Point Of Convergence Research Articles

Association of Accommodation and Convergence with Axial Length Elongation in Children with Basic Intermittent Exotropia: A 12-Month Observational Study.

The aim of the study was to investigate the association of parameters related to accommodation and convergence and axial elongation in basic intermittent exotropia (IXT) patients and the potential clinical predictors of axial length (AL) growth. A total of 140 basic IXT patients were recruited in this study. The medians of AL growth in different age brackets were chosen to divide the subjects into group A (slower axial elongation group, n = 69) and group B (faster axial elongation group, n = 71). Parameters of dominant and nondominant eyes were compared and analyzed during the 12-month follow-up period. The parameters, including baseline refraction, angle of deviation, Newcastle control score (NCS), accommodative amplitude (AMP), accommodative facility (AMF), accommodative response, positive or negative relative accommodation (PRA/NRA), and near point of convergence (NPC), were analyzed via univariate and multivariate regression. Subjects in the faster axial elongation group tended to have more myopic spherical equivalents (t = 3.956, p < 0.001), greater AMPs of dominant eyes (t = -2.238, p = 0.027), and fewer near points of convergence (t = 2.347, p = 0.020) than in the slower axial elongation group. For dominant eyes, logistic and linear regression analysis revealed that more negative spherical equivalents (OR = 0.603, p < 0.001; β = -0.045, p < 0.001), greater AMPs (OR = 1.201, p = 0.027; β = 0.023, p = 0.010), and less near points of convergence (OR = 0.883, p = 0.021; β = -0.012, p = 0.019) were correlated with the faster axial elongation. For nondominant eyes, a more myopic spherical equivalent (OR = 0.682; p = 0.001; β = -0.029, p = 0.005) was the only parameter correlated with faster axial elongation through regression analysis. In children with basic IXT, faster axial elongation in the dominant eyes was associated with more myopic spherical equivalents, greater AMPs, and lower NPCs. These accommodative parameters can serve as potential clinical indicators for monitoring myopia progression in addition to AL.

CPD Success With Technagogy in Health Professions: Determinants and Merits.

Continuing professional development (CPD) has become a common strategy to address the gaps in knowledge and competencies during the pandemic. Given the drastic changes in the learning environment, this study explored "technagogy" or teaching with technology in CPD in the health professions. A mixed-methods study was used to ascertain the determinants and merits of CPD success from the participants' perspectives (n = 237). The quantitative data underwent structural equation modeling using partial least squares. We also thematically analyzed the qualitative responses and synthesized concurrent findings. The structural model accounted for a 64% variance in the CPD success. Its significant direct predictors (P < .05) were instructional, curriculum, and nurturant effects. From the participants' experiences, we generated four themes as the merits of CPD: learning, teaching, knowledge, and technology scholarships. Finally, we constructed a synthesized model, the CPD Determinants and Intrinsic Assets in Learning, which can offer modest guidance in navigating CPD with technagogy. The study findings emphasize the convergence and divergence points as considerations in teaching and learning with technology. It also offers valuable insights into relevant implications of technagogy in CPD, including its theory, practice, policy, and research.

Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs

Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C. septicum spores is still unknown. Here, we observe that C. septicum germinates in response to specific bile salts. Putative bile salt recognition genes are identified in C. septicum based on their similarity in sequence and organization to bile salt-responsive csp genes in Clostridioides difficile. Inactivating two of these csp orthologs (cspC-82 and cspC-1718) results in mutant spores that no longer germinate in the presence of their respective cognate bile salts. Additionally, inactivating the putative cspBA or sleC genes in C. septicum abrogates the germination response to all bile salt germinants, suggesting that both act at a convergent point downstream of cspC-82 and cspC-1718. Molecular dynamics simulations show that both CspC-82 and CspC-1718 bear a strong structural congruence with C. difficile’s CspC. The existence of functional bile salt germination sensors in C. septicum may be relevant to the association between infection and malignancy.

