Correct Choice Responses Research Articles

Prior experience modifies acquisition trajectories via response-strategy sampling.

Few studies have considered how signal detection parameters evolve during acquisition periods. We addressed this gap by training mice with differential prior experience in a conditional discrimination, auditory signal detection task. Naïve mice, mice given separate experience with each of the later correct choice options (Correct Choice Response Transfer, CCRT), and mice experienced in conditional discriminations (Conditional Discrimination Transfer, CDT) were trained to detect the presence or absence of a tone in white noise. We analyzed data assuming a two-period model of acquisition: a pre-solution and solution period (Heinemann EG (1983) in The Presolution period and the detection of statistical associations. In: Quantitative analyses of behavior: discrimination processes, vol. 4, pp. 21-36). Ballinger. http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.536.1978andrep=rep1andtype=pdf ). The pre-solution period was characterized by a selective sampling of biased response strategies until adoption of a conditional responding strategy in the solution period. Correspondingly, discriminability remained low until the solution period; criterion took excursions reflecting response-strategy sampling. Prior experience affected the length and composition of the pre-solution period. Whereas CCRT and CDT mice had shorter pre-solution periods than naïve mice, CDT and Naïve mice developed substantial criterion biases and acquired asymptotic discriminability faster than CCRT mice. To explain these data, we propose a learning model in which mice selectively sample and test different response-strategies and corresponding task structures until they exit the pre-solution period. Upon exit, mice adopt the conditional responding strategy and task structure, with action values updated via inference and generalization from the other task structures. Simulations of representative mouse data illustrate the viability of this model.

Taking pigeons to heart: Birds proficiently diagnose human cardiac disease.

In two experiments, we trained pigeons (Columba livia) to sort visual images (obtained by clinical myocardial perfusion imaging techniques) depicting different degrees of human cardiac disfunction (myocardial hypoperfusion of the left ventricle) into normal and abnormal categories by providing food reward only after correct choice responses. Pigeons proved to be highly proficient at categorizing pseudo-colorized images as well as highly sensitive to the degree of the perfusion deficit depicted in the abnormal images. In later testing, the pigeons completely transferred discriminative responding to novel stimuli, demonstrating that they had fully learned the normal and abnormal categories. Yet, these pigeons failed to transfer discriminative responding to grayscale images containing no color information. We therefore trained a second cohort of pigeons to categorize grayscale image sets from the outset. These birds required substantially more training to achieve similar levels of performance. Yet, they too completely transferred discriminative responding to novel stimuli by relying on both global and local disparities in brightness between the normal and abnormal images. These results confirm that pseudo-colorization can enhance pigeons' categorization of human cardiac images, a result also found with human observers. Overall, our findings further document the potential of the pigeon as a useful aide in studies of medical image perception.

The Differential Outcomes Procedure Enhances Adherence to Treatment: A Simulated Study with Healthy Adults.

Memory for medical recommendations is a prerequisite for good adherence to treatment, and therefore to ameliorate the negative effects of the disease, a problem that mainly affects people with memory deficits. We conducted a simulated study to test the utility of a procedure (the differential outcomes procedure, DOP) that may improve adherence to treatment by increasing the patient’s learning and retention of medical recommendations regarding medication. The DOP requires the structure of a conditional discriminative learning task in which correct choice responses to specific stimulus–stimulus associations are reinforced with a particular reinforcer or outcome. In two experiments, participants had to learn and retain in their memory the pills that were associated with particular disorders. To assess whether the DOP improved long-term retention of the learned disorder/pill associations, participants were asked to perform two recognition memory tests, 1 h and 1 week after completing the learning phase. The results showed that compared with the standard non-differential outcomes procedure, the DOP produced better learning and long-term retention of the previously learned associations. These findings suggest that the DOP can be used as a useful complementary technique in intervention programs targeted at increasing adherence to clinical recommendations.

