Correlation Of Vitamin Research Articles

The role of salivary vitamin D and interleukin-6 on non-scarring Alopecia.

Alopecia, or hair loss, is an emerging global disease. Its etiopathogenesis includes nutritional deficiencies, oxidative stress, and deficiency of physiological factors. Around 2% of the general population has the probability of developing alopecia at any one period. Vitamin D and interleukin-6 (IL-6) have a major role in alopecia. The present goal of research is to investigate the role of vitamin D and IL-6 in the saliva of patients with non-scarring alopecia. The study involved 51 cases of non-scarring alopecia and 50 healthy controls with an age range between 18 and 40 years. A detailed history and clinical examination were done. Salivary vitamin D and IL-6 were determined to compare within the groups. The average vitamin D level in cases (104.64 ± 46.95 pmol/L) was significantly lower as compared to controls (223 ± 12.03 pmol/L) (p < 0.001). Whereas the average amount of IL-6 was significantly higher (170.54 ± 63.68 ng/L) than the control group (56.38 ± 46.52 ng/L) (p < 0.001). No correlation of vitamin D level with IL-6 was detected in study subjects. Vitamin D significantly influences the development of non-scarring alopecia. Patients with non-scarring alopecia had low amount of vitamin D indicate its role in etiology of hair loss. IL-6 may cause a collapse of the hair bulb, having a significant part in the pathogenesis of alopecia indicating chronic inflammatory or autoimmune condition. This research will aid in diagnosing scalp disease using salivary biomarkers and improve the treatment of alopecia.

Effect of Diabetes Mellitus Type 2 on the Correlation of Vitamin D with Lipid Profile in Iraqi Patients

Vitamin D deficiency has been linked to several conditions, including type 2 diabetes. The purpose of this study is to determine if there is an effect of type 2 diabetes on the association between vitamin D level, glycemic indices, and lipid profiles. The study was conducted at Al-Noamman Hospital, included 257 patients with type 2 diabetes and 40 healthy participants of both sexes with matching ages ranging from 26 to 80 years. The lipid profile, postprandial glucose (PPG), HbA1C, and serum vitamin D were measured. The results showed that 89 (34.6%) of diabetics have vitamin D insufficiency (less than 30 ng/mL). 155 diabetic patients (uncontrolled glycemic) with elevated HbA1C (9.07% ± 2.5), and from those, about 33.5% have vitamin D insufficiency; they are of age ≥ 55 years, 58.1% female, and 41.9% male, and they have a significant correlation (r = 0.17, P &lt; 0.05) between HbA1C and vitamin D. All diabetic patients who are classified according to HbA1C subgroups have highly significant correlations (P &lt; 0.01) among age and vitamin D; cholesterol with VLDL and LDL; and TG with VLDL. In controlled diabetes patients (HbA1C ˂ 5.7%), a highly significant correlation was found between HDL and vitamin D (r = 0.50, P ˂ 0.01(. We conclude that vitamin D level is highly significantly related to age and sex in diabetic patients who displayed highly significant dyslipidemia and were associated with 34.6% vitamin D insufficiency (significantly with uncontrolled diabetes mellitus patients).

Correlation of Vitamin D and Calcium Concentration in Infant of Mother with High Risk of Vitamin D Deficiency

Vitamin D deficiency is a significant concern during pregnancy, and its prevention is critical for neonatal health. However, there is a lack of comprehensive studies on screening vitamin D and calcium concentrations in neonates born to high-risk mothers. This study aimed to assess serum 25OHD and calcium concentrations in neonates from mothers previously identified as high risk for vitamin D deficiency, and to explore how these measurements might influence the management of such neonates. A cohort study, initiated in 2018 and continuing through 2023, was conducted using 241 venous blood samples from neonates aged 7 days. The concentrations of serum 25OHD and calcium were analyzed, and the relationship between the variables was evaluated using bivariate analysis and logistic regression. The results revealed a high prevalence of vitamin D insufficiency (85%, 30–50 nmol/L) and deficiency (37%, &lt; 30 nmol/L) in neonates from this high-risk group. Additionally, a statistically significant and strong correlation (r: 0.965, P &lt; 0.05) was observed between 25OHD and serum calcium concentrations. Interestingly, most venous samples collected within the first 24 hours postpartum exhibited hypercalcemia. These findings suggest that while vitamin D insufficiency and deficiency are common in neonates of high-risk mothers, the risk of neonatal hypocalcemia due to vitamin D deficiency is relatively low. Given the financial and physical burdens of neonatal blood screening, routine supplementation of vitamin D from birth, without the need for screening, may be a more efficient approach to managing this issue.

