Coriander Sativum Research Articles

MALAYSIAN JOURNAL OF CHEMISTRY (MJChem) MJChem is double-blind peer reviewed journal published by the Malaysian Institute of Chemistry (Institut Kimia Malaysia) E-ISSN: 2550-1658 About Editor Reader Author Reviewer Register Login Vol 26 No 5 (2024): Malaysian Journal of Chemistry Date Published: 21 October 2024 Antioxidant and Antibacterial Activities of Coriander (Coriander sativum L.) Seeds Essential Oil Mazlin Mohideen*, Anis Mohd

MALAYSIAN JOURNAL OF CHEMISTRY (MJChem) MJChem is double-blind peer reviewed journal published by the Malaysian Institute of Chemistry (Institut Kimia Malaysia) E-ISSN: 2550-1658 About Editor Reader Author Reviewer Register Login Vol 26 No 5 (2024): Malaysian Journal of Chemistry Date Published: 21 October 2024 Antioxidant and Antibacterial Activities of Coriander (Coriander sativum L.) Seeds Essential Oil Mazlin Mohideen*, Anis Mohd

Elucidation of the Possible Molecular Mechanism for the Anti-Apoptotic Effect of Terpene-Rich Extract of Amomum subulatum and Coriandrum sativum against Rodent Model of Cardiotoxicity

Background: Spices, including Amomum subulatum and Coriander sativum, are not only popular for improving food flavour but are also accepted worldwide for their health benefits in various disorders. Objective: This study aimed to elucidate the possible mechanism for the anti-apoptotic effect of terpene-rich extract of Amomum subulatum and Coriandrum sativum against the rodent model of cardiotoxicity. Methods: Effects of standardized terpenoids-rich aqueous methanolic extract of two commonly used spices, viz. Amomum subulatum Roxb. and Coriandrum sativum Linn., were investigated on doxorubicin-induced apoptotic changes and cardiotoxicity in Wistar rats with the aim of in-vestigating the mechanism. Prior to the in vivo experiment, the extracts were subjected to quan-titative estimation of possible bioactive markers of the terpenes by employing a newly devel-oped, optimized, and validated GC-MS method along with TLC profiling. Results: Cardiotoxicity was evident from elevated creatinine kinase (CK-MB), lactate dehydro-genase (LDH), and malondialdehyde (MDA) levels in the toxic control group after treatment with doxorubicin (2.5mg/kg i.p. given twice a week for three weeks). Caspase-3, Tumor necrosis factor-α (TNF-α), and Interleukin-6 (IL-6) were also induced in animals treated with doxorubi-cin. Treatment with Amomum subulatum and Coriandrum sativum at the doses of 100 and 200mg/kg exhibited significant (P<0.001) reversal of CK-MB, LDH, MDA, Caspase-3, TNF-α, and IL-6 levels. This protective effect was further supported by the results of DNA gel electro-phoresis and histopathological observations. Conclusion: This study supports the cardioprotective role of selected spices against doxorubicin-induced cardiotoxicity through the anti-apoptotic mechanism.

تأثير جسيمات النانو من السيليكون على مكونات الفوتوكيمياء (النشاط البيولوجي) والخصائص الفسيولوجية لنبات الكزبرة تحت ضغط الماء

The present study was accomplished to scrutinize the efficiency of Nano silicon (NSi) as a foliar spray on (Coriander sativum) plants under water stress conditions during 2021/2022 season. Coriander plants were subjected to three water levels (100, 70 and 30% of field capacity). Plant leaves were sprayed with NSi in three different concentrations (3, 5 and 10 ppm) 14 days after germination. The results revealed that Coriander plants growth was significantly decreased under water stress, while NSi treatment showed a significantly enhanced plant growth (length and number of leaves per plant). Regarding biochemical constituents activity, total of alkaloids, phenol, flavonoids and fatty acids increased under water stress. Also, nutrient elements (P & Mg and Na) increased. Plant hormones such as gibberellic acid (GA3) and ascorbic acid (vitamin C) significantly decreased under both 70% and 30% FC, while abscise acid (ABA) increased. In the interim, the three different concentrations of NSi significantly improved carbohydrates concentration and adjustment of osmotic stress. Application of NSi at different concentrations significantly improved nutrients contents (N, P, K, Mg, Ca, Fe, Zn, Mn) mainly under moderate and severe water stress (70%, 30% FC). Generally, the profound concentration of NSi tested during the experiment was 5 ppm for ameliorating water stress. The present investigation showed that the application of NSi might be a promising method to enhance the plant growth, biochemical ingredients and crop productivity of Coriander plants grown under water stress conditions.

