Conventional Forms Research Articles

Formulation and Evaluation of Solid-Self Nano Emulsifying Drug Delivery System of Darunavir

The main aim of this research article is to Formulate and Evaluate the S-SNEDDS of Darunavir. Darunavir is an anti-retroviral protease inhibitor which is in use from long time, but it has poor bioavailability because of poor aqueous solubility and extensive first pass metabolism, when used in the form of conventional dosage form. As it is a BCS Class II drug, which shows low solubility and high permeability. The S-SNEDDS of Darunavir was prepared to improve its oral bioavailability and its release rate was evaluated by in vitro release. The solubility of Darunavir in various oils was to decide and identify the oil phase of formulations. Different oils, surfactants and co-surfactants were screened for their ability to emulsify the selected oil. The pseudo ternary phase diagram was used to know the self -emulsification region of formulation. The optimized S-SNEDDS formulation contain Darunavir (150mg), Caproyl®90(50mg), Labrasol® and Transcutol® mix (45 mg). The data of the FTIR confirms that there is no interaction observed and the drug and excipients was compatible with each other. The developed SNEDDS formulations were examined for nano emulsifying capabilities, and the resulting nano emulsions were investigated for self-emulsification efficiency, dispersibility and in-vitro dissolution. Centrifugation tests, particle size distribution, heating cooling cycle, zeta potential, and freeze thaw cycling were performed on the optimised formulations to establish the stability of the produced SNEDDS formulation. Further produced S-SNEDDS micromeritics studies were done. The formulation was shown to significantly improve drug release, with total drug release occurring within 60 minutes. Darunavir self-emulsifying formulation was thus effectively produced.

Examining the Awareness, Acceptability, and Adoption of Conventional and non-conventional Forms of Pre-Exposure Prophylaxis (PrEP) for HIV Prevention Among jail-involved Black Sexual Minority men (BSMM) and Black Transgender Women (BTW) in Two Diverse US Cities.

Black sexual minority men (BSMM) and Black transgender women (BTW) are disproportionately impacted by HIV and incarceration in the United States. In-depth interviews (N=34) and ongoing thematic analysis guided by the Exploration Phase of the Exploration, Preparation, Implementation, Sustainment framework were conducted to uncover key themes focused on the awareness, acceptability, and early adoption of conventional (i.e., daily oral pill) and non-conventional forms of PrEP (i.e., long-acting injectable, e-prescription for pick up post release) among jail-involved BSMM and BTW in Chicago, Illinois and Baton Rouge, Louisiana. The majority of participants were cisgender BSMM (88%) and were enrolled in Chicago (65%). There was greater awareness, availability, and adoption of conventional PrEP and non-conventional PrEP e-prescription for pick up post release among Chicago participants compared with Baton Rouge participants. Participants were largely receptive to all three forms of PrEP and stated a high need for HIV prevention in jails and immediately following release. PrEP stigma emerged as a major barrier to conventional daily PrEP adoption while incarcerated; potential misuse (e.g., pill selling) as a potential barrier to PrEP eprescription; and needle aversion and added clinic time as potential barriers to longacting injectable (LAI)-PrEP. Participants indicated that PrEP e-prescription could help support continuity of care post release and highlighted reduced stigma, convenience, and longer-term HIV protection as benefits for LAI-PrEP. Study findings provided context-specific information to inform the implementation of future PrEP interventions for jail-involved BSMM and BTW in two highly HIV-impacted jurisdictions.

Carnap's philosophy of mathematics

AbstractFor several decades, Carnap's philosophy of mathematics used to be either dismissed or ignored. It was perceived as a form of linguistic conventionalism and thus taken to rely on the bankrupt notion of truth by convention. However, recent scholarship has revealed a more subtle picture. It has been forcefully argued that Carnap is not a linguistic conventionalist in any straightforward sense, and that supposedly decisive objections against his position target a straw man. This raises two questions. First, how exactly should we characterise Carnap's actual philosophy of mathematics? Secondly, is his position an attractive alternative to established views? I will tackle these issues by looking at Carnap's response to the incompleteness theorems. Drawing on arguments put forward by Gödel and Beth, I show that some crucial aspects of Carnap's positive account have remained underdeveloped. Suggestions on what a full evaluation of Carnap's position requires are made.

