Correct Time Research Articles

Multiarmed Bandit Algorithms on Zynq System-on-Chip: Go Frequentist or Bayesian?

Multiarmed Bandit (MAB) algorithms identify the best arm among multiple arms via exploration-exploitation trade-off without prior knowledge of arm statistics. Their usefulness in wireless radio, Internet of Things (IoT), and robotics demand deployment on edge devices, and hence, a mapping on system-on-chip (SoC) is desired. Theoretically, the Bayesian-approach-based Thompson sampling (TS) algorithm offers better performance than the frequentist-approach-based upper confidence bound (UCB) algorithm. However, TS is not synthesizable due to Beta function. We address this problem by approximating it via a pseudorandom number generator (PRNG)-based architecture and efficiently realize the TS algorithm on Zynq SoC. In practice, the type of arms distribution (e.g., Bernoulli, Gaussian) is unknown, and hence, a single algorithm may not be optimal. We propose a reconfigurable and intelligent MAB (RI-MAB) framework. Here, intelligence enables the identification of appropriate MAB algorithms in an unknown environment, and reconfigurability allows on-the-fly switching between algorithms on the SoC. This eliminates the need for parallel implementation of algorithms resulting in huge savings in resources and power consumption. We analyze the functional correctness, area, power, and execution time of the proposed and existing architectures for various arm distributions, word length, and hardware-software codesign approaches. We demonstrate the superiority of the RI-MAB algorithm and its architecture over the TS and UCB algorithms.

Complication rates rise with age and Haller index in minimally invasive correction of pectus excavatum: A high-volume, single-center retrospective cohort study

ObjectivesThe study objectives were to describe the compounded complication rate of minimally invasive repair of pectus excavatum, identify predisposing risk factors, and evaluate the optimal timing of correction. Minimally invasive repair of pectus excavatum is the standard treatment for pectus excavatum and consists of 2 invasive procedures, for example, correction with bar insertion followed by bar removal after 2 to 3 years. MethodsA retrospective cohort study identifying children, adolescents, and adults of both genders corrected for pectus excavatum with minimally invasive repair of pectus excavatum between 2001 and 2022. Information on complications related to bar insertion and removal procedures for each individual patient was compiled into a compounded complication rate. Complication severities were categorized according to the Clavien-Dindo classification. ResultsA total of 2013 patients were corrected by minimally invasive repair of pectus excavatum with a median age (interquartile range) for correction of 16.6 (5) years. Overall compounded complication rate occurred at a frequency of 16.4%, of which 9.3% required invasive reinterventions (Clavien-Dindo classification ≥IIIa). The complication rate related to bar insertion was 2.6-fold higher compared with bar removal (11.8% vs 4.5%, respectively). Multivariable analysis revealed age (adjusted odds ratio, 1.05; P < .001), precorrection Haller Index (adjusted odds ratio, 1.10; P < .033), and early-phase institutional experience (adjusted odds ratio, 1.59; P < .002) as independent predisposing risk factors. The optimal age of correction was 12 years, and the compounded complication rate correlated exponentially with age with a doubling time of 7.2 years. Complications increased 2.2-fold when the Haller index increased to 5 or more units. ConclusionsMinimally invasive repair of pectus excavatum is associated with a high compounded complication rate that increases exponentially with age and high Haller Index. Consequently, we recommend repair during late childhood and early adolescence, and emphasize the importance of informing patients and relatives about the significant risks of adult correction as well as the need of 2 consecutive procedures taking the complication profile into account before planning surgery.

Does the Presence of Asymptomatic Flatfoot Deformity Impact the Clinical and Radiographic Outcomes of the Minimally Invasive Chevron and Akin Bunionectomy?

