Although Orthogonal Frequency Division Multiplexing (OFDM) technology is still the key transmission waveform technology in 5G, traditional channel estimation algorithms are no longer sufficient for the high-speed multipath time-varying channels faced by both existing 5G and future 6G. In addition, the existing Deep Learning (DL) based OFDM channel estimators are only applicable to Signal-to-Noise Ratios (SNRs) in a small range, and the estimation performance of the existing algorithms is greatly limited when the channel model or the mobile speed at the receiver does not match. To solve this problem, this paper proposes a novel network model NDR-Net that can be used for channel estimation under unknown noise levels. NDR-Net consists of a Noise Level Estimate subnet (NLE), a Denoising Convolutional Neural Network subnet (DnCNN), and a Residual Learning cascade. Firstly, a rough channel estimation matrix value is obtained using the conventional channel estimation algorithm. Then it is modeled as an image and input to the NLE subnet for noise level estimation to obtain the noise interval. Then it is input to the DnCNN subnet together with the initial noisy channel image for noise reduction to obtain the pure noisy image. Finally, the residual learning is added to obtain the noiseless channel image. The simulation results show that NDR-Net can obtain better estimation results than traditional channel estimation, and it can be well adapted when the SNR, channel model, and movement speed do not match, which indicates its superior engineering practicability.