Selection of Constitutive Material Model for the Finite Element Simulation of Pressure-Assisted Single-Point Incremental Forming

Pressure-assisted single-point incremental forming (PA-SPIF) is one of the emerging forming techniques for sheet metals that have been the subject of rigorous research over the past two decades. Understanding of its forming mechanisms and capabilities is growing as a result. Open gaps are still present in material constitutive modelling for accurate numerical predictions and finite-element simulations as the characteristics of localised deformation behaviour in SPIF are different from those of conventional sheet metal forming. The current investigation focused on the comparison of three different material models for the finite-element analysis of PA-SPIF of cold-rolled, dual-phase steel DP600. Experimental trials using different fluid pressures showed good agreement with simulation results with discrepancies in deformed blank thickness and shape geometry predictions of 3–11% and 10–21%, respectively. Within the tested materials and range of parameters, the fracture-forming-limit diagram (FFLD) material model was identified to be of superior accord with experiments.

Evaluation of the Efficacy of Amphotericin B and Terbinafine Microemulsions and Their Combination on Cutaneous Leishmaniasis and Comparison with the Conventional Drug Form in BALB/c Mice.

Intracellular parasitic protozoa of Leishmania sp. causes leishmaniasis. The restricted access of the drugs to affected cells in the treatment of intracellular infections such as leishmaniasis is frequently hampered. Furthermore, most of today's drugs have limited uses due to some containing toxic compounds, and drug resistance is on the rise. In the present investigation, Amphotericin B (AmB) and Terbinafine (Tbf) were loaded in microemulsion (ME) in combination and alone, and the in vivo efficacy was considered in BALB/c mice infected with Leishmania major (L. major). The wound size at the base of the mouse tail was measured, and real-time PCR was performed to quantify the parasite load after the infection challenge. The study demonstrated that the ME-AmB and ME-Tbf formulations are safe and effective compounds for the treatment of cutaneous leishmaniasis by enhancing the effectiveness of AmB and Tbf in reducing the parasite burden.

Политический абсентеизм как часть мировоззрения студенческой молодежи города Москвы

The article examines the factors influencing the non-active participation of Moscow students in the political life of society. It is noted that, as a rule, passive and active political absenteeism is distinguished in the worldview of the capital's youth. The results of the study conducted by the authors showed that the majority of respondents are interested in political events in the country and the capital, but only a small part of them purposefully follow the changes and dynamics of political life in Moscow and Russia. The Internet as the main source of information of the capital's students, other popular channels provide many opportunities to gain the necessary knowledge about politics in a digital society, but a large information flow and its lack of consistency, and often frankly "fake", distorted information do not allow students to fully understand various aspects of political life, respondents often demonstrate the superficiality of their political views. The purpose of our work is to study the nature of political absenteeism in the worldview of Moscow students. The consideration of the problem was based on the results of an initiative targeted political and sociological study among students of three Moscow universities conducted through the Internet platform Google Forms. A sociological survey in the form of an online questionnaire was chosen as the most representative method of collecting empirical data. The sample is a target, quota by gender (N=210). To analyze the results obtained, the following general scientific methods were used: description, analysis, synthesis, classification. The analysis of the survey results showed that municipal elections arouse the least interest among respondents, federal elections are the greatest, but at the same time every third respondent is subject to absenteeism. Among the main reasons was the lack of confidence in the institution of elections, as well as the predictability of their results. The upcoming presidential elections of the Russian Federation in 2024 arouse considerable interest among students. The respondents' protest potential was also studied. The majority of respondents prefer conventional forms of protest and have a sharply negative attitude to various manifestations of extremism. The novelty of the study is to identify the features of the manifestation of absenteeism of student youth in a megalopolis. The prospect of further research is to consider the dynamics of the attitude of students to political participation, as well as regional differences in the types and manifestations of absenteeism in the worldview of the younger generation of Russia.

The Optimization and Evaluation of Flibanserin Fast-Dissolving Oral Films.