Correlation of Vitamin D Levels with Severity of Asthma in Children Between 6 to 12 Years

Background: Millions of children worldwide suffer from chronic asthma, a serious respiratory disease that has a major influence on everyday living and health outcomes. There are significant public health concerns regarding the estimated 10-15% frequency of asthma in children in India. Vitamin D, which is recognized for its immunomodulatory qualities, according to recent studies reduces the severity. In this study, children aged 6 to 12 years old's vitamin D levels and the severity of their asthma were examined. Materials and Methods: At a tertiary care teaching hospital, 100 children between the ages of 6 and 12 who were presenting with acute exacerbations of bronchial asthma were the subjects of a prospective cohort study from August 2021 to August 2022. ELISA was used to evaluate serum 25-hydroxyvitamin D levels, and the GINA recommendations were used to determine the severity of asthma. Based on their levels of vitamin D, the kids were divided into three groups: sufficient (&gt;30 ng/mL), insufficient (20–30 ng/mL), and deficient (&lt;20 ng/mL). Children who were deficient in vitamin D were given supplements and monitored for three months. With SPSS 27, statistical analysis was carried out. Findings: The results of the study showed a strong correlation between increased asthma severity and inadequate asthma control and reduced vitamin D levels. Children with the most acute and uncontrollably asthmatic episodes were those with low vitamin D levels (&lt;20 ng/mL). Significant improvements in asthma control, decreased activity limits, and decreased need for rescue medication were noted after three months of vitamin D administration. Conclusion: This study shows a clear link between children's asthma control issues and higher asthma severity when there is a vitamin D Deficiency. Supplementing with vitamin D significantly improved asthma outcomes, indicating a possible therapeutic role for this nutrient. Future studies with larger sample sizes and longer follow-up periods are recommended to validate these findings and further elucidate the underlying mechanisms.

Correlation of Vitamin C with Risk Factors of Coronary Artery Disease to Measure the Disease Prognosis to Prepare a Diagnostic Strategy

Abstract BACKGROUND: Reports depicted insufficient plasma Vitamin C levels and significant associations to both acute and chronic inflammation. Recently, use of intravenous Vitamin C has gained visibility for its effectiveness in coronavirus-19 treatment. There were no studies available currently to detect the clinical correlation between plasma Vitamin C with risk factors of coronary artery disease (CAD). The present aim of the study is to estimate the Vitamin C levels in CAD patients as well as to correlate with clinical and laboratory variables to assess the severity of CAD and also to formulate a diagnostic strategy. METHODS: A prospective comparative study was conducted in 100 diagnosed cases of CAD and estimate plasma Vitamin C levels and compared with healthy individuals. Spearman correlation analysis was performed between Vitamin C levels and risk factors of CAD. RESULTS: Maximum CAD cases were in the age group of 60–70 years. The mean age was 58.54 ± 11.60 years in the CAD patients. Among risk factors, 54% of patients had hypertension, 54% of patients had diabetes mellitus, and 27% of patients had dyslipidemia. There significant association noted between diabetes and type of CAD (P = 0.015). Among CAD cases, 70% of patients had ST-elevation myocardial infarction (STEMI), 11% of patients had a non-ST-elevation myocardial infarction (NSTEMI), 17% of patients had unstable angina (USA), and only 2% of patients had central sleep apnoea (CSA). Angiogram diagnosis shows that 34% of patients had single-vessel disease (SVD), 28% of patients had double-vessel disease (DVD), 8% of patients had triple-vessel disease (TVD), 2% of patients had left main coronary artery (LMCA) disease, 13% patients had mild CAD, and 15% patients had normal epicardial coronaries. The range of plasma Vitamin C concentrations level was from 33.25 to 92.5 μmol/L in CAD patients. The mean plasma Vitamin C concentration levels in CAD patients were lower than in healthy individuals (66.96 ± 13.6 vs. 71.33 ± 10.8 μmol/L). There was no statistically significant difference between CAD and non-CAD for plasma Vitamin C concentration levels (P = 0.085). The mean Vitamin C level was higher in DVD (70.6 ± 10.9) than the TVD, LM (71.6 ± 5.82), SVD (68.49 ± 12.4), mild CAD (65.55 ± 13.1), and TVD (62.92 ± 8.9). There was no statistically significant difference in plasma Vitamin C levels in the coronary angiogram (CAG) diagnosis for CAD cases (P = 0.103). The mean plasma Vitamin C levels were higher in NSTEMI (72.98 ± 10.8) than the STEMI (69.5 ± 12.5), USA (63.6 ± 15.2), and CSA (58.45 ± 3.5) μmol/L. There was no statistically significant difference in plasma Vitamin C levels in the type of CAD (P = 0.135). A negative correlation is noted between Vitamin C and low-density lipoprotein (LDL) cholesterol (r = −0.32, P = 0.02). Similarly, there is a negative correlation between Vitamin C and TGL (r = −0.28, P = 0.0067), whereas there is a positive correlation between Vitamin C and high-density lipoprotein (HDL) (r = 0.27, P = 0.0025). CONCLUSION: The mean of Vitamin C concentration levels was lower in CAD patients than in healthy individuals. There is a significant negative correlation between Vitamin C and LDL and between Vitamin-C and TGL. A positive correlation was observed between Vitamin-C and HDL. Vitamin C along with HDL was markedly decreased in CAD and may be the cause. Hence, the combination of Vitamin C, LDL, and HDL can be considered prognostic detectors to know the CAD at its early stages.