Flatfoot deformity is believed to play a role in hallux valgus development and recurrence. While symptomatic flatfoot deformity can be treated with separate procedures at the time of hallux valgus correction, the question remains whether the patient undergoing correction of a symptomatic hallux valgus deformity should have their asymptomatic flatfoot concurrently addressed. We aimed to investigate whether the presence of asymptomatic flatfoot influences patient-reported and radiographic outcomes of the minimally invasive chevron and Akin bunionectomy. A total of 104 patients were included in this study. Forty-two asymptomatic patients met the radiographic criteria for flatfoot while 62 had a normal arch. Patient-reported outcomes were evaluated and compared between the two groups using validated PROMIS measures preoperatively and at a minimum one-year postoperatively. Radiographic outcomes including hallux valgus angle (HVA), intermetatarsal angle (IMA), Meary's angle, calcaneal pitch (CP), and talonavicular coverage angle (TNCA) were measured and compared preoperatively and minimum six-months postoperatively. Both groups demonstrated similar preoperative and postoperative PROMIS scores with significant improvements in physical function, pain interference, pain intensity, and global physical health. Preoperatively, HVA was similar between both groups, however the flatfoot group showed a greater IMA, Meary's angle, TNCA, and lower CP. Postoperatively, HVA and IMA were similar between groups, although patients in the flatfoot group retained a significantly greater Meary's angle, TNCA, and lower CP. Both groups showed significant improvements in HVA, IMA, and TNCA. Our study indicates that the minimally invasive chevron and Akin bunionectomy leads to improved clinical and radiographic hallux valgus outcomes without adversely impacting radiographic flatfoot parameters. Therefore, the MIS bunionectomy may be an effective option for hallux valgus correction in patients with mild, asymptomatic flatfoot. Level III, retrospective cohort.

Infant and Young Child Feeding Practice among Mothers in Rural Areas of Gazipur District, Bangladesh

A cross-sectional, descriptive study was conducted among 599 mothers who had at least one child aged 0–23-month to determine infant and young child feeding practice (IYCF) in rural areas of Bangladesh. The study was conducted between November 2019 and March 2020 in rural areas of Gazipur district. A pre-tested semi-structured questionnaire was used to collect data. Out of 599 respondents, the majority (62.93%) were in the 21-30 years age-group. Only 6.67% were illiterate and the rest of the respondents were literate with different levels of education. About one third (33.38%) of the respondents had monthly income between BDT 5001- 15000. 27% of the mothers could not give colostrum to the babies; half of them (50%) mentioned that baby could not suck well, while 43.83% mentioned being advised by the elders (not to give colostrum) and 6.17% mentioned their own illness. Pre-lacteal feeding practice was observed among 27% mothers and common pre-lacteal food was honey (61.25%), sugar water (35.63%) and animal milk (4.32%). Breastfeeding was initiated within the first hour of birth among 73.29% of mothers. 53.26% percent of mothers practice exclusive breastfeeding (EBF). Difficulties faced by mothers for EBF are insufficient secretion of breast milk (46.42%), not having knowledge about EBF (42.51%), and mother’s illness (11.07%). Most of the mothers (81.63%) gave complementary feeding in the correct time (6 months) and predominant complementary food was Khichuri (51.91%); however, most of them (60.77%) gave complementary food ≤3 times in a day. Our data suggests that the practice of IYCF was not optimum among the rural mothers. To improve this condition, it is necessary to motivate mothers through proper health education about the positive impacts of IYCF on child health. CBMJ 2024 January: vol. 13 no. 01 P: 28-34

Effect of Hybridization on the Nutrient Compositions of Two Cultivars of Solanum aethiopicum L. (Solanaceae) Found in Anambra State

The desire for modification of valuable crop species for human nutritional fulfilment and economic growth is essential. Two cultivars of Solanum aethiopicum L. found in Anambra State were hybridized to raise an F1 that might combine the attributes of the parental lines for enhancement in yield and biochemical contents for health nutritional requirements. The emasculation method was adopted, using Solanum aethiopicum var “Anara Adazi as the female parent and transference of functional pollen from Solanum aethiopicum var “Anara” to the stigmas of the emasculated plant at the correct time. Nutrient analysis of the fruits of F1 and the parental plants was carried out using the standard method. Analysis of variance was used for data analysis. Results revealed that parental plants and F1 contained investigated nutrients in varied amounts. Ash content, crude fiber and protein were higher in the fruit of F1 hybrid (10.90±0.11, 21.50±1.51, and 5.01±0.24) respectively when compared to the fruits of the parental plants. Data obtained indicated that when two Solanum aethiopicum plants of different but closely related cultivars are crossbred, a new hybrid that possesses enhanced characteristics of the two parent plants are produced. Results of the nutrients analysis demonstrated that hybridization could significantly increase food nutrients in eggplant (S. aethiopicum).