Exploring the effects of non-thermal plasma pre-treatment on coriander (Coriander sativum L.) seed germination efficiency

This study investigates the effects of non-thermal plasma (NTP) treatment on the germination characteristics of coriander seeds (Coriandrum sativum L.). Different germination factors, water imbibition rate and changes in mass, were analyzed. The results indicate that a suitable duration of NTP treatment (180 s and 300 s) enhances seed germination characteristics, whereas prolonged exposure (420 s) leads to adverse effects. Furthermore, shorter NTP exposures (180 s) improved water absorption and surface properties of seeds, while longer exposures (420 s) caused mass loss and compromised seed vigor. Overall, the findings demonstrate the significance of optimizing NTP treatment conditions for enhancing seed germination characteristics.

<i>In silico</i> screening of phytochemicals against Ypd1 protein of a destructive storage fungi, <i>Aspergillus</i>

One of the most common pests in stored grain is Aspergillus. This group of fungi produces a carcinogenic toxin, Aflatoxin during their growth and development. Contamination of Aspergillus in food grains during storage leads to food insecurity. In the present-day scenario, using plant-based derivatives in controlling Aspergillus is one of the efficient and eco-friendly ways. Hence an in silico study was carried out to know the effective phytochemicals present in Citrus, Carum carvi, Coriander sativum, Aloysia citriodora, Mentha citrate, Spent hops, Nardostachys jatamansi, Feoniculum vulgare, Zingiber officinale, Lantana camara, Chamaecyparis obtusa, Ocimum kilimandscharium, Tagetes filifolia against Aspergillus. Results revealed that the photochemicals viz. Eugenol, zingiberene, carvone, citronellal, limonene, coumaran, linalool, linalyl acetate, esdragol, menthol, E-anethole, camphor, bornyl acetate, xanthohumol and aristolone present in the selected plants can inhibit the normal functioning of Ypd1 protein of Aspergillus by blocking its active site. Thus, the present study makes a base for future researchers to find the most effective phytochemicals in controlling Aspergillus following in vivo method.

Green Synthesis, Characterization, and Potential Biomedical Applications of AgNPs Using Coriander sativum and Olea europaea

Background: Over the last few decades, metallic nanoparticles, especially silver nanoparticles (AgNPs), have gained the focus of researchers globally due to their unique properties and a broad range of applications. Aim: This research study focused on the green synthesis of AgNPs by using Coriandrum sativum, Olea europaea leaf extract, and their bovine serum albumin conjugates. Materials and Methods: Biogenic AgNPs were characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, dynamic light scattering, and scanning electron microscopy analysis. The potential biomedical applications of AgNPs and their conjugates were also evaluated through in vitro assays. AgNPs synthesis was confirmed by observing UV-visible absorption peaks at 380nm, 460nm (AgNPs derived from C.sativum and O. europaea respectively), 580nm, and 577nm (conjugates of particles from C.sativum and O. europaea respectively). Results: FTIR analysis revealed the presence of various functional groups on the surface of AgNPs. The average diameters of C. sativum and O. europaea derived AgNPs were 1025 d.nm and 134 d.nm, whereas the average size of AgNPs was 500nm, 200nm, 100nm, and 300nm with uniform morphology. Results of biomedical activity showed that AgNPs and their albumin conjugates were potential antidiabetic, anti-oxidant, and anti-hyperlipidemic with significant IC50 values compared to standard. The antimicrobial potential of AgNPs and their conjugates were tested against gram-positive and gram-negative bacterial strains and the best zone of inhibition of C. sativum derived conjugated AgNPs was observed against Salmonella enterica i.e. 29 mm. Conclusion: The research project provides an ecofriendly green synthesis method of AgNPs and their conjugates as well as their potential for the treatment of different diseases.