Correlation of vitamin A levels in umbilical cord blood with neonatal pulmonary diseases

ObjectiveTo study the relationship between umbilical cord blood vitamin A (VA) and neonatal lung diseases and explore the impact of umbilical cord blood VA on neonatal lung diseases. MethodUmbilical vein blood was collected at birth, and its VA content was measured. According to the VA levels in umbilical cord blood, a VA deficiency (VAD) group, a marginal deficiency group and a normal group were created and followed up until 28 days after birth. ResultsThe umbilical cord blood VA level in the neonatal group with lung disease was 0.13 ± 0.05 mg/L, while the result for the VA level in the non-lung disease group was 0.15 ± 0.05 mg/L. The umbilical cord blood VA levels in the neonatal lung disease group were significantly lower than those in the non-lung disease group. The incidence of neonatal pulmonary diseases was highest in the VAD group, and the incidence decreased as the level of VA in umbilical cord blood increased. Umbilical cord blood VAD and premature birth were found to be independent risk factors for neonatal respiratory disease. ConclusionUmbilical cord blood VAD and premature birth are independent risk factors for neonatal pulmonary diseases. The lower the level of VA in umbilical cord blood, the more susceptible infants will be to neonatal respiratory infections in the neonatal period.

Bone Health at Stake: Alarming Prevalence and Predictors of Vitamin D Deficiency in Karachi Children.

Background: Vitamin D insufficiency is a major public health problem for Pakistani children. The purpose of this cross-sectional research was to determine the prevalence and possible correlates of vitamin D insufficiency in young children under the age of five living in Karachi, Pakistan.&#x0D; Methods: We analysed data from 400 children aged 0 to 5 years who had vitamin D testing (serum 25-hydroxyvitamin D) at a diagnostic laboratory in Karachi between January and December 2022. Participants' vitamin D levels were classified as adequate (≥30 ng/ml) or insufficient (&lt;30 ng/ml). Logistic regression with robust standard errors adjusted for clustering in the laboratory environment.&#x0D; Results: The prevalence of vitamin D insufficiency was disturbingly high at 71.8% (287/400), near national prevalence. Age emerged as a major risk factor, with older children being more likely to be deficient (OR: 1.20 per year increase in age, 95% CI: 1.11-1.30, p 0.001). Winter months increased the incidence of deficit compared to summer (OR: 1.80, 95% CI: 1.21-2.89, p = 0.010). Gender had no significant connection with deficit.&#x0D; Conclusions: Our data show that vitamin D insufficiency is a major problem among children in Karachi. To address this public health concern and protect children's health and development, targeted initiatives encouraging safe sun exposure, diversifying diets with vitamin D-rich foods, and investigating fortified staples or regular supplementation are urgently required.