Aprendizaje de adultos mayores con deterioro cognitivo asociado a la edad mediante consecuencias diferenciales

Este experimento tuvo como objetivo estudiar el ECD (efecto de consecuencias diferenciales) en el aprendizaje de elección condicional de adultos mayores con deterioro cognitivo asociado a la edad, comparado con el de adultos jóvenes sin problemas de memoria. Los 16 participantes (hombres y mujeres de entre 60 y 74 años y 28 y 42 años, respectivamente) aprendían una tarea donde la presentación de un estímulo era seguida después de 2, 4, 8 y 16 s. de demora por dos alternativas de elección; los participantes tenían que elegir una de las alternativas y si elegían correctamente eran reforzados. En el grupo de consecuencias diferenciales (CD) había una consecuencia específica para cada alternativa correcta de elección; en el grupo de consecuencias comunes (ND) en cada alternativa de elección correcta, se presentó cada consecuencia la mitad de las veces. Los resultados mostraron que los participantes del grupo de adultos jóvenes de CD no mostraron una mayor precisión en el aprendizaje de la tarea, a pesar del tiempo de demora. Tampoco mostraron un mayor número de aciertos que los participantes del grupo de adultos jóvenes de ND. Los participantes adultos mayores del grupo CD, en general, presentaron un mejor aprendizaje de la tarea de manera similar al grupo de adultos jóvenes CD. Estos resultados son coherentes con la literatura del ECD y son similares a los observados por Savage y et al. (1999) en ratas viejas y jóvenes, y demuestran que el ECD mejora el aprendizaje de organismos con problemas de memoria asociados a la edad.

Aprendizaje de adultos mayores con deterioro cognitivo asociado a la edad mediante consecuencias diferenciales

Este experimento tuvo como objetivo estudiar el ECD (efecto de consecuencias diferenciales) en el aprendizaje de elección condicional de adultos mayores con deterioro cognitivo asociado a la edad, comparado con el de adultos jóvenes sin problemas de memoria. Los 16 participantes (hombres y mujeres de entre 60 y 74 años y 28 y 42 años, respectivamente) aprendían una tarea donde la presentación de un estímulo era seguida después de 2, 4, 8 y 16 s. de demora por dos alternativas de elección; los participantes tenían que elegir una de las alternativas y si elegían correctamente eran reforzados. En el grupo de consecuencias diferenciales (CD) había una consecuencia específica para cada alternativa correcta de elección; en el grupo de consecuencias comunes (ND) en cada alternativa de elección correcta, se presentó cada consecuencia la mitad de las veces. Los resultados mostraron que los participantes del grupo de adultos jóvenes de CD no mostraron una mayor precisión en el aprendizaje de la tarea, a pesar del tiempo de demora. Tampoco mostraron un mayor número de aciertos que los participantes del grupo de adultos jóvenes de ND. Los participantes adultos mayores del grupo CD, en general, presentaron un mejor aprendizaje de la tarea de manera similar al grupo de adultos jóvenes CD. Estos resultados son coherentes con la literatura del ECD y son similares a los observados por Savage y et al. (1999) en ratas viejas y jóvenes, y demuestran que el ECD mejora el aprendizaje de organismos con problemas de memoria asociados a la edad.

A critical experimental study of the classical tactile threshold theory

BackgroundThe tactile sense is being used in a variety of applications involving tactile human-machine interfaces. In a significant number of publications the classical threshold concept plays a central role in modelling and explaining psychophysical experimental results such as in stochastic resonance (SR) phenomena. In SR, noise enhances detection of sub-threshold stimuli and the phenomenon is explained stating that the required amplitude to exceed the sensory threshold barrier can be reached by adding noise to a sub-threshold stimulus. We designed an experiment to test the validity of the classical vibrotactile threshold. Using a second choice experiment, we show that individuals can order sensorial events below the level known as the classical threshold. If the observer's sensorial system is not activated by stimuli below the threshold, then a second choice could not be above the chance level. Nevertheless, our experimental results are above that chance level contradicting the definition of the classical tactile threshold.ResultsWe performed a three alternative forced choice detection experiment on 6 subjects asking them first and second choices. In each trial, only one of the intervals contained a stimulus and the others contained only noise. According to the classical threshold assumptions, a correct second choice response corresponds to a guess attempt with a statistical frequency of 50%. Results show an average of 67.35% (STD = 1.41%) for the second choice response that is not explained by the classical threshold definition. Additionally, for low stimulus amplitudes, second choice correct detection is above chance level for any detectability level.ConclusionsUsing a second choice experiment, we show that individuals can order sensorial events below the level known as a classical threshold. If the observer's sensorial system is not activated by stimuli below the threshold, then a second choice could not be above the chance level. Nevertheless, our experimental results are above that chance level. Therefore, if detection exists below the classical threshold level, then the model to explain the SR phenomenon or any other tactile perception phenomena based on the psychophysical classical threshold is not valid. We conclude that a more suitable model of the tactile sensory system is needed.

