Convergent Strategy Research Articles

Mediation and Convergent Sociality: Toward a Theory of Social Dialogue

The article investigates the mechanisms shaping a new quality of social development in contemporary Russia amidst growing societal challenges. Four key mechanisms are explored: mediation, social dialogue, polysubjectivity, and convergence. These are analyzed for their role in fostering novel forms of social integration and development. The mechanisms serve as tools for studying and shaping the current interplay between tradition and innovation, cultural stasis and social dynamics across various sociocultural contexts and transitional processes. The paper draws upon works presented at the All-Russian Scientific Conference “Individualization and Collectivism in Contemporary Russian Society,” offering an original interpretation that synthesizes and structures these studies. Notable contributions include V.A. Lektorsky’s concept of “the supra-individual as social universality,” which advances our understanding of socio-individual meaning formation and transcends the individual-society dichotomy. A.A. Auzan’s analysis of the dual-core structure of Russian culture aptly captures the unique challenges of social development in Russia. O.V. Aksenova’s examination of the contradictory nature of social action subjects in an increasingly technologized society illuminates the complexities of balancing freedom with necessity, and uniformity with diversity in social action. V.M. Rozin’s approach is considered for its potential to facilitate mediational social dialogue in Russian society. The author argues that neither the individualistic nor the collectivist cores of Russian culture can independently drive effective modernization. Instead, the concept of convergence is proposed as a means to transcend the extremes of ego-individualism and totalitarian collectivism. Three primary directions for implementing convergent strategies are identified: synthesizing individual and social aspects in social action and dialogue, optimizing center-periphery interactions in governance, and developing public-private partnership models as a form of economic convergence. The study emphasizes the need for new forms of social integration and concludes that Russia’s sustainable social development requires an integrative socio-individual model, combining elements of individual freedom and collective solidarity.

Convergent Regularization in Inverse Problems and Linear Plug-and-Play Denoisers

AbstractRegularization is necessary when solving inverse problems to ensure the well-posedness of the solution map. Additionally, it is desired that the chosen regularization strategy is convergent in the sense that the solution map converges to a solution of the noise-free operator equation. This provides an important guarantee that stable solutions can be computed for all noise levels and that solutions satisfy the operator equation in the limit of vanishing noise. In recent years, reconstructions in inverse problems are increasingly approached from a data-driven perspective. Despite empirical success, the majority of data-driven approaches do not provide a convergent regularization strategy. One such popular example is given by iterative plug-and-play (PnP) denoising using off-the-shelf image denoisers. These usually provide only convergence of the PnP iterates to a fixed point, under suitable regularity assumptions on the denoiser, rather than convergence of the method as a regularization technique, thatis under vanishing noise and regularization strength. This paper serves two purposes: first, we provide an overview of the classical regularization theory in inverse problems and survey a few notable recent data-driven methods that are provably convergent regularization schemes. We then continue to discuss PnP algorithms and their established convergence guarantees. Subsequently, we consider PnP algorithms with learned linear denoisers and propose a novel spectral filtering technique of the denoiser to control the strength of regularization. Further, by relating the implicit regularization of the denoiser to an explicit regularization functional, we are the first to rigorously show that PnP with a learned linear denoiser leads to a convergent regularization scheme. The theoretical analysis is corroborated by numerical experiments for the classical inverse problem of tomographic image reconstruction.

Staged hybrid convergent procedure versus pulsed field ablation for pulmonary veins and posterior wall isolation in the treatment of atrial fibrillation

