Copolymerization Of Methyl Methacrylate Research Articles

Kinetic Study of the Free Radical Copolymerization of Methyl Methacrylate with 2-Perfluorooctyl Ethyl Methacrylate by Quantum Computational Approach

Fluorinated copolymers with perfluoroalkyl side chains have widespread use in applications requiring superior technology due to their unique surface properties. Kinetic analysis of copolymerization of fluorinated acrylates with conventional acrylates is necessary to synthesize such copolymers efficiently. However, kinetic investigation of such reactions are limited in the literature due to the experimental difficulties. In this study, the kinetic of copolymerization of methyl methacrylate with 2-perfluorooctyl ethyl methacrylate in toluene medium using AIBN initiator was investigated using quantum chemistry postulates as an alternative to experimental methods. Reaction rate constants (kp) for propagation were determined using transition state theory. A terminal effect models were used to examine four different addition reactions involving monomeric and dimeric radicals and monomers for both self- and cross-propagation. Reactant and product conformations were optimized with a DFT method using PBE0 function. The Evans-Polanyi relationship was used to calculate the rate of self- and cross-propagation of monomers. The results showed that the reactivity ratio of 2-perfluorooctyl ethyl methacrylate was found to be higher than that of methyl methacrylate. In addition, it was observed that the reaction conditions caused the random polymer structure due to the different rate constants in self and cross propagation.

Graft Copolymerization of Methyl Methacrylate and Vinyltriethoxysilane onto Natural Rubber

Preparation and characterization of natural rubber grafted with methyl methacrylate (MMA) and vinytriethoxysilane (VTES) were performed in the present work. Graft copolymerization of methyl methacryate was carried out in latex stage, and VTES was added during the graft copolymerization of MMA. FTIR and NMR spectroscopy were used to investigate the structure of graft copolymer and determination of conversion and grafting efficiency of MMA. It confirmed that the poly(methyl methacrylate) (PMMA) and silica particles (PVTES) were successfully formed in NR-graft-PMMA-PVTES graft copolymer. Conversions of MMA were about 90-100%; however, MMA grafting efficiency decreased as the MMA concentrations increased. Tensile property of NR-graft-PMMA-PVTES was found to improve compared with that of pure NR.

Molecular modeling of methacrylic composite materials doped with nonlinear optical azochromophores with various acceptor fragments

The methacrylate-based composite polymer materials with various weight content of azochromophores-guests – aminoazobenzenes with various acceptor moieties: AAB-NO2, AAB-DCV, AAB-TCV, and AAB-TCP, – are studied by atomistic modeling. Polymer matrices are PMMA, copolymer of methyl methacrylate and methacrylic acid, MMA-MAA, and copolymer MMA-MAZ, MAZ unit containing azochromophore, covalently attached to the side chain via spacer. The realization of various non-covalent interactions (hydrogen and π-π interactions) is considered, special emphasis is given to the role of chromophore structure and polymer matrix nature.It is shown that rather uniform distribution of chromophores in composite materials is retained even at 30 wt% content. In all composites with chromophore content growth both the number of non-covalently bound chromophores and the proportion of chromophores bound inter se increase, while the proportion of chromophores, bound with polymer matrix, decreases.The number of hydrogen bonds (HBs) between chromophores-guests is determined mostly by the nature of the acceptor group of the chromophore, maximum number of HBs being formed by AAB-TCP. The MMA-MAA matrix allows realization of greater number of inter-chain HBs compared to MMA-MAZ matrix, while such bonds are absent in PMMA.Azochromophores in MAZ units of MMA-MAZ matrix form π-π-stacking structures with mostly codirected chromophore dipole moments, besides AAB-TCV guests form such stacking structures with host matrix chromophores. Chromophores in MAZ units more easily interact with guests than with each other via π-π stacking. The studied matrices could be considered promising to be used as hosts at developing composite materials with quadratic nonlinear optical response.

Backbone-Degradable Polymers via Radical Copolymerizations of Pentafluorophenyl Methacrylate with Cyclic Ketene Acetal: Pendant Modification and Efficient Degradation by Alternating-Rich Sequence.

