence and progression rates of approximately 55-75% and 5-45% respectively. After diagnosis, risk stratification guides management decisions regarding surveillance, intravesical therapy or surgery. This prospective cohort of patients from Stockholm County is ideal for external validation of the current risk stratification models used in clinical practice.The cohort consisted of 395 patients diagnosed with bladder cancer across all the hospitals in Stockholm County between the years 1995-96, with up to 25 years follow up. All patients with pathologic Ta or T1 disease were included. Patients with muscle invasive disease (MIBC) referred for radical treatment at diagnosis were excluded. External validation of EORTC, CUETO and updated EAU Sylvester et al. (2021) models was done and multivariate Cox regression analysis was performed to generate hazard ratios for covariables of interest using both WHO '73 and WHO '04/16 pathological grade classifications.Overall Harrel's C-indices (CIs) for EORTC and CUETO models for recurrence were 0.66 and 0.63 respectively. The CIs for the EORTC, CUETO and EAU Sylvester et al. (2021) WHO '73 and '04/16 models for progression were higher at 0.82, 0.84, 0.83 and 0.83 respectively. All models tended to underestimate both recurrence and progression rates at 1 and 5 yrs. A simplified model devised to include only multifocality, tumor stage, size and grade performed with similar accuracy to all models for both recurrence and progression.Current risk stratification models are clinically useful but only moderately accurate across different patient populations, and the results of this study suggest a model using fewer variables is of similar accuracy to all models tested. In the future, research into the use of genomic classifiers will hopefully contribute to more accurate, modern risk stratification models.

The Quality and Efficiency of Public and Private Firms: Evidence from Ambulance Services

Abstract Economic theory predicts that outsourcing public services to private firms reduces costs, but the effect on quality is ambiguous. We explore quality differences between publicly and privately owned ambulances in Stockholm County, Sweden, a setting where patients are as good as randomly assigned to ambulances with different ownership status. We find that private ambulances reduce costs and perform better on contracted measures such as response time, but perform worse on noncontracted measures such as mortality. In fact, a patient has a 1.4% higher risk of death within three years if a private ambulance is dispatched (in aggregate, 420 more deaths each year). We also present evidence of the mechanism at work, suggesting that private firms cut costs at the expense of ambulance staff quality.

First Mile/Last Mile Problems in Smart and Sustainable Cities: A Case Study in Stockholm County

ABSTRACT The first mile/last mile (FM/LM) problem in public transport refers to the spatial accessibility of public transport and is the most important factor determining whether an individual will choose public transport. The FM/LM problem in Stockholm County, Sweden, was evaluated using a Geographic Information System estimating distances to public transport for the years 2019 and 2035. Overall, the population in Stockholm County, have good access to public transport. However, access varies with abilities, with elderly having 50 percent and elderly impaired 15 percent of their area within walking distance to public transport compared with the average citizen. Planned developments can provide good access to public transport, with extensive improvements for the elderly. However, inadequate planning for population increase will likely decrease the perceived public transport accessibility. Apartments and commercial buildings in the study area have high access to public transport. Elderly people have good access within city and regional centers, while access could be improved in other areas. Inclusion of FM/LM in the planning support system used in Stockholm could help mitigate FM/LM problems and extend access to public transport to all people of different abilities. This is vital in creating sustainable mobility networks and achieving sustainable development in smart cities.

Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes.

Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development of diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this study, we hypothesized that ROS overproduction was secondary to the impaired responses to hypoxia due to the inhibition of hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. The ROS levels were analyzed in the blood of healthy subjects and individuals with type 1 diabetes after exposure to hypoxia. The relation between HIF-1, glucose levels, ROS production and its functional consequences were analyzed in renal mIMCD-3 cells and in kidneys of mouse models of diabetes. Exposure to hypoxia increased circulating ROS in subjects with diabetes, but not in subjects without diabetes. High glucose concentrations repressed HIF-1 both in hypoxic cells and in kidneys of animals with diabetes, through a HIF prolyl-hydroxylase (PHD)-dependent mechanism. The impaired HIF-1 signaling contributed to excess production of mitochondrial ROS through increased mitochondrial respiration that was mediated by Pyruvate dehydrogenase kinase 1 (PDK1). The restoration of HIF-1 function attenuated ROS overproduction despite persistent hyperglycemia, and conferred protection against apoptosis and renal injury in diabetes. We conclude that the repression of HIF-1 plays a central role in mitochondrial ROS overproduction in diabetes and is a potential therapeutic target for diabetic complications. These findings are timely since the first PHD inhibitor that can activate HIF-1 has been newly approved for clinical use. This work was supported by grants from the Swedish Research Council, Stockholm County Research Council, Stockholm Regional Research Foundation, Bert von Kantzows Foundation, Swedish Society of Medicine, Kung Gustaf V:s och Drottning Victorias Frimurarestifelse, Karolinska Institute's Research Foundations, Strategic Research Programme in Diabetes, and Erling-Persson Family Foundation for S-B.C.; grants from the Swedish Research Council and Swedish Heart and Lung Foundation for T.A.S.; and ERC consolidator grant for M.M.

Childhood infections and autism spectrum disorders and/or intellectual disability: a register-based cohort study

ObjectiveTo explore the associations between childhood infections and subsequent diagnoses of autism spectrum disorder (ASD), intellectual disability (ID), and their co-occurrence.MethodsThe association between specialized care for any infection, defined by ICD-codes, and later ASD or ID was investigated in a register-based cohort of 556,732 individuals born 1987–2010, resident in Stockholm County, followed from birth to their 18th birthday or December 31, 2016. We considered as potential confounders children’s characteristics, family socioeconomic factors, obstetric complications, and parental histories of treatment for infection and psychiatric disorders in survival analyses with extended Cox regression models. Residual confounding by shared familial factors was addressed in sibling analyses using within-strata estimation in Cox regression models. Sensitivity analyses with the exclusion of congenital causes of ASD/ID and documented risk for infections were also performed.ResultsCrude estimates indicated that infections during childhood were associated with later ASD and ID with the largest risks observed for diagnoses involving ID. Inclusion of covariates, exclusion of congenital causes of ASD/ID from the population, and sibling comparisons highlighted the potential for confounding by both heritable and non-heritable factors, though risks remained in all adjusted models. In adjusted sibling comparisons, excluding congenital causes, infections were associated with later “ASD without ID” (HR 1.24, 95%CI 1.15–1.33), “ASD with ID” (1.57, 1.35–1.82), and “ID without ASD” (2.01, 1.76–2.28). Risks associated with infections varied by age at exposure and by age at diagnosis of ASD/ID.ConclusionsInfections during childhood may contribute to a later diagnosis of ID and ASD.

Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals

BackgroundImmunocompromised individuals are highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Whether vaccine-induced immunity in these individuals involves oral cavity, a primary site of infection, is presently unknown.MethodsImmunocompromised patients (n = 404) and healthy controls (n = 82) participated in a prospective clinical trial (NCT04780659) encompassing two doses of the mRNA BNT162b2 vaccine. Primary immunodeficiency (PID), secondary immunodeficiencies caused by human immunodeficiency virus (HIV) infection, allogeneic hematopoietic stem cell transplantation (HSCT)/chimeric antigen receptor T cell therapy (CAR-T), solid organ transplantation (SOT), and chronic lymphocytic leukemia (CLL) patients were included. Salivary and serum immunoglobulin G (IgG) reactivities to SARS-CoV-2 spike were measured by multiplex bead-based assays and Elecsys anti-SARS-CoV-2 S assay.FindingsIgG responses to SARS-CoV-2 spike antigens in saliva in HIV and HSCT/CAR-T groups were comparable to those of healthy controls after vaccination. The PID, SOT, and CLL patients had weaker responses, influenced mainly by disease parameters or immunosuppressants. Salivary responses correlated remarkably well with specific IgG titers and the neutralizing capacity in serum. Receiver operating characteristic curve analysis for the predictive power of salivary IgG yielded area under the curve (AUC) = 0.95 and positive predictive value (PPV) = 90.7% for the entire cohort after vaccination.ConclusionsSaliva conveys vaccine responses induced by mRNA BNT162b2. The predictive power of salivary spike IgG makes it highly suitable for screening vulnerable groups for revaccination.FundingKnut and Alice Wallenberg Foundation, Erling Perssons family foundation, Region Stockholm, Swedish Research Council, Karolinska Institutet, Swedish Blood Cancer Foundation, PID patient organization of Sweden, Nordstjernan AB, Center for Medical Innovation (CIMED), Swedish Medical Research Council, and Stockholm County Council (ALF).

