Abstract
Mice, normally not susceptible to audiogenic seizures, can be made susceptible by exposing the animal to a loud auditory stimulus (priming) and then retesting the same animal at a later time (retest). δ 9-Tetrahydrocannabinol (THC) was found to decrease susceptibility when administered either prior to priming or prior to retest. This decrease in susceptibility was dependent upon both time and dose. The effectiveness of THC in blocking seizures when administered before priming points to a relatively unique action of this compound. In general, it appears the THC is active at loci involved in predetermining convulsive states precipitated by auditory stimuli.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