This work deals with syntheses of backbone-degradable polymers via the radical copolymerization of pentafluorophenyl methacrylate (PFMA) with 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), which undergoes ring-opening propagation to afford an ester-bonded backbone. The combination of the electron-deficient methacrylate with the electron-rich cyclic monomer allowed high crossover copolymerization, and the electronic effect was clarified by the comparison with the copolymerization of methyl methacrylate (MMA) and BMDO. The PFMA units of the resultant copolymer underwent quantitative alcoholysis or aminolysis transformation into methacrylate or methacrylamide units along with the pendant functionalization. The alternating-rich sequence was achieved by feeding an excess ratio of BMDO, which was supported by MALDI-TOF-MS of the copolymer obtained by the RAFT copolymerization. The methanolysis-transformed copolymer carrying MMA units was decomposed under basic condition, and the degradation efficiency was superior to that of the copolymer obtained via radical copolymerization of MMA with BMDO because of the alternating-rich sequence.

Photoluminescent Nanoinks with Multilevel Security for Quick Authentication of Encoded Optical Tags by Sunlight: Effective Physicochemical Parameters on Responsivity, Printability, and Brightness.

Investigation of developed photoactive security inks and anticounterfeiting technologies in recent years indicates significant challenges for future of this research area, such as increase of security, fast responsivity, and facile authentication. Here, amine-functionalized latex nanoparticles were synthesized by emulsion copolymerization of methyl methacrylate (MMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). Size of the latex nanoparticles was increased as a function of poly(dimethylaminoethyl acrylate) (PDMAEMA) contents, and also a decrease of particle size was obtained in response to an increase of temperature from 25 to 70 °C, above the lower critical solution temperature (LCST) of PDMAEMA. Surface physical modification of the functional latex nanoparticle with spiropyran photoswitches led to the development of anticounterfeiting nanoinks that have multilevel security and photochromic/fluorescence properties with a higher intensity and also brightness. The photoluminescent nanoinks were made of spiropyran latex nanoparticles and used for printing of the encoded optical security tags on cellulosic papers and banknotes. The results displayed that an increase of the particle size above 100 nm and an increase of the PDMAEMA contents led to a remarkable decrease of printability, fluorescent emission, brightness, intensity of photochromism, and also resolution of the printed security tags. As a significant advantage of the developed security inks, the printed security tags could be authenticated easily and fast upon sunlight irradiation by means of photochromism. The responsivity of encoded tags from the invisible to visible state is immediate upon sunlight irradiation for some seconds, whose intensity of coloration is appropriate and detectable clearly by naked eyes. The security anticounterfeiting inks based on spiropyran with multilevel security have been reported for the first time for applying in printing of encoded security tags on cellulosic papers, banknotes, and other documents, where the printed marks are detectable on sunlight exposure.

Preparation of a Composite Material by Graft Copolymerization of Methylmethacrylate and Fish Gelatin Using a Photocatalyst - Complex Oxide RbTe<sub>1.5</sub>W<sub>0.5</sub>O<sub>6</sub>

A new composite material based on fish gelatin (FG) was obtained by graft copolymerization of methylmethacrylate (MMA) onto fish gelatin. The process was initiated by radicals formed by the RbTe1.5W0.5O6 photocatalyst under visible light (λ=400-700 nm) irradiation at room temperature. The characteristics of the new polymer material were obtained by the methods of elemental and physico-chemical analyses.

Amphiphilic copolymers of dimethyl aminoethyl methacrylate and methyl methacrylate with controlled hydrophilicity for antialgal activity

AbstractBiofouling due to algae mass attachment has detrimental effects on the performance and economy of many manufacturing processes. In consideration of this, present research is focused to mitigate such effect through the development of environmentally benign active antialgal cationic amphiphilic copolymers of poly(2‐(dimethylamino)ethyl methacrylate) (PDMAEMA) and methyl methacrylate (MMA). The copolymers compositions were synthesized to tailor various characteristics to control surface biofilm formation and antialgal activities were determined through suspension assay. Biofilm formation of Dictyosphaerium sp. algae on the synthesized copolymers of different surface energies was ascertained by measuring chlorophyll A content and percent adhesion of algae. The copolymers antialgal performance enhanced with increase in PDMAEMA concentration as it exhibited the lowest contact angle as well as adhesion and minimum chlorophyll A contents. Algal adhesion on the surface of materials was also observed by optical microscopy. The copolymers with higher concentration of DMAEMA resulted in greater hydrophilicity which exhibited low adhesion of Dictyosphaerium algae due to possibility of stronger hydration effect and wettability as evident from their lower water contact angle. The developed benign cationic polymers of PDMAEMA and PMMA with varying compositions can lead to important breakthrough in the subject area of antialgal research in several manufacturing processes.