Antioxidant and antifungal efficacy of green synthesized silver nanoparticles

The use of herbs have gained momentum in the contemporary research, as they possess several biological activities. Green synthesised nanoparticles are extensively under exploration due to their multi-faceted roles. The present work details the comparative antioxidant potentials of the leaves and seeds extracts of the herbs Coriander sativum (coriander), Trachyspermum ammi (Ajwain), Trigonella foenum-graecum (menthi) and synthesis of silver nanoparticles. The antifungal effects of the synthesized nanoparticles against a pathogenic species of Aspergillus flavus and the mode of action was also analysed. Results of the investigation showed that the seed extract of Ajwain and leaf extract of coriander exhibited the highest antioxidant properties and were used as reducing agents for silver nanoparticles synthesis. The nanoparticles were characterized by UV-visible absorption spectrum, Scanning Electron Microscopy-Energy Dispersive Spectra (SEM-EDS) and Transmission Electron Microscopy (TEM). The silver nanoparticles showed enhanced antioxidant activity when compared to the extracts. The antifungal studies showed that both the nanoparticles were effective against A. flavus, while C. sativum silver nanoparticle (Cs-AgNP) exhibited the highest activity. The mechanism of antifungal effect showed that the nanoparticles exerted a membranolytic activity on the pathogenic A. flavus. SEM images showed highly wrinkled mycelia in nanoparticles-treated samples and membrane permeabilization was evident from the 1- N-phenyl napththyl amine assay in nanoparticle-treated fungal samples. The activity of a transmembrane enzyme calcium ATPase was also significantly decreased in treated samples confirming the membrane damage effects of nanoparticles. Among the nanoparticles, Cs-AgNP showed the maximum effect. The efficacy of these green synthesized nanoparticles provides insight into their use as effective antifungal agents.

Comparison of Antioxidant activity of Various Phytopharmaceuticals

Herbal drugs are playing a pivotal role in the Indian medicine economy. The edible parts of plants are used to treat various types of diseases. There are many researches going on antioxidant activity, but our aim is to conduct Invitro and in-vivo comparison of antioxidant activity of various herbal plants to prove that natural antioxidants are more effective than synthetic antioxidants. Free radicals cause oxidative stress in the human body. Free radicals are substance with unpaired electrons which are ready to bind to cells and cause damage in the human body. For the inhibition of free radicals in the living organisms ethanolic extracts of five plants are used for the antioxidant activity. The extracts of six herbals, amla fruit powder (Phyllanthus emblica), Tulasi leaf powder (Ocimum tenuflorium), hibiscus leaf powder (Hibiscus rosa sinensis), coriander leaf powder (coriander sativum), lemon leaf powder (citrus limon) and the antioxidant activity of henna leaf powder (lawsonia inermis) was determined. Using the hydrogen peroxide free radical scavenging activity technique, the amount of antioxidant activity present in the plant extracts was evaluated. UV Spectroscopy was used to evaluate the strong antioxidant activity of the plant extract to the reference alpha tocopherol and vitamin C. This research will assist us in determining antioxidant activity profiles, revealing that herbals are more effective than commercially available alpha tocopherol and ascorbic acid.