Abstract Background There are limited effective treatment options for persistent atrial fibrillation (AF) patients, with pulmonary veins (PV) isolation alone being considered suboptimal for many patients. Hybrid convergent ablation has been shown to improve clinical outcomes when compared to an endocardial-only radiofrequency (RF) strategy. Pulsed field ablation (PFA) has recently gained growing interest for its efficacy and safety profile in PV and posterior wall (PW) ablation. Objectives To compare clinical outcomes of hybrid convergent RF ablation versus endocardial PFA for PV and PW isolation in patients with persistent AF. Methods From July 2022, 86 persistent AF consecutive patients, receiving endocardial PFA of PV and PW (PFA group, N = 44) or receiving hybrid convergent RF ablation (Hybrid group, N = 42) at our institution were enrolled. Recurrence was defined as any atrial tachyarrhythmia following the 3-month blanking period. Results No differences were found between PFA and Hybrid groups regarding age (PFA 66.0±7.4 years vs Hybrid 63.9±10.6 years; p=0.193) and left atrial volume index (PFA 45.5 [36.7-57.2] ml/m² vs Hybrid 45.0 [39.2-59.7] ml/m²; p=0.920). Differences regarding left ventricular ejection fraction were borderline significant among groups (PFA 55.0 [49.5-62.0]% vs Hybrid 60.5 [52.3-65.0]%; p=0.048), both showing an overall normal LV function. There were no significant differences regarding AF duration (PFA 38.0 months [IQR: 19.2 to 99.0 months] vs Hybrid 70.0 months [IQR: 46.0 to 118.0 months]; p = 0.063). Redo ablation patients’ rate was higher in the hybrid group (PFA n=16, 36.4% vs Hybrid n=28, 66.6%; p<0.001). Procedure duration was Ionger in the hybrid group (179.9±60.1 minutes) compared to PFA endocardial ablation (PFA 106.2±30.7 minute; p<0.01). After a median follow-up of 233.0 [179.0–331.8] days, there was no difference in atrial tachyarrhythmias recurrence rate (PFA n=11, 25.0% vs Hybrid n=10, 23.8%; p=0.897); no difference in the antiarrhythmic drug use rate was found (PFA n=24, 54.5% vs Hybrid n=19, 45.2%; p=0.388). Conclusions PFA of PV and PW, compared with the hybrid convergent ablation strategy, is an endocardial-only, less invasive, and faster procedure. 6-month rhythm outcomes were similar in both groups.

A synthetic strategy for the preparation of alkoxy‐functionalized bis‐1,2,4‐triazinyl‐2,6‐pyridines

AbstractHeteroaryl‐1,2,4‐triazine complexants are commonly utilized in separation science for the selective chelation of minor An from Ln in simulated high‐level waste. To facilitate access to relevant chemical entities for hypothesis‐driven inquiry toward improved separations performance, a synthetic method to construct various alkoxy‐complexant derivatives was required. In this work, a convergent synthetic strategy for the production of 3,3′‐ and 4,4′‐tetraalkoxy‐bis‐1,2,4‐triazinyl‐2,6‐pyridines from readily available starting materials via a dealkylation/alkylation/condensation approach is described. Synthetic method development, substrate scope, preliminary solubility, and hydrolytic stability data in various process‐relevant diluents are reported herein.

Success starts with the first step: insight problem-solving stages and their underlying cognitive strategies

ABSTRACT This study models the underlying cognitive processes of insight, gained after problem solvers encounter an impasse, by dividing the problem-solving process into two stages: initial search for solutions (pre-impasse) and problem-representation restructuring (from impasse to solution). Shorter initial searches were found to be associated with longer restructuring, implying that although the former leads to impasse, it still impacts restructuring and success. This time pattern was associated with faster solutions, higher success rates, and reasoning and convergent thinking-skills. Accordingly, two successful insight problem-solving modes were identified: Some solvers initially apply typical linear-analytic strategies and switch to multi-directional thinking (dissociative strategy) upon impasse. After producing multiple ideas, they associatively combine several of them through insightful solutions (convergent strategy); others apply multi-directional thinking, from the initial search through restructuring. The latter mode prolongs the initial search and, ultimately, the entire solving process. Hence, standard linear-analytic strategies are more effective in insight-based problem solving.

Role of Stakeholders’ Collaboration in the Implementation of School Feeding Programme: A Case of Twelve Years Basic Education Schools in Nyabihu District, Rwanda (2020-2022)

This study was carried out to assess the role of stakeholders’ collaboration in the implementation of school feeding programme of twelve years basic education schools in Nyabihu District, Rwanda. The study utilized a convergent research strategy to collect both quantitative and qualitative data simultaneously. Questionnaires, interviews, documentations and observation were the techniques employed to obtain the primary data and secondary data. The population of the study comprised of 75 stakeholders. Census sampling was used and samples of 75 stakeholders were drawn. For collecting data, researcher organized well-structured questionnaire; data were edited and sorted for the next stage. The data were presented in statistical tables, with frequencies and percentages for classifications of responses by statistical package of social sciences (SPSS) for easier analysis and interpretation. Data from interview sessions was obtained from 4 chairpersons of school general assembly committees. Data from documentation was obtained from school records whereas data from observation were obtained before and during lunch periods. The results indicated that there is positive and significant effect on the role of parents’ engagement on the implementation of school feeding program in twelve years basic education schools (R=.979, p<0.05). To make implementation of school feeding program very successful, parents should make timely payments for their school food donations. To administer the school feeding program, parents should collaborate closely with school administration. Parents must participate in the school meal program rather than believing that it should only be funded by the government.