The Impact of Optimized Blinking on Vision and Related Parameters in Individuals With Computer Vision Syndrome: A Single-Blind Randomized Controlled Trial.

Computer vision syndrome (CVS) has become a significant issue for individuals working on computers and digital devices for extended periods. The ocular and periocular symptoms and signs associated with CVS are a major concern, affecting individuals physically and financially. Additionally, CVS has been linked to the rapid progression of myopia, exacerbating the situation. Blinking has been one of the major treatment methods for the treatment of CVS. This study presents a unique and novel randomized controlled therapeutic trial that evaluates the impact of extended blinking therapyon eyehealth and vision, along with other related parameters. Materialsandmethods: The present studyis a randomized controlled trial conducted from September 2022 to April 2024. Participants aged 18-40 with CVSand a computer vision syndrome questionnaire (CVS-Q)score of ≥6, with mild to moderate refractive error (between -6D and +4D), were included. The sample size was determined based on a pilot study, resulting in a minimum required sample size of 36 patients (18 cases and 18 controls). Participants were randomly assigned to either the case (interventional) or control (conventional) group and were followed up for six months. Cases received conventional CVS treatment plus optimized blinking exercises, while controls received conventional therapy only. Comprehensive ocular assessments were conducted bi-monthly over six months, evaluating changes in uncorrected visual acuity (UCVA), refractive error, near point of accommodation (NPA), near point of convergence (NPC), Schirmer's test, and tear film breakup time (TBUT). The study included 20 patients in the case group and 18 in the control group, primarily aged 20-29 (60.5%). Most patients used laptops for their activities (55.26%). The CVS-Q score significantly decreased in both groups following treatment, with both cases and controls showing significant improvement (p<0.001 for both groups). UCVA in the right eye (RE) and left eye (LE) of the cases improved significantly post-treatment in the interventional group (RE: p=0.002; LE: p<0.001). A significant change in refractive error, which is measured as spherical equivalent (SE), was seen among cases following treatment (RE: p<0.001; LE: p=0.021). Controls showed no significant changes in visual acuity or refractive error. The NPAin the cases improved significantly in the RE (p=0.027) but not in the left. The NPC in the intervention group showed no significant change, while controls showed considerable improvement (p=0.042). Schirmer's test results showed no significant change in either group. However, TBUTin the cases improved significantly (RE: p<0.001; LE: p<0.001). In the controls, TBUT decreased significantly, indicating a deterioration in tear film stability. Asthenopia grades improved considerably in cases, while controls showed only some improvement. Severe symptoms still remained in the control group, emphasizing the potential benefits of the blinking exercise in reducing asthenopia symptoms. Optimized blinking therapy significantly improves vision and refractive error, tear film stability, and discomfort, making it beneficial for chronic computer users to maintain ocular health and enhance productivity and quality of life.

From convergence insufficiency to functional reorganization: Alongitudinal randomized controlled trial of treatment-induced connectivity plasticity.

