Chemicals are important tools in our effort to control livestock ectoparasites, and they are likely to remain so in the foreseeable future. Chemical control is the most widely used and in most cases the only method available to the producer. Therefore, it is imperative that we continue to seek new chemicals as well as new systems for delivery of those chemicals in an effective, efficient, and safe manner. New approaches to chemical control involve both new chemicals and new delivery systems in a complementary and often a synergistic relationship. Three relatively new classes of chemicals, pyrethroids, insect growth regulators, and avermectins, have provided special opportunities for development of new delivery systems. The development of the insecticidal ear tag has been perhaps the most significant new approach to chemical control of livestock ectoparasites in recent years. Although originally developed for control of ear ticks, the tag has had its greatest impact on control of the horn fly, a major pest of cattle in the U.S. The pyrethroid tags provided season-long control of horn flies in most climates and at the same time dramatically reduced the use of pesticide. Unfortunately, the problem of resistance to pyrethroids in the tags has been encountered. Unless effective techniques for resistance management can be developed, the producer may lose this valuable new tool. Sustained-release boluses provide a means of delivering IGR's, such as methoprene and diflubenzuron, for control of immature stages of the horn fly and face fly in manure of cattle. These devices are designed to lodge in the reticulum of cattle and release the chemical to the digestive tract over an extended period. Bolus formulations may in fact provide a tool for management of horn fly resistance to pyrethroids. Ivermectin, a potent new chemical from a new class of agricultural pesticides, provides an important opportunity for developing innovative delivery systems for control of livestock pests. Its systemic activity against ticks and blood-sucking flies at extremely low dosages provides potential for development of long-lasting subcutaneous implants. Its ability to control immature stages of dung-breeding flies, such as the horn fly and face fly, offers the potential for development of sustained-release boluses for larvicidal treatments. These three selected examples of new approaches to chemical control of livestock ectoparasites point to two obvious trends: 1) reduction in quantity of a chemical to be applied without sacrifice of efficacy and 2) use of controlled-release technology to prolong effectiveness of the chemical. Although the examples presented are focused on applications to cattle, similar approaches have application for other livestock. New approaches such as these have important implications in implementation of either area-wide or IPM control programs. Such programs will need convenient and effective chemical delivery systems to be successful if in fact chemicals are to be a part of the programs.