Vitamin D supplementation in patients with Hashimoto’s disease

Introduction : Hashimoto’s thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism in the world. The condition results in damage to the thyroid gland, brought about by the infiltration of lymphocytes. For the majority of individuals with Hashimoto's thyroiditis, a lifelong requirement for levothyroxine substitution is required. The potential contribution of diet and supplements to the management of HT is frequently overlooked. Low vitamin D levels are said to play a significant role in occurrence and severity of autoimmune thyroiditis. Currently, there is a continuing discussion regarding the optimal plasma concentration of 25-hydroxyvitamin D necessary for preventing or treating autoimmune diseases.&#x0D; &#x0D; Aim of the study : The purpose of this literature review is to evaluate the influence of vitamin D supplementation on the course of Hashimoto’s thyroiditis in the light of most up to date research.&#x0D; &#x0D; Materials and methods. This article is a review of publications obtained from the PubMed database, published between 2017-2023, based on the keywords "Hashimoto thyroiditis" "vitamin D" and "autoimmune thyroid disease".&#x0D; &#x0D; Conclusions. The correlation of vitamin D supplementation and Hashimoto’s disease still remains unclear due to conflicting results from numerous studies. Further research is necessary to accurately determine the effect of vitamin D supplementation on Hashimoto’s thyroiditis.

Correlation of Vitamin D Levels with Insulin Resistance in women with PCOS

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder. Since PCOS impacts insulin metabolism and fertility, gene transcription and hormone regulation play a role in its development. The symptoms of PCOS, namely insulin resistance, ovulation, menstrual irregularities, infertility, hyperandrogenism, obesity, and an increase in the risk of cardiovascular disease can be worsen by decrement of 25(OH)D level. This study aimed to determine the phenotype distribution of PCOS; to know the levels of Vitamin D in women with PCOS; to know the picture of insulin resistance in women with PCOS with excess body weight; to analyze the relationship of Vitamin D with insulin resistance in women with PCOS. This study used analytical test with randomization on PCOS patients. The phenotypes of the study samples were phenotype 1 (6 patients = 30%) and phenotype 4 (14 patients = 70%), phenotypes 2 and 3 were not found; There was no relationship between vitamin D and insulin (12.635±4.2721 vs 11.407±4.2721; p= 0,068);There was no relationship between vitamin D and glucose (12.635 ±4.2721 vs 102.75±10.015; p= 0,835); There is a relationship between vitamin D and HOMA IR (12.635± 4.2721 vs 2.880±.4213; p = 0,026; r -0,497) with a negative correlation between the two variables and there is a relationship between BMI with HOMA-IR and vitamin D (p=0,001 and p= 0,003).There is a negative relationship between vitamin D and HOMA-IR, namely a decrease in vitamin D causes an increase in HOMA-IR (insulin resistance).

Correlation of Vitamin D and Core Stabilization Exercise in Low Back Pain: A Narrative Review

Background and Aim: Low back pain is a complex condition that can have various causes and its management involves multiple treatment strategies as per the cause. Use of vitamin D supplementation for LBP has gained attention due to its anti-inflammatory effect and helps to improves bone density whereas core stabilization exercises can help to strengthen core and spinal muscles and stabilize the spine. While there is evidence to suggest that both Vitamin D and core stabilization exercise may have potential benefits for low back pain, the direct correlation between these two factors is not well established. So the aim of this narrative review is to find out the correlation of Vitamin D and Core Stabilization exercise in low back pain. Methods: We searched the articles using PubMed and Google Scholar regarding the correlation of Vitamin D and Core Stabilization exercise in male and female low back pain subjects. Results: Evidence from human studies suggest that Vitamin D and core stabilization exercises both are important for overall functioning of intervertebral disc integrity and its stability. Vitamin D is a vital nutrient that plays a critical role in maintaining bone health, regulating the immune system, and reducing inflammation whereas Core stabilization exercises improves core and spinal muscle strength that stabilizes the spine. Conclusions: Clinicians caring for patients must be aware of this Vitamin D and Core stabilization exercises to find the right treatment course for each patient. In many cases quick Vitamin D supplementation along with Core stabilization exercises may be used to manage LBP. While there is a rightful role for Vitamin D in management of lumbar low back pain, non-pharmacological options like Core stabilization exercises should also be considered as they can play an important role in physiotherapy management of low back pain.