Convergence Insufficiency (CI) is the most prevalent oculomotor dysfunction of binocular vision that negatively impacts quality of life when performing visual near tasks. Decreased resting-state functional connectivity (RSFC) is reported in the CI participants compared to binocularly normal control participants. Studies report that therapeutic interventions such as office-based vergence and accommodative therapy (OBVAT) can improve CI participants' clinical signs, visual symptoms, and task-related functional activity. However, longitudinal studies investigating the RSFC changes after such treatments in participants with CI have not been conducted. This study aimed to investigate the neural basis of OBVAT using RSFC in CI participants compared to the placebo treatment to understand how OBVAT improves visual function and symptoms. A total of 51 CI participants between 18 and 35 years of age were included in the study and randomly allocated to receive either 12 one-hour sessions of OBVAT or placebo treatment for 6 to 8 weeks (1 to 2 sessions per week). Resting-state functional magnetic resonance imaging and clinical assessments were evaluated at baseline and outcome for each treatment group. Region of interest (ROI) analysis was conducted in nine ROIs of the oculomotor vergence network, including the following: cerebellar vermis (CV), frontal eye fields (FEF), supplementary eye fields (SEF), parietal eye fields (PEF), and primary visual cortices (V1). Paired t-tests assessed RSFC changes in each group. A linear regression analysis was conducted for significant ROI pairs in the group-level analysis for correlations with clinical measures. Paired t-test results showed increased RSFC in 10 ROI pairs after the OBVAT but not placebo treatment (p < 0.05, false discovery rate corrected). These ROI pairs included the following: Left (L)-SEF-Right (R)-V1, L-SEF-CV, R-SEF-R-PEF, R-SEF-L-V1, R-SEF-R-V1, R-SEF-CV, R-PEF-CV, L-V1-CV, R-V1-CV, and L-V1-R-V1. Significant correlations were observed between the RSFC strength of the R-SEF-R-PEF ROI pair and the following clinical visual function parameters: positive fusional vergence and near point of convergence (p < 0.05). OBVAT, but not placebo treatment, increased the RSFC in the ROIs of the oculomotor vergence network, which was correlated with the improvements in the clinical measures of the CI participants.

Current Antithrombotic Treatments for Cardiovascular Diseases: A Comprehensive Review.

Antithrombotic therapies (ATT) play a pivotal role in the management of cardiovascular diseases, aiming to prevent ischemic events while maintaining a delicate balance with the patient's bleeding risk. Typically, ATT can be classified into antiplatelet and anticoagulant therapies. Their application spans a broad spectrum of cardiovascular conditions, ranging from ischemic heart disease to atrial fibrillation, encompassing venous thromboembolisms and innovative structural interventional cardiology procedures. The global burden of cardiovascular diseases is steadily increasing, often giving rise to overlapping clinical presentations. Accordingly, the adoption of combined pharmacological approaches becomes imperative, potentially disrupting the delicate equilibrium between ischemic and bleeding risk, thus leading to nuanced pharmacotherapeutic pathways. In this context, contemporary investigations strive to identify a convergence point that optimizes the duration of medical therapy while addressing the need for antithrombotic effects, especially in the context of ischemic heart disease. This review aims to comprehensively revisit the main antithrombotic strategies in cardiovascular diseases, with the intention of enhancing a systematic approach which is key for the effective clinical management of these patients. Also, the review will examine the most impactful studies that have established the groundwork for current scientific evidence, with acknowledgement of special populations. Finally, we will cast a gaze into the future of this dynamic and evolving research field, exploring forthcoming perspectives and advancements.

Neoliberal Nationalism in Television Commercials: Discursive Representations of Exploring and Entrepreneurial Indonesians

AbstractThe article examines the intertwinement of neoliberalism with nationalism and the new conceptualizations of Indonesianness that it generates. The principles of the two paradigms are often seen as antitheses, but this article shows that the growing neoliberal ideas and practices have informed notions of the nation and Indonesianness. The conjunction of the two paradigms indicates a shift in Indonesia, where until 1998, the state portrayed neoliberal principles as un‐Indonesian. Examining 212 nationalistic television commercials aired between 2005 and 2021, two discourses of Indonesianness can be identified. The first depicts Indonesians as passionately productive and entrepreneurial people, and the second frames the partaking in the marketization and promotion of exotic cultural diversity as acts of nationalism. These discourses reflect the growing acceptance of neoliberal values, especially among the middle class. Despite the relatively new conjunction of neoliberalism and nationalism, these new imaginings continue to build on the older state's discourse that excludes socio‐economic and ethnic minorities. Thus, diverging from the vision of a democratic post‐authoritarian Indonesia, this point of convergence between nationalism and neoliberalism continues to marginalize minorities.

