As modern control systems involve a growing number of actuators, the consequent number of faults occurrence, which may deteriorate the closed-loop system performance, is increasing. Focusing on the containment control problem of generic nonlinear high-order heterogeneous uncertain Multi-Agent Systems, this study proposes a novel distributed adaptive fault-tolerant Proportional-Integral-Derivative control protocol to improve the reliability and the resilience of the whole networked systems against actuator failures. The Lyapunov theory, combined with the Barbalat lemma, provides the design of suitable adaptive mechanisms that adjust the PID control actions to ensure the asymptotic convergence of the closed-loop containment errors for the overall network, hence implying the convergence of each agent state toward the convex region shaped by the multiple leaders, despite the occurrence of actuators faults. The fulfillment of the fault-tolerant containment objective is ensured by requiring a lower computational burden with respect to alternative solutions, hence resulting in more attractive for wider practical engineering applications. Numerical simulation results, also including a comparison analysis with a state-of-the-art controller, corroborate the efficiency and the advantages of the proposed distributed PID controller.