Profiling of Antifungal Activities from the Leaf Extract of Selected Apiaceae Family Plants against <i>Aspergillus fumigates</i>

Many ethnic plants are used as a source of traditional medicine to cure a variety of illnesses in both humans and animals. Developing secondary metabolites in plants with antifungal characteristics, offer alternative medications for reasonably priced and safe treatments. In the present study, methanolic, ethanolic, hexane and ethyl acetate leaves extracts of fifteen Apiaceae family plants were taken on the premise of their ethno botanical uses. The antifungal activity was assessed against significant fungal strain; Aspergillus fumigates by measuring minimum inhibitory concentration (MIC) and Zone of inhibition compared with standard drug fluconazole. Ethanol and methanol extracts of the plants were more effective than the hexane and ethyl acetate extracts against A. fumigates. Extracts of Cuminum cyminum, Pastinca sativa, Carum carvi, Dacus carota, Centella asiatica, Anthriscus cerefolium, Trachyspermum ammi, Pimpenella anisum and Apium graveolens showed relatively low inhibition effects between 3.5 to 8.5 mm. The MIC value of extracts was determined ranging between 0.8 to 0.43 μg/ml. The extract of Petroselinum crispum, Foeniculum vulgare, Ferula assaefoetida, Bunium persicum, Anethum graveolens and Coriander sativum could be considered as potential source of antifungal compounds for treating diseases in humans. Conclude remarks that these six extracts show astonishing fungicidal properties that can be used to discover drugs of very high potential.

Lipid profile improving effect of Coriandrum sativum seed extract in rats

Background: Hyperlipidaemia is a common disease in middle-aged and elderly people. It has received attention, as it indirectly affects the normal metabolism, blood viscosity and vital organ functions. It is a risk factor for cardiovascular and cerebrovascular diseases. Therefore, the aim of the present study was to evaluate the possible antihyperlipidemic effect of Coriander sativum seed extract (CSSE) in rats fed on high-fat diet.Methods: A parallel study design was adopted on 42 albino rats, divided randomly into 7 groups with different treatments. After a 6 week-experimental course, blood samples were collected and analysed for lipid and organ function parameters. Phytochemical analysis was conducted on the used seed extract to detect the active principles underlying its effects.Results: CSSE (150 and 300 mg/kg, orally, once daily) along with a high-fat (1.5% cholesterol+1.5% coconut oil, in diet) diet resulted in a significant (p≤0.05) improvement in plasma lipid parameters, including, total cholesterol, triacyglycerols and lipoproteins, compared to the high-fat group. group. The extract significantly (p≤0.05) improved hepatic (total proteins, albumin, globulins, total conjugated and unconjugated bilirubins, AST, ALT, GGT), cardiac (CK-MB and troponin-I) and renal (urea, creatinine & uric acid) biomarkers. Phytoanalysis of CSSE revealed presence of phlobatannin and flavonoids. The protection % produced by small and large doses of CSSE were dose-dependent and parallel to those of the standard antihyperlipidemic rosuvastatin (2 mg/dl orally, daily).Conclusions: These data indicate that CSSE has a marked antihyperlipidemic effect and could be a source for a promising nutraceutical antihyperlipidemic drug depending on its high phenolic and flavonoid content.

Construction of network pharmacology-based approach and potential mechanism from major components of Coriander sativum L. against COVID-19

Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Despite the fact that various therapeutic compounds have shown potential prevention or treatment, no specific medicine has been developed for the COVID-19 pandemic. Natural products have recently been suggested as a possible treatment option for COVID-19 prevention and treatment. This study focused on the potential of Coriander sativum L. (CSL) against COVID-19 based on network pharmacology approach. Interested candidates of CSL were identified by searching accessible databases for protein–protein interactions with the COVID-19. An additional GO and KEGG pathway analysis was carried out in order to identify the related mechanism of action. In the end, 51 targets were obtained through network pharmacology analysis with EGFR, AR, JAK2, PARP1, and CTSB become the core target. CSL may have favorable effects on COVID-19 through a number of important pathways, according to GO and KEGG pathway analyses. These findings suggest that CSL may prevent and inhibit the several processes related to COVID-19.

