Control Options Research Articles

Adoption of herbicide resistance tests in German arable farming: Insights from the theory of planned behaviour

AbstractAn increasing number of herbicide‐resistant weeds challenge farming systems worldwide. Bans on active ingredients in chemical crop protection, which result in fewer weed control options, emphasise the importance of herbicide resistance management in arable farming. Resistance testing allows farmers to get an objective overview of the prevailing herbicide resistances on their land and to adjust their management strategies accordingly. Nevertheless, no study has examined farmers' adoption of herbicide resistance tests. For this purpose, an online survey with 197 German arable farmers was conducted. The adoption decision was investigated by applying the theory of planned behaviour framework. The results suggest that informing farmers of the economic benefits associated with herbicide resistance tests can facilitate widespread adoption. Furthermore, awareness of the availability of herbicide resistance tests needs to be raised through both advertising and crop consultants. Results from this study are relevant for several interest groups as the usage of herbicide resistance tests can help reduce the emergence of new resistance by optimising herbicide use at the farm level.

Bacteriophage vB_kpnS-Kpn15: Unveiling its potential triumph against extended-spectrum beta-lactamase-producing Klebsiella pneumoniae - Unraveling efficacy through innovative animal alternate models

Aim –To isolate bacteriophages targeting extended-spectrum beta-lactamase-producing K. pneumoniae and evaluate their effectiveness across diverse models, incorporating innovative alternatives in animal testing. Methods and resultsvB_kpnS-Kpn15 was isolated from sewage sample from Thane district. It produced a clear plaques on K. pneumoniae ATCC 700603. It has a flexible, non-contractile long tail and an icosahedral head and the Siphoviridae family of viruses in the order Caudovirales matched all of its structural criteria. Sequencing of vB_kpnS-Kpn15 revealed a 48,404 bp genome. The vB_KpnS-Kpn15 genome was found to contain 50 hypothetical proteins, of which 16 were found to possess different functions. The vB_KpnS-Kpn15 was also found to possess enzymes for its DNA synthesis. It was found to be lytic for the planktonic cells of K. pneumoniae and bactericidal for up to 48 h and potentially affected established K. pneumoniae biofilms. It demonstrated a broad host range and caused lytic zones on about 46 % of K. pneumoniae multi-drug resistant strains. In an in vitro wound and burn infection model, phage vB_kpnS-Kpn15 in combination with other phages resulted in successful cell proliferation and wound healing. Based on vB_kpnS-Kpn15's lytic properties, it can be incorporated in a bacteriophage cocktail to combat ESBL strains. ConclusionsThe phages isolated during this research are better candidates for phage therapy, and therefore provide new and exciting options for the successful control of antibiotic-resistant bacterial infections in the future. The utilization of animal alternative models in this study elucidates cellular proliferation and migration, underscoring its significance in screening novel drugs with potential applications in the treatment of wound and burn infections. Significance and impact of the researchThe findings of this research have implications for the creation of innovative, promising strategies to treat ESBL K. pneumoniae infections.

ROS-Responsive Nanoprobes for Bimodal Imaging-Guided Cancer Targeted Combinatorial Therapy.

Chemotherapy mediated by Reactive oxygen species (ROS)-responsive drug delivery systems can potentially mitigate the toxic side effects of chemotherapeutic drugs and significantly enhance their therapeutic efficacy. However, achieving precise targeted drug delivery and real-time control of ROS-responsive drug release at tumor sites remains a formidable challenge. Therefore, this study aimed to describe a ROS-responsive drug delivery system with specific tumor targeting capabilities for mitigating chemotherapy-induced toxicity while enhancing therapeutic efficacy under guidance of Fluorescence (FL) and Magnetic resonance (MR) bimodal imaging. Indocyanine green (ICG), Doxorubicin (DOX) prodrug pB-DOX and Superparamagnetic iron oxide (SPIO, Fe3O4) were encapsulated in poly(lactic-co-glycolic acid) (PLGA) by double emulsification method to prepare ICG/ pB-DOX/ Fe3O4/ PLGA nanoparticles (IBFP NPs). The surface of IBFP NPs was functionalized with mammaglobin antibodies (mAbs) by carbodiimide method to construct the breast cancer-targeting mAbs/ IBFP NPs (MIBFP NPs). Thereafter, FL and MR bimodal imaging ability of MIBFP NPs was evaluated in vitro and in vivo. Finally, the combined photodynamic therapy (PDT) and chemotherapy efficacy evaluation based on MIBFP NPs was studied. The multifunctional MIBFP NPs exhibited significant targeting efficacy for breast cancer. FL and MR bimodal imaging clearly displayed the distribution of the targeting MIBFP NPs in vivo. Upon near-infrared laser irradiation, the MIBFP NPs loaded with ICG effectively generated ROS for PDT, enabling precise tumor ablation. Simultaneously, it triggered activation of the pB-DOX by cleaving its sensitive moiety, thereby restoring DOX activity and achieving ROS-responsive targeted chemotherapy. Furthermore, the MIBFP NPs combined PDT and chemotherapy to enhance the efficiency of tumor ablation under guidance of bimodal imaging. MIBFP NPs constitute a novel dual-modality imaging-guided drug delivery system for targeted breast cancer therapy and offer precise and controlled combined treatment options.

