Cost Components Research Articles

A comprehensive design pipeline for FCEV powertrain configuration considering the evolutionary development process and extreme economic performance

Due to stringent emission regulations, the zero-emission hydrogen fuel cell electric vehicles (FCEVs) are gaining significant attention, but their slow power response requires careful selection of auxiliary energy sources and power systems to optimize energy efficiency. This paper presents a comprehensive design pipeline for the FCEV powertrain, encompassing methods for powertrain configuration design, feasible domain design for component parameters, and parameter matching. Initially, a powertrain configuration design method based on evolutionary game theory is introduced, forecasting trends in energy-efficient powertrain configurations using a dynamic cost function that adjusts based on the proportions of different configurations. Next, a feasible domain design method is developed to establish fixed constraints on component parameters, ensuring a fair balance between performance needs and overall costs, including development and lifecycle expenses associated with the powertrain configuration. Subsequently, dynamic programming (DP) is used for parameter matching, assessing the utmost energy-saving potential. The cost function in this method incorporates the degradation cost of powertrain components, underscoring the economic performance of the target FCEV over its lifespan. Finally, simulation assessments indicate that the proposed design pipeline effectively identifies the optimal powertrain configuration for FCEVs, endowing each possible configuration with exceptional economic efficiency across different component parameters.

The costs of implementing anaemia reduction interventions among women fish processors in Ghana

BackgroundAnaemia among women of reproductive age (WRA) remains persistently high in Ghana, affecting 41% in 2022. Women in low-income communities in Ghana engaged in fish processing activities are at increased risk of anaemia due to inadequate diets, exposure to infectious pathogens, and pollutants. The Invisible Fishers (IFs) project was implemented among women fish processors in their reproductive age in Central and Volta regions of Ghana to mitigate anaemia. Despite the efficacy, feasibility and scalability of the intervention, the cost of implementing the intervention is unknown. The objective of this study was to estimate the costs of implementing the IFs project in Ghana.MethodsWe used micro-costing approach to analyse the costs of implementing the IFs project. Data were collected as part of a pilot randomized control trial with three interventions: Behaviour Change Communication (BCC), Strengthening Market Engagement of fish processors plus Behaviour Change Communication (SME + BCC), and Fish Smoking Technology and Practices plus Behaviour Change Communication (FST + BCC). The interventions were delivered to 60 women fish processors in the Central region and 60 in Volta region. The cost of the intervention was estimated from the societal perspective. Economic costs were categorized as direct costs (i.e. personnel, transportation, meetings, training, and monitoring) and indirect cost (i.e. value of productive time lost due to women and community volunteers’ participation in the activities of the IFs project).ResultsThe FST + BCC had the highest average cost per beneficiary (US$11898.62), followed by the SME + BCC (US8962.93). The least expensive was the BCC (US$4651.93) over the intervention period of 18 months. Recurrent costs constituted the largest component of economic costs (98%). Key drivers of direct costs were personnel (58%), administrative expenses (14%), and transportation (7%).ConclusionThere is a high cost for implementing interventions included in the IFs project. Planning and scaling -up of the interventions across larger populations could bring about economies of scale to reduce the average cost of the interventions.

Circular economy: Extending end-of-life strategies

The transition from linear economy to circular economy (CE) has gained mainstream status in recent times, not only at product and process levels, but also at component level. In order to adopt the CE as common practice, there is a need to reimagine the product end-of-life (EoL) phase to include assessment of individual component health status. Implementation of EoL strategies on products designed based on wear and tear, robustness, and safety concerns is, however, complex. The purpose of this study is to explore the potential of designing for CE by applying a visual health-based analysis (VHA) at the component level at the EoL stage. The application of this diagnostic tool is exemplified in a case at a large Swedish outdoor power product manufacturer by analyzing components for reuse, remanufacture, refurbishment, recycling, and recovery strategies. The VHA results in the calculation of a CE potential at the component-product level based on individual component's cost, complexity, health, and diagnostic approach. This study presents a diagnostic tool for practitioners to understand circularity at the component-level in the effort to identify EoL strategies. Furthermore, in supporting the CE principle of maximizing resource recovery, the study potentially contributes to the EU's CE action plan and the UN-SDGs 8, 9, 12, and 13.