Laser performance and investigation of the optimal density functional and the dependence of the basis sets for (E, E)-2,5-bis (3,4-dimethoxystyryl) pyrazine (BDP) molecule

This manuscript includes some photophysical parameters and some optical properties such as absorption and emission spectra of the (E, E)-2,5-bis (3,4-dimethoxystyryl) pyrazine (BDP) by applying sol–gel and copolymer matrices. The BDP molecular structure is incorporated in sol–gel matrix and copolymer of methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA). In case of sol–gel matrix, the BDP molecular structure has higher quantum yield in addition to photostability maxima. The laser behavior of this molecular structure containing sol–gel matrix is good senior compared to copolymer one via using diode laser (450 nm) as pumping laser of power 160 mW. Also, the fluorescence profile of the BDP molecular structure is sensitized via using cadmium sulfide (CdS) quantum dots (QDs) by applying sol–gel host. The optimized structure of the BDP molecule is obtained via applying B3LYP/6-31G(d) level of theory. The electronic absorption and emission spectra of the BDP molecular structure in ethanol solvent were calculated using time-dependent density functional theory (TDDFT) at CAM-B3LYP/6-31G + + (d, p) level. The obtained theoretical results were compared to experimental ones.

Magnetic thermosensitive polymer composite carrier with target spacing for enhancing immobilized enzyme performance

A novel magnetic thermosensitive polymer composite carrier with target spacing was developed. In this strategy, thermosensitive polymer grafted on magnetic Fe3O4 for enhancing immobilized penicillin G acylase (PGA) performance and introduce immobilized target spacing into magnetic carriers for the first time. Fe3O4 nanoparticles were synthesized by a reverse microemulsion method. The modifier used was the silane coupling agent γ-methylacryloxypropyl trimethoxysilane (KH570) and then reacting with a reversible-adaptive fragmentation chain transfer (RAFT) reagent, 2-cyano-2-propyldodecyl trithiocarbonate (CPDTC). The thermo-sensitive nanoparticle-composite carrier of Fe3O4-grafted-poly N, N-diethyl acrylamide-block-poly β-Hydroxyethyl methacrylate-block-random copolymer of glycidyl methacrylate and methyl methacrylate (Fe3O4-g-PDEA-b-PHEMA-b-P(MMA-co-GMA)) were synthesized by RAFT polymerization technique that used N, N-diethyl acrylamide (DEA), β-Hydroxyethyl methacrylate (HEMA), Glycidyl methacrylate (GMA) and Methyl methacrylate (MMA) as monomer, then which were employed as functional carriers for the immobilization of PGA. Within the carrier, the epoxy group of GMA segment was a target immobilization site for PGA and the introduction of MMA reflected the target space of immobilized PGA to improve catalytic activity and catalytic activity recovery rate of the immobilized PGA. Characterizations demonstrated that the triblock copolymers grafted Fe3O4 nanoparticles were successfully fabricated by the structure design. Besides, under these circumstances the enzyme activity (EA), enzyme loading capacity (ELC) and catalytic activity recovery ration (CAR) reached 31235 U/g, 128.39 mg/g and 93.32 %, respectively. The catalytic activity of immobilized PGA maintained 87.4 % of initial value and the recovery ratio (R) of immobilized PGA reached 96.22 % after recycling 12 times. Furthermore, the immobilized PGA exhibited advantages of low temperature homogeneous catalysis and magnetic separation, which indicated broad application prospects in the biocatalysts’ field.

Polymer/Laponite Nanocomposite Films Produced from Surfactant-Free Latexes using Cationic Macromolecular Reversible Addition-Fragmentation Chain Transfer Copolymers

In this work, the use of positively charged macromolecular reversible addition-fragmentation chain transfer (RAFT) copolymers (macro-RAFTs) in the synthesis of Laponite RD-based nanocomposite latex particles is described. For this purpose, two different amphiphilic copolymers composed of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and nbutyl acrylate (BA) units are investigated. In the first step, the macroRAFT is adsorbed onto Laponite, and then, in the second step, the macroRAFTmodified clay platelets are used in the emulsion copolymerization of methyl methacrylate (MMA), methyl acrylate (MA), or styrene (Sty), with BA. By acting as both coupling agents and stabilizers, the macroRAFT agents lead to the formation of partially encapsulated particles and dumbbell structures. When hydrophobic monomer mixtures that can form film are used, these morphologies result in nanocomposite films with increased stiffness, in comparison to the pure polymer matrix. As observed by dynamic mechanical analysis, the high Young's modulus level presented by the composite films in the rubbery plateau (above 100 MPa when filled with 10 wt% of clay) highlights the strong mechanical reinforcement. Such an improvement can be attributed to the formation of two percolating networks, one of homogeneously distributed and connected platelets and one of macroRAFT chains, within the polymer matrix.