Modular chemoenzymatic synthesis of ten fusicoccane diterpenoids.

Fusicoccane diterpenoids display intriguing biological activities, including the ability to act as modulators of 14-3-3 protein-protein interactions. However, their innate structural complexity and diverse oxygenation patterns present enormous synthetic challenges. Here we develop a modular chemoenzymatic approach that combines de novo skeletal construction and late-stage hybrid C-H oxidations to achieve the synthesis of ten complex fusicoccanes in 8-13 steps each. A convergent fragment coupling strategy allowed rapid access to a key tricyclic intermediate, which was subjected to chemical and enzymatic C-H oxidations to modularly prepare five oxidized family members. We also conceived a complementary biomimetic skeletal remodelling strategy to synthetically access five rearranged fusicoccanes with unusual bridgehead double bonds. This work may facilitate future investigation into the biological activities of the fusicoccanes and also inspire the implementation of similar hybrid strategies to provide family-level synthetic solutions to other natural product scaffolds.

Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways

Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are molecularly heterogeneous, we hypothesized convergent adaptive strategies to common host selection forces can be inferred from patterns of epigenetic and genetic evolutionary selection in similar tumors. We systematically investigated gene mutations and expression changes in lung adenocarcinomas with no common driver genes (n = 313). Although 13,461 genes were mutated in at least one sample, only 376 non-synonymous mutations evidenced positive evolutionary selection with conservation of 224 genes, while 1736 and 2430 genes exhibited ≥ two-fold increased and ≥ 50% decreased expression, respectively. Mutations under positive selection are more frequent in genes with significantly altered expression suggesting they often “hardwire” pre-existing epigenetically driven adaptations. Conserved genes averaged 16-fold higher expression in normal lung tissue compared to those with selected mutations demonstrating pathways necessary for both normal cell function and optimal cancer cell fitness. The convergent LUAD phenotype exhibits loss of differentiated functions and cell–cell interactions governing tissue organization. Conservation with increased expression is found in genes associated with cell cycle, DNA repair, p53 pathway, epigenetic modifiers, and glucose metabolism. No canonical driver gene pathways exhibit strong positive selection, but extensive down-regulation of membrane ion channels suggests decreased transmembrane potential may generate persistent proliferative signals. NCD LUADs perform niche construction generating a stiff, immunosuppressive microenvironment through selection of specific collagens and proteases. NCD LUADs evolve to a convergent phenotype through a network of interconnected genetic, epigenetic, and ecological pathways.

Conversion of Contaminated Post-Consumer Polyethylene Terephthalate into a Thermoset Alkyd Coating Using Biosourced Monomers.

The synthesis of a high-performance oxidative cross-linked thermoset alkyd coating is described that utilizes a novel recycling strategy from contaminated postconsumer waste polyethylene terephthalate (wPET). A single-stage "depolymerization-repolymerization" process has been developed that allows the exploitation of a waste stream from a commercial PET recycling process with 95% efficiency, which, when copolymerized with glycerol and tall oil fatty acid, delivers a sustainable fatty acid-functional polyester suitable for use in thermoset alkyd coatings. Physical drying challenges have been tackled via the development of a convergent polymer formulation strategy from a single source of wPET and the formulation of the resulting fatty acid-functional polymers with commercial alkyd driers, delivering a thermoset alkyd coating suitable for industrial applications.

Information Source Attributes and Terrorism Risk Preparedness among the Residents of Nairobi City County