A cost-of-illness study of eosinophilic esophagitis in Italy: assessing direct and indirect costs

BackgroundEosinophilic esophagitis (EoE) is a chronic and progressive type 2 inflammatory disease affecting the esophagus. Its prevalence has increased in recent years due to increased awareness, evolving clinical guidelines, and heightened sensitivity among healthcare professionals managing the condition. The exact causes behind EoE’s development remain unknown, and its clinical presentation varies, often leading to significant diagnostic delays depending on the age at which symptoms manifest. Consequently, achieving long-term disease control through heightened awareness becomes imperative. EoE generates a significant clinical burden, resulting in substantial economic consequences for patients, healthcare systems, and society. This study aimed to assess the economic and social impacts on EoE patients within the Italian context.MethodsA cost-of-illness analysis was conducted from two perspectives: the National Health System (NHS) and the societal perspective. This analysis encompassed direct healthcare, indirect healthcare, and non-healthcare costs. Data were collected and assessed through a survey administered to a panel of expert clinicians and EoE-affected patients.ResultsManaging EoE incurs a significant burden on healthcare systems, amounting to €6,852.28 per patient per year. The primary cost component appears to be direct costs, comprising 60.73% of the total cost per patient for this condition, while indirect costs contribute to 29.68% of the overall management expenses.ConclusionThis analysis underscores a substantial financial burden on both the healthcare system and patients affected by eosinophilic esophagitis. It emphasizes the imperative need for a continuous and combined effort from clinicians, patients, and families to promptly recognize symptoms and adaptive behavior to mitigate diagnostic delays.

Use of hydroponic fertilizers in growth media for Chlorella vulgaris for producing affordable protein in developing countries

ABSTRACT Chlorella vulgaris (Chlorophyta) stands out as a promising microalga for single-cell protein production, particularly due to its potential to address the need for affordable nutrition in less-developed regions. Given this context, the quest for more economic fertilization methods is essential. Among the viable alternatives, hydroponic fertilizer (HF) emerges as a widely available option, particularly in regions such as Indonesia. Typically, HF is supplied in two distinct forms, powdered Mix-A and Mix-B, to prepare the stock solutions. This study investigates the impact of varying concentrations and stock solution ratios on both the growth rate and biomass yield of C. vulgaris. Additionally, an economic analysis of cultivation activities is conducted, with a specific focus on comparing the feasibility of utilizing hydroponic fertilizer against conventional methods. The findings reveal that specific ratios and concentrations of the tested growth media outperform standard media in promoting the growth rate and biomass yield of cultivated C. vulgaris. Furthermore, the economic analysis assesses two primary cost components: fertilizer and energy. All tested hydroponic media offered a more cost-effective cultivation solution compared to conventional methods, primarily attributed to the lower cost of the hydroponic fertilizers.

To Analysis the Meritorious Advantages of Precast Structure over Cast In Situ Building Construction In Allied With Time And Cost At Mumbai Region

Most construction projects use cast-in-place concrete, in which the wet mixture is poured andformed directly at the construction site. Since this often takes place on a construction site, the term sitecast concrete has become the standard. An analogy is drawn to the usage of precast concrete, in whichpieces are cast off-site and then transported to the construction site. Concrete for on-site casting isoften delivered using the iconic revolving-barrel concrete mixer trucks. In a centralized batching plant,where stricter quality control over the components may be maintained, the mixture is prepared. At everystage of the process—from transport to the site to proper mixing in the truck to unloading anddepositing in the forms and handling for placement, finishing, and curing—the level of responsibility andcompetence exercised by the people involved is vital. Extreme steps may need to be taken to ensureclose monitoring of each stage of production if accessibility and weather at the work site have a majorinfluence on the quality of the work. While the focus here is not on construction management orprocedures, a basic understanding of these topics would aid in the creation of workable designs forconcrete buildings. Cast-in-place concrete and precast concrete are two competing constructiontechniques supplied by various contractors for the structural elements, and a breakeven formula isestablished to help evaluate and pick the best solution. The criteria for selection is the one that will havethe least financial impact. The quantity of works, in this case concrete, is taken into account apart fromother factors. Finding that the transportation and shifting cost of Precast components significantlyimpacted the entire cost of construction, this research aims to help decision-makers and engineersanalyze both concrete building approaches early in the construction planning stage.