A new behavioral test for assessment of drug effects on attentional performance and its validity in cynomolgus monkeys

The assessment of drug effects on attention is important in non-clinical pharmacology, for both evaluation of safety and therapeutic efficacy of medicinal products. In the present study, we have developed a two-lever choice behavioral test to assess drug effects on attentional performance in monkeys. In each trial of this experiment, one of two lamps in front of a monkey was randomly illuminated for a brief period of time and the monkey was required to press a lever beneath the lamp 30 times to obtain a food reward. The percentage of correct responses, response latency of correct choice responses and response speed were measured. Using this test, we examined the effects of three sedative drugs, diazepam (0.25, 1 and 4 mg/kg, i.g.), ethanol (0.5, 1 and 2 g/kg, i.g.), and pentobarbital (0.25, 1 and 4 mg/kg, i.v.). Diazepam and pentobarbital lengthened response latency without significantly affecting the percentage of correct responses, response and response speed, suggesting selective disruptive effects on attentional performance. In contrast, ethanol at the high dose tested caused deterioration in all three measurements, which is thought to reflect a general sedative effect including motor impairment as reflected by lengthening response speed. It is suggested that the present behavioral test method could detect drug effects on attentional performance in monkeys and could be a useful tool for safety assessment in drug development.

Rats' Knowledge of Incorrect Responses in a Matching-to-Sample Task

The idea that rats possess some knowledge about having been incorrect when having previously made an incorrect response is proposed. A matching-to-sample task with a second choice was used to assess the hypothesis. Only if the correct lever was chosen on the second choice was the animal rewarded. Further, the second choice was offered whether the animal was initially correct or incorrect in its first choice, preventing it from "knowing" if it had been correct in its initial decision. If rats possessed some knowledge whether they had been correct or not, then the number of correct second choice responses after an incorrect first one should have been greater than chance. The current experiment provided some evidence that the rats did "know" when its choices were incorrect.

The effect of reinforcer delays on the form of the forgetting function.

Pigeons were trained in a matching-to-sample procedure with retention intervals of 0, 2, 4, 6, and 8 s mixed within each session. In different conditions, reinforcement was delayed by 0, 1, 2, 4, 6, or 8 s from correct choice responses. Discriminability decreased with increasing retention-interval duration and with increasing reinforcer delay. Exponential forgetting functions were fitted to discriminability measures plotted as a function of retention interval. Initial discriminability (intercept of the fitted functions) decreased with increasing reinforcer delay. Rate of forgetting (slope of the fitted functions) increased with reinforcer delay, suggesting an interaction between the effects of reinforcer delay and retention interval. The data were well described by multiplying an exponential function describing the effects of retention interval by a hyperbolic function describing the effect of reinforcer delay. This description included an interaction term that allowed for a greater effect of reinforcer delay at longer retention intervals.

Stimulant medication improves recognition memory in children diagnosed with attention-deficit/hyperactivity disorder.

The effect of stimulant medication on recognition memory was examined in 18 children with attention-deficit/hyperactivity disorder (ADHD). Recognition memory was assessed using a delayed matching-to-sample task at 6 delays ranging from 1 to 32 s. Each child was tested on 2 separate occasions, once 60 to 90 min after taking stimulant medication and the other at least 18 hr after taking medication. Children performed significantly better on medication than off. Stimulant administration significantly increased accuracy and the number of nickel reinforcers earned. Decreases in observing response latency and correct choice response latency occurred after taking stimulant medication. The results indicate that stimulant medication improved recognition memory for children with ADHD.

Correspondence as conditional stimulus control: insights from experiments with pigeons.

Correspondence between saying and doing, typically studied in young children and individuals with developmental disabilities, was examined as an instance of conditional stimulus control. In Experiment 1, 3 pigeons were exposed to a two-component repeated-trials procedure. In the first-sample or say-component, two response keys transilluminated by different colored lights were presented and the pigeon pecked one of the keys. After 1 s of darkness in the chamber, the second-choice or do-component was presented, in which the two keys again were transilluminated, one by the color selected in the first component and the second by another color. Selecting the color that matched that selected in the say component resulted in access to food. Selecting the other color produced a blackout of the chamber. After an intertrial interval (ITI), the next say component was programmed, and the procedure was repeated. Correspondence remained at chance levels through several manipulations of ITI duration and sample response requirement. When a correction procedure was added such that only the originally selected sample stimulus was re-presented until a correct choice response occurred, reliable correspondence developed in 2 pigeons. This correspondence was eliminated by making reinforcement independent of correspondence and subsequently was reestablished when reinforcement again depended on correspondence. In Experiment 2, 3 other pigeons rapidly acquired correspondence under the final procedure used in Experiment 1. Increasing the time interval between the say and do components diminished correspondence. The results of the two experiments suggest how correspondence may be considered an instance of conditional stimulus control and that it is possible to construct a homologue of human say-do correspondence with pigeons.