Flibanserin (FLB) is a drug used for female hypotensive sexual desire disorder approved by the FDA in August 2015. FLB exhibits extensive hepatic first-pass metabolism and low aqueous solubility, hence poor oral bioavailability. In this study, beta hydroxypropyl cyclodextrin-FLB inclusion complexes were incorporated into orally fast dissolving films. This dosage form was expected to improve FLB aqueous solubility, which would give fast onset of action and decrease presystemic metabolism, hence improving oral bioavailability. The inclusion complex at a ratio of 1:1 was prepared by the kneading method. Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and powder X-ray diffractometry (XRD) were used to confirm complex formation. The Box–Behnken design (15 different formulae of FLB fast-dissolving oral films (FLBFDOFs) were utilized for the optimization of the prepared films. The Expert Design 11 program was utilized to examine the effects of three selected factors, polymer concentration (X1), plasticizer concentration (X2), and disintegrant concentration (X3) on four responses: disintegration time (DT), initial dissolution rate (IDR), dissolution efficiency (DE), and film quality (QF). Numerical optimization was performed by minimizing disintegration time (Y1), while maximizing the initial drug dissolution rate (Y2), dissolution efficiency (Y3), and the quality factor (Y4). The statistical analysis showed that X1 has a significant positive effect on the disintegration time and a significant negative effect on IDR. While X2 and X3 produced a nonsignificant negative effect on IDR. Dissolution efficiency was maximized at the middle concentration of both X2 and X3. The best film quality was observed at the middle concentration of both X1 and X2. In addition, increasing X3 leads to an improvement in film quality. The optimized film cast from an aqueous solution contains hydroxypropyl cellulose (2%) as a hydrophilic film-forming agent and propylene glycol (0.8%) as a plasticizer and cross povidone (0.2%) as a disintegrant. The prepared film released 98% of FLB after 10 min and showed good physical and mechanical properties. The optimized formula showed a disintegration time of 30 s, IDR of 16.6% per minute, DE15 of 77.7%, and QF of 90%. This dosage form is expected to partially avoid the pre-systemic metabolism with a fast onset of action, hence improving its bioavailability that favors an advantage over conventional dosage forms.

The conduct and reporting of qualitative evidence syntheses in health and social care guidelines: a content analysis

Background:This paper is part of a broader investigation into the ways in which health and social care guideline producers are using qualitative evidence syntheses (QESs) alongside more established methods of guideline development such as systematic reviews and meta-analyses of quantitative data. This study is a content analysis of QESs produced over a 5-year period by a leading provider of guidelines for the National Health Service in the UK (the National Institute for Health and Care Excellence) to explore how closely they match a reporting framework for QES.Methods:Guidelines published or updated between Jan 2015 and Dec 2019 were identified via searches of the National Institute for Health and Care excellence (NICE) website. These guidelines were searched to identify any QES conducted during the development of the guideline. Data relating to the compliance of these syntheses against a reporting framework for QES (ENTREQ) were extracted and compiled, and descriptive statistics used to provide an analysis of the of QES conduct, reporting and use by this major international guideline producer.Results:QES contributed, in part, to 54 out of a total of 192 guidelines over the five-year period. Although methods for producing and reporting QES have changed substantially over the past decade, this study found that there has been little change in the number or quality of NICE QESs over time. The largest predictor of quality was the centre or team which undertook the synthesis. Analysis indicated that elements of review methods which were similar to those used in quantitative systematic reviews tended to be carried out well and mostly matched the criteria in the reporting framework, but review methods which were more specific to a QES tended to be carried out less well, with fewer examples of criteria in the reporting framework being achieved.Conclusion:The study suggests that use, conduct and reporting of optimal QES methods requires development, as over time the quality of reporting of QES both overall, and by specific centres, has not improved in spite of clearer reporting frameworks and important methodological developments. Further staff training in QES methods may be helpful for reviewers who are more familiar with conventional forms of systematic review if the highest standards of QES are to be achieved. There seems potential for greater use of evidence from qualitative research during guideline development.

Characterizations of Liquid Crystals as A Transdermal Drug Delivery System

The outermost layer of skin, the stratum corneum, has a role as the primary barrier against water evaporation from the body and drug entry through skin into the body. Thus, overcoming the stratum corneum barrier is important to develop transdermal drug delivery systems. Transdermal administration of drugs represents an excellent alternative to conventional pharmaceutical dosage forms. However, insufficient penetration of the active pharmaceutical substance through the skin is a common problem. Thus, in the present review we discussed the characterizations and the skin permeation enhancing ability of liquid crystal (LC) topical formulations.

Clarifying the “People Like Me”: Racial Efficacy and Political Behavior

Political efficacy, or a sense of confidence that “people like me” can understand politics and receive responsiveness from government, is central to the study of political behavior. However, the reference group that respondents view as “people like me” is not always immediately clear. This limits our ability to infer how efficacy informs political participation. We propose a specific concept and operationalization of racial group efficacy, and we distinguish this concept from racial identity, group consciousness, and conventional efficacy measures. Analyses of data from the 2016 Collaborative Multiracial Post-Election Survey reveal that for white, Black, Asian, and Latina/o Americans, racial efficacy is a more consistent and robust predictor of political participation than standard internal and external efficacy measures. Further, we show that racial efficacy exhibits associations with conventional and unconventional forms of participation that distinguish whites from people of color. We conclude by discussing how people’s racial efficacy informs their engagement in politics, from voting to protests.