Something to talk about; crosstalk disruption at the neurovascular unit during HIV infection of the CNS

Abstract Although treatable with antiretroviral therapy, HIV infection persists in people living with HIV (PLWH). It is well known that the HIV virus finds refuge in places for which antiretroviral medications do not reach therapeutic levels, mainly the CNS. It is clear that as PLWH age, the likelihood of developing HIV-associated neurological deficits increases. At the biochemical level neurological dysfunction is the manifestation of altered cellular function and ineffective intercellular communication. In this review, we examine how intercellular signaling in the brain is disrupted in the context of HIV. Specifically, the concept of how the blood-brain barrier can be a convergence point for crosstalk, is explored. Crosstalk between the cells of the neurovascular unit (NVU) (endothelium, pericytes, astrocytes, microglia and neurons) is critical for maintaining proper brain function. In fact, the NVU allows for rapid matching of neuronal metabolic needs, regulation of blood-brain barrier (BBB) dynamics for nutrient transport and changes to the level of immunosurveillance. This review invites the reader to conceptually consider the BBB as a router or convergence point for NVU crosstalk, to facilitate a better understanding of the intricate signaling events that underpin the function of the NVU during HIV associated neuropathology.

Integration analysis of pituitary proteome and transcriptome reveals fertility-related biomarkers in FecB mutant Small Tail Han sheep.

The Booroola fecundity mutation (FecB) in Small Tail Han sheep has been shown to enhance ovulation rates and litter sizes by affecting the hypothalamic-pituitary-gonadal (HPG) axis. Despite the pituitary's role in reproductive regulation, its involvement in FecB-induced ovulation remains understudied. Our study aimed to fill this gap by analyzing pituitary tissues from FecB homozygous (BB) and wild-type (WW) ewes during luteal and follicular phases using tandem mass tag-based protein quantification and the DIABLO framework for proteomic and transcriptomic data integration. Significant differences in 277 proteins were observed across estrus periods, with network analysis highlighting the voltage-dependent calcium channel L-type alpha-1C as a key convergence point in oxytocin signaling and GnRH secretion pathways. The DIABLO method revealed a strong correlation (0.98) between proteomic and transcriptomic datasets, indicating a coordinated response in FecB ewes. Notably, higher expression levels of Follicle Stimulating Hormone Subunit Beta (FSHB) and Luteinizing Hormone Subunit Beta (LHB) were found in BB ewes during the follicular phase, potentially due to elevated E2 concentrations. Furthermore, our analysis identified genes related to the Gamma-aminobutyric acid type A receptor family (GABRA2, GABRG1, GABRB1) in the pituitary, with GABRB1 showing higher expression in BB ewes. This suggests a role for GABA in modulating GnRH and gonadotropin feedback loops, potentially contributing to the FecB mutation's effect on ovulation. This study provides novel insights into the pituitary's role in fertility among FecB sheep, identifying GABA as a potential regulatory factor within the HPG axis. The findings also open avenues for discovering new biomarkers in pituitary endocrinology for sheep breeding purposes.

Association of smartphones use, ocular symptoms and binocular dysfunctions in adolescents: a hospital-based cross-sectional study

