Abstract
Introduction and Aim:Emergence of different applications of metallic nanoparticles in various field leads to innovation of new synthetic strategies. Besides being non-toxic to mammalian cells, zinc oxide nanoparticles (ZnONPs) has gained paramount attention due to its excellent antibacterial potential. This study illustrates a comparative analysis of antibacterial and cytotoxic activity of both phytochemically synthesized and chemically synthesized commercially available ZnONPs.
 
 Materials and Methods:As a source of reducing agent, leaf extract of Coriander sativum was employed in case of green synthesis of ZnONPs. Several techniques, such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Dynamic light Scattering (DLS) and Field emission Scanning Electron Microscopy (FESEM) were performed to characterize both green synthesized and commercial ZnONPs.Antibacterial potential of both theZnONPs were investigated on Gram-positive and Gram-negative bacterial strains to draw a correlative outcome. Hepatocellular cell line was used to determine the cytotoxic activity of both ZnONPs.
 
 Results:Both the nanoparticles showed antibacterial and cytotoxic activity with measurable degree of difference.
 
 Conclusion: From these studies it can be concluded, the green synthesized nanoparticles showed greater antibacterial as well as cytotoxic activity in comparison to the commercial ZnONPs.
Highlights
Introduction and AimEmergence of different applications of metallic nanoparticles in various field leads to innovation of new synthetic strategies
Interpretation of the results of X-ray diffraction (XRD) studies, revealed that the hexagonal Wurtzite zinc oxide nanoparticles (ZnONPs) structure approved by Joint Committee on Powder Diffraction Studies Standards (JCPDS card number 008, 82-1042 and 5-0664) resembles the observed plane values obtained in case of synthesized ZnONPs [12]
Results of this study indicate that the average size and crystalline structure of both ZnONPs are almost similar
Summary
Introduction and AimEmergence of different applications of metallic nanoparticles in various field leads to innovation of new synthetic strategies. Electrostatic adsorption of the particles to the bacterial surface and formation of Hydrogen peroxide are considered to be the reason of efficient antibacterial activity of ZnONPs [4] Based on this potent antibacterial efficacy, ZnONPs gained enough advantage in the arena of food and wood preservation, wound dressing, nano-medicines, cosmetics and disinfectant agents. These innumerable numbers of applications of ZnONPs build up the demand for different synthetic strategies [5]. Multiple chemical and physical synthesis procedures are reported, of which all comprised of hazardous chemicals, resulting in usage of toxic substances Performing these synthesis protocols are tedious and expensive.
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