A plant's perception of growth-promoting bacteria and their metabolites.

Many recent studies have highlighted the importance of plant growth-promoting (rhizo)bacteria (PGPR) in supporting plant's development, particularly under biotic and abiotic stress. Most focus on the plant growth-promoting traits of selected strains and the latter's effect on plant biomass, root architecture, leaf area, and specific metabolite accumulation. Regarding energy balance, plant growth is the outcome of an input (photosynthesis) and several outputs (i.e., respiration, exudation, shedding, and herbivory), frequently neglected in classical studies on PGPR-plant interaction. Here, we discuss the primary evidence underlying the modifications triggered by PGPR and their metabolites on the plant ecophysiology. We propose to detect PGPR-induced variations in the photosynthetic activity using leaf gas exchange and recommend setting up the correct timing for monitoring plant responses according to the specific objectives of the experiment. This research identifies the challenges and tries to provide future directions to scientists working on PGPR-plant interactions to exploit the potential of microorganisms' application in improving plant value.

Is the Corrected Carotid Flow Time a Clinically Acceptable Surrogate Hemodynamic Parameter for the Left Ventricular Ejection Time?

ObjectiveThe corrected left ventricular ejection time (cLVET) comprises the phase from aortic valve opening to aortic valve closure corrected for heart rate. As a surrogate measure for cLVET, the corrected carotid flow time (ccFT) has been proposed in previous research. The aim of this study was to assess the clinical agreement between cLVET and ccFT in a dynamic clinical setting. MethodsTwenty-five patients with severe aortic valve stenosis (AS) were selected for transcatheter aortic valve replacement (TAVR). The cLVET and ccFT were derived from the left ventricular outflow tract (LVOT) and the common carotid artery (CCA) respectively, using pulsed wave Doppler ultrasound. Bazett's (B) and Wodey's (W) equation were used to calculate cLVET and ccFT. Measurements were performed directly before (T1), and after (T2) TAVR. Correlation, Bland-Altman, and concordance analyses were performed. ResultsThe cLVET decreased from T1 to T2 (p<0.001), with a relative reduction of 11% (B) and 9% (W). The ccFT decreased (p<0.001) with a relative reduction of 12% (B) and 10% (W). The correlation between cLVET and ccFT was strong for B (ρ=0.74, p<0.001), and W (ρ=0.81, p<0.001). The bias was -39 ms (B) and -37 ms (W), and the upper and lower level of agreement were 19 ms and -98 ms (B) and 5 ms and -78 ms (W), respectively. The trending ability between cLVET and ccFT was good (concordance 96%) for both B and W. ConclusionIn TAVR patients, the clinical agreement between cLVET and ccFT was acceptable, indicating that ccFT could serve as a surrogate measure for cLVET.

An in silico study of the effects of cardiovascular aging on carotid flow waveforms and indexes in a virtual population.