Direct Economic Burden of Cubital Tunnel Surgery in the United States: Total Payments and Components of Cost

Despite its widespread prevalence, the cost of cubital tunnel syndrome (CuTS) in the United States to patients and insurers is not well understood. The purpose of this study was to quantify the direct payments associated with operative treatment of CuTS. We hypothesized that CuTS represents a substantial cost to the payer in facility fees, surgeon fees and other expenses. Utilizing the MarketScan database of insured patients (commercial and Medicaid), we identified a cohort of 41,777 patients aged 18-64 years with surgically treated CuTS from 2006 to 2018. We estimated the median 90-day payments from encounters associated with cubital tunnel release (CuTR) and/or ulnar nerve transposition surgery by summing all payments for claims within 90 days after the index surgery. Published estimates of the annual number of cubital tunnel surgeries were used to calculate the annual expenditure. Of 41,777 patients, the median (interquartile range [IQR]) values of total direct payments were $5,522 [$3,426, $9,541]. With an estimated 94,645 cases/year, this leads to an annual payment of more than $522 million. Index facility payments (median[IQR] $2,555 [$1,359, $4,708] were the highest, followed by index provider payments ($1,691 [$1,328, $2,217]). The median index surgeon payment (median[IQR] $905 [$707, $1,184]) represented just over half of the provider payments. Post-operative care had a median [IQR] payment of $377 ($424, $1,987). Limitations of claims databases prevented assessment of other indirect costs associated with cubital tunnel surgery. Payments for the surgical treatment of CuTS from the index surgery to 90 days post-operatively have an estimated median of $5,522 per patient, totaling $52 million annually. Index facility fees are responsible for more than 46% of payments, while index payments to surgeons represent approximately 16%. Defining this data is critical to understanding one component of the economic impact of CuTS. Level IV.

Exploring Heterogeneity in the Cost-Effectiveness of High-Flow Nasal Cannula Therapy in Acutely Ill Children—Insights From the Step-Up First-line Support for Assistance in Breathing in Children Trial Using a Machine Learning Method

ObjectivesTo investigate heterogeneity in the cost-effectiveness of high-flow nasal cannula (HFNC) therapy compared with continuous positive airway pressure (CPAP) for acutely ill children requiring noninvasive respiratory support. MethodsUsing data from the First-line Support for Assistance in Breathing in Children trial, we explore heterogeneity at the patient and subgroup levels using 2 causal forest approaches and a seemingly unrelated regression approach for comparison. First-line Support for Assistance in Breathing in Children is a noninferiority randomized controlled trial (ISRCTN60048867) involving 24 UK pediatric intensive care units. The Step-up trial focuses on acutely ill children aged 0 to 15 years, requiring noninvasive respiratory support. A total of 600 children were randomly assigned to HFNC and CPAP groups in a 1:1 allocation ratio, with 94 patients excluded because of data unavailability. ResultsThe primary outcome is the incremental net monetary benefit (INB) of HFNC compared with CPAP, using a willingness-to-pay threshold of £20 000 per quality-adjusted life year gain. INB is derived from total costs and quality-adjusted life years at 6 months. Subgroup analysis showed that some subgroups, such as male children, those aged less than 12 months, and those without severe respiratory distress at randomization, had more favorable INB results. Patient-level analysis revealed heterogeneity in INB estimates, particularly driven by the cost component, with greater uncertainty for those with higher INBs. ConclusionsThe estimated overall INB of HFNC is significantly larger for specific patient subgroups, suggesting that the cost-effectiveness of HFNC can be heterogeneous, which highlights the importance of considering patient characteristics in evaluating the cost-effectiveness of HFNC.

