Left ventricular speckle tracking echocardiography in predicting of fibrosis in children after correction of anomalous origin of the left coronary artery from the pulmonary artery in the late postoperative period

Abstract

The aim of our study is a comprehensive echo assessment of the LV function using the speckle tracking technique in children with abnormal origin of the left coronary artery from the pulmonary artery in the late postoperative period аnd a comparative analysis segmental longitudinal and circumferential LV deformation with cardiac magnetic resonance late enhancement of myocardium. Methods. The search is a prospective observational study. We examined and analyzed 25 children with AOLCA from PA in late postoperative period. Obtained morphofunctional LV and RV echo parameters were compared with LV ejection fraction and dimensions, the grade of mitral insufficiency and age at the time of operation. CMR was performed in 15 patients (60%; n = 15/25) using Avanto 1.5T. The average age of children at the time of the study was 8.8 ± 3.5 years.Results. 1) Reduce of LV segmental longitudinal deformation is unique in each patient’s case. The largest number of segments with reduced longitudinal deformation was detected in the 2d (anteroseptal basal); in 4th (inferior basal); 5th (inferolateral basal), 6th (anterolateral basal), 11th (inferolateral middle) segments of LV myocardium. 2) There is no relationship between LV global longitudinal and circumferential deformation in children in the late postoperative period after correction of AOLCA from PA and initial LV morphological and functional echo data (at the time of defect correction). 3) Segmental LV longitudinal deformation Area Under the Curve is 0.64 (0.56–0.72) with “cut-off” 9.5% with a sensitivity of 92% and a specificity of 85% and circumferential segmental deformity Area Under the Curve is 0.48 (0.40–0.56) in the predicting of fibrosis according to CMR data.