The Stockholm CREAtinine Measurements (SCREAM) project: Fostering improvements in chronic kidney disease care.

SCREAM (Stockholm CREAtinine Measurements project) was initiated in 2010 in collaboration with the healthcare provider of Stockholm County healthcare to quantify potential medication errors, estimate the burden of chronic kidney disease (CKD) and to illustrate the value of incorporating measures of kidney function into the medical decision process. Because most patients are unaware of their CKD and diagnoses are seldom issued, SCREAM took advantage of the commonness of serum/plasma creatinine testing, which can be used to estimate the glomerular filtration rate (eGFR) and classify the stage of CKD severity. SCREAM is periodically updated, and at present contains healthcare information of all residents in Stockholm region during 2006-2019 (about 3 million people), enriched with a broad range of laboratory measurements for those in whom creatinine or albuminuria has been measured (about 1.8 million people). This health information was linked with national administrative and quality registries via the unique personal identification number of each Swedish citizen, conforming the richest characterization in Sweden of the population's journey through health and disease. This review discusses the context of its creation, strengths and weakness, key findings and plans for the future. We summarize our findings related to the burden of CKD in Sweden, its adverse health risks (such as risk of infections, cancer or dementia) and how underlying kidney function alters the risk-benefit ratio of common medications. Results have had clinical impact and demonstrate the importance of population-based research in the spectrum of clinical research to improve health.

Chronic Urticaria: A Swedish Registry-based Cohort Study on Population, Comorbidities and Treatment Characteristics.

Swedish databases present unique opportunities to research population data on diseases and treatments. The current study is, to our knowledge, the most comprehensive registry-based study on a chronic urticaria population in Sweden to date. The aim of this study was to describe the chronic urticaria population in Stockholm County regarding epidemiology, demographics, comorbidity, healthcare usage and treatment patterns in relation to current international guidelines. Real-world data were extracted between 2013 and 2019, yielding 10,642 adult patients. Study period prevalence of chronic urticaria was 0.53%, the mean annual incidence was approximately 0.08%, and 68% of patients were female. Regarding diagnosis, 58% were first diagnosed in primary care, approximately 50% were diagnosed before the age of 40 years. Regarding type of urticaria, 89% had chronic spontaneous urticaria, 11% had chronic inducible urticaria, and 5% of patients with chronic urticaria had coexisting angioedema. Common coexisting diagnoses were, for example, asthma, allergy, psychiatric and behavioural disorders and cardiometabolic disorders. Treatment patterns generally followed guidelines, yet data indicated that guidelines were not fully implemented, especially in primary care.

Management of Common Bile Duct Stones Encountered During Cholecystectomy in Patients With Previous Gastric Bypass.

Background: Rapid weight loss following gastric bypass (GBP) predisposes to the development of gallstones, and in those who develop gallstone disease there is a high prevalence of common bile duct stones (CBDS). Furthermore, in these patients, CBDS are difficult to extract due to the altered upper gastrointestinal anatomy following GBP. The aim of the present study was to assess outcome after various management methods applied in the counties of Stockholm and Uppsala, Sweden.Methods: Data from the Swedish Register for Gallstone Surgery and ERCP (GallRiks) and the Swedish Obesity Surgery Register (SoReg) were crossmatched to identify all patients who had undergone gallstone surgery after GBP, where CBDS were found at intraoperative cholangiography, in the Stockholm and Uppsala counties 2009–2013. A retrospective review of patient records was performed for all patients identified.Results: In all, 55 patients were identified. These were managed as follows: expectancy (N = 11); transgastric ERCP (N = 2); laparoscopic choledochotomy (N = 3); open choledochotomy (N = 5); transcystic stone extraction (N = 12); and other approach (N = 13). In nine cases, data on management could not be found. There were nine cases of minor postoperative complication. No retained stones were registered. The operation time was longer for transgastric ERCP (p = 0.002), and the postoperative stay was longer following open and laparoscopic choledochotomy (p < 0.001). There was no statistically significant difference between any of the methods regarding the incidence of postoperative complications (p = 0.098).Discussion: Further development of techniques for managing CBDS discovered in patients undergoing cholecystectomy after previous GBP are needed, as well as more comparative studies with greater statistical power.