Acceptance of contraception in couples receiving contraceptive counselling in antenatal period.

Objective: To conduct research in order to determine the effect that antenatal counseling has on the use of contraception during the immediate postpartum period in the conservative society that exists in the rural areas surrounding Lahore, Pakistan. Study Design: Randomized Clinical Trial. Setting: Central Park Teaching Hospital in Lahore, Pakistan. Period: Jan, 2022 to April, 2022. Methods: A random selection was used to divide 400 antenatal patients who were at least 28 weeks along in their pregnancies into two groups. Patients who did not receive antenatal counseling regarding birth control options were included in Group X while patients who received antenatal counseling regarding the use of birth control were included in Group Y. A pre-designed proforma was completed following a written informed consent. Data was analyzed using SPSS 26. Results: Data was collected from 400 females (200 in each group) who visited CPTH. The mean age of the female participants was 27.26 + 4.78 years. Most of the participants lived in extended family systems. Nearly one third of the females was illiterate or has primary level of education. Approximately one-fourth of the females were graduated or above. After first pregnancy, 68% in group I and 86% in group II mentioned that they used contraceptive method, (p = 0.005, statistically significant). After second and fifth pregnancy, effect of counseling was affective and difference was statistically significant. The most common contraceptive method was barrier method followed by injection after first and second pregnancy. Conclusion: Antenatal contraceptive counseling proves to be a highly effective intervention in enhancing the acceptance and utilization of contraceptives within the conservative societies of Pakistan. Health care providers ought to undergo comprehensive training and exhibit unwavering motivation in order to effectively engage in antenatal contraceptive counseling.

Scabies: current knowledge and future directions

Scabies is a global public health issue, with approximately 455 million new cases worldwide each year. Scabies is a parasitic skin disease caused by infestation with the mite Sarcoptes scabiei var. hominis that can lead to secondary skin infections such as impetigo. In 2017, scabies was added to the World Health Organization’s list of neglected tropical diseases renewing calls for effective management and control of the disease. Mass drug administration has emerged as an effective strategy to control scabies, especially in highly endemic settings. In this review, we detail scabies epidemiology and risk factors, clinical characteristics and diagnosis, as well as control options, and future areas for scabies research.

Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies

Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies

Three-year analysis of results, safety and progression in patients with open-angle glaucoma or ocular hypertension, undertaking trabecular microsurgery

