Continuous Process Research Articles

Vahagn: VisuAl Haptic Attention Gate Net for slip detection

IntroductionSlip detection is crucial for achieving stable grasping and subsequent operational tasks. A grasp action is a continuous process that requires information from multiple sources. The success of a specific grasping maneuver is contingent upon the confluence of two factors: the spatial accuracy of the contact and the stability of the continuous process.MethodsIn this paper, for the task of perceiving grasping results using visual-haptic information, we propose a new method for slip detection, which synergizes visual and haptic information from spatial-temporal dual dimensions. Specifically, the method takes as input a sequence of visual images from a first-person perspective and a sequence of haptic images from a gripper. Then, it extracts time-dependent features of the whole process and spatial features matching the importance of different parts with different attention mechanisms. Inspired by neurological studies, during the information fusion process, we adjusted temporal and spatial information from vision and haptic through a combination of two-step fusion and gate units.Results and discussionTo validate the effectiveness of method, we compared it with traditional CNN net and models with attention. It is anticipated that our method achieves a classification accuracy of 93.59%, which is higher than that of previous works. Attention visualization is further presented to support the validity.

Numerical Thermo-Hydraulic Simulation of Infiltration and Evaporation of Small-Scale Replica of Typical Dike Covers

Measurements taken on a historical dike in the Netherlands over one year showed that interaction with the atmosphere led to oscillation of the piezometric surface of about 0.7 m. The observation raised concerns about the long-term performance of similar dikes and promoted a deeper investigation of the response of the cover layer to increasing climatic stresses. An experimental and numerical study was undertaken, which included an investigation in the laboratory of the unsaturated behavior of a scaled replica of the field cover. A sample extracted from the top clayey layer in the dike was subjected to eight drying and wetting cycles in a HYPROP™ device. Data recorded during the test provide an indication of the delayed response with depth during evaporation and infiltration. The measurements taken during this continuous dynamic process were simulated by means of a finite element discretization of the time-dependent coupled thermohydraulic response. The results of the numerical simulations are affected by the way in which the environmental loads are translated into numerical boundary conditions. Here, it was chosen to model drying considering only the transport of water vapor after equilibrium with the room atmosphere, while water in the liquid phase was added upon wetting. The simulation was able to reproduce the water mass balance exchange observed during four complete drying–wetting cycles, although the simulated drying rate was faster than the observed one. The numerical curves describing suction, the amount of vapor and temperature are identical, confirming that vapor generation and its equilibrium is control the hydraulic response of the material. Vapor generation and diffusion depend on temperature; therefore, correct characterization of the thermal properties of the soil is of paramount importance when dealing with evaporation and related non-steady equilibrium states.

Biomimetic Elastic Single-Atom Protrusions Enhance Ammonia Electrosynthesis.

Electrocatalytic nitrogen (N2) reduction reaction (eNRR) is a promising route for sustainable ammonia (NH3) generation, but the eNRR efficiency is dramatically impeded by the sluggish reaction kinetics. Herein, inspired by the dynamic extension-contraction of sea anemone tentacles in response to environmental changes, we propose a biomimetic elastic Mo single-atom protrusion on vanadium oxide support (pSA Mo/VOH) electrocatalyst featuring a symmetry-breaking Mo site and an elastic Mo-O4 pyramid for efficient eNRR. In-situ spectroscopy and theoretical calculations reveal that the protruding Mo-induced symmetry-breaking structure optimizes the d electron filling of Mo, enhancing the back-donation to the π* antibonding orbital, effectively polarizing the N≡N bond and reducing the barrier from *N2 to *N2H. Notably, the elastic Mo-O4 pyramidal structure of pSA Mo provides a dynamic Mo-O microenvironment during continuous eNRR processes. This optimizes the electronic structure of the Mo sites based on different reaction intermediates, enhancing the adsorption of various N intermediates and maintaining low barriers throughout the six-step hydrogenation process. Consequently, the elastic pSA Mo/VOH exhibits an excellent NH3 yield rate of 50.71 ± 1.12 μg h-1 mg-1 and a Faradaic efficiency of 35.38 ± 1.03%, outperforming most electrocatalysts.