An off-target scale limits the utility of Short Warwick-Edinburgh Mental Well-Being Scale (SWEMWBS) as a measure of well-being in public health surveys

ObjectivesTo assess the utility and measurement properties for the well-being scale Short Warwick–Edinburgh Mental Well-Being Scale (SWEMWBS) in a Swedish general population survey. Study designA cross-sectional survey study. MethodsData were retrieved from the 2018 public health survey in Stockholm County, containing a random sample of 22 856 persons stratified to be representative for the municipalities and districts within the region. The data were analyzed according to Rasch Measurement Theory. ResultsPerson attribute values are positively skewed (mean 2.32, SD 1.85), with wide gaps in the item threshold attribute values. Overall item fit statistics were acceptable, and person measurement separation reliability was 0.83, indicating three statistically distinct ranges in the estimated well-being values. ConclusionWhile the SWEMWBS items indicated acceptable fit to the Rasch measurement model, targeting of items to sample is skewed toward lower levels of well-being, and there is a ceiling effect. Thus, we suggest a careful reconsideration of SWEMWBS as a tool for use in general public health surveys, especially for assessing change over time and group differences, as there are large measurement uncertainties for the majority of cases when the population as a whole is sampled. We encourage revisions applying a coherent and comprehensive ordinal construct theory for well-being to fill the gaps in the upper end of the SWEMWBS scales' item thresholds. The addition of more challenging items would improve targeting for population-based surveys, increase reliability, and provide more actionable information that could be useful in improving individuals' well-being.

Systemic diseases and their association with open-angle glaucoma in the population of Stockholm

ObjectiveWe aimed to study open-angle glaucoma in association with somatic comorbidities in the total population of adults in Region Stockholm.MethodsThe study population included all living persons aged 19 years and above who resided in Stockholm County, Sweden, on 1 January 2017 (N = 1 703 675). Subjects with specified diseases were identified with data from all registered consultations and hospital stays during 2008–2019. As outcome, the risk of being associated with a diagnosis of open-angle glaucoma was identified during 2012–2018. Analyses were performed by gender, controlling for age and socio-economic status. Age-adjusted odds ratios (ORs) with 95% confidence intervals (95% CI) for women and men with open-angle glaucoma, using individuals without this as referents, were calculated. Socio-economic status was assessed based on the neighbourhood the subjects lived in.ResultsIn total, 16,299 cases of open-angle glaucoma were identified during 2012–2018, 9204 women and 7095 men. Higher fully adjusted OR (95% CI) for risk of being associated with open-angle glaucoma was for women and men with diabetes 1.138 (1.074–1.207) and 1.216 (1.148–1.289), cancer 1.175 (1.120–1.233) and 1.106 (1.048–1.166), hypertension 1.372 (1.306–1.440) and 1.243 (1.179–1.311); and for women with thyroid diseases 1.086 (1.030–1.146), chronic lung diseases 1.153 (1.093–1.216), and inflammatory arthropathies 1.132 (1.006–1.275). Higher glaucoma incidence was observed in individuals residing in high socio-economic status neighbourhoods.ConclusionThe risk of glaucoma is increased in some somatic diseases, especially in individuals with diabetes, hypertension and cancer; and in higher socio-economic neighbourhoods as compared to lower socio-economic neighbourhoods.