AimTo evaluate the efficacy, safety, structural and functional progression following the insertion of iStent inject ® implants in patients with open-angle glaucoma or ocular hypertension at a tertiary-level hospital. Materials and methodsA retrospective study included 98 eyes (57 males and 41 females) with open-angle glaucoma or ocular hypertension, which underwent iStent inject W® implantation (Glaukos, Corporation, CA) between December 2018 and December 2022. Differences in intraocular pressure (IOP), the number of hypotensive eye drops used, and structural and functional tests were assessed between preoperative values and subsequent reviews during a follow-up period of one (n = 98), two (n = 55), and three years (n = 15) after surgery. ResultsAmong the 98 eyes studied, 85% were diagnosed with open-angle glaucoma (50% mild, 32% moderate, and 18% severe) and 15% with ocular hypertension. There was a statistically significant reduction in IOP compared to preoperative values for all visits except the 1-month (p = 0.36) and 3-year (p = 0.39) visits. Visual acuity increased from 0.39 ± 0.25 to 0.72 ± 0.24 (p < 0.01), considering that a significant portion of the interventions included cataract surgery. Before surgery, 66% of the sample used 2 or more hypotensive medications. Post-surgery, the number of hypotensive medications decreased (from 1.88 ± 0.84 to 0.21 ± 0.59 at 3 years) (p < 0.01), with an 88.9% reduction in the number of medications over three years. After surgery, 75% of cases did not require any medication.Regarding structural and functional tests, thickness of retinal nerve fiber layers (RNFL (p = 0.35), excavation / papilla ratio E/P (p = 0.31), visual function index(VFI (p = 0.06), and deviation mean (MD (p = 0.06) showed no statistically significant differences post-intervention. However, standard deviation of the pattern (DSM) did exhibit differences, decreasing from 5.46 ± 4.03 dB to 5.34 ± 3.48 dB (p = 0.02). ConclusionThe results of this study suggest that the iStent inject W® technique constitutes an effective and safe option for tension control and glaucoma treatment.

Staged Excision Technique for Periocular Cutaneous Melanoma: Long-Term Outcomes of the Square Procedure.

To examine the long-term outcome of the staged excision via the square procedure for the treatment of periocular thin cutaneous melanoma. A retrospective chart review of 95 periocular cutaneous melanoma-in-situ and microinvasive melanoma tumors that were treated with the square procedure between April 1, 1994 and December 31, 2018 at the University of Michigan. Demographic and clinical data were evaluated. Of 95 cases, 19 (20%) were atypical junctional melanocytic proliferation with features of early melanoma-in-situ, 63 (66.3%) were melanoma-in-situ and 13 (13.7) were microinvasive melanoma with Breslow depth less than 1 mm. Tumor-free margins were achieved with a median margin of 10 mm (range 5-40 mm). Most cases (68.4%) required multiple excision stages. Surgical revision was necessary in 17.9% of cases and was associated with larger defect size. Local recurrence was noted in 8 patients (8.4%) at a median of 42 months postreconstruction. No tumor characteristics were found to predict recurrence. The square procedure for periocular melanoma offers an 8.4% recurrence rate, consistent with literature reports on similar staged excision approaches. The staged excision provides an excellent option for comprehensive margin review and tumor control with acceptable cosmetic results after reconstruction.

Ultra-Fast Nonlinear Model Predictive Control for Motion Control of Autonomous Light Motor Vehicles

Advanced Driver Assistance System (ADAS) is the latest buzzword in the automotive industry aimed at reducing human errors and enhancing safety. In ADAS systems, the choice of control strategy is not straightforward due to the highly complex nonlinear dynamics, control objectives, and safety critical constraints. Nonlinear Model Predictive Control (NMPC) has evolved as a favorite option for optimal control due to its ability to handle such constrained, Multi-Input Multi-Output (MIMO) systems efficiently. However, NMPC suffers from a bottleneck of high computational complexity, making it unsuitable for fast real-time applications. This paper presents a generic framework using Successive Online Linearization-based NMPC (SOL-NMPC) for for the control in ADAS. The nonlinear system is linearized and solved using Linear Model Predictive Control every iteration. Furthermore, offset-free MPC is developed with the Extended Kalman Filter for reducing model mismatch. The developed SOL-NMPC is validated using the 14-Degrees-of-Freedom (DoF) model of a D-class light motor vehicle. The performance is simulated in matlab/Simulink and validated using the CarSim® software (Version 2016). The real-time implementation of the proposed strategy is tested in the Hardware-In-the-Loop (HIL) co-simulation using the STM32-Nucleo-144 development board. The detailed performance analysis is presented along with time profiling. It can be seen that the loss of accuracy can be counteracted by the fast response of the proposed framework.