Correlation of Vitamin D status with TSH levels in postmenopausal women; A pilot study

Vitamin D (VitD) insufficiency is present in over half of population worldwide. Over a billion people worldwide are vitamin D deficient or insufficient. It has been long known that VitD insufficiency contributes to development of osteopenia and osteoporosis. We performed a retrospective review of data of 60 patients in postmenopausal age group (45-75 years) during their routine blood investigation for the first time at Government Medical College and Guru Nanak Dev Hospital Amritsar over a period of 3 months (February 2023 to April 2023). Vitamin D levels were insufficient (10-30 ng/mL) in 35% of the patients, deficient (10 ng/mL) in 18.5%, and normal in the remaining 35%. TSH levels were low (less than 0.3 mIU/L) in 5%, high (more than 4.5 mIU/L) in 18.3%, and normal (0.3-4.5 mIU/L) in the remaining 76.6%. 54% (n-11) of individuals with elevated TSH had vitamin D deficiency, while 18% had insufficient vitamin D. 100%(n-3) patients with low TSH had normal vitamin D levels. TSH and vitamin D levels were normal in 22 individuals. High TSH levels was associated with low vitamin D levels, low TSH levels was associated with normal serum vitamin D level. Hence association was linear between TSH and vitamin D in post-menopausal women.

Correlation of vitamin D receptor genotypes, specific IgE levels and other variables with asthma control in children

Introduction Asthma is a common condition affecting millions of children globally. The main goal of this study is to assess factors related to asthma management, particularly atopy level and the impact of genetic variants of the vitamin D receptor (VDR) gene. Methods Asthmatic children were enrolled in an outpatient respiratory clinic. Information on patients’ medication adherence, medical and medication factors, and sociodemographic were gathered. Spirometry FEV1% and FVC% measurements, and the asthma control test were used to evaluate the severity of asthma, and genotyping of the VDR gene and radioallergosorbent test (RAST) were conducted. Regression analyses were conducted to evaluate variables associated with asthma control and spirometry measures. Results A total of 313 participants (67.4% males) were recruited in the current study. The mean age was 9.37 (±3.45) years. The mean score for adherence was 4.26 (±2.52), and only 46% of the participants had controlled asthma. Forward conditional stepwise binary regression showed that low and moderate Inhaled corticosteroids (ICS) dose (OR= 0.42 (95% CI 0.20–0.90), p = 0.026; OR = 0.371 (95% CI 0.2–0.72), p = 0.003, respectively) decreased the odds of being in the controlled asthma group, while higher inhaler score (OR = 2.75 (95% CI 2.17–3.49, p < 0.001)) increased the odds of being in the controlled asthma group. However, results found no association between VDR genotype and asthma control, spirometry values or hospitalization due to asthma. Conclusions The results indicated that many of the asthma patients had poorly controlled asthma. Factors that were associated with poor asthma control included poor inhaler technique.

An investigation into the correlation of vitamin D status and management outcomes in patients with severe COVID-19 at a South African tertiary hospital

BackgroundSevere coronavirus disease 2019 (COVID-19) has a poor prognosis, and biomarkers may predict disease severity. The aim of this study was to assess the effect of baseline vitamin D (VitD) inadequacy on the outcomes of patients with severe COVID-19 admitted to the intensive care unit (ICU) of a tertiary hospital in South Africa. MethodsPatients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited during wave II of the pandemic in Cape Town. Eighty-six patients were included in the study. They were categorized into three groups: VitD deficient, VitD insufficient, and VitD sufficient. The VitD deficient and VitD insufficient groups were combined to form a ‘VitD inadequate’ group. Cox regression analysis was done to assess the association between VitD status and mortality. Factors with P < 0.05 in the adjusted multivariable Cox regression analysis were considered statistically significant. ResultsThe proportion of VitD inadequacy was 64% (55/86); this group had a significantly higher proportion with hypertension (66%; P = 0.012). The Kaplan–Meier curve showed no significant difference in the probability of survival among the COVID-19 patients admitted to the ICU with or without VitD inadequacy. However, patients with elevated serum creatinine were significantly more at risk of dying (adjusted hazard ratio 1.008, 95% confidence interval 1.002–1.030; P = 0.017). ConclusionsThis study found a high prevalence of VitD inadequacy (combined deficiency and insufficiency) in COVID-19 patients admitted to the ICU. This may indicate a possible risk of severe disease. Whilst there was no statistically significant relationship between VitD status and mortality in this cohort, baseline VitD may be an important prognostic biomarker in COVID-19 patients admitted to the ICU, particularly in those with comorbidities that predispose to VitD deficiency.

