The growth, spectroscopy and lasing performance of Tm/Ho: CaYAlO4 and Tm/Ho: CaGdAlO4 crystals are reported. The crystal exhibited a broad emission band from 1600nm to 2200nm. Single- and multi-wavelength operations of Tm/Ho:CaYAlO4 and Tm/Ho:CaGdAlO4 lasers have been investigated in detail, respectively. The maximum output powers of 376mW for Tm/Ho:CaGdAlO4 crystal and 582mW for Tm/Ho:CaYAlO4 crystals have been obtained, respectively. Red-shift of the emission wavelengths was obviously observed with the increasing of the absorbed pump power.