Precipitation is a crucial component of the water cycle and is essential for the livelihood of people and ecosystems; therefore, understanding precipitation parameters is vital. Stable isotopes in precipitation can provide important information on precipitation sources, atmospheric circulation patterns, and hydrological processes. In this study, stable isotopes in precipitation for four cities in India were analyzed, namely New Delhi, Hyderabad, Shillong, and Calicut, using data from the International Atomic Energy Agency (IAEA) Global Network for Isotopes in Precipitation (GNIP). The GNIP data were supplemented with in-situ measurements. Results showed the correlations between climate-related factors such as surface air temperature and precipitation levels with the stable isotope composition of precipitation. The relationships critically explore interannual variations in the isotope data over the last three decades. The Local Meteoric Water Line (LMWL) for New Delhi and Hyderabad had intercepts less than 10‰, implying a higher evaporation effect over precipitation, consistent with arid and semi-arid regions with increased altitude. The weighted average value of d-excess for southern and Himalayan points were 10.7 and 12.7, respectively, and the average value of δ¹⁸O were − 3.65 and − 5.84, and δ²H were − 16.8 and − 35.8. The d-excess value was significantly lower in the Northern part (New Delhi), with an average weighted value of 6.6. The key values include the isotopic composition of rainfall in different regions of India, the LMWL for different stations, the d-excess value, and the consistency of meteoric water lines with regional and global values. The results of this study provide valuable information on the variability of stable isotopes in precipitation in India. The study's outcomes can be compared with the isotopic composition of surface water and groundwater. This discovery offers more understanding of the isotopic differences that occur on a smaller scale during organized convection and the factors that affect them. As a result, it enhances our ability to decipher the paleoclimate data in arid, semi-arid, and subtropical monsoon regions.