Inoculum sources and management of bean scab caused by Elsinoë phaseoli

AbstractBean scab caused by Elsinoë phaseoli is a major challenge to common bean cultivation in Kenya. However, knowledge about its epidemiology and management is limited. This study conducted three experiments in Kakamega, Kenya, evaluating scab inoculum sources and control options. The first experiment evaluated three different inoculum sources over two seasons; bean crop residue caused the highest scab incidence in both the 2021 (62.1%) and 2022 (81.1%) seasons. The second experiment assessed the effect of rotation history on scab over three seasons. Scab incidence consistently surpassed 90% within the first 30 days after planting in half‐yearly rotated fields across all seasons, while the disease was absent after planting in fields with no recent history of legumes. Fields rotated out of legumes consistently had the highest grain yield, averaging 1.5 t ha−1 over the seasons. Additionally, the rotation land treatment displayed significantly more pods per plant during the 2021 (9.7), 2022a (9.8), and 2022b (12.5) seasons. In the third experiment, the impact of five fungicides and four cropping systems on bean scab was investigated over two seasons. Neither fungicide treatments nor cropping systems had an effect on bean scab incidence even when only severe symptoms were considered. Carbendazim had the highest yield (1.9 t ha−1) outperforming the unsprayed control only in the 2022 season while none of the other fungicides outperformed the control treatment in yield parameters in either season. This study emphasizes the challenge of managing bean scab without proper crop rotation and underscores the role of crop residue as a critical inoculum source.

Response of sod webworm Chrysoteuchia topiaria Zeller (Lepidoptera: Crambidae) to endophyte infection and mycotoxin profiles of cool‐season turfgrass species grown for seed in Oregon

AbstractThe subterranean sod webworm, also known as cranberry girdler (Chrysoteuchia topiaria), is one of the most damaging insect pests in cool‐season grass grown for seed crops in Oregon. Chemical control options are limited and require irrigation or rainfall for adequate insecticide incorporation to control C. topiaria larvae. Epichloë endophytes associated with cool‐season turfgrass species and their mycotoxin profiles are well‐documented in offering plant protection against invertebrates; these fungi may offer sustainable pest management tools. Our objectives were to characterize endophyte‐mediated resistance to C. topiaria in 19 commercially available cultivars of tall fescue, perennial ryegrass, and fine fescue grown for seed in Oregon. Endophyte status (presence and viability) of fungal endophytes and their mycotoxin profiles were measured using polymerase chain reaction, and liquid chromatography‐tandem mass spectrometry, respectively. No‐choice assays were conducted in the laboratory to measure the impact of endophyte status on C. topiaria larvae in two separate no‐choice experiments. Our results suggested that increased mortality of C. topiaria larvae (R2 = 0.8526, Experiment 1; R2 = 0.6628, Experiment 2) in tall fescue cultivars was most influenced by total peramine and ergot alkaloid, and total ergoline concentrations in Experiment 1 and 2, respectively. However, no significant effect on insect mortality was found in the perennial ryegrass and fine fescue cultivars included in this study. Overall, these findings suggest a viable grass–endophyte association can be utilized as a sustainable alternative to foliar insecticides for C. topiaria management in tall fescue seed crops.

Research on Botrytis cinerea-caused gray rot disease in strawberries with Carpathian genus bees and entomovector technology

Gray rot is a widespread disease that is harming a lot of cultivated plants worldwide. It seriously impairs the strawberry industry's profitability by causing harm to the crop both during and after harvest. The article describes how biocontrol tests were conducted against the gray rot disease that affects strawberry plants, with the use of entomovector technology that uses biopreparations and bees. As a consequence of the study of the disease of gray rot of strawberries caused by the fungus Botritis cinerea with entomovector technology, the fight against the disease is carried out. Carpathian genus pollinating bees are employed as an entomovector agent during the investigation. They are members of a widely distributed bee order, and before this study, there was ample evidence that they boost production through plant pollination. The pathogen Gliocladium catenulatum, which is the basis for the medicine Prestop-Mix, as well as Trichoderma asperellum Botrytis cinerea identified from local soil, are suppressed by the drug as a biopreparation, according to research using entomovector technology. The article presents the results of a study of the disease of gray rot in experimental areas of strawberry fields in the Eastern region, caused by the fungus Botritis cinerea, using entomovector technology. By comparing the results with control options, it was determined that using Carpathian bees to apply biofungicide is one of the most efficient ways to combat gray rot damage to strawberry plants. Dispensers were placed in specially designed apiaries. During an investigation into the battle against Gray rot disease in Symphony strawberries cultivated in dedicated research areas, the impact of fruit weight following pollination as well as the effect of both pollination and the biocontrol agent on overall weight were discovered. Both the quantity of strawberry blooms and fruit production are rising. The study's findings demonstrated that one of the best strategies for preventing gray rot damage to strawberry plants is to employ biofungicide in conjunction with Carpathian genus bees. However, weather conditions will directly affect how successful control efforts are.