AN INVESTIGATION OF THE DIFFERENTIAL‐OUTCOMES EFFECT WITHIN SESSIONS

The differential-outcomes effect is manifest as more accurate performance of a delayed conditional discrimination when alternative choice responses are followed by different reinforcers than when they are followed by the same reinforcer. In Experiment 1, a differential-outcomes effect was demonstrated within sessions by signaling the duration of food access for correct responses with stimuli appearing in conjunction with the sample stimuli. The delayed matching-to-sample performance of 5 pigeons was more accurate when green choice responses (matching a green sample) were followed by 3.5-s food access and red choice responses (matching a red sample) were followed by 0.5-s food access (different-outcome trials) than when the correct choice responses were both followed by 1.5-s reinforcers (same-outcome trials). In Experiment 2, the acquisition of this differential-outcomes effect was characterized by a progressive decrease in rate of forgetting on different-outcome trials and no change in rate of forgetting on same-outcome trials. In addition, accuracy at the shortest delay intervals for both different-outcome and same-outcome trials increased over acquisition, but to a greater extent for different-outcome trials. These data suggest that both memorial and attentional (time-dependent and time-independent) factors contribute to the differential-outcomes effect.

Matching and oddity learning in pigeons: Effects of penalty time for incorrect responding

In simultaneous matching-to-sample and oddity-from-sample tasks, briefly delaying the offset of trial stimuli following an incorrect choice response was found to facilitate task acquisition (Experiment 1). Because thispenalty-time procedure also resulted in longer choice-response latencies, it was hypothesized that any procedure that increased response latency would facilitate task acquisition. However, in Experiment 2, no evidence of facilitation was found when a 2-sec pause was imposed prior to the choice response. The results of Experiment 3 suggest that penalty-time facilitation of acquisition was not due to either the added differential outcome on correct versus incorrect trials (i.e., incorrect choice responses do not darken the keys as do correct choice responses) or the aversive effects associated with trial prolongation (i.e., incorrect responses not only result in the absence of reinforcement but also delay the start of the next trial). Instead, results suggest that birds trained with the penalty-time procedure review the trial stimuli following an incorrect choice.

Temporal discrimination of visual stimuli in pigeons.

Characteristics of the discrimination of brief visual stimuli were examined in three pigeons by a psychophysical procedure. In a two-choice discrimination task, the difference between the duration to be compared and the standard duration, which yielded 75% correct choice responses, was determined as the difference threshold for each of four standard durations ranging from .25 to 1.0 sec by a variant of the up-down method. It was found that the difference threshold was roughly proportional to the standard duration: Weber’s law provided a reasonable approximation. The value of the Weber fraction was about .25, which is in accord with the results of discrimination experiments with longer durations in pigeons.

Perceptual context effects on line discriminations by monkeys as measured by choice response accuracy and eye movements

Stumptailed monkeys (Macaca arctoides) were given two two-choice line-discrimination problems in which the lines were presented either alone or embedded in a patterned context that was the same in all cases. When the stimuli were a left- and a right-tilting line, the addition of the context significantly improved performance, as measured by frequency of correct choice responses. It also decreased choice response latency, duration of visual fixations, and frequency of scanning back and forth between the two stimuli. When the stimuli were a horizontal and a vertical line, the addition of the context had the opposite effect on all the performance measures. These results are very similar to those found with adult and infant humans when given the same stimuli. They suggest that the pattern perception of monkeys, like that of humans, involves top-down or holistic processing of incoming visual information.