Cardiovascular aging is strongly associated with increased risk of cardiovascular disease and mortality. Moreover, health and lifestyle factors may accelerate age-induced alterations, such as increased arterial stiffness and wall dilation, beyond chronological age, making the clinical assessment of cardiovascular aging an important prompt for preventative action. Carotid flow waveforms contain information about age-dependent cardiovascular properties, and their ease of measurement via noninvasive Doppler ultrasound (US) makes their analysis a promising tool for the routine assessment of cardiovascular aging. In this work, the impact of different aging processes on carotid waveform morphology and derived indexes is studied in silico, with the aim of establishing the clinical potential of a carotid US-based assessment of cardiovascular aging. One-dimensional (1-D) hemodynamic modeling was employed to generate an age-specific virtual population (VP) of N = 5,160 realistic carotid hemodynamic waveforms. The resulting VP was statistically validated against in vivo aging trends in waveforms and indexes from the literature, and simulated waveforms were studied in relation to age and underlying cardiovascular parameters. In our study, the carotid flow augmentation index (FAI) significantly increased with age (with a median increase of 50% from the youngest to the oldest age group) and was strongly correlated to local arterial stiffening (r = 0.94). The carotid pulsatility index (PI), which showed less pronounced age variation, was inversely correlated with the reflection coefficient at the carotid branching (r = -0.88) and directly correlated with carotid net forward wave energy (r = 0.90), corroborating previous literature where it was linked to increased risk of cerebrovascular damage in the elderly. There was a high correlation between corrected carotid flow time (ccFT) and cardiac output (CO) (r = 0.99), which was not affected by vascular age. This study highlights the potential of carotid waveforms as a valuable tool for the assessment of cardiovascular aging.NEW & NOTEWORTHY An age-specific virtual population was generated based on a 1-D model of the arterial circulation, including newly defined literature-based specific age variations in carotid vessel properties. Simulated carotid flow/velocity waveforms, indexes, and age trends were statistically validated against in vivo data from the literature. A comprehensive study of the impact of aging on carotid flow waveform morphology was performed, and the mechanisms influencing different carotid indexes were elucidated. Notably, flow augmentation index (FAI) was found to be a strong indicator of local carotid stiffness.

Adapting bandit algorithms for settings with sequentially available arms

Many real-world applications involve a sequential decision-making process where the options presented simultaneously. However, other applications, such as, Internet campaign management and environmental monitoring, the available options are presented sequentially to the decision-maker who, at each time, is asked to select the proposed option or not. This scenario is defined as the Sequential Pull/No-Pull setting The present study aims at developing a meta-algorithm, namely Sequential Pull/No-pull for MAB (Seq), to adapt any classical MAB (Multi-Armed Bandit) policy for this setting both in the case of regret minimization (RM) and best-arm identification (BAI) problems. This is achieved by exploting the sequential nature of the these settings allowing to select multiple arms and gather more information compared to classical policies. The proposed Seq meta-algorithm provides the same theoretical guarantees as the MAB policy employed, but was shown to provide improved performance compared to several classical MAB policies in RM and BAI problems employing real-world data. In particular, in the RM scenario regarding Internet advertising optimization, Seq-adapted algorithm resulted, on average, in ≈10% lower regret during the whole time horizon than using classical MAB policies. When tested in a BAI problem involving the identification of the time of the day characterized by the highest concentration of pollutants in a water monitoring scenario, Seq identified the correct time in less than 4 days and 28 measurement.

A self-training end-to-end mask optimization framework based on semantic segmentation network

As the process advances and the minimum linewidth gets closer to the physical limit, inverse lithography technique (ILT) is widely used for optical proximity correction (OPC). However, the computational overhead of the ILT method is high, and the printability of the mask is poor. In response to these limitations, we proposed ERFNet-ILT, a self-training method for an end-to-end learning framework for generating optimized masks directly from layout patterns, which introduces a feature fusion module at the end of the encoder and uses dilated convolution to expand the receptive field, thereby extracting layout pattern information such as edges, vertices and corners of the layout pattern from the feature map. The framework has shorter model building time and higher mask printability. Compared with the state-of-the-art methods, experimental quantitative results show that the proposed framework achieves 2.5 % squared L2 error and 7.9 % process variation band reduction within a comparable mask correction time.

Weaning, food allergens and potential risk factors for delayed introduction: a cross-sectional study

Much evidence supports that the early introduction of allergenic foods in weaning is useful to prevent food allergies later in life. Real life is often different, with factors related to mothers and infants. Our study aimed to deepen the timing of introducing the foods responsible for most allergic reactions during the weaning and why parents delay their introduction. 110 mothers participated in the study, compiling a questionnaire. Exclusive breastfeeding was associated with a delayed introduction of allergenic foods at 4 months (r = 0.433, p < 0.01) and 1 year (r = 0.486, p < 0.01). Large-for-gestational age at birth was inversely associated with a delayed introduction of allergenic foods (r=-0.204, p < 0.05). This study demonstrates that introducing many allergens is delayed during the weaning. Parents with infants fed with exclusive breastfeeding could need more information about the correct time of introduction of potential allergens in the weaning.