Development of a Herbal Tea with Potential Antiglycation Effects using <em>Phyllanthus emblica</em> (Indian Gooseberry), <em>Zingiber officinale</em> (Ginger), and <em>Coriander sativum</em> (Coriander)

The study was conducted to investigate the capability of developing a herbal tea using Phyllanthus emblica (PE) fruit, Zingiber officinale (ZO) rhizome, and Coriander sativum (CS) seeds and to assess its anti-glycation effects. Phyllanthus emblica, ZO, and CS are common and individually used materials in traditional medicine in Sri Lanka. No evidence is found in using combinations of these plant materials being used in commercial tea / herbal infusion production in Sri Lanka. The herbal tea was formulated with powdered form of PE fruits, ZO rhizome and CS seeds in three different formulations; PE-50% + ZO-25% + CS-25%; PE-25% + ZO-50% + CS-25%; and PE-25% + ZO-25% + CS-50%. The three formulated teas were subjected to a five-point hedonic scale sensory evaluation. The formula with PE fruits 50%, ZO rhizome 25%, and CS seeds 25% was selected for further analysis. The phytochemicals of the selected formulation were analyzed, and the results bared the presence of glycosides, alkaloids, terpenoids, saponins, and tannins, which ensures a high antioxidant quality of the formulated tea. The tested parameter for the shelf-life determination study concluded that the product is shelf-stable for 14 days under 0 °C temperature. An in vitro assay using Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis was used to test the antiglycation effects. Results showed that the herbal tea was able to inhibit glycation-induced protein cross-linking over prolonged incubation periods with strong glycating conditions. Therefore, this product could also have a potential to be used as a home remedy to prevent diabetic complications.

Comprehensive Study on Indian Plant Extracts Mediated Biocompatible ZnO Nanostructures: A Green Initiative

Zinc oxide nanostructures of variable morphology are extensively used in diversified applications of biomedical sector like antibacterial, anticancer, antifungal and targeted drug delivery utilizations. However, their biocompatibility and cytotoxicity are major issues restricting their commercial development for biomedical applications. Green chemistry is a game touting strategy to fabricate biocompatible zinc oxide nanoparticles for diversified biomedical applications. It eliminates the various bottlenecks associated with physical (high power consumption) and chemical (environmental contamination) fabrication strategies utilized for nanomaterial synthesis.Green strategies majorly use biomass and related materials such as plant extract, essential oils or bacteria, as bio reducing, capping and stabilizing agents for facile fabrication of metal based nanoparticles. It turns these techniques into economic, simpler, eco friendly, non-toxic and less contaminating strategies with high scope of scalable optimization and production. Indian herbs and plants like Mangifera indica, Coriander sativum, Aloe vera are being traditionally used as medicinal remedies and possess high antimicrobial efficacies. The extracts from different parts of these plants like leaves, roots, stem or flower (essential oil) are proven for their bio reducing and stabilizing capabilities in nanomaterial fabrication. This review, for the first time, focuses on the usage of several India-based plants for green production of zinc oxide nanostructures with diverse morphologies and physicochemical properties. The present study covers many parameters affecting the morphologies of plant-mediated ZnO NSs and their benefits over traditional approaches. Besides associated challenges, alternate solutions and prospects are able to attain the United Nations sustainable development goal for environmental sustainability, good health and well being.

Antiviral effect of herbal mixture (garlic, nilavembu, turmeric, coriander, and fenugreek) against Newcastle disease virus in ovo

An experimental trial was undertaken to explore the effect of herbal mixture consisiting of Curcuma longa, Coriander sativum, Allium sativum, Andrographis paniculata, and Trigonella foenum graceum by an in ovo assay and the results demonstrated that the ethanolic extracts significantly reduced the virus titres (P < 0.05) with no detectable level of virus being observed in the plant extract treated groups. Phytochemical analysis of the extract revealed the presence of alkaloids, flavonoids, saponins, tannins, terpenoids, hydrolysable tannin and glycosides which has been considered as novel antiviral agents and can be considered as a viable means to control the economically important Newcastle disease of poultry. These herbs can thus be recommended for its antiviral property and can very well be used as a substitute over the conventionally used antibiotics owing to its synergistic effect to control secondary bacterial infections. Thus the problems of drug resistance and drug residues in poultry meat arising out of usage of synthetic drugs can be minimized and thereby assuring safety and quality. However, in vivo trials are needed to validate the use of this herbal mixture in controlling New castle disease in chickens.