Amphiphilic Statistical Copolymers from Catalytic Chain Transfer as Reactive Surfactants in Emulsion Polymerization

Statistical copolymers of methacrylic acid (MAA) and methyl methacrylate (MMA), butyl methacrylate (BMA), or lauryl methacrylate (LMA) were synthesized via cobalt(II)-mediated catalytic chain transfer polymerization (CCTP) and used as macromonomeric stabilizers in the emulsion polymerization of MMA. By varying the composition, length, and concentration of the macromonomers, we were able to tune the particle size, molar mass, and rheological behavior of the latexes. Most latexes stabilized with macromonomers containing BMA and LMA showed rheological properties such as small yield stress and shear thinning behavior similar to those of binders for coating applications.

Synthesis and Characterization of Photo‐Graft Copolymers of Sodium Salt of Partially Carboxymethylated Tamarind Kernel Powder

AbstractIn the present case, the functionalization of sodium salt of partially carboxymethylated tamarind kernel powder (Na‐PCMTKP, = 0.15), an industrially important natural polymer, is carried out through photo‐graft copolymerization of methyl methacrylate (MMA) and ethyl methacrylate (EMA) onto it using ceric ammonium nitrate (CAN) as a photo‐initiator. The effects of the concentrations of photo‐initiator (CAN), nitric acid, methacrylate monomers (MMA and EMA) and the amount of Na‐PCMTKP as well as reaction time and temperature on photo‐graft copolymerization are being investigated to achieve the maximum graft yields (%G = 232.2 and %GE = 91.0 in the case of MMA and %G = 206.2 and %GE = 90.0 in the case of EMA). A suitable mechanism to explain the photo‐graft copolymerization is being proposed. The kinetics aspect of the photo‐graft copolymerization is also studied and the values of the overall activation energy for the photo‐graft copolymerization in the case of MMA and EMA are found to be 8.10 and 10.49 kJ mol−1, respectively. Besides kinetics study, the chemical structure and thermal properties of the graft copolymers of Na‐PCMTKP containing PMMA and PEMA is studied by FTIR, TGA, and SEM techniques and the results ascertains the evidence of the successful photo‐graft copolymerization of both the methacrylate monomers onto Na‐PCMTKP. The synthesized novel graft copolymers may find their potential applications to be used as metal adsorbents as well as novel excipients for direct compression matrix tablets.

Development of highly ionic conductive cellulose acetate-g-poly (2-acrylamido-2-methylpropane sulfonic acid-co-methyl methacrylate) graft copolymer membranes

A novel cellulose acetate-g-poly (2-acrylamido-2-methylpropane sulfonic acid-co- methyl methacrylate) copolymer was prepared via free radical polymerization for the first time. The chemical structure of the graft copolymer was confirmed using FT-IR, 1H NMR and EDX. The TGA and DSC investigated the thermal changes. Factors affecting the grafting process were studied and various grafting characteristic parameters such as grafting efficiency (%), grafting yield (%) and add-on value (%) were determined. Flexible membranes based on different graft copolymer compositions were fabricated by simple solution casting. Physicochemical properties including ion exchange capability (IEC), water uptake (WU) and proton conductivity (σ) were evaluated. These membranes demonstrated higher IEC, WU and conductivity than the pristine CA. The maximum proton conductivity of the CA-g-poly (2-acrylamido-2-methylpropane sulfonic acid-co- methyl methacrylate) copolymer membrane (68%; Add-on %) was found to be 6.44 × 10−3 S/cm compared with 0.035 × 10−3 S/cm of the pristine CA. Thus, the appropriate graft copolymer composition will allow fine-tuning of the physical characteristics and led to several potential applications, such as polyelectrolyte fuel cells membranes or biodiesel production.

