Generally, incorporation of nano-particles with conventional concrete (CC) materials expands the bulk belongings of concrete by renovating molecular structures and permits the cement-based materials converted high-strength and durable products. The concentrated tensile possessions of the concrete confines its submissions where the flexural and tensile possessions of the concrete are major. In this steel and synthetic-fibres are expressively enhanced the tensile, toughness, impact resistance and energy-absorption capacity (EAC) of the concrete. Even yet the presence of fibre enhanced the tensile strength capacity (TSC) of the concrete, it hasn’t better the compressive strength capacity (CSC) of concrete suggestively. Therefore, it is very overbearing in growth of compressive strength of the concrete where the compressive tensile belongings to the concrete are major for its application. Investigation was carried to study the impact of nano-Al2O3, nano-Fe2O3, and their hybrid combinations on the setting time, microstructure, fresh, and strength properties of conventional cement concrete. Binding material of concrete mixtures was replaced by different nanoparticles, namely nano-Fe2O3 and nano-Al2O3, with four replacement rates (up to 4 %) that makes somewhat of change in building materials and gives energy to the building. The slump cone test was performed to assess the workability of concrete mixtures. Strength characteristics were evaluated, including the compressive, split tensile, and flexural strengths, for mixtures hardened after 7, 28, and 90 days. Moreover, the slump value of the mixture was decreased with an increase in the replacement rate of nanoparticles. However, slump values were within the acceptable workability and did not affect concrete compaction. However, the strength enhancement of the hybrid nano mixtures was relatively equal to that of the mixtures with only nano-Fe2O3 or nano-Al2O3. The test results revealed that nanoparticles can enhance the strength and microstructure properties of concrete.