Nanofluid is one of the solutions of heat transfer, which can apply in devices fields as nuclear power, Nano-electronics systems, and solar fluid heating. In this work, the natural convection of Cuwater nanofluid is examined using the Lattice Boltzmann Method (LBM) as a mesoscopic approach. The main objectives of this work are to study the performance and pattern of Cu-water nanofluid and to demonstrate that the nanofluids behave differently while improving their energy transfer compared to pure fluids. The set goal was achieved by solving the tasks: based on the streamlines and isotherms profiles to demonstrate how the convection process and temperature gradients improve. Also, conducting study on heat transfer of nanofluid by calculate the Nusselt number. Depending on the nanoparticle volume percentage, the Grashof number Gr , and the hot obstacle have a significant impact on the convection flow and rate of heat transfer. The most important result is the enhancement of heat transfer with the increasing of volume fraction for a particular Grashof number, also it improves with the rising of Grashof number for a particular nanoparticles volume fraction. Therefore, the aspect ratios of the enclosure have played a significant part in Nusselt number variation. In addition, we found that the Nusselt number avg Nu is higher in the case of cavity without hot obstacle more than for cavity with hot obstacle, so the heat transfer improves in the case of cavity without hot obstacle. The significance of the obtained results consists that the nanofluid is one of the ways to improve heat transfer due to its specific characteristics and properties.