Comparative evaluation of the antibacterial and cytotoxic activity of green synthesized and commercially available ZnO nanoparticles

Introduction and Aim:Emergence of different applications of metallic nanoparticles in various field leads to innovation of new synthetic strategies. Besides being non-toxic to mammalian cells, zinc oxide nanoparticles (ZnONPs) has gained paramount attention due to its excellent antibacterial potential. This study illustrates a comparative analysis of antibacterial and cytotoxic activity of both phytochemically synthesized and chemically synthesized commercially available ZnONPs.&#x0D; &#x0D; Materials and Methods:As a source of reducing agent, leaf extract of Coriander sativum was employed in case of green synthesis of ZnONPs. Several techniques, such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Dynamic light Scattering (DLS) and Field emission Scanning Electron Microscopy (FESEM) were performed to characterize both green synthesized and commercial ZnONPs.Antibacterial potential of both theZnONPs were investigated on Gram-positive and Gram-negative bacterial strains to draw a correlative outcome. Hepatocellular cell line was used to determine the cytotoxic activity of both ZnONPs.&#x0D; &#x0D; Results:Both the nanoparticles showed antibacterial and cytotoxic activity with measurable degree of difference.&#x0D; &#x0D; Conclusion: From these studies it can be concluded, the green synthesized nanoparticles showed greater antibacterial as well as cytotoxic activity in comparison to the commercial ZnONPs.&#x0D;

Detection of Epistasis for Seed and Some Phytochemical Traits in Coriander under Different Irrigation Regimes

Coriander (Coriander sativum L.) is an annual herb mainly cultivated for its seed characteristics. Drought stress is a major problem which affects coriander behaviour through biochemical responses. This study aimed to determine the nature and magnitude of epistasis in inheritance of seed yield (SY), percent of dehulled seed (PODS), percent of seed hulls (POSH), essential oil content (EOC), essential oil yield (EOY), dehulled seed fatty acid content (DSFAC), hull fatty acid content (HFAC), fatty acid content (FAC), and fatty acid yield (FAY), and to estimate additive and dominance variance for the traits not influenced by epistasic effects. Three testers, TN-59-158 (highly drought-susceptible), TN-58-230 (highly drought-tolerant, but low-yielding), and their F1 hybrid were each crossed for six genotypes. The experiment was performed under different levels of water deficit: control (C), moderate water deficit (MWD), and severe water deficit (SWD) conditions. Epistasis affected the expression of SY, EOC, EOY, FAC, and FAY in all water conditions, PODS in C, POSH in SWD, HFAC in MWD, and DSFAC in both C and MWD conditions. Total epistasic effects were partitioned, showing that both [i] and [j + l] type interactions were significant, with a prevalent influence of [i] type interactions on these traits except for POSH and FAC in the SWD condition, which exhibited a higher value of the [j + l] type. Both additive and non-additive gene actions were significant for those traits not significantly affected by epistasis in C, MWD, or SWD conditions. An additive type of gene action was preponderant for PODS in MWD and SWD, POSH in MWD, DSFAC in SWD, and HFAC in C and SWD conditions.

Antimicrobial activity of green synthesized tri-metallic oxide Ni/Cr/Cu nanoparticles

The tri-metallic oxide Ni/Cr/Cu nanoparticles (NPs) were synthesized using Coriander sativum extract as the reducing agent. The precursors namely CuSO4.5H2O, Ni(NO3)2·6H2O and Cr (NO3)3·9H2O were used for the green synthesis. Further, the prepared NPs were characterized using Ultraviolet-Visible (UV-Vis) spectroscopy and X-ray diffraction (XRD) studies. Its antimicrobial property against two fungal and two bacterial species was determined by measuring the respective zone of inhibition (ZOI) in well diffusion method. A dose dependent inhibition was observed in all the four species of pathogens including Escherichia coli, Staphylococcus aureus, Aspergillus flavus and Penicillium sp. This antimicrobial property of tri-metallic oxide NPs may be utilized in the field of medical research, pharmaceutical industries and environmental sciences.

