Due to the intertwined and parallel interests of the great powers in Kosovo and Metohija, a kind of geopolitical knot has been created, as a field of aggressive geopolitical actions by non-Balkan and Balkan neighbouring political factors, which is reflected in current events, making them politically and security complex. After 2008, we have witnessed the unilaterally recognized so-called independence of Kosovo, which continued the process of internal transition and territorial fragmentation of Serbia that is clearly marked as a challenge and threat even in the current geopolitical and security context. Therefore, the paper has tried to show and explain the importance of the southern Serbian province, first of all emphasizing its geographical and geopolitical importance as a central area on the Balkan Peninsula, which makes it very important for the control of traffic, economic, communication, strategic and other corridors. The second part of the paper presents a geopolitical analysis of the current events in the south of Serbia and the consequences for the country's internal political structure and international position. In addition, the security aspects of the Kosovo-Metohija knot have been analysed, with a focus on national security and security problems caused by the violent exclusion of the Serbian territory and the self-proclamation of the so-called independence of Kosovo, in order to find sustainable solutions for the security situation in the south of Serbia.