The aims of this study were to analyze 1) the influence of soft skills on the work readiness of students at Mechanical Engineering Vocational High Schools in the city of Palembang; 2) the effect of machining knowledge on the work readiness of students of Mechanical Engineering Vocational High Schools in the city of Palembang; 3) the effect of 5S work culture on the work readiness of students of Mechanical Engineering Vocational High Schools in Palembang city; and 4) the influence of soft skills, machining knowledge, and 5S work culture simultaneously on the work readiness of students of the Mechanical Engineering Vocational High School in the city of Palembang. The research method used is correlational research. The subjects of this research were class XII students of Mechanical Engineering Vocational Schools in Palembang City, recruited using a purposive sampling technique with the provision that students would work after graduating from Vocational High School. Thus, for a population of 360, the total sample was 187 respondents. The technique of collecting data for this research is a questionnaire and multiple-choice tests. Data analysis techniques were performed using correlational statistical analysis and regression analysis. The results of the study were the following: 1) Soft skills have a positive and significant effect on work readiness by 34.56%; 2) Machining knowledge has no effect on job readiness; 3) 5S work culture has a significant and positive effect on work readiness by 15.90%; and 4) Soft skills, machining knowledge, and 5S work culture have a positive and significant effect on work readiness by 53.5%.