Agricultural path detection systems using Canny-edge detection and Hough transform

Navigation is one of the crucial aspects of automation technology within the field of agriculture, such as robotics systems or autonomous agricultural vehicles. Despite many navigation systems having been developed for agricultural land, due to their high development and component costs, these systems are difficult to access for farmers or organizations with limited capital. In this study, the Canny-edge detection and Hough transform methods are implemented in a path detection system on agricultural land to find an alternative, cost-effective navigation system for autonomous farming robots or vehicles. The system is tested on ground-level view images, which are captured from a low perspective and under three different lighting conditions. The testing and experimentation process involves adjusting the parameters of the Canny-edge detection and Hough transform methods for different lighting conditions. Subsequently, an evaluation is conducted using Intersection over Union to obtain the best accuracy results, followed by fine-tuning of the canny-edge detection and Hough transform method parameters. The identified parameters, specifically a 15×15 Gaussian kernel, low threshold of 50, high threshold of 150, Hough threshold, minimum line length of 150, and maximum line gap, have been discerned as optimal for the canny-edge and Hough transform algorithms under medium lighting conditions (G=1.0). The observed efficacy of these parameter configurations suggests the method’s viability for implementation in path detection systems for agricultural vehicles or robots. This underscores its potential to deliver reliable performance and navigate seamlessly across diverse lighting scenarios within the agricultural context.

The Resilience Hub approach for addressing mental health of health and social care workers during the COVID-19 pandemic: a mixed-methods evaluation.

Resilience Hubs provide mental health screening, facilitation of access and direct provision of psychosocial support for health and social care keyworkers in England affected by the coronavirus disease 2019 pandemic. To explore implementation of the Hubs, including characteristics of staff using the services, support accessed, costing data and a range of stakeholder perspectives on the barriers and enablers to Hub use and implementation of staff well-being support within the context of the pandemic. Mixed-methods evaluation. Four Resilience Hubs. Findings were integrated via mixed-method case studies, including: analyses of Hub mental health screening (N = 1973); follow-up questionnaire data (N = 299) on service use and health status of Hub clients; economic information provided by the Hubs; 63 interviews with Hub staff, wider stakeholders, Hub clients and keyworkers who did not use the Hubs. Findings were consistent across Hubs and workstreams. Most Hub clients were NHS staff. Under-represented groups included men, keyworkers from minority ethnic communities, care homes and emergency services staff. Clients reported comorbid mental health needs across multiple domains (anxiety; depression; post-traumatic stress; alcohol use; functioning). Their health status was lower than population norms and relevant pre-pandemic data. Several factors predicted higher needs, but having pre-pandemic emotional well-being concerns was one of the most robust predictors of higher need. Sixty per cent of participants who completed follow-up questionnaires reported receiving mental health support since Hub screening, most of which was directly or indirectly due to Hub support. High levels of satisfaction were reported. As in many services, staffing was the central component of Hub cost. Hubs were predominantly staffed by senior clinicians; this staffing model was consistent with the generally severe difficulties experienced by clients and the need for systemic/team-based working. Costs associated with health and social care use for Hub clients were low, which may be due to barriers to accessing support in general. Enablers to accessing Hubs included: a clear understanding of the Hubs, how to self-refer, and managerial support. Barriers included confusion between Hubs and other support; unhelpful beliefs about job roles, unsupportive managers, negative workplace cultures and difficulties caused by systemic issues. Some keyworkers highlighted a perceived need for further diversity and cultural competency training to improve reach to under-represented communities. Other barriers for these groups included prior negative experiences of services, structural inequalities and stigma. Some wider stakeholders had concerns around growing waiting times for Hub-provided therapy, and insufficient data on Hub usage and outcomes. Feedback was otherwise very positive. Main limitations included lack of comparative and pre-pandemic/baseline data, small numbers from under-represented groups limiting fine-grained analysis, and participant self-selection. Findings highlighted the value of the Hub model of outreach, screening, support navigation and provision of direct support during the coronavirus disease 2019 pandemic, and as a potential model to respond to future crises. The research provided recommendations to improve Hub promotion, equality/diversity/inclusion access issues, management of specialist resources and collection of relevant data on Hub outcomes and activities. Broader recommendations for the primary prevention of mental health difficulties across the health and care system are made, as individual support offers should be an adjunct to, not a replacement for, resolutions to systemic challenges. Research recommendations are made to conduct more robust evaluations of the clinical and cost-effectiveness of the Hubs, using larger data sets and comparative data. This study is registered as researchregistry6303. This award was funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme (NIHR award ref: NIHR132269) and is published in full in Health and Social Care Delivery Research; Vol. 12, No. 29. See the NIHR Funding and Awards website for further award information.