Stability of Ocular Alignment After Teprotumumab Therapy in a Cohort of Patients With Thyroid Eye Disease and Baseline Diplopia.

Teprotumumab is a monoclonal antibody that is effective in treating patients with thyroid eye disease (TED) and has been shown to produce subjective improvements in diplopia in this group. The aims of this study were to evaluate the rate and timing of recurrence/worsening of diplopia after teprotumumab treatment in a cohort of patients with TED presenting with diplopia at baseline. A retrospective chart review of 15 patients with diplopia secondary to TED, treated with teprotumumab, was conducted in a single-center academic institution. The primary outcome was the rate of recurrence/worsening of diplopia after completing teprotumumab. Secondary outcomes include the time to recurrence/worsening of diplopia and clinical activity scores (CAS) to correlate with changes in ocular alignment. Fifteen patients met the inclusion criteria for this study, and 7 of these had recurrence of diplopia (46.7%). Two patients had worsening of CAS to ≥4, 6 had worsening of CAS to 3, and the other 7 had CAS ≤2 during the follow-up period. The mean follow-up period was 20.4 months (SD 7.2) after completing teprotumumab. The mean time to diplopia recurrence/worsening was 8.8 months (range 6.7-12.2, SD 1.8). Patients with TED and baseline diplopia have a substantial rate of recurrence/worsening of diplopia after teprotumumab therapy, suggesting that they may not have stable ocular alignment immediately after treatment. Strabismus surgeons may need to weigh the significant risk of disease relapse when planning optimum timing for surgical correction.

Increasing compliance rate of administration timing of antimicrobial prophylaxis in elective surgery within four months at a 100-bed capacity hospital

Objective: This quality improvement project aimed to work towards achieving more than 80% compliance with correct preoperative antibiotic administration timing within four months. Methods: Data obtained from the operating room (OR) during a four-month period from February to September, 2023 were retrospectively analyzed. All patients who underwent elective surgery were included in the study. Therefore, the recovery room (RR) was used as a holding area to ensure that the patients received antibiotic prophylaxis at the appropriate time. The ward nurse endorsed the patients along with the antibiotic prophylaxis, which was then administered by the OR nurse under the supervision and monitoring of an anesthesia physician. A clear procedure guideline was written in the form of a flowchart to be followed pre-surgery. Results: There was an increase in the mean correctly timed administration of preoperative antimicrobial prophylaxis from 59.6% at baseline to 81.45% during the post-intervention period (P = 0.013). Conclusion: Using the RR as a holding area helped us to achieve more than 80% compliance with correct preoperative antimicrobial prophylaxis timing. It also brought us closer to achieve 100% on-time compliance with preoperative antibiotic administration.

Orchid fruit and root movement analyzed using 2D photographs and a bioinformatics pipeline for processing sequential 3D scans.

Most studies of the movement of orchid fruits and roots during plant development have focused on morphological observations; however, further genetic analysis is required to understand the molecular mechanisms underlying this phenomenon. A precise tool is required to observe these movements and harvest tissue at the correct position and time for transcriptomics research. We utilized three-dimensional (3D) micro-computed tomography (CT) scans to capture the movement of fast-growing Erycina pusilla roots, and built an integrated bioinformatics pipeline to process 3D images into 3D time-lapse videos. To record the movement of slowly developing E. pusilla and Phalaenopsis equestris fruits, two-dimensional (2D) photographs were used. The E. pusilla roots twisted and resupinated multiple times from early development. The first period occurred in the early developmental stage (77-84 days after germination [DAG]) and the subsequent period occurred later in development (140-154 DAG). While E. pusilla fruits twisted 45° from 56-63 days after pollination (DAP), the fruits of P. equestris only began to resupinate a week before dehiscence (133 DAP) and ended a week after dehiscence (161 DAP). Our methods revealed that each orchid root and fruit had an independent direction and degree of torsion from the initial to the final position. Our innovative approaches produced detailed spatial and temporal information on the resupination of roots and fruits during orchid development.

Design and Evaluation of Haptic Guidance in Ultrasound-Based Needle-Insertion Procedures.