ABSTRACT Purpose Given the current scenario of increased smartphone use in youth, this study aims to evaluate the proportion of ocular symptoms and binocular dysfunction and their association with smartphone use in adolescents through a hospital-based cross-sectional study. Methods The participants were asked to fill out questionnaires related to smartphone use and symptoms of eyestrain experienced (Balik et al. and Kucer). They were asked about the following seven symptoms: blurring of vision, redness, visual disturbance, secretion, inflammation, lacrimation, and dryness. Each symptom out of the 7, was scored on a scale of 0–1 and was used to calculate an Ocular Symptom Score (OSS) by summing the scores of each symptom.Depending upon the duration of smartphone usage, the participants were classified into four groups: <2 hours/day, 2–4 hours/day, 4–6 hours/day, and >6 hours/day. Binocular functions were assessed using near point of convergence (NPC), near point of accommodation (NPA), Accommodative convergence/Accommodation (AC/A) ratio, dissociated heterophoria, and binocular accommodative facility (BAF). Results A total of 123 smartphone user adolescents, aged 10–19 years were included in this study. The mean age of the study population was 16.58 + 2.8 years, out of which 52.03% were males. Prevalence of ocular symptoms was higher in groups with greater duration of smartphone use (2 to 4, 4 to 6, and >6 hours/day as compared to <2 hours/day: 90.48%, 94.74%, 100% vs. 75% respectively). The mean of NPC was 8.51, it was highest in subjects using smartphones for >6 hours. (p-value = .001). The mean AC/A ratio was 2.83 + 1.03: 1. A low AC/A ratio was associated with a longer duration of smartphone usage (p-value = .0001). The mean of BAF was 7.4 + 3.18 cycles/min, only 30 (24.4%) participants had BAF beyond the normal range (<5 cycles/min). The mean of BAF was lowest in the group with >6 hours/day of smartphone use (p-value < .0001). No significant change was found in NPA and dissociated heterophoria with the duration of smartphone usage. Conclusion Higher duration of smartphone use (>2 hours/day) is associated with various ocular symptoms and binocular dysfunction. However, additional research is necessary to authenticate the results of the study.

Alliances between social occupational therapy and critical occupational science: Propositions to mobilize social justice

ABSTRACT Committed to the necessity of international dialogues in occupational therapy and occupational science, we have developed a proposal for alliance between social occupational therapy and critical occupational science based on a series of theoretical dialogues between Brazilian and Canadian researchers. Through these dialogues, we have aimed to understand and propose contributions that articulate the shared intent of social transformation enhancing social justice of these disciplines. While acknowledging points of difference, we propose an alliance based on points of convergence, including emergence from concerns related to justice and equity; development coming from the ‘margins’; mobilization of critical social theory to orient knowledge production and question power relations within and outside the discipline and the profession; and an intent to work towards social justice, especially with marginalized groups. Our key arguments are informed by theoretical concepts from three authors: Judith Butler’s conceptualizations of vulnerability, precarity, and alliance; Nancy Fraser’s propositions regarding social justice; and Paulo Freire’s concept of dialogue. Through dialogue that recognizes and respects different knowledges and practices, an alliance is produced toward social justice, one that aims to realize more complex theoretical and practical resources for critical thinking about social reality. In turn, possibilities for apprehending how different oppressions impact and influence the possibilities of living can be expanded, informing approaches to building inhabitable worlds and proposing practices of freedom with persons and communities facing oppression.

Some properties of the basins of attraction of the Newton’s method for simple nonlinear geodetic systems

Abstract The research presented in this paper concerns the determination of the attraction basins of Newton’s iterative method, which was used to solve the non-linear systems of observational equations associated with the geodetic measurements. The simple observation systems corresponding to the intersections or linear and angular resections used in practice were considered. The main goal was to investigate the properties of the sets of convergent initial points of the applied iterative method. Therefore, the answers to the questions regarding the geometric structure of the basins, their limitations, connectedness, or self-similarity were sought. The research also concerned the iterative structures of the basin: maps of the number of iterations which are necessary to achieve the convergence of the Newton’s method. The determined basins were compared with the areas of convergence that result from theorems on the convergence of the Newton’s method: the conditions imposed on the eigenvalues and norms of the matrices of the studied iterative systems. One of the significant results is the indication that the obtained basins of attraction contain areas resulting from the theoretical premises. Their diameters can be comparable with the sizes of the analyzed geodetic structures. Consequently, in the analyzed cases, it is possible to construct methods that enable quick selection of the initial starting points or automation of such selection. The paper also characterizes the global convergence mechanism of the Newton’s method for disconnected basins and, as a consequence, the non-local initial points located far from the solution points.

