The objective of this study was to determine the chemical composition, DE and ME contents, and apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of AA in 7 cottonseed co-products fed to growing pigs. The 7 cottonseed co-products were: cottonseed meals (solvent extracted) with CP level of 46%, 50%, and 55% (46CSM, 50CSM, and 55CSM), cottonseed protein with CP level of 50% and 55% (50CSP and 55CSP), fermented cottonseed meal (CSMF), and expelled cottonseed meal (CSME). The DE and ME contents of the 7 test ingredients were measured using 48 crossbreed barrows (BW: 44.1 ± 4.2 kg) and 8 diets (including a corn-soybean meal basal diet) in a completely randomized design. The AID and SID of AA of the 7 test ingredients were determined using 7 crossbreed barrows (initial BW: 67.4 ± 8.5 kg) in a 6 × 8 Youden square design with 6 periods and 8 diets (including one N-free diet). The DE and ME values of the 7 cottonseed co-products varied from 12.72 to 15.63 MJ/kg and 12.24 to 14.83 MJ/kg, respectively. Among the 7 cottonseed co-products, 55CSP and CSME had the greatest (P < 0.05) ME and DE values compared to the other cottonseed co-products. In addition, 55CSP had the greatest (P < 0.05) AID and SID of all the AA tested except for Gly and Pro. In contrast, 46CSM or 55CSM had the lowest (P < 0.05) AID and SID of all the AA tested except for Gly and Pro. The 55CSP also had the greatest (P < 0.05) concentrations of standardized ileal digestible CP and all the AA tested except for Gly and Pro. In conclusion, the chemical composition, energy, and AA digestibility of cottonseed co-products with different processing techniques varied widely. Based on the energy and AA digestibility, cottonseed protein with CP level of 55% is a better dietary ingredient for growing pigs compared with the other cottonseed co-products.