OFFICE ADMINISTRATION MANAGEMENT THROUGH MODERN ARCHIVES MANAGEMENT TRAINING IN IMPROVING PUBLIC SERVICES

This service is motivated by the needs and problems of partners. The results of initial observations made by the service team, the service team found various partner problems related to the management of Archives in Naiola Village, TTU District, including the following: First, Lack of knowledge and skills of village officials related to archives; Second, lack of facilities and infrastructure to store existing archival documents; Third, there is no part of the Village Apparatus that specifically takes care of the management of Archives; Fourth, partners only carry out conventional archive management. In fact, the Village Government is asked to be able to document all Village activities both in conventional form or in electronic form because basically archive management that only relies on conventional types is not reliable because it is not effective and efficient enough. Therefore, efforts are needed to improve the skills of village officials and equip village officials with additional knowledge and skills of village administration management through modern archive management training to improve public services. This service activity is carried out according to the predetermined plan. This service activity received a lot of support, especially from the village head of Naiola Kab.TTU who also thought that this activity provided motivation and a more modern picture for village officials related to technological advances that must be utilized properly by village officials as an effort to improve public services.

Mobile sensing in psychological and educational research: Examples from two application fields

Digital technologies play an important role in our daily lives. Smartphones and tablet computers are very common worldwide and are available for everybody from a very early age. This trend offers the opportunity to track digital usage data for psychological and educational research purposes. The current paper introduces two research projects, the PhoneStudy and Learning4Kids that both use mobile sensing software to collect ecologically valid data on the usage of applications installed on smartphones and tablets. This usage data is used for statistical analyses, for a reward system, and to provide feedback to the study participants. The advantages and challenges of using mobile sensing compared to conventional forms of assessments, and the potential applications of mobile sensing in psychological and educational research are discussed.

The superiority of the nanoparticle form of metformin over its conventional form on glucose levels and SIRT -1 gene expression in diabetic male rats

The superiority of the nanoparticle form of metformin over its conventional form on glucose levels and SIRT -1 gene expression in diabetic male rats

Lipid Engineered Nanoparticle Therapy for Burn Wound Treatment.

Skin is the largest organ of the human body protecting the underlying organs and tissues from any foreign attack. Any damage caused in the skin may sometimes result in serious consequences within the internal body tissues. Burn is one such issue that damages the layers of the skin and thereby making the skin vulnerable and prone to any foreign matter entering and causing serious diseases. An online literature assessment was steered for the lipid nanoparticles, burn wound treatments, and different types of nanoformulation. Appropriate information was taken from different electronic scientific databases such as Web of Science, Elsevier, Science Direct, Springer, PubMed, Google Scholar etc. Additional data was summarized from textbooks, local prints and scripts. Recent innovations and developments in nanotechnology-based drug delivery systems have shown promising results in minimizing the drawbacks associated with conventional therapies. Lipid based nanoparticles possess capabilities to deliver active agents to their target site without the possibility of degradation. Conventional therapy of burn wound is costly and the treatment is long lasting, making the patient uncomfortable. Moreover, it also doesn't yield satisfactory results or narrow effects. Encapsulation of bioactives inside the lipid core protects the active entity from pH and enzymatic degradations. This review highlights the drawbacks associated with conventional dosage forms. A lot of consideration is focused on the advancement of nanomaterials using innovative methods in wound care for treating burn wounds with a faster healing effect. This review article highlights recent developments in lipid based nanoformulations for the treatment of burn wound injury.

Matthew Higgs interviewed by Andrew Hunt

This interview considers Matthew Higgs’s role in programming work by self-taught artists and those with developmental disabilities within the context of White Columns, a non-profit artist-run space located in Chelsea, New York City. The conversation describes the active support of work before any critical or institutional consensus emerges around it and explores how painting by self-taught artists and those with developmental disabilities can provide a productive counterpoint to self-reflexive work or art more critical of the narrative of painting as a medium. The term ‘outsider’ is also scrutinized as a useful generalization for painting that operates outside of conventional forms of education and existing foundational narratives in culture. Also discussed is the impact of exemplary historical curators and dealers in the United States and Germany who serve to act as model ‘maverick iconoclasts’.