Pirate Terrors: Rome’s Ancient War on Piracy as an Analogue for Contemporary Wars on Terror

Abstract This article offers an analogy between the Roman wars against Mediterranean piracy in the 70s and 60s BCE, especially on Crete and in Cilicia, and the United States’ long wars against terror, which now span more than two decades (2002–), especially in Afghanistan, until recently, and Iraq. The article hopes to show that there are fruitful points of convergence, especially useful for drawing ethical and political lessons from history. Wars against piracy are waged against non-state actors and nearly impossible to prosecute to a negotiated settlement. Such wars quite naturally result in “mission creep,” particularly when situated in a region with broader strategic interests.

Evaluation of near point of convergence and amplitude of accommodation after treatment of malaria with artemether-lumefantrine

Evaluation of near point of convergence and amplitude of accommodation after treatment of malaria with artemether-lumefantrine

KLF10: a point of convergence in cancer cachexia.

Cancer-associated cachexia is a wasting syndrome entailing loss in body mass and a shortened life expectancy. There is currently no effective treatment to abrogate this syndrome, which leads to 20-30% of deaths in patients with cancer. While there have been advancements in defining signaling factors/pathways in cancer-induced muscle wasting, targeting the same in the clinic has not been as successful. Krüppel-like factor 10 (KLF10), a transcription factor implicated in muscle regulation, is regulated by the transforming growth factor-beta signaling pathway. This review proposes KLF10 as a potential convergence point of diverse signaling pathways involved in muscle wasting. KLF10 was discovered as a target of transforming growth factor-beta decades ago but more recently it has been shown that deletion of KLF10 rescues cancer-induced muscle wasting. Moreover, KLF10 has also been shown to bind key atrophy genes associated with muscle atrophy in vitro . There is an elevated need to explore targets in cachexia, which will successfully translate into the clinic. Investigating a convergence point downstream of multiple signaling pathways might hold promise in developing effective therapies for cachexia.

OculoMotor & Vestibular Endurance Screening (MoVES) Normative, Repeatability, and Reliability Data.

This study aims to assess oculomotor and vestibular endurance by utilizing the Oculomotor and Vestibular Endurance Screening (MoVES) assessment in athletes' pre-season and post-season and after a suspected head injury to detect impairment. Athletes (N = 311, 19.4 ± 1.3 years) were recruited to perform the following seven tasks: (1) horizontal saccades, (2) vertical saccades, (3) vergence jumps, (4) horizontal vestibular-oculomotor reflex (VOR), (5) vertical VOR, (6) amplitude of accommodation (AoA), and (7) near point of convergence (NPC). At pre-season, the observed number of eye movements in 60 s are horizontal saccades (74 ± 13 initial 30 s; 67 ± 11 latter 30 s), vertical saccades (70 ± 13; 66 ± 10), vergence jumps (48 ± 12; 45 ± 13), horizontal VOR (38 ± 11; 38 ± 11), and vertical VOR (8 ± 11; 38 ± 11). These results establish a normative database for eye movements within the MoVES assessment and show consistency in the number of movements from pre-season to post-season. The initial results show a trending decrease in the number of eye movements in the initial days post-head injury, which improves to pre-season measures 14-21 days post-injury. This foundation can be used by future studies to explore the extent of binocular and vestibular endurance dysfunctions caused by head injuries that subside within two weeks.

Professional identity of public librarians, archivists and museum professionals in five European countries

PurposeThe purpose is to investigate the professional identity of public library, archive and museum (LAM) professionals in Denmark, Germany, Hungary, Norway and Sweden.Design/methodology/approachThe data have been gathered through the administration of three questionnaires. A comprehensive analysis is conducted to explore the variations in the professionals’ perceptions of their professional proximities to the other LAM professions and other related professions, considering demographic factors such as age, education, gender and immigrant background of participants.FindingsThrough a lens of micro- and macro-professional identities, the findings underscore both clearly perceived role separation between the LAM professions and notable points of convergence, suggesting opportunities for collaborative efforts. The implications of these discoveries are discussed, offering a foundation for future research endeavors.Originality/valueThe study highlights the professions perceived to have the most and least similarity to LAMs based on questionnaire responses, providing valuable insights into the interplay between various professional domains.