Accelerating whole-sample polarization-resolved second harmonic generation imaging in mammary gland tissue via generative adversarial networks.

Polarization second harmonic generation (P-SHG) imaging is a powerful technique for studying the structure and properties of biological and material samples. However, conventional whole-sample P-SHG imaging is time consuming and requires expensive equipment. This paper introduces a novel approach that significantly improves imaging resolution under conditions of reduced imaging time and resolution, utilizing enhanced super-resolution generative adversarial networks (ESRGAN) to upscale low-resolution images. We demonstrate that this innovative approach maintains high image quality and analytical accuracy, while reducing the imaging time by more than 95%. We also discuss the benefits of the proposed method for reducing laser-induced photodamage, lowering the cost of optical components, and increasing the accessibility and applicability of P-SHG imaging in various fields. Our work significantly advances whole-sample mammary gland P-SHG imaging and opens new possibilities for scientific discovery and innovation.

Costs, challenges and opportunities of decentralised chimeric antigen receptor T-cell production: a literature review and clinical experts’ interviews

The objectives were to summarise the evidence and clinical experts’ views comparing the use of decentralised produced chimeric antigen receptor (CAR) T-cell therapies versus commercially available products, regarding drug costs,...

Dynamic Characterization of Diameter for Round Surfaces using a Non-contact Optical Measurement System

Ensuring uniformity in the final round product's diameter is essential to production line operations because it permits adherence to geometry specifications and fulfills client demands. Non-contact diameter measurement systems are essential for manufacturing cost savings as well as quality monitoring. However, because of their non-linear movement, lengthy manufactured specimens like rods might be difficult to measure the diameter of precisely. Typically, analysis systems rely on costly and intricate optical components, limiting accessibility to small businesses. This research aims to address this issue by presenting a low-cost and practical optical system for measuring the diameters of round samples in continuous lines. The aim here is to obtain instant feedback through dynamic measurement and to create a continuous control mechanism that will contribute to sustainability. Experimental results show that the proposed method exhibits a high level of precision, with a measurement accuracy of 0.25% of nominal diameter.

Bipolar membrane electrodialysis for amine regeneration from amine chloride stream: Closing the amine utilization loop

The amine-based CO2 capture & mineral carbonation (CCMC) using alkaline slag emerges as a decarbonation means. However, being the most costly component in the process, amine is consumed in large quantity yet its regeneration is overlooked. Thus, to close the material utilization loop, this work proposed the bipolar membrane electrodialysis (BMED) technology for amine regeneration from its chloride streams. With customized BMED configurations, the recovery of two different amines(monoethanolamine (MEA) & 2-(Diethylamino)ethanol (DEAE)) was investigated respectively to reveal the separation mechanisms. This novel concept was firstly proved with a three-compartment configuration, where the cations (MEA+ or DEAE+) can pass through the cation exchange membrane and react with OH− generated by the bipolar membrane thus producing pure amine. The respective MEA and DEAE regeneration reached up to 95.1 % and 92.4 % within 10 h; while the yield of a useful byproduct 1.8 wt% HCl reached ∼ 71 %, which can be reused in CCMC. The results showed that the membrane played a key role: with standard anion exchange membrane (AEM), the Cl− transfer rate decreased with increasing feed concentration. Although the proton blocking AEM avoided H+ cross-over, the Cl− transfer was stable but exhibited up to 2.5-times lower transfer rate. Via a comprehensive parametric study, a modest current density (150 A/m2) was chosen to avoid significant energy penalty, corresponding to a power consumption of 10.3 kWh/(kg amine). Compared to the acid model, the base model of two-compartment configuration, had 2x higher amine yield and higher energy efficiency. This study revealed the performance-limiting factors in BMED, inspiring future design of efficient amine regeneration system for closed-loop CCMC process and contributing to sustainable processing towards carbon neutrality.

