ABSTRACT In recent years, due to the special structure and performance, more and more techniques and methods were developed for preparing core-spun yarn. In this article, the submicron-cotton/polyester composite core-spun yarn is produced on conventional ring spinning, in which the polyester staple fibers as core and the sheath were submicron-cotton (Sm-C) fibers, the Sm-C sliver produced by carding machine equipped with a dish-shaped electrospinning device and the core-spun polyester roving covered Sm-C sliver was produced by the roving frame with the modified bell mouth. Three different ratios of submicron-cotton/polyester roving were spun based on the prepared Sm-C sliver, which shows roving formed a core-sheath structure. The coverage rate reaches 100%. The 85Sm-C/15T performance shows that the weight CV (1.0%) and evenness CV (5.0%), then use it to prepare three kinds of spun yarns with 800TPM, 900TPM, and1000TPM, when the twist was increased the structure of the yarn becomes more compact, the long-staple cotton fibers and submicron fibers were intermingled and entangled with each other, and the strength of 900TPM increases by 18.79% compared with 800TPM, the evenness CV decreases by 2.22%, compared with 900TPM, the 1000TPM elongation breaking decreased 9.33%. Consequently, the modified spinning methodology improved the coverage rate, structure, and mechanical properties of submicron-cotton/polyester composite core-spun yarn.