The objective: to evaluate the changes in hematological indicators as early predictors of the development of preeclampsia.Materials and methods. A retrospective cohort study was conducted with the participation of 49 pregnant women in the period from March 2020 to January 2022. All women were observed in the women’s consultation of the private medical center “Leleka”.Pregnant women were divided into two groups: the main group – women who were diagnosed with preeclampsia at >20 weeks of pregnancy, n=20), and the control group (n=29) – women without preeclampsia during pregnancy.Each woman underwent a general blood test, the systemic inflammatory response index (SIRI), allergy index (AI), immunoreactivity index (II), adaptation index (А) in I (up to 12 weeks), II (13–27 weeks) and III (from 28 weeks) trimesters of pregnancy, respectively, were calculated.Results. Pregnant women, in whom subsequently preeclampsia developed, had statistically significant differences in white blood cell count and erythrocyte sedimentation rate (ESR) compared to controls.The AI index decreased statistically significantly in the control group in the II trimester compared to the I trimester (р=0.05), while the changes in the main group were statistically insignificant. The median AI indicator in the main group decreases by 22.7% in the II trimester, and increases by 8.9% in the III trimester; in the control group the median AI decreases by 12.3% and 7.5%, respectively.The median adaptation index in the main group statistically significantly decreases by 25.7% in the II trimester and increases by 19.2% in the III trimester. In the control group, this index does not increase in the III trimester.Conclusions. The dynamics of the main hematological indicators and calculated indices can be useful for predicting of preeclampsia development. Carrying out a general blood test as a widely available method is possible in order to stratify the individual risk of preeclampsia development in combination with other generally accepted factors of this complication.High values of leukocytes and ESR in the early terms of pregnancy in women who subsequently developed preeclampsia confirm the role of inflammation as an etiopathogenetic factor. A change in the integral hematological indices of allergy and adaptation can be an early predictor of preeclampsia.The results of this study predict the presence of preeclampsia clusters, the determination of the mechanisms of which will allow to expand the possibilities of preventive measures, which needs to be confirmed in large-scale randomized studies in the future.