Strategic management of CO2: A scalable model for CCS in decarbonised societies

In future decarbonised energy systems, residual carbon emissions require strategic planning and management. In environmental management, an evaluation of carbon removal considering local geographic frameworks is needed. This paper introduces a scalable and adaptable model for evaluating the economics and geography of future carbon capture and storage (CCS) configurations across geographical scales, covering capture, transport, and storage of carbon. The model is applied to the North Denmark Region, showing that future energy production carbon sources will be concentrated in Thisted and Jammerbugt, while industrial sources remain in Aalborg and Rebild municipalities. Carbon transport configurations, including truck, pipeline, and shipping are assessed, for the carbon to be stored in onshore and offshore geological storages. The regional scale findings suggest that pipelines and onshore storage provide the most economical configuration. However, a sensitivity study using a smaller geographical scope indicates potential for optimising carbon transport by evaluating both carbon volume and distance. The paper discusses how the model's flexibility and scalability enable the integration of alternate cost components, thereby supporting the calculation of the carbon repurposing potentials, including carbon capture, utilisation, and storage (CCUS) configurations.

Analysis of economic viability of commercial mulberry saplings regeneration using conventional stem propagation method

The economics of stem cutting propagation in mulberry provides a profound insight into the cost-effectiveness and financial benefits of this method compared to other propagation techniques. Stem cutting propagation are widely recognized for its efficiency which involves taking cuttings from a mature mulberry plant and rooting them to produce new plants. This method is particularly advantageous due to its lower initial costs and simplicity compared to alternatives like tissue culture or seed propagation. Economically, stem cutting eliminates the need for expensive seeds and reduces the risk associated with seedling variability thereby leading to more consistent crop quality and yield. The initial capital investment is relatively modest and covering primarily labour and materials for the cuttings and rooting environment. Furthermore, the reduced time frame for producing mature plants accelerates the return on investment thereby providing a quicker pathway to profitability. Analyzing the cost components including labour, equipment and consumables, reveals that while there are ongoing expenses such as maintenance and care of the cuttings these are often outweighed by the savings and benefits derived from a successful propagation cycle. Stem cutting propagation also offers scalability thereby allowing for the expansion of mulberry cultivation with minimal additional costs. The method's ultimate economic advantage lies in its capacity to deliver high-quality, uniform plants at a lower cost, enhancing the overall productivity of mulberry farms. Additionally, examining case studies and regional data highlights variations in economic outcomes based on local conditions, such as soil quality, climate and market access. The ultimate success and profitability of stem cutting propagation are influenced by these factors which can either amplify or mitigate the method’s inherent advantages. In regions where conditions are optimal, the benefits of stem cutting propagation are maximized thereby leading to substantial economic gains.

Part-load analysis and preliminary annual simulation of a constant inventory supercritical CO2 power plant for waste heat recovery in cement industry

The present work investigates the part-load performance of a MW-scale sCO2 power plant designed as waste heat recovery unit for an existing cement plant located in Czech Republic, in the framework of the H2020 funded project CO2OLHEAT. The study first presents the selected power plant configuration and then focuses on the evaluation of its part-load operation due to variation of flue gas mass flow rate and temperature. The range of flue gas conditions at the outlet of the upstream process is retrieved from a preliminary statistical analysis of historical trends obtained through the cement plant monitoring. The numerical model developed for this study aims at providing realistic results thanks to the adoption of turbomachinery performance maps provided by the turbomachinery manufacturer of the project. Moreover, heat exchangers have been modelled through a discretized approach which has been validated against manufacturer data, while piping inventory and pressure losses have been assessed through a preliminary sizing that considers the actual distances to be covered in the cement plant. Performance decay is estimated for the whole range of flue gas conditions, reporting the most significant power cycle parameters, and identifying the main causes of efficiency loss. The part-load analysis is carried out considering a constant CO2 inventory, in order to reduce the system complexity and capital cost and simplify plant operation. Results show that the operation entails minor variation of the compressors operative points in the whole range of operating conditions of the cement plant, avoiding the risk of anti-surge bypass activation. Moreover, the plant is able to work close to the nominal thermodynamic cycle efficiency (20.5 %–23.0 %) for most of the year and benefits from part-load operation in terms of overall performance. In the last part of the work, a preliminary techno-economic analysis of the plant is also presented to highlight the potential advantages of sCO2 technology for waste heat recovery applications. The results of the part-load performance of the plant are combined with the flue gases data obtained from the preliminary statistical analysis and the cement plant historical monitoring. An annual electricity production equal to 13′909.7 MWh is obtained, corresponding to 6560 equivalent hours and a system capacity factor of 74.9 %. The investment cost of each CO2OLHEAT plant component is estimated by means of cost correlations obtained from literature and the non-discounted payback time is computed as a function of the electricity selling price. The results show that, even considering electricity prices before 2022, the payback time of the CO2OLHEAT plant is estimated to be lower than 8 years, justifying the industrial interest in the proposed technology.