Purpose: The main purpose of the study was to establish the association of source attributes and terrorism risk preparedness among the residents of Nairobi City County.
 Materials and Methods: This study followed a mixed-methods design comprising mainly of a questionnaire survey complemented by observation, key informant interviews and document analysis, The design employed the Concurrent Convergent (Triangulation) Parallel strategy. According to the Kenya National Bureau of Statistics, Nairobi City County has a resident population of 4,397,073. A further estimated 2.5 million non-residents visit the city-county daily for business, work, or as tourists and travelers in transit to other counties. Therefore, the target population for this study was approximately 6.5 million. The study population was drawn using stratified purposive random sampling technique where the list of all the sampling locations was categorized into four strata. The sample size was 640 respondents who were proportionately randomly drawn from four different strata. 
 Findings: Regression of coefficients showed that source attributes and terrorism risk preparedness were positively and significantly related (β=0.379, p=0.000). Specifically, 53.6% of the respondents agreed with the statement that receiving information from credible sources on terrorism attacks provides motivation for preparedness in case of a terrorist attack. Similarly, 64.8% agreed with the statement that consistency in terrorism risks communications provides motivation to preparedness behaviour adoption 62.6% of the respondents were in concurrence that competence among that communication terrorism risk preparedness was a motivating factor for preparedness. Further, only 43.1% of the respondents indicated that their organisations were using experts in terrorism risk communication and preparedness. 64.6% were of the opinion that involving non experts in decisions related to terrorism risk communications and preparedness can result in preparedness action taking laxity.
 Implications to Theory, Practice and Policy: The study recommends that professionals charged with emergency risk communication for terrorism preparedness should particularly: demonstrate expertise and competence in the subject matter to instill confidence in their audiences that the information is reliable and useful. This can be achieved by involving qualified professionals, experts, or organizations with relevant experience in emergency risk preparedness and build trust by being transparent, honest, and reliable in communication. Trust can also be enhanced by providing accurate information, acknowledging uncertainties when applicable, and addressing any concerns or doubts promptly.

A Rolling Convergent Equivalent Consumption Minimization Strategy for Plug-in Hybrid Electric Vehicles

A Rolling Convergent Equivalent Consumption Minimization Strategy for Plug-in Hybrid Electric Vehicles

The Biological Activities of Polyether Ionophore Antibiotic Routiennocin is Independent of Absolute Stereochemistry.

Carboxylic polyether ionophores (CPIs) are among the most prevalent agricultural antibiotics (notably in the US) and these compounds have been in use for decades. The potential to reposition CPIs beyond veterinary use, e. g. through chemical modifications to enhance their selectivity window, is an exciting challenge and opportunity, considering their general resilience towards resistance development. Given the very large societal impact of these somewhat controversial compounds, it is surprising that many aspects of their mechanisms and activities in cells remain unclear. Here, we report comparative biological activities of the CPI routiennocin and two stereoisomers, including its enantiomer. We used an efficient convergent synthesis strategy to access the compounds and conducted a broad survey of antibacterial activities against planktonic cells and biofilms as well as the compounds' effects on mammalian cells, the latter assessed both via standard cell viability assays and broad morphological profiling. Interestingly, similar bioactivity of the enantiomeric pair was observed across all assays, strongly suggesting that chiral interactions do not play a decisive role in the mode of action. Overall, our findings are consistent with a mechanistic model involving highly dynamic behaviour of CPIs in biological membranes.

Total synthesis of cypripedin

AbstractThe first facile synthesis of cypripedin (1) was achieved using commercially available 2,3‐dihydroxybenzaldehyde (2) and 5‐bromovanillin (4) via a convergent strategy involving the Mizoroki–Heck reaction and photocyclization as key steps.

Convergent analysis of food products using molecular barcodes, based on LC-HRMS data

There are various analytical techniques available to address the growing interest in the composition of food products. LC-HRMS(/MS) is the most comprehensive technique, providing detailed information at the molecular level. However, given the vast number of different molecules encountered in food products, it is important to obtain a global overview of the dataset before focusing on similarities and differences. Therefore, a convergent strategy was employed, going from non-targeted to targeted analysis, with insightful data representations, most notably Molecular Barcode. Additionally an intermediate, semi-targeted analysis was defined, aimed at the specific detection of animal tissue in food products, using pG+ and related fragments after all ion fragmentation. The use of Molecular Barcode as a starting point to obtain relevant molecular data was also demonstrated. In conclusion, the convergent approach facilitates the design of suitable targeted methods, either to discriminate between samples or to find a generic target.

Safety climate in the operating room in the pre-pandemic and pandemic period of COVID-19: A mixed method study.

