In this study, the influence of microstructure and buffer system on the corrosion behaviour of Mg-1 wt. % Zn is examined. The grain size of the alloy was refined from 700 µm to under 15 µm by rolling with varying reduction percentages per pass. The effects of the rolling procedure on the resulting corrosion profile were analysed with immersion and electrochemical methods. Though the rolling procedure resulted in significant grain refinement, the as-cast samples had the lowest corrosion rate of 2.8 mm/yr, while those of the rolled samples were as high as 15.8 mm/yr. The HEPES buffer system did not control the pH or support the formation of insoluble precipitates as well as the NaHCO3/CO2 buffer system, leading to more severe localised pitting corrosion in samples immersed in HEPES buffered media. While reducing grain size generally corresponds to a lower corrosion rate in Mg alloys, this study provides evidence that other factors such as texture and buffer system must also be considered to accurately test candidate alloys for biodegradable orthopaedic applications.