Cost-effective, open-source light shutters with Arduino control

In optical experiments, shutters are devices that open or close a path of light. They are often used to limit the duration of light exposure onto a target or onto a detector to reduce possible light-induced damage. Many commercial shutters are available for different applications – some provide very fast opening and closing times, some can handle large optical powers, and others allow for fail-safe operation. Many of these devices are costly and offer limited control options. Here we provide an open-source design for a low-cost, general purpose shutter system based on ubiquitous actuators (servo motors or solenoids) that are connected to an Arduino-based controller. Several shutters can be controlled by one controller, further reducing system cost. The state of the shutters can be controlled via a display built into the controller, by serial commands via USB, or by electrical control lines. The use of a microcontroller makes the shutter controller adaptable – only control options that are used need to be included, and the design accommodates a selection of display and actuator options. We provide designs for all required components, including 3D print files for the actuator holders and cases, the Arduino code, libraries for serial communication (C and python), and example graphical user interfaces for testing.

БИОЛОГИЧЕСКИЕ ОСОБЕННОСТИ И УРОЖАЙНОСТЬ СОРТОВ БАЗИЛИКА ПРИ ВЫРАЩИВАНИИ В ЛЕНИНГРАДСКОЙ ОБЛАСТИ

New varieties of basil created by breeders over the past 15 years differ in their morpho-biological characteristics and need to be assessed for adaptability to specific climatic and soil conditions in a particular growing region. In 2021-2023 In the Leningrad region, on the experimental field of St. Petersburg State University, an agrobiological assessment of 11 varieties of basil from the collection of the All-Russian Research Institute named after N.I. was carried out. Vavilov when growing them for greens in a film greenhouse: Yerevan, Green Openwork, Georgia, Emerald, Mauritanian, Metallica, Moskvoretsky Semko, Red Ruby, Stella, Troll and Magician. The Yerevan variety was chosen as a control option. According to biometric indicators, the varieties Stella, Troll, Mavritansky, Moskvoretsky Semko stood out: height 40-47 cm, number of side shoots 12.5-14.5 pcs., number of leaves 133-164 pcs. The highest yield of basil greens, 19-32 % higher than the control variant (1.87 kg/m2), was formed by the varieties Stella and Georgia - 2.47 kg/m2, Charodey - 2.4 kg/m2, Moskvoretsky Semko 2.27 kg/m2 and Mauritanian 2.23 kg/m2. When analyzing the chemical indicators of fresh basil greens, the following varieties Izumrud, Azhur green, Moskvoretsky Semko, Charodey, Stella were identified for their high amount of ascorbic acid - 5.2-5.9 mg/100g, varieties Izumrud, Charodey for their high chlorophyll content 196-204 mg /100g, and varieties Charodey and Troll for their high amount of carotenoids - 20-22.3 mg/100g. Among dried herbs, the maximum data on a set of chemical indicators were obtained from the basil varieties Charodey, Stella, and Moskvoretsky Semko. Dried basil greens of the Izumrud, Azhur green and Charodey varieties retained the most ascorbic acid - 18.2-21.3 mg/100g. The highest amount of carotenoids in dried basil greens was noted in the varieties Charodey - 88.1 mg/100g and Troll - 80.6 mg/100g. In terms of the amount of chlorophyll, the leading varieties are Izumrud - 706 mg/100g, Charodey - 632 mg/100g, Moskvoretsky Semko - 619 mg/100g.

Lure and starve: Host root exudates to suppress field populations of cyst nematodes

Plant parasitic nematodes are a burden to global food security, accounting for substantial yield losses in agricultural production worldwide. Increasing concerns over the environment and health issues have led to diminishing control options at the disposal of agricultural producers. Lure and starve, a strategy that is based on stimulating hatching of second stage juveniles (J2) of some cyst forming plant parasitic nematodes in the absence of their host plant seems a promising approach to maintain sustainability in crop production. Here we examined in-situ hatching of encysted eggs of the potato cyst nematode Globodera pallida and the carrot cyst nematode Heterodera carotae following exogenous applications of host root exudates in repeated field experiments during autumn and spring seasons. Population densities (viable J2 g−1 of soil) were assessed prior and post-application of root exudates. Results showed hatching induction of up to 83 % for G. pallida and 54 % for H. carotae in field plots drenched with their respective host root exudates. Spring season experiments were characterised by limited soil moisture and did not reduce nematode population densities for G. pallida. The potential for host root exudates in suppressing field population of cyst nematode in lure and starve strategies looks promising for both cyst nematode species investigated.