Interactive Effect of Seeds of Coriandrum Sativum L. With Glimepiride in Streptozotocin-Induced Diabetic Rats

Diabetes mellitus is a serious and most prevailing glycemic disorder mainly managed by using allopathic medicines. Due to various side effects of allopathic drugs, till today medicinal plants were widely used in treating diabetes. Among them, spices like Coriander sativum L. play a prominent role in managing diabetes. Type-2 diabetic patients use oral hypoglycemic drugs and also follow herbal remedies. There is a probability of interactions when herb interferes with the drug action in the body. The aim of the present study was to assess the interaction of aqueous extract of seeds of Coriandrum sativum with oral hypoglycemic drug glimepiride in streptozotocin-induced diabetic rats. In the present study, animals were grouped into seven of six each. Group-I, Group-II, Group-III, Group-IV, Group-V, Group-VI, and Group-VII included normal control, glimepiride, Coriandrum sativum, diabetic control, diabetic animals treated with glimepiride, diabetic animals treated with Coriandrum sativum, and diabetic animals treated with glimepiride and Coriandrum sativum, respectively. Pharmacokinetic and pharmacodynamic interactions were studied. The animals treated with both Coriandrum sativum and glimepiride showed significant activity in pharmacokinetic parameters by increasing the levels of the maximum serum concentration (Cmax), Time taken to reach maximum serum concentration (Tmax) and Volume of distribution (Vd). Further pharmacodynamic studies showed promising hypoglycemic effects by decreasing blood glucose levels and ameliorating lipid profile compared with monotherapy of glimepiride or Coriandrum sativum treated in diabetes rats. The observations revealed that a significant herb-drug interaction occurred between Coriandrum sativum and glimepiride. In conclusion, Coriandrum sativum can elevate the bioavailability of glimepiride which seems to be beneficial in diabetic patients receiving glimepiride.Â

Green synthesis, characterization, enhanced functionality and biological evaluation of silver nanoparticles based on Coriander sativum.

The present study focused on the green synthesis of silver nanoparticles from Coriander sativum (CS) containing structural polymers, phenolic compounds and glycosidic bioactive macromolecules. Plant phenolic compounds can act as antioxidants, lignin, and attractants like flavonoids and carotenoids. Henceforth, silver nanoparticles (AgNPs) were prepared extracellularly by the combinatorial action of stabilizing and reduction of the CS leaf extract. The biologically synthesized CS-AgNPs were studied by UV-spectroscopy, zeta potential determination, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis to characterize and confirm the formation of crystalline nanoparticles. The synthesized nanoparticles demonstrated strong antimicrobial activity against all microbial strains examined with varying degrees. The scavenging action on free radicals by CS-AgNPs showed strong antioxidant efficiency with superoxide and hydroxyl radicals at different concentrations as compared with standard ascorbic acid. The presence of in vitro anticancer effect was confirmed at different concentrations on the MCF-7 cell line as revealed with decrease in cell viability which was proportionately related to the concentration of CS-AgNPs illustrating the toxigenic nature of synthesized nanoparticles on cancerous cells.

Chemometrics-based models hyphenated with ensemble machine learning for retention time simulation of isoquercitrin in Coriander sativum L. using high-performance liquid chromatography.

In this research, two nonlinear models, namely; adaptive neuro-fuzzy inference system and feed-forward neural network and a classical linear model were employed for the prediction of retention time of isoquercitrin in Coriander sativum L. using the high-performance liquid chromatography technique. The prediction employed the use of composition of mobile phase and pH as the corresponding input parameters. The performance indices of the models were evaluated using root mean square error, determination co-efficient, and correlation co-efficient. The results obtained from the simple models showed that subclustering-adaptive-neuro fuzzy inference system gave the best results in both the training and testing phases and boosted the performance accuracy of the simple models. The overall comparison of the results showed that subclustering-adaptive-neuro fuzzy inference system ensemble demonstrated outstanding performance and increased the accuracy of the single models and ensemble models in the testing phase, up to 35% and 3%, respectively.