Effects of graphite oxide on thermal and electrical behaviors of coumarin‐based methacrylate copolymers: Its single chain polymer molecule via intramolecular cyclobutane formation

AbstractThe random copolymers of methyl methacrylate (MMA) and 4‐methyl‐2‐oxo‐2H‐chromen‐7‐yl methacrylate (COUMA) [poly (COUMA0.49‐co‐MMA)] (COMCOP1) and [poly(COUMA0.36‐co‐MMA)] (COMCOP2) were prepared via the conventional radical polymerization method. The copolymers were characterized by 1H‐NMR, Fourier‐transform infrared spectroscopy (FT‐IR), UV–visible (UV–vis), thermogravimetric analysis, and differential scanning calorimetry instruments. A kinetic study of the thermal decomposition of COMCOP1 and COMCOP1/GO 16 wt% was investigated using thermogravimetric analyzer with non‐isothermal methods selected for analyzing solid‐state kinetics data. The average activation energy values were calculated via Flynn Wall and Ozawa (FWO) and Kissinger‐Akahira‐Sunose models in a period of α = 0.10–0.70. The average values of activation energy obtained from Kissinger method for COMCOP1 and COMCOP1/GO 16 wt% were 94.5 and 78.4 kJ/mol, respectively, whereas, those of estimated by FWO method were 103.5 and 87.0 kJ/mol. We indicate that well‐defined single chain polymer molecule (SCPM) via intramolecular cyclobutane formation could be obtained by the intrachain photodimerization of coumarin groups during UV irradiation at 365 nm diluted solution of COMCOP1. The photodimerization of coumarin groups in the copolymer was confirmed by UV–vis, FT‐IR, and 1H‐NMR instruments. Dielectric and electrical behaviors of the composites having a semiconductor behavior filled GO were investigated. The activation energy values based on dc conductivity for COMCOP1 loaded GO 10 and 12 wt% were decreased from 0.206 to 0.069 eV. Also, the Ea values estimated for COMCOP2‐loaded GO 12 and 13.6 wt% were 0.0580 and 0.0859 eV, respectively.

Effect of styrene acrylonitrile copolymer on the performance of TEP/PMMA composites

In this paper, TEP/PMMA composites system and SAN/TEP/PMMA composites system were prepared by in situ polymerization using methyl methacrylate (MMA), triethyl phosphate (TEP) and styrene acrylonitrile copolymer (SAN) as raw materials. The results show that TEP can improve the flame retardant performance of PMMA, and the oxygen index increases from 18.35% to 23.75%, when the content of TEP reaches 20 wt%, UL-94 reaches the V-0 level, but its thermal and mechanical properties are affected by ester group in TEP, which decreases significantly with the increase of TEP content; the mechanical and thermal properties of the composites system are improved with the increase of SAN content and tensile strength. The tensile strength increased from 37.06 MPa to 45.5 MPa, the bending strength increased from 44.58 MPa to 55.01 MPa, and the shore hardness increased from 80HD to 82HD. SAN/TEP/PMMA composites system can improve the initial decomposition temperature and increase 16 °C, the flame retardant performance of SAN/TEP/PMMA composites system is not affected by SAN content, and the visible light transmittance of both TEP/PMMA and SAN/TEP/PMMA composites system can reach 88%. This research will be of great significance in many fields such as architecture, automobile, home decoration, advertising and so on.

Cooligomerization of γ-butyrolactone with (meth)acrylates catalyzed by N-heterocyclic carbene: Low possibility of hybrid copolymerization

Copolymerization between lactones and vinyl monomers has significant implications for the synthesis of new polymeric materials; however, a highly reactive cyclic monomer, e.g., ε-caprolactone (CL), leads to a copolymeric product but with a complex structure remaining to be elucidated. Herein, we present cooligomerizations of γ-butyrolactone (γBL), a low-polymerizable cyclic monomer, with (meth)acrylates catalyzed by an N-heterocyclic carbene (NHC) under conditions in which no reaction occurs in the absence of either comonomer. Several experimental studies indicate that the product is not a hybrid cooligomer with an ester linkage in the main chain but a graft cooligomer. The reaction mechanism involves the generation of the γBL enolate by the NHC to initiate oligomerizations of γBL and (meth)acrylates followed by the transesterification of oligo (γBL) with an ester unit of (meth)acrylates. These results prompted us to investigate the previously reported structure of copolymer of CL and methyl methacrylate obtained by a phosphazene base catalyst. The hydrolysis experiment revealed that the copolymeric product turned out not to be a hybrid random copolymer.