Physiological and growth responses of milk thistle (Silybum marianum (L.) Gaertn.) to soil-applied herbicides

Milk thistle (Silybum marianum (L.) Gaertn.) is cultivated globally as a valuable medicinal plant. The presence of weeds poses numerous challenges to milk thistle production, making weed management the primary concern in milk thistle fields. Chemical weed management is an economical and promising approach to controlling weeds in cropping systems. Therefore, to investigate the tolerance of milk thistle to soil-applied herbicides, in the spring of 2022, we conducted a pot experiment as a completely randomized factorial design with four replications at the research greenhouse of the University of Birjand, Iran. The applied herbicides included metribuzin, pendimethalin, trifluralin, and ethalfluralin at six doses (0, 50, 75, 100, 125, and 150% of the recommended dose (ai ha−1)). Herbicide treatments had adverse effects on the root and shoot growth of milk thistle. Compared to the control, ethalfluralin at 150% (−60.1%) and metribuzin at 50% (−13.3%) had the highest and lowest herbicide negative effects on root dry weight, respectively. In contrast to the control, we found that ethalfluralin at 150% (−64.4%) and metribuzin at 50% (−9.3%) of the recommended dose had the highest and lowest impacts on shoot dry weight, respectively. Furthermore, herbicide applications decreased the membrane stability index (MSI) and relative water content (RWC). Root and leaf levels of malondialdehyde (MDA), total phenol, DPPH scavenging, soluble carbohydrates, and proline increased after all herbicide treatments, compared to the control. Metribuzin and pendimethalin had fewer negative effects on milk thistle growth. Consequently, these herbicides could be considered as potential options for weed control in milk thistle fields.

Immunotherapy for pediatric low-grade gliomas.

Pediatric low-grade gliomas (pLGGs) are the most common brain tumor types affecting children. Although gross-total resection remains the treatment of choice, many tumors are not amenable to complete removal, because they either involve midline structures, such as the optic chiasm or hypothalamus, and are not conducive to aggressive resection, or have diffuse biological features and blend with the surrounding brain. Historically, radiation therapy was used as the second-line option for disease control, but with the recognition that this often led to adverse long-term sequelae, particularly in young children, conventional chemotherapy assumed a greater role in initial therapy for unresectable tumors. A variety of agents demonstrated activity, but long-term disease control was suboptimal, with more than 50% of tumors exhibiting disease progression within 5 years. More recently, it has been recognized that a high percentage of these tumors in children exhibit constitutive activation of the mitogen-activated protein kinase (MAPK) pathway because of BRAF translocations or mutations, NFI mutations, or a host of other anomalies that converged on MAPK. This led to phase 1, 2, and 3 trials that explored the activity of blocking this signaling pathway, and the efficacy of this approach compared to conventional chemotherapy. Despite initial promise of these strategies, not all children tolerate this therapy, and many tumors resume growth once MAPK inhibition is stopped, raising concern that long-term and potentially life-long treatment will be required to maintain tumor control, even among responders. This observation has led to interest in other treatments, such as immunotherapy, that may delay or avoid the need for additional treatments. This chapter will summarize the place of immunotherapy in the current armamentarium for these tumors and discuss prior results and future options to improve disease control, with a focus on our prior efforts and experience in this field.

