A synthetic strategy for the preparation of alkoxy‐functionalized bis‐1,2,4‐triazinyl‐2,6‐pyridines

Abstract

AbstractHeteroaryl‐1,2,4‐triazine complexants are commonly utilized in separation science for the selective chelation of minor An from Ln in simulated high‐level waste. To facilitate access to relevant chemical entities for hypothesis‐driven inquiry toward improved separations performance, a synthetic method to construct various alkoxy‐complexant derivatives was required. In this work, a convergent synthetic strategy for the production of 3,3′‐ and 4,4′‐tetraalkoxy‐bis‐1,2,4‐triazinyl‐2,6‐pyridines from readily available starting materials via a dealkylation/alkylation/condensation approach is described. Synthetic method development, substrate scope, preliminary solubility, and hydrolytic stability data in various process‐relevant diluents are reported herein.