Thermal Healing of Copolyacrylate Elastomer Based on Catalyst‐Free Transketalization

AbstractCopolyacrylate can heal via dynamic covalent bonds when it is exposed to external stimuli, such as pH value, ionic strength, humidity, and light, but the incorporation of dynamic covalent bonds will result in a decrease in the thermal stability of materials. It is still a great challenge to design a healable copolyacrylate with high thermal stability. The transketalization is confirmed by the reaction of model compounds including acetophenone glycerol ketal (AGK) and ethylene glycol (EG) in the absence of catalyst. The copolyacrylate elastomers are prepared by copolymerization of methyl methacrylate (MMA), butyl acrylate (BA), 2,3‐dihydroxypropyl methacrylate (DHPMA), and ketal‐containing diacrylate as a cross‐linking agent. The results show that the ketal‐containing copolyacrylate (KCPA) can achieve a 96% of healing efficiency at 120 °C, meanwhile, it has high thermal stability. The healing of copolyacrylate elastomers originates from the transketalization between ketal and o‐dihydroxyl groups, which is confirmed by comparison with those of the ketal‐free control samples. The study will expand the scope of self‐healing polymers based on dynamic covalent bonds.

Graft copolymerization of methyl methacrylate and vinyltriethoxysilane binary monomers onto natural rubber

Graft copolymerization of methyl methacrylate and vinyltriethoxysilane binary monomers onto natural rubber

Metal Affinity Immobilization of the Processive Endoglucanase EG5C-1 from Bacillus subtilis on a Recyclable pH-Responsive Polymer

Establishing a suitable immobilization strategy to improve the accessibility of immobilized cellulase for insoluble cellulose and subsequently recover the enzyme from the remaining substrate is crucial to promote the industrialization of biofuels. Here, using iminodiacetic acid (IDA) and Ni2+ ions, a novel metal-chelated copolymer of methacrylic acid and methyl methacrylate was prepared for the immobilization of His-tagged processive endoglucanase EG5C-1 via affinity interaction between polyhistidine tag and Ni2+. The optimum loading capacity of the functionalized polymer (Eud-IDA-Ni2+) for EG5C-1 was about 280 mg/g, where more than 80% of the activity was recovered. Immobilized EG5C-1 exhibited improved thermal and pH stability and better reusability than the free one, and after five cycles of usage, the hydrolysis productivity remained above 70% of the initial value. The Eud-IDA-Ni2+/EG5C-1 biocomposite displayed reversibly soluble–insoluble characteristics with pH change, which was in the soluble state during the enzyme reaction process but could be recovered in an insoluble form by lowering the pH after the reaction. Thus, the yield obtained from the hydrolysis of an insoluble phosphoric acid-swollen cellulose substrate was similar for the free and immobilized form of EG5C-1. Our combined results suggested that a metal-ion-chelated, pH-responsive polymer had the potential for His-tagged cellulase immobilization to improve both the operational efficiency and economic benefit of the cellulosic biorefinery industry.

Exploring novel carrier for improving bioavailability of Itraconazole: Solid dispersion through hot-melt extrusion

Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion) which is used for taste masking and moisture protection, has shown the ability for forming solid dispersion. The present study aimed to check its feasibility for improvement of pharmacokinetics when studied in-vivo in comparison to model high melting point drug-like Itraconazole. Hot-melt extrusion (HME) is a very well commercially accepted technology for solubility enhancement. However, there are limited polymers that can be utilized due to narrow processing window, low thermoplastic behavior or impart stability to the formed amorphous solid dispersion. Thus, having a carrier, which can address all these concerns, will give the industry an additional choice of the carrier for the development of formulations. Thus, the authors have tried to address this issue and demonstrated the ability of the novel carrier to be exploited into HME technology. Solid dispersions of Itraconazole were prepared, characterized, and tested for in-vivo performance in rats. The results indicated that the carrier exhibited good thermoplastic behavior over a temperature range of 120 °C–220 °C. Itraconazole had a plasticizing effect on the carrier. The in-vitro results indicated 20 fold improved solubility over plain Itraconazole. The results of thermal analysis fosters the possibility of the formation of solid solution which converts into an amorphous form. Kollicoat® Smartseal has shown high potential as a carrier to be used in HME for solubility enhancement of highly insoluble drugs like Itraconazole. It offered no processing challenges and the in-vivo results are in good agreement with in-vitro studies.