Case Reports1 February 1960NEUROLOGIC COMPLICATIONS OF MYXEDEMA: CONVULSIONSEDWIN C. EVANS, M.D., F.A.C.P.EDWIN C. EVANS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-434 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe principal clinical features of myxedema have been well known since the report of the study of 109 cases by the Myxedema Commission of the Clinical Society of London in 1888.1In the past, the endocrine and cardiovascular manifestations have been stressed, with occasional reports of major psychic disturbances. Only recently has emphasis been placed upon the fact that neurologic abnormalities are prominent in the great majority of cases. It has not been generally recognized that convulsions occur as a part of the clinical syndrome of myxedema, and there are no reports of convulsions early in the course of this...Bibliography1. : Report on myxedema, Suppl. to Vol. 34, Clin. Soc. Trans., 1888, Longmans, Green and Co., Ltd., London. Google Scholar2. NickelFrame SNB: Neurologic manifestations of myxedema, Neurology 8: 511, 1958. CrossrefMedlineGoogle Scholar3. Means JH: The thyroid and its diseases, 2nd Ed., 1948, J. B. Lippincott Company, Philadelphia, p. 232. Google Scholar4. UyematsuCobb SS: Preliminary report on experimental convulsions, Arch. Neurol. and Psychiat. 7: 660, 1922. Google Scholar5. ElsbergStookey CABP: Studies on epilepsy. I. Convulsions experimentally produced in animals compared with convulsive states in man, Arch. Neurol. and Psychiat. 9: 613, 1923. CrossrefGoogle Scholar6. LennoxCobb WGS: Epilepsy, Medicine Monographs 14: 68, 1928. Google Scholar7. 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Med. 44: 30-39 (Jan.) 1956. LinkGoogle Scholar19. BlumgartFreedbergKurland HLASGS: Hypercholesteremia, myxedema, and atherosclerosis, Am. J. Med. 14: 665, 1953. CrossrefMedlineGoogle Scholar20. ScheinbergSteadBrannonWarren PEAESJV: Correlative observations on cerebral metabolism and cardiac output in myxedema, J. Clin. Investigation 29: 1139, 1950. CrossrefMedlineGoogle Scholar21. SensenbachMadisonEisenbergOchs WLSL: The cerebral circulation in hyperthyroidism and myxedema, J. Clin. Investigation 33: 1434, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 23, 1959.From the Department of Medicine, St. Josephs Infirmary and the Emory University School of Medicine, Atlanta, Georgia.Requests for reprints should be addressed to Edwin C. Evans, M.D., 1211 West Peachtree Street, N.E., Atlanta, Georgia. 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