Biomimetic Elastic Single‐Atom Protrusions Enhance Ammonia Electrosynthesis

Electrocatalytic nitrogen (N2) reduction reaction (eNRR) is a promising route for sustainable ammonia (NH3) generation, but the eNRR efficiency is dramatically impeded by the sluggish reaction kinetics. Herein, inspired by the dynamic extension‐contraction of sea anemone tentacles in response to environmental changes, we propose a biomimetic elastic Mo single‐atom protrusion on vanadium oxide support (pSA Mo/VOH) electrocatalyst featuring a symmetry‐breaking Mo site and an elastic Mo−O4 pyramid for efficient eNRR. In‐situ spectroscopy and theoretical calculations reveal that the protruding Mo‐induced symmetry‐breaking structure optimizes the d electron filling of Mo, enhancing the back‐donation to the π* antibonding orbital, effectively polarizing the N≡N bond and reducing the barrier from *N2 to *N2H. Notably, the elastic Mo−O4 pyramidal structure of pSA Mo provides a dynamic Mo−O microenvironment during continuous eNRR processes. This optimizes the electronic structure of the Mo sites based on different reaction intermediates, enhancing the adsorption of various N intermediates and maintaining low barriers throughout the six‐step hydrogenation process. Consequently, the elastic pSA Mo/VOH exhibits an excellent NH3 yield rate of 50.71 ± 1.12 μg h−1 mg−1 and a Faradaic efficiency of 35.38 ± 1.03%, outperforming most electrocatalysts.

Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production

AbstractProkaryotic cells are pivotal in meeting the global demand for biopharmaceuticals. However, challenges such as the absence of advanced technology for real‐time monitoring, standardized testing methodologies, and quality risk assessment of microbial activity have led to increased production costs, delays, and shortages of biopharmaceutical products. A thorough understanding of how biomolecule production interacts with microbial population structure and function is vital for improving continuous manufacturing and process automation. In this review, we discuss the current microbiological techniques that meet good manufacturing practice requirements in industrial settings, explore the advantages of monitoring and measuring biomass growth efficiency and turnover rates beyond regulatory criteria for product release, and provide a critical assessment of the current state of knowledge on bioassays and engineering tools for biomolecule yield measurement and monitoring. Furthermore, we identify areas for future development, potential applications, and the need for interdisciplinary innovation to drive future research, including advancing bioassays for biopharmaceutical wastewater risk.

Machine Vision AI in Railroad Safety: Advanced Inspection Techniques

This article explores the transformative impact of machine vision AI in railroad safety, focusing on advanced inspection techniques. It examines the integration of technologies such as line scan cameras, LiDAR, and IoT sensors in enabling comprehensive 360-degree inspections of railway infrastructure and rolling stock. The article discusses key innovations in continuous monitoring, data processing, and AI-driven analysis, highlighting their potential to significantly enhance defect detection accuracy, reduce maintenance costs, and prevent accidents. Real-world applications in structural integrity assessment and overhead line inspection are presented, along with an analysis of current challenges and future developments in the field. The article underscores the paradigm shift from reactive to proactive maintenance strategies, promising a safer and more efficient future for rail transport.

Fibrillated Films for Suspension Catalyst Immobilization—A Kinetic Study of the Nitrobenzene Hydrogenation

The immobilization of suspension catalysts in flexible, fibrillated films offers a promising solution to the mass transfer limitations often encountered in three-phase hydrogenation reactions. This study investigates the catalytic performance and mass transfer properties of fibrillated films in the hydrogenation of nitrobenzene to aniline, comparing them to free-flowing powdered catalysts. Fibrillated films were prepared from Pd/C catalysts with varying thicknesses (100–400 µm), and their performance was evaluated through kinetic studies in both batch reactors and microreactors. The specific activity of the films was significantly influenced by film