Immediate Effects of Pencil Push-Up Exercise on Visual Accommodation Skills in Amateur Badminton Players: A Randomized Controlled Trial

Background Visual skills are crucial for peak athletic performance, with Visual Accommodation (VA) playing a vital role. However, the immediate effects of interventions on VA in sports remain unclear. Objective To investigate the acute effects of a 10-minute Pencil Push-Up (PPU) exercise on VA skills in amateur badminton players. Methods A two-arm, parallel, randomized controlled trial was conducted with twenty-eight amateur badminton players. Participants were matched by age, duration, and frequency of badminton practice, as well as visual health, and randomly assigned to either a Trained Group (TG) or an untrained group (NT). The TG performed a 10-minute PPU exercise, while the NT rested with closed eyes for the same duration. VA parameters, including Amplitude of Accommodation (AA), Accommodative Facility (AF), and Near Point of Convergence (NPC), were assessed before and after the intervention. Results Significant improvements in AA and AF were observed in the TG from pre- to post-intervention (AA: p &lt; .0001, Cohen's d = 1.68; AF: p &lt; .0001, Cohen's d = 3.10). However, no significant changes were observed in NPC (p= .45, Cohen's d =0.60). Furthermore, the TG exhibited greater improvements in AA and AF compared to the NT at post-intervention (AA: 95%CI= [-2.812 to -0.2314], p = .02; AF: 95%CI= [-8.363 to -3.680], p &lt; .0001). No changes were observed in the NT group. Conclusion A single session of pencil push-up exercise acutely enhanced visual accommodation skills, specifically amplitude of accommodation and accommodative facility, in amateur badminton players. This suggests that visual accommodation training methods like pencil push-ups could improve visual performance in sports. Clinical Trials Registry TCTR20240531002 (https://www.thaiclinicaltrials.org/show/TCTR20240531002).

Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability.

Memory processes rely on a molecular signaling system that balances the interplay between positive and negative modulators. Recent research has focused on identifying memory-regulating genes and their mechanisms. Phospholipase C beta 1 (PLCβ1), highly expressed in the hippocampus, reportedly serves as a convergence point for signal transduction through G protein-coupled receptors. However, the detailed role of PLCβ1 in memory function has not been elucidated. Here, we demonstrate that PLCβ1 in the dentate gyrus functions as a memory suppressor. We reveal that mice lacking PLCβ1 in the dentate gyrus exhibit a heightened fear response and impaired memory extinction, and this excessive fear response is repressed by upregulation of PLCβ1 through its overexpression or activation using a newly developed optogenetic system. Last, our results demonstrate that PLCβ1 overexpression partially inhibits exaggerated fear response caused by traumatic experience. Together, PLCβ1 is crucial in regulating contextual fear memory formation and potentially enhancing the resilience to trauma-related conditions.

Local smooth convergence of 𝔽-limit flows

The metric flow is introduced and extensively studied by Bamler [Compactness theory of the space of super Ricci flows, preprint (2020), arXiv:2008.09298; Structure theory of non-collapsed limits of Ricci flows, preprint (2020), arXiv:2009.03243], especially as an [Formula: see text]-limit of a sequence of smooth Ricci flows with uniformly bounded Nash entropy, in which case each regular point on the limit is a point of smooth convergence. In this note, we shall consider the [Formula: see text]-convergence of a sequence of [Formula: see text]-limit flows, and, like Bamler, show that each regular point on the limit is also a point of smooth convergence. The main result will be applied in another work of the authors [P.-Y. Chan, Z. Ma and Y. Zhang, Dimension reduction for positively curved steady solitons, preprint (2023), arXiv:2310.14020].