Abstract Funding Acknowledgements This research has been funded by the research grant PlaqueImage, contract number 26/01.09.2016, SMIS code 103544, Project funded by the European Union Aims Coronary shear stress (CSS) has been recently recognized to play a significant role in coronary plaque progression and vulnerabilisation. However, the evolution of CSS after implantation of different types of coronary stents is still under investigation. The aim of this study was to assess the evolution of the CSS along the coronary lesions following implantation of bioabsorbable vascular scaffolds (BVS), to determine the impact of BVS on coronary flow haemodynamics. Methods and results This was a single center prospective pilot study which enrolled 15 patients (aged 58.35 +/- 7.79 years, 13 males) with coronary artery disease undergoing BVS implantation in a major epicardial vessel. In all patients, angio CT scanning (Siemens Somatom Sensation scanner, Erlangen, Germany) was performed prior to the BVS implantation and repeated after 12 months. Lumen information was extracted from the vessels of interest and coronary rest hemodynamics, including CSS, were calculated using a computational fluid dynamics solver. All shear stress calculations were performed at baseline and repeated after 1 year. Average CSS was determined proximally, distally, and at the level of the minimal lumen area (MLA). Average CSS along the stented segment significantly decreased after BVS implantation, from 2.87 +/- 1.64 Pa at baseline to 1.9 +/- 0.49 at 1 year (p = 0.0001). Maximum CSS along the segment also exhibited a significant decrease, from 11.78 +/- 10.06 Pa to 6.35 +/- 3.08 Pa (p = 0.0009). Proximally to the MLA, CSS significantly decreased after BVS implantation, from 3.39 +/- 1.93 Pa at baseline to 1.91 +/- 0.68 Pa at 1 year (p <0.0001). However, this decrease in CSS was not significant distally to the MLA (1.3 +/- 0.72 Pa vs 1.59 +/- 0.65 Pa, p = 0.9). Conclusions Implantation of BVS leads to a significant decrease of CSS after 1 year, especially within coronary segments located proximally to the stenosis. This underlines the role of BVS in re-establishing a physiological pattern of coronary flow in diseased coronary vessels. The feature (mentioned herein) is not commercially available. Due to regulatory reasons its future availability cannot be guaranteed.