Risk Evaluate and Control of Volunteer Firefighters Using Group Decision Making

Risk management encompasses all measures taken before the occurrence of risk events to mitigate potential future losses. Although volunteer firefighters serve in a voluntary capacity, their disaster response duties expose them to various risks similar to those faced by professional firefighters. Furthermore, due to differences in training, auxiliary methods, and physical conditions, they may encounter distinct risk factors and potentially higher disaster risks. This paper explores risk identification, control, and reduction for volunteer firefighters through organizational responsibilities and risk management perspectives, employing a group decision making model. Utilizing the Operational Risk Management Integration Tools (ORMIT) and the modified Delphi method, the analysis identifies 54 major risk factors for Taitung County&amp;#39;s volunteer firefighters during disaster response duties. These risk factors are categorized according to the 5M model (Man, Machine, Media, Management, Mission), prioritized and addressed using the Main Operational Risk Management List (MOL) and the Risk Control Option Matrix (COM). After proposing corresponding risk control measures, the Average Risk Index (ARI) for the &amp;quot;Potential Risks in Volunteer Firefighters&amp;#39; Disaster Response Duties&amp;quot; decreased from 14.31 to 5.06. The Average Risk Rating (ARR) improved from a high-risk level (H-7) to a low-risk level (L-16). The results demonstrate that through risk identification, assessment, and control procedures, the potential risks faced by volunteer firefighters in disaster response can be significantly reduced.

Comparative susceptibility of adult house fly (Diptera: Muscidae) and an important predator, Carcinops pumilio (Coleoptera: Histeridae), to Beauveria bassiana (Hypocreales: Cordycipitaceae).

House flies (Musca domestica L.) (Diptera: Muscidae) are challenging pests to control. Biological control using Carcinops pumilio beetles may help to reduce house fly populations. However, it is unknown if C. pumilio beetles are compatible with Beauveria bassiana, another house fly biological control option. Five strains of commercially available (GHA, HF23, and L90) and newly discovered (NFH10 and PSU1) strains of B. bassiana were used to test the comparative susceptibility of adult house flies and adult C. pumilio using different laboratory exposure methods. Adult house flies were susceptible to B. bassiana in contact filter paper assays (89%-98% mortality) and immersion assays (100% mortality) at the same 108 conidia suspension using 0.1% CapSil as an aqueous surfactant. Carcinops pumilio were less susceptible than flies to B. bassiana infection using the contact and immersion assays at the same 108 conidial concentration, with 4.4%-12.2% and 8.3%-24.6% mortality, respectively. Immersion in an aqueous conidial suspension resulted in higher mortality compared to contact with treated filter papers at the same 108 concentration with house flies and beetles. We conclude that C. pumilio can safely be used as a biological control agent for house flies with B. bassiana in animal production systems.

Análisis a tres años de resultados, seguridad y progresión en pacientes con glaucoma de ángulo abierto o hipertensión ocular, intervenidos de microcirugía trabecular

AimTo evaluate the efficacy, safety, structural and functional progression following the insertion of iStent inject ® implants in patients with open-angle glaucoma or ocular hypertension at a tertiary-level hospital. Materials and methodsA retrospective study included 98 eyes (57 males and 41 females) with open-angle glaucoma or ocular hypertension, which underwent iStent inject W® implantation (Glaukos, Corporation, CA) between December 2018 and December 2022. Differences in intraocular pressure (IOP), the number of hypotensive eye drops used, and structural and functional tests were assessed between preoperative values and subsequent reviews during a follow-up period of one (n=98), two (n=55), and three years (n=15) after surgery. ResultsAmong the 98 eyes studied, 85% were diagnosed with open-angle glaucoma (50% mild, 32% moderate, and 18% severe) and 15% with ocular hypertension. There was a statistically significant reduction in IOP compared to preoperative values for all visits except the 1-month (p=0.36) and 3-year (p=0.39) visits. Visual acuity increased from 0.39±0.25 to 0.72±0.24 (p<0.01), considering that a significant portion of the interventions included cataract surgery. Before surgery, 66% of the sample used 2 or more hypotensive medications. Post-surgery, the number of hypotensive medications decreased (from 1.88±0.84 to 0.21±0.59 at 3 years) (p<0.01), with an 88.9% reduction in the number of medications over three years. After surgery, 75% of cases did not require any medication.Regarding structural and functional tests, thickness of retinal nerve fiber layers (RNFL (p=0.35), excavation / papilla ratio E/P (p=0.31), visual function index(VFI (p=0.06), and deviation mean (MD (p=0.06) showed no statistically significant differences post-intervention. However, standard deviation of the pattern (DSM) did exhibit differences, decreasing from 5.46±4.03dB to 5.34±3.48dB (p=0.02). ConclusionThe results of this study suggest that the iStent inject W® technique constitutes an effective and safe option for tension control and glaucoma treatment.