Sleep-Related Problems and Associations with Occupational Factors among Home Care Personnel

Recent demographic developments in Europe have increased the demand for home care. Working in other people’s home environment is challenging. Home care personnel’s musculoskeletal disorders are common, and care personnel overall often have sleep disturbances. In this study, associations between occupational physical and psychosocial factors and possible sleep-related problems among home care personnel were explored using a questionnaire. The questionnaire was distributed to 19 workplaces in Stockholm County in 2017–2019, and 665 home care personnel answered. Several factors, including job contentment, physical burden of care, client-related burnout, quantitative demands, and pain, were significantly associated with sleep-related problems. The results highlight the need for implementing measures to improve psychosocial and organizational working conditions in home care service.

Peri-implant marginal bone loss and systemic statin use: A retrospective cohort pilot study.

ObjectivesThe aim was to analyze clinical parameters of peri‐implantitis in human subjects exposed and non‐exposed to use of systemic statins.Material and methodsThis retrospective cohort pilot study compared patient records of 60 exposed individuals to 196 non‐exposed individuals as of 2011 throughout 2017. Source of records were specialist and general dentistry clinics in Public Dental Service, Stockholm County, Sweden. Extent/severity of peri‐implantitis and peri‐implant bone loss were registered as well as intake of systemic statins. Background variables considered were bleeding on probing, bone‐loss, age, gender, earlier periodontitis, prosthetic quality, and smoking. Stepwise linear and logistic regression analysis at the individual level was adopted in order to study the influence of statin use on the severity of peri‐implantitis and the incidence of peri‐implant bone loss. Results were considered statistically significant at p < 0.05.ResultsPeri‐implant bone loss was significantly correlated to use of statin after compensation for age and sex.ConclusionsThe results render an actual effect of statins on peri‐implant bone loss plausible. Further research is warranted.

Precarious Employment and Psychosocial Hazards: A Cross-Sectional Study in Stockholm County.

Precarious employment (PE) has been linked to adverse health effects, possibly mediated through psychosocial hazards. The aim of this cross-sectional study is to explore if higher levels of PE are associated with psychosocial hazards (experiences of violence, sexual harassment, bullying, discrimination, high demands, and low control) and to explore gender differences in these patterns. The study is based on survey- and register data from a sample of 401 non-standard employees in Stockholm County (2016–2017). The level of PE (low/high) was assessed with the Swedish version of the employment precariousness scale (EPRES-Se) and analysed in relation to psychosocial hazards by means of generalized linear models, with the Poisson family and robust variances. After controlling for potential confounders (gender, age, country of birth, and education), the prevalence of suffering bullying (PR 1.07, 95% CI: 1.01–1.13) and discrimination (PR 1.52, 95% CI: 1.00–2.32) was higher among individuals with a high level of PE. Regarding the demand/control variables, a high level of PE was also associated with low control (PR 1.59, 95% CI: 1.30–1.96) and passive work (the combination of low demands and low control) (PR 1.60, 95% CI: 1.23–2.08). Our findings suggest that workers in PE are more likely to experience psychosocial hazards, and these experiences are more prevalent among women compared to men. Future longitudinal studies should look further into these associations and their implications for health and health inequalities.

Geographic and socioeconomic equity in PHC performance among the elderly in three Nordic countries

Abstract Denmark, Finland, and Sweden pursue equity in health for their citizens through universal health care. It is however unclear if these services reach the elderly population equally between different socioeconomic positions (SEP) or living-areas. Our aim was to assess both socioeconomic and geographic equity in primary health care (PHC) performance among the elderly 2000-2015 in the City of Copenhagen, Metropolitan Area of Helsinki, and Stockholm County. Hospitalisations for ambulatory care sensitive conditions (ACSC) was applied as a proxy for PHC performance. Hospitalization data for population aged ≥45 was acquired from the Danish National Patient Register, Finnish Care Register HILMO and patient administrative register from Stockholm County Council. Over time development of geographical variation in ACSC within each metropolis was analysed with Poisson multilevel models. These models were adjusted with individual SEP to distinguish between geographic and socioeconomic disparities. When compared to Stockholm, incidence rate ratios of ACSCs were higher both in Copenhagen (IRR 1.25; CI 95% 1.17-1.35) and in Helsinki (1.39; 1.30-1.49). While the average effect of time slightly decreased in each of the three capital regions (0.97; 0.96-0.98), this decrease was slightly more pronounced in Helsinki than in Stockholm (0.98; 0.97-0.99). Geographic variation in ACSCs seemed the highest both in Copenhagen and in Helsinki. Over time these variations seemed to reduce in Helsinki and in Stockholm, but not in Copenhagen. Adjusting for individual SEP seemed to explain a half of this variance in Helsinki and a third in both Stockholm and Copenhagen - after which over time geographic variation seemed to reduce also in Copenhagen. Geographic disparities in PHC performance among the elderly seem to have narrowed in Finland and in Sweden but remained stable in Denmark. However, in Denmark this seems to rather reflect socioeconomic disparities than stagnant development of PHC. Key messages Despite the universal health care in Denmark, Finland and Sweden, there seems to persist both socioeconomic and geographic disparities in PHC performance among their elderly populations. Among the elderly, over time geographic disparities in PHC performance seem to have improved in both Finland and Sweden – but stagnated in Denmark due to the socioeconomic disparities.