To verify whether the COVID-19 pandemic has had an impact on the safety climate based on the perception of the multiprofessional team in the operating room and to analyze the domains of the safety climate during the pre-pandemic and pandemic period of COVID-19, demonstrating the intersections of quantitative and qualitative approaches. Mixed-method research using a convergent approach strategy, carried out in the operating room of a university hospital, located in Rio de Janeiro, Brazil. The nature of the quantitative phase was cross-sectional, and the nature of the qualitative phase was descriptive. We used the Pillar Integration Process to integrate the data. This research considered the pre-pandemic period was defined as before March 2020 and for the pandemic period, the 2nd and 3rd global waves. Research was approved by the institution's board management and ethics committee. 145 health professionals participated in the quantitative approach, and 20 in the qualitative approach. The impact of the COVID-19 pandemic was highlighted in the domains 'Perceived stress' (p-value = 0.017); 'Working conditions' (p-value = 0.040). Six categories emerged from the qualitative analysis, namely: Stress and professional performance due to COVID-19; Patient safety protocols in the operating room; Responsibility for patient safety, lack of effective communication and performance feedback; Biosafety of the professional staff in the operating room; Security culture maturity; Fair culture, organizational learning, and reporting mistakes. As a result of the data integration, 6 pillars were identified: Perception of communication in the operating room; Evolution of safety culture; Overview of protocol management and implementation; Fair organizational culture; Perception of stress due to COVID-19; Perception of professional performance due to COVID-19. The impact that COVID-19 had on the safety climate in the operating room is evident. It underlines the need to implement strategies that support the solidification of attitudes aimed at patient safety, even in emergencies.

Stereoselective synthesis of thailandamide A methyl ester.

A convergent strategy for the stereoselective synthesis of the methyl ester of the structurally challenging and highly labile antibacterial polyene polyketide natural product thailandamide A has been developed. The key steps include the Zincke aldehyde reaction, Stille cross coupling, Negishi reaction, Julia-Kocienski olefination, cross metathesis, and the less explored Pd(I)-based Heck coupling to access different unsaturation bonds. Additionally, Urpi acetal aldol, Evans methylation, and Crimmins acetate aldol reactions were employed to construct four out of six asymmetric centers of the molecule.

A Biotinylated Glycosylphosphatidylinositol (GPI) as the Universal Platform To Access GPI-Anchored Protein Analogues.

A glycosylphosphatidylinositol (GPI) derivative with biotin linked to its mannose III 6-O-position was prepared by a convergent strategy. This biotinylated GPI was demonstrated to bind avidinated proteins readily through biotin-avidin interaction and, therefore, can serve as a universal platform to access various biologically significant GPI-anchored protein analogues.

Formal Total Synthesis of Batrachotoxin Enabled by Radical and Weix Coupling Reactions.

Batrachotoxin (1), originally isolated from a Columbian poison-dart frog, is a steroidal alkaloid. Its 6/6/6/5-membered carbocycle (ABCD-ring) contains two double bonds, one nitrogen, and five oxygen functionalities. We developed a radical-based convergent strategy and realized the total synthesis of 1 in 28 steps. The AB-ring and D-ring fragments were efficiently synthesized and linked by exploiting a powerful Et3B/O2-mediated radical coupling reaction. Vinyl triflate and vinyl bromide were then utilized for a Pd/Ni-promoted Weix coupling reaction to cyclize the C-ring. A hydroxy group of the C-ring was stereoselectively installed by a decarboxylative hydroxylation reaction to prepare an advanced intermediate of our previous total synthesis of 1.

Total Syntheses of Rhodomollins A and B.

The first and asymmetric total syntheses of rhodomollins A and B, two rhodomollane type grayanoids featuring a d-homograyanane carbon skeleton and an oxa-bicyclo[3.2.1] core, were accomplished via a convergent strategy. A Stille coupling and a lithium-halogen exchange/intramolecular nucleophilic addition to the aldehyde sequence were employed to assemble two enantioenriched fragments. The oxa-bicyclo[3.2.1] core was achieved through an intramolecular SN2 substitution of cyclic sulfate of 1,2-diols (Williamson ether synthesis). The A ring oxidation states were adjusted by a Payne/Meinwald rearrangement sequence and subsequent redox transformations.

Total Synthesis of Aleutianamine.

Aleutianamine is a recently isolated pyrroloiminoquinone natural product that displays potent and selective biological activity toward human pancreatic cancer cells with an IC50 of 25 nM against PANC-1, making it a potential candidate for therapeutic development. We report a synthetic approach to aleutianamine wherein the unique [3.3.1] ring system and tertiary sulfide of this alkaloid were constructed via a novel palladium-catalyzed dearomative thiophene functionalization. Other highlights of the synthesis include a palladium-catalyzed decarboxylative pinacol-type rearrangement of an allylic carbonate to install a ketone and a late-stage oxidative amination. This concise and convergent strategy will enable access to analogues of aleutianamine and further investigation of the biological activity of this unique natural product.