This article presents two haptic guidance systems designed to help a clinician keep an ultrasound probe steady when completing ultrasound-assisted needle insertion tasks. These procedures demand spatial reasoning and hand-eye coordination because the clinician must align a needle with the ultrasound probe and extrapolate the needle trajectory using only a 2D ultrasound image. Past research has shown that visual guidance helps the clinician align the needle, but does not help the clinician keep the ultrasound probe steady, sometimes resulting in a failed procedure. We created two separate haptic guidance systems to provide feedback if the user tilts the ultrasound probe away from the desired setpoint using (1) vibrotactile stimulation provided by a voice coil motor or (2) distributed tactile pressure provided by a pneumatic mechanism. Both systems significantly reduced probe deviation and correction time to errors during a needle insertion task. We also tested the two feedback systems in a more clinically relevant setup and showed that the perceptibility of the feedback was not affected by the addition of a sterile bag placed over the actuators and gloves worn by the user. These studies show that both types of haptic feedback are promising for helping the user keep the ultrasound probe steady during ultrasound-assisted needle insertion tasks. Survey results indicated that users preferred the pneumatic system over the vibrotactile system. Haptic feedback may improve user performance in ultrasound-based needle-insertion procedures and shows promise in training for needle-insertion tasks and other medical procedures where guidance is required.

Time calibration and synchronization of the scintillation light detection system in ICARUS-T600

The ICARUS-T600 Liquid Argon (LAr) Time Projection Chamber (TPC) is presently taking data in the Short Baseline Neutrino (SBN) program at Fermilab (U.S.A.) to search for a possible LSND-like sterile neutrino signal at Δm 2 ≈ 1 eV2 with the Booster Neutrino Beam (BNB). A light detection system, based on 360 large area Photo-Multiplier Tubes (PMTs), has been realized for ICARUS-T600 to detect VUV photons produced by the passage of ionizing particles in LAr. This system is fundamental for the TPC operation, providing an efficient trigger and contributing to the 3D reconstruction of events. Moreover, since the detector is exposed to a huge flux of cosmic rays due to its shallow depths installation, the light detection system allows for the time reconstruction of events, contributing to the identification and to the selection of genuine neutrino interactions. The correct time reconstruction of events requires the precise knowledge of the delay of each PMT channel and a good synchronization of recording electronics, this last based on fast sampling digitizers. To achieve a time resolution better than 1 ns, we perform three consecutive timing corrections deployed at different stages of the optical data flow. Results demonstrate the capability of the ICARUS-T600 light detection system to allow a precise reconstruction of the temporal evolution of each event occurring in the detector and the association of neutrino events with the bunched structure of BNB.

Line-field confocal optical coherence tomography of eyelid margin growths: A case series.

The clinical differential diagnosis of lesions arising on the eyelid margin may be challenging and an unneeded surgical approach may have serious functional and aesthetic consequences. Nonetheless, early recognition and treatment of malignant tumors of the eyelid margin is mandatory. Line-field confocal optical coherence tomography (LC-OCT) is a novel tool for the in vivo, real-time skin imaging. The aim of the study was to identify and analyze the LC-OCT features of a series of eyelid margin growths and to correlate these features with the histopathological findings. Patients with eyelid margin growths who were scheduled for lesion excision underwent LC-OCT examination. Inclusion criteria were a challenging clinical aspect of the lesions and a clinical history of recent onset (up to 12 months). In all cases, the histopathological examination of the excised lesions was performed for the final diagnosis. A total of 31 lesions located on the upper (13 cases) or lower (18 cases) eyelid margin from 28 consecutive patients (male=15, female=13; mean age: 64.7 years, range: 44-87 years) were evaluated and excised. The histopathologic diagnoses were nodular basal cell carcinoma (BCC) (nine cases), squamous cell carcinoma (SCC) (three cases), compound nevus (four cases), dermal nevus (two cases), seborrheic keratosis (four cases), pyogenic granuloma (one case), trichilemmal cyst (three cases), and hidrocystoma (five cases). LC-OCT allowed the in vivo recognition of the main microscopic features of the examined lesions. LC-OCT represents a promising tool for the evaluation of eyelid margin lesions. Advantages of non-invasive diagnosis particularly relevant in such a sensitive region include a more correct planning of the treatment and, in case of surgery, the most appropriate surgical approach and, importantly, a correct timing of intervention.

