For the first-order unstable object with time delay, the PD control parameter tuning method based on the traditional definition lacks consideration of the lower boundary of amplitude margin, resulting in a certain deviation between the result and the reality. In this paper, through analyzing the control loop of quadrotor UAV (QUAV), the integral link is moved from the controlled object to the controller, and the QUAV becomes a first-order unstable object, realizing the conversion of PD to PI in the hovering state. The system stability margin remains unchanged, and the position and attitude control objectives can be realized synchronously. By means of parameter setting method, the upper boundary of stability margin is obtained. Pade approximation is carried out for the time delay link, and then the lower margin of the amplitude margin is deduced according to Routh stability criterion, so as to obtain a more accurate reachable stability margin region. To avoid the high gain feedback of attitude angular velocity of QUAV, a numerical analytical setting formula for PD attitude control is derived to meet the requirements of gain and phase margin. The graph shows that the reachable region obtained by the strict definition of stability margin analysis decreases significantly. The proposed method can not only give the reachable region intuitively, but also give the tuning formula of the control parameters concisely, which has important engineering application value.