Association between vitamin D level and blood eosinophil count in healthy population and patients with chronic obstructive pulmonary disease

To investigate the prevalence of vitamin D deficiency and its association with blood eosinophil count in healthy population and patients with chronic obstructive pulmonary disease (COPD). We analyzed the data of a total 6163 healthy individuals undergoing routine physical examination in our hospital between October, 2017 and December, 2021, who were divided according to their serum 25(OH)D level into severe vitamin D deficiency group (< 10 ng/mL), deficiency group (< 20 ng/mL), insufficient group (< 30 ng/mL) and normal group (≥30 ng/mL). We also retrospectively collected the data of 67 COPD patients admitted in our department from April and June, 2021, with 67 healthy individuals undergoing physical examination in the same period as the control group. Routine blood test results, body mass index (BMI) and other parameters were obtained from all the subjects, and logistic regression models were used to investigate the association between 25(OH)D levels and eosinophil count. The overall abnormal rate of 25(OH)D level (< 30 ng/mL) in the healthy individuals was 85.31%, and the rate was significantly higher in women (89.29%) than in men. Serum 25(OH)D levels in June, July, and August were significantly higher than those in December, January, and February. In the healthy individuals, blood eosinophil counts were the lowest in severe 25(OH)D deficiency group, followed by the deficiency group and insufficient group, and were the highest in the normal group (P < 0.05). Multivariable regression analysis showed that an older age, a higher BMI, and elevated vitamin D levels were all risk factors for elevated blood eosinophils in the healthy individuals. The patients with COPD had lower serum 25(OH)D levels than the healthy individuals (19.66±7.87 vs 26.39±9.28 ng/mL) and a significantly higher abnormal rate of serum 25(OH)D (91% vs 71%; P < 0.05). A reduced serum 25(OH)D level was a risk factor for COPD. Blood eosinophils, sex and BMI were not significantly correlated with serum 25(OH)D level in patients with COPD. Vitamin D deficiency is common in both healthy individuals and COPD patients, and the correlations of vitamin D level with sex, BMI and blood eosinophils differ obviously between healthy individuals and COPD patients.

The correlation of vitamin D level with body mass index in women with PCOS.

The aim of this study is to analyze correlation between vitamin D level and BMI in polycystic ovary syndrome (PCOS) women. The study group consisted of 311 patients with PCOS. Patients were categorized according to four phenotypes. All of the women participating in the study had their blood tested in the appropriate phase of the menstrual cycle and after proper preparation for the tests. The ultrasound examination and anthropometric measurements were performed. Vitamin D concentration was assessed in all study subgroups. The majority of patients had vitamin D deficiency or insufficient level. Variables included in the study, such as level of vitamin D, low density lipoprotein (LDL), sex hormone binding globulin (SHBG), testosterone, androstenedione, Anti-Müllerian Hormone (AMH) and BMI were correlated. A negative correlation was observed with the the level of SHBG, vitamin D and AMH. Subsequently, positive correlations were shown with testosterone, LDL and free testosterone level. An analysis of the correlation between BMI and vitamin D concentration showed that in phenotype I of PCOS this correlation was statistically significant and in the remaining PCOS phenotypes the correlation was close to statistical significance. Most PCOS patients have a deficiency or insufficient level of vitamin D. Women with PCOS have shown a significant negative correlation between BMI and SHBG serum level and between BMI and AMH level. A positive correlation exists between BMI and total and free testosterone and LDL. There is a negative correlation between BMI and vitamin D level in PCOS patients and in phenotype I this correlation was statistically significant.

Correlation of Vitamin D and nutritional status in pediatric systemic lupus erythematosus

Correlation of Vitamin D and nutritional status in pediatric systemic lupus erythematosus

Correlation of vitamin D deficiency and anti-mullerian hormone levels in infertile females

Correlation of vitamin D deficiency and anti-mullerian hormone levels in infertile females

Correlation of Vitamin D Level and Bone Mineral Density in Epilepsy Children Who Received Oral Antiepileptic Drug