Effect of Sodium Chloride Concentration on Cooking Time Calculation and Sensory Evaluation of Fish Sausage

This research was conducted to evaluate the effect of the addition of sodium chloride (NaCl) at different concentrations (0–3.0%) on the theoretical and real cooking time and sensory evaluation of the fish sausage. The fish sausage was prepared using 2:1.2:1 minced fish, sago starch, and water with added NaCl at a concentration of 1.5% to the formulation, and the sausage was cooked for 180 seconds (3 min) at 180°C to accomplish both the correct cooking time and sensory evaluation properties. Theoretical and real cooking time methods were calculated using a pre-calibrated thermocouple to reach the target core temperature of 75oC at the centre of the sausage. The optimum NaCl concentration and cooking time were identified from the cooking methods and sensory evaluation. The results revealed that increasing the addition of NaCl to the sausage formulations significantly increased the core temperature of the sausage during cooking. There was a reverse relationship between the added percentage of sodium chloride and the calculated cooking time; as the addition of sodium chloride increased, a shorter cooking time was obtained until we reached the target core temperature of 75oC. The predicted cooking time was 195.171 seconds, and the real cooking time was 180 seconds.

Left ventricular speckle tracking echocardiography in predicting of fibrosis in children after correction of anomalous origin of the left coronary artery from the pulmonary artery in the late postoperative period

The aim of our study is a comprehensive echo assessment of the LV function using the speckle tracking technique in children with abnormal origin of the left coronary artery from the pulmonary artery in the late postoperative period аnd a comparative analysis segmental longitudinal and circumferential LV deformation with cardiac magnetic resonance late enhancement of myocardium. Methods. The search is a prospective observational study. We examined and analyzed 25 children with AOLCA from PA in late postoperative period. Obtained morphofunctional LV and RV echo parameters were compared with LV ejection fraction and dimensions, the grade of mitral insufficiency and age at the time of operation. CMR was performed in 15 patients (60%; n = 15/25) using Avanto 1.5T. The average age of children at the time of the study was 8.8 ± 3.5 years.Results. 1) Reduce of LV segmental longitudinal deformation is unique in each patient’s case. The largest number of segments with reduced longitudinal deformation was detected in the 2d (anteroseptal basal); in 4th (inferior basal); 5th (inferolateral basal), 6th (anterolateral basal), 11th (inferolateral middle) segments of LV myocardium. 2) There is no relationship between LV global longitudinal and circumferential deformation in children in the late postoperative period after correction of AOLCA from PA and initial LV morphological and functional echo data (at the time of defect correction). 3) Segmental LV longitudinal deformation Area Under the Curve is 0.64 (0.56–0.72) with “cut-off” 9.5% with a sensitivity of 92% and a specificity of 85% and circumferential segmental deformity Area Under the Curve is 0.48 (0.40–0.56) in the predicting of fibrosis according to CMR data.

Model E-Asesmen Berbasis Aplikasi pada Sekolah Menengah Atas di Era Digital: Systematic Literature Review

Education in today's digital era is required to be adaptive and accommodating to the development of information and communication technology. The education process is carried out dynamically according to civilisation. One of the significant changes that occur today is the transfer of assessment practices from conventional-traditional to electronic assessment practices which are then called E-Assessment. This electronic assessment is developed with various variants, starting from web-based, applications, and so on. Internet access has been massive and widespread throughout the region, making most people assume that E-assessment is relevant to be applied in today's learning world. This research is a type of qualitative research with a systematic literature review (SLR) approach. Data sources come from research journal articles and books that are in accordance with the theme of the discussion. The data analysis technique uses content analysis. The findings or results of the study are that E-assessment is relevant to be implemented in senior high schools because of their skills in accessing and operating various applications. The digital literacy possessed by today's millennial generation greatly supports the E-assessment process in schools. Application-based E-Assessment can be developed with several applications, such as kahoot, quizizz, moodle, and others. The application of E-assessment has several advantages, such as saving money, reducing time for correction, feedback and evaluation results can be received in real time, and improving the digital skills of educators and students