A brief overview of sustained released drug delivery system

The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated dosing. Sustained release drug delivery has a range of advantages over conventional dosage forms, including increased patient compliance due to less frequent drug administration, significantly reduced steady state drug level fluctuations, maximum drug utilization, the increased safety margin of potent drugs, lower healthcare costs due to improved therapy, and shorter treatment times. The present review focuses on design, fabrication, and various factors that influence the performance of sustained-release dosage forms.

Systematyka operowych duchów

Ghosts have been an attractive element of operatic dramaturgy since the beginning of the genre’s history, and their stage presence influences the metaphysical and fantastic features of the works. In seventeenth- and eighteenth-century operas, conventional forms of musical presentation and characteristics of ghosts were developed, and in the nineteenth century a conventionalized method of musical presentation of ghosts in opera was shaped, which was also due to the great popularity of the theme of various spectres and phantoms in romantic culture. The proposed systematics concerns the ghosts presented in operatic works. Three criteria of division have been introduced: the existential status of ghosts, their number (singularity or multiplicity), and the types of afterlife the ghosts are associated with. The systematics is accompanied by the distinction of the means of musical characteristics used by opera composers in order to suggestively represent ghosts in their works.

Chordoma-An update

Chordomas are rare malignant tumors of the axial skeleton with notochordal differentiation. From amorphological point of view, chordomas display abroad spectrum ranging from the classical, conventional form not otherwise specified (NOS) to forms with hepatoid or renal carcinoma-like differentiation or even poorly or dedifferentiated variants. The detection of brachyury is highly characteristic, though not exclusive. The morphological differential diagnosis from abenign notochordal tumor (BNCT) requires integration of imaging since BNCT is limited to the vertebral bodies and is not osteolytic. Targeted therapy is a current research focus and cell lines as in vitro models are aprecondition for the establishment and validation of this approach.

Formulation development and Evaluation of Colon Specific Delivery System of Anti- amoebic Drug (Tinidazole) using different Polysaccharide carriers

Amoebiasis is an infection of the large intestine caused by Entamoeba histolytica. Tinidazole is the preferred drug used in the treatment of intestinal amoebiasis. The conventional tablet dosage form provides minimal amount of drug in the colon with undesirable adverse effect due to variation in the transit time. Hence, to target the drug directly to the site of action in the colon, there is need to develop colon targeted drug delivery systems that will enhance the therapeutic drug level, increases the bioavailability of active medicament and reduce the dose of drug. The fast disintegrating core tablet of Tinidazole was prepared by direct compression method. The core tablet was evaluated for hardness, thickness, Friability, weight variation, drug content, in vitro disintegration time and in vitro drug release studies. Using the optimized formulation (C3), different formulations (F1-F6) of coated tablet was prepared by using different polymers like chitosan and xanthan gum. The formulated coated tablet were evaluated for various parameters like for hardness, thickness, Friability, weight variation, drug content, swelling study and in vitro dissolution study. The optimized formulation F3 shows 6.24% drug release in Stomach and Small Intestine and maximum drug release up to 96.53% in the colon. The kinetic data analysis of formulations indicated that it fits to Korsmeyer -Peppas Model and follows zero order release kinetics. The mechanism of drug release from the tablet followed non-Fickian (super case-11) transport. The stability studies of the optimized formulation were investigated as per ICH guidelines. There were no significant changes in thickness, hardness, weight variation, friability, drug content and in vitro drug release. These findings suggest that compression coated tablet using polysaccharide carriers provide more site specific delivery, reduced degradation and release of drug in stomach and small intestine.

Insights into various approaches of Phytosomes for Enhanced Therapeutic Potential of Bioactives

Efficient delivery of phytoconstituents is almost challenging task for scientific community owing to predominantly imbalanced hydrophilicity and lipophilicity considerations. Phytoconstituents are mainly hydrophilic and reveal large molecular size which exhibit less absorption and poor bioavailability. Vesicular systems for instance phytosomes are recognized as unique and novel approach to enhance solubility and bioavailability of phytoconstituents and herbal extracts. These are complexed form of phytoconstituents and phospholipid molecules which are also called as phytophospholipid complex or herbosomes. Phytophospholipid complex has shown enhanced pharmacokinetic as well as pharmacodynamic properties in comparison to conventional dosage forms. Different methods have been utilized across the globe for phytosomes preparation such as solvent evaporation, anti-solvent precipitation, co-solvent lyophilization etc. The present review focuses on various approaches commonly employed in the preparation of phytosomes. Significant attributes, characterization aspects along with selection of dosage form for phytosomes have also been highlighted.