EFFECTS OF RATIO REINFORCEMENT SCHEDULES ON DISCRIMINATION PERFORMANCE BY JAPANESE MONKEYS

In Experiment 1, Japanese monkeys were trained on three conditional position-discrimination problems with colors as the conditional cues. Within each session, each problem was presented for two blocks of ten reinforcements; correct responses were reinforced under continuous-reinforcement, fixed-ratio 5, and variable-ratio 5 schedules, each assigned to one of the three problems. The assignment of schedules to problems was rotated a total of three times (15 sessions per assignment) after 30 sessions of acquisition training. Accuracy of discrimination increased to a moderate level with fewer trials under CRF than under ratio schedules. In contrast, the two ratio schedules, fixed and variable, were more effective in maintaining accurate discrimination than was CRF. With further training, as asymptotes were reached, accuracy was less affected by the schedule differences. These results demonstrated an interaction between the effects of reinforcement schedules and the level of acquisition. In Experiment 2, ratio sizes were gradually increased to 30. Discrimination accuracy was maintained until the ratio reached 20; ratio 30 strained the performance. Under FR conditions, accuracy increased as correct choice responses cumulated after reinforcement.

Verification of Donders' subtraction method.

In an experiment on 6 young adults advance (precued) information of the correct choice response was utilized completely: (a) For precue-to-stimulus intervals (PSIs) clearly shorter than the difference between mean choice and simple reaction time (RT), median response latency (L) measured from precue onset was invariant; (b) For clearly longer PSIs, median RT was very near the value for simple RT. This precue-utilization effect would be expected if response actualization had been delayed until the response had been selected and if the requirement for discrimination and selection had no adverse effect on readiness to respond. Donders' (1868/1969) hypothesis in his initial application of the subtraction method, that choice and simple reactions are identical except for the serial insertion of discrimination and selection operations in the former, is thereby strongly supported. If this formulation is accepted, models that hold that response processing can overlap other processing stages may be considered valid only for response selection, not response actualization.

Stimulus discriminability in free-operant and discrete-trial detection procedures.

Six pigeons were trained to discriminate different light intensities in four experimental procedures. Experiment 1 compared stimulus discriminability in a yes-no signal-detection task with discriminability measures obtained from two free-operant procedures. Discriminability estimates were significantly lower in the detection procedure. Experiment 2 showed this lowered discriminability to be a function of the delay between stimulus presentation and the availability of the choice-response keys in the standard detection task. In addition, reinforcement sensitivity was lowest when correct choice responses were intermittently, rather than continuously, reinforced.

INDEPENDENCE OF SENSITIVITY TO RELATIVE REINFORCEMENT RATE AND DISCRIMINABILITY IN SIGNAL DETECTION

Six pigeons were trained to detect differences between two white stimuli, S1 and S2, differing in duration and arranged probabilistically on the center key of a three-key chamber. Detection performance was measured at two levels of discriminability. At one level, S1 was five seconds and S2 was thirty seconds. At the other level, S1 was twenty seconds and S2 was thirty seconds. The procedure was a standard signal-detection yes-no design in which stimulus-presentation probability was varied from .1 to .9 at both discriminability levels. On completion of the center-key stimulus, a peck on the center key darkened the center-key light and turned on the two red side keys. A left-key response was "correct" on S1 trials, and a right-key response was "correct" on S2 trials. Correct responses produced food reinforcement on a variable-ratio 1.3 schedule. Incorrect responses produced three second blackout. Discriminability was higher for the five-second versus thirty-second conditions than for the twenty-second versus thirty-second conditions, but there were no differences in sensitivity of behavior to reinforcement variation for the two stimulus pairs. Response bias was a function of the relative reinforcement rate for correct choice responses.

REINFORCEMENT CONTINGENCIES AS DISCRIMINATIVE STIMULI: II. EFFECTS OF CHANGES IN STIMULUS PROBABILITY

Three pigeons were trained on a matching procedure involving a sample component and a choice component. Responding in the sample component, according to either a differential-reinforcement-of-low-rate schedule on some trials or a differential-reinforcement-of-other-behavior schedule on other trials, produced access to the choice component in which each of two keys was illuminated with a unique color. The correct choice response was defined by the contingency that was met to produce the choice. The food hopper operated for 1.5 seconds following an appropriate sample response and for 3 seconds following a correct choice response. A signal-detection analysis showed that variations in the probability of presentation of the different contingencies systematically affected response bias but not sensitivity to the contingencies as stimuli. Substitution of a blackout for food at the end of the sample component did not differentially affect performance, but elimination of the delay between sample and choice components generally increased the sensitivity measure. The findings suggest a role for reinforcement contingency discrimination in schedule-controlled responding.