Start-Up and Implementation Costs for the Trust Based Relational Intervention.

Capturing costs associated with prevention activities related to substance use disorders (SUD) and mental health (MH) is critical. In this study, Trust Based Relational Intervention (TBRI®), an attachment-based, trauma-informed intervention, is conceptualized as a preventive intervention to reduce substance and opioid use among youth involved with the legal system. When implemented alongside community reentry, TBRI leverages family systems as youth transition from secure residential care into communities through emotional guidance and role modeling. Activity-based cost (ABC) analysis was used to guide cost data collection and analysis for both start-up and implementation of the TBRI intervention. Start-up costs were estimated using data across eight sites during their start-up phase. All components, activities, personnel involved, and time associated with implementation of TBRI sessions according to protocol were defined. National wages were extracted from O*NET and utilized to calculate total costs for each TBRI component. Total and average TBRI intervention costs were calculated with a breakdown by TBRI sessions and number of staff and participants. A sensitivity analysis was conducted to estimate TBRI implementation costs with travel. The total cost for the TBRI intervention, representing 42 sessions, ranges from $6,927, without travel expenses or $12,298, with travel expenses. The average per family cost ranges from $1,385 (without travel) to $2,460 (with travel). Costs are primarily generated by time investments from primary interventionists. The sensitivity analysis shows costs for responsive coaching would double with travel costs included. Results aim to show that using ABC for prevention activities, like TBRI, to understand cost drivers can facilitate future intervention sustainability.Clinical Trail.gov ID: NCT04678960.

Linoleum waste as PLA filler for components cost reduction: Effects on the thermal and mechanical behavior

Polylactic acid (PLA) is a biodegradable polymer from renewable resources with mechanical properties comparable to traditional polymers, but with a higher cost. A solution to this issue is the production of bio-based composites to partially replace the PLA matrix with industrial wastes characterized by a zero-cost, e.g., linoleum, to also valorize them in a circular economy perspective. Linoleum heterogeneous nature deriving from the simultaneous presence of lignocellulosic and inorganic fillers and oil/rosin binders, made the evaluation of matrix/filler compatibilization strategies necessary. Two approaches were considered, one from the filler perspective with NaOH and silane treatments, and the other one from the matrix perspective by adding a chain extender (C.E.). The first approach marginally improved tensile stiffness (by 1.6 %) compared to neat PLA but caused a significant decrease of 32.8 % in strength. Considering this, the costs and disposal of the chemicals and the increased environmental impact of the process, this approach was discarded. One the contrary, the introduction of C.E. does not modify the manufacturing process and increases tensile stiffness and elongation at break of 7.2 % and 415.5 % compared to neat PLA with a tolerable reduction in strength, i.e., 16.6 %, thus being a suitable way to exploit linoleum as zero-cost filler.

Emergency Logistics and Distribution Modeling and Methods

With the frequent occurrence of all kinds of emergencies, the importance of emergency logistics distribution has become increasingly prominent. This thesis focuses on the field of emergency logistics distribution, aiming to analyze distribution models and methods to improve the efficiency and effectiveness of emergency material distribution. First, the characteristics and needs of emergency logistics distribution are analyzed in depth, including time urgency, uncertainty and multi-targeting. Then, for the two key aspects of cost and benefit, cost components such as transportation cost, warehousing cost, labor cost, loss and damage cost, and benefit indicators such as rescue effect, economic benefit and social benefit are elaborated in detail. It also explains that factors such as material response time, transportation speed, completion rate and accuracy should be considered. Meanwhile, in the cost and benefit analysis, methods such as cost-benefit ratio (CBA), cost-efficiency analysis (CEA) and benefit assessment are illustrated, and finally recommendations covering various aspects are put forward to improve the emergency logistics and distribution system.