Periodontitis and cardiovascular outcome – a prospective follow-up of the PAROKRANK cohort

Abstract Background There is an association between periodontitis (PD) and myocardial infarction (MI). Whether that is related to shared risk factors or it is causal is debated. The Periodontitis and Its Relation to Coronary Artery Disease (PAROKRANK) case-control study previously reported on an independent association between PD and a first MI. Purpose This follow-up of the PAROKRANK study tests the hypothesis that PD increases the risk for new cardiovascular (CV) events. Methods Between 2010–2014 805 patients (age &amp;lt;75 years; females 19%) with a first MI and 805 controls without MI, matched for gender, age (mean 62±8 years) and living area underwent a CV and dental examination including panoramic x-ray. The PD was categorised in three grades: healthy (≥80% remaining alveolar bone height), moderate (79–66%) or severe (&amp;lt;66%). The composite primary endpoint was the first of all-cause death, non-fatal MI or stroke, or severe heart failure until December 2018. The first of CV-death, non-fatal MI or stroke, or severe heart failure served as a secondary CV-endpoint. Data on outcomes were provided via linkage to the National Patient Registries and the Cause of Death Registry. Cumulative event rates, stratified by PD status at baseline in the combined cohort of cases and controls, were calculated using logistic regression and the Kaplan-Meier method. Results A total of 1587 participants with evaluated PD-status were followed for a mean of 6.2 (range 0.2–8.5) years. The total number of primary events and CV-events was 205 and 158 respectively. The number of deaths was 68. Baseline PD-status was healthy in 985 (mean age 60.4 years), moderate in 489 (mean age 65.1 years) and severe in 113 (mean age 64.3 years) participants. The figure presents the time to primary event by the three PD grades in the combined cohort (patients and controls). Time to the primary endpoint differed between the three PD grades (log-rank test 0.0148), however, significant only for patients (log-rank test patients vs. controls: 0.0382 vs. 0.608). Replacing the primary endpoint with the secondary CV-endpoint just changed the outcome slightly (log-rank 0.0976), possibly due to a low number of CV-deaths within the CV-event. Compared to participants without PD, the presence of PD at baseline was associated with the primary endpoint in the total cohort (Odds Ratio (OR): 1.49; 95% Confidence Interval (CI): 1.11–2.00) as well as the CV-endpoint (OR 1.42; 95% CI 1.02–1.98). PD was not associated with total mortality (OR 1.57; 95% CI 0.97–2.56). Conclusion In this up to 8-years follow up of the PAROKRANK cohort there was a graded increase in the risk for new CV-events by the presence of PD. This was in particular seen in the MI-patients. Together with the previous case-control based report from PAROKRANK, on an association between PD and a first MI, the findings during the follow-up supports the assumption that there may be a causal relationship between PD and CV-disease. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The PAROKRANK study was supported by grants from AFA Insurance, Swedish Heart-Lung Foundation, Swedish Research Council, Swedish Society of Medicine, Stockholm County Council (ALF project and Steering committee KI/SLL for odontological research), and The Baltic Child Foundation. Figure 1