BACKGROUND: Vitamin D plays an essential role in achieving adequate bone mineralization. Antiepileptic drug (AED) will cause a change in calcium serum levels and bone mineral density (BMD) through increase catabolism of Vitamin D in the liver, as well as having a direct effect on the bone. AIM: The aimed of this study was to know the correlation of Vitamin D [25(OH)D] level and BMD in epilepsy children who received oral AED. METHODS: This cross-sectional study was conducted from May to September 2016. Subjects were collected using consecutive sampling in 1−11-year-old epilepsy children who went to the pediatric Neurology and Endocrinology outpatient clinic at Sanglah Hospital. Age, sex, body weight, body height, type and number of AED used, and duration of treatment were recorded. Measurement of 25(OH)D level and BMD was performed. Pearson test was used to analyze the strength of correlation based on normality test result. RESULTS: Thirty subjects were collected, male (19/63.33%), mean age was 7.22 years, mean treatment duration was 1.71 years. Type of AED was inducer AED (18/60%) and non-inducer AED (12/40%). Mean Vitamin D level was 27.19 ng/mL and mean BMD was 0.78 g/cm2. Partial correlation test of Vitamin D level with BMD after controlling age found r = 0.118 with p = 0.54. CONCLUSION: There was weak correlation between Vitamin D level and BMD in epilepsy children who received oral AED, but the correlation analysis was not sufficient to prove the relationship.

Correlation of vitamin D and bone mineral density in diabetic patients with chronic renal disease: A single institute study

Background: Diabetes metabolic dysregulation directly or indirectly affects almost all the organs of the body, including renal system, bone mass, and its metabolism. Bone composition and metabolism related to minerals start to change with the onset of chronic kidney disease (CKD). Osteoporosis oftenly coexists with CKD mineral and bone disorder, which is the most common metabolic bone disease resulting in fragility fractures. To design a treatment plan and prevent complications in patients of CKD with low bone mineral density (BMD), understanding the pathophysiology of these two bone disorders is necessary. Aims and Objectives: The aim is to study the BMD and vitamin D in diabetic patients suffering from CKD and to compare the BMDs among patients with the chronicity of disease. Materials and Methods: A case–control study was conducted to study the BMD and vitamin D levels among diabetic patients with CKD attending the Medicine and Nephrology Outdoor at M.D.M. Hospital, Jodhpur India. Vitamin D estimation was done by chemiluminescence immunoassay and BMD measured by DEXA scan at lumbar spine L4–L5 for both case and control groups. Results: Incidence of low BMD and low vitamin D levels is very high in patients suffering from CKD, but it is more profound in patients suffering from diabetes. Majority of them were male and more from rural area. Mean age of patients was 50 ± 8.75 years. Overall 63.34% of CKD patients had low vitamin D level, 36.67% had osteopenia, and 36.67% had osteoporosis. Similarly, 51.62% diabetic patients had osteoporosis, 38.7% had osteopenia, and 83.86% had low vitamin D. Conclusion: Correlation of vitamin D deficiency with low BMD was statistically highly significant in patients of diabetes with CKD. Early intervention in diabetes patients to prevent low BMD and vitamin D supplements can decrease the complications of low BMD and low vitamin D.

Povezanost kvaliteta života i nivoa vitamina D kod benigne hiperplazije prostate

Introduction: Epidemiological studies have suggested an association between vitamin D deficiency and benign prostatic hyperplasia (BPH). The prevalence of vitamin D deficiency in the male population with urological symptoms suggests a relationship between BPH and vitamin D. Methods: This paper will present information from relevant professional/scientific sources regarding the correlation of vitamin D levels with symptom intensity and quality of life of patients with BPH, as well as patient education and health care. Topic: The incidence of BPH is increasing with ageto such extent that it is unusual to find a histologically normal prostate in a man over 70 years of age, thus rising a question whether it should be considered an abnormality at all. From the beginning, the disease was classified as "the agony of the aged man" because benign gland enlargement carries a significant risk of morbidity due to urinary flow obstruction. Due to the long course of benign prostate hyperplasia, which significantly affects the quality of life and quality of sleep, the mental pressure in patients increases, resulting from both physical and mental pain. Therefore, the priority is to focus on medical measures which would improve the quality of life of elderly patients with BPH. Conclusion: After reviewing the literature, we came to the conclusion that the level of vitamin D is responsible for the quality of life of patients with benign prostatic hyperplasia. Health care integration emphasizes the integration of existing resources within the overall health policy planning, and professionally trained medical staff provides medical treatment, rehabilitation, home care, psychological counseling and hospital care for elderly patients with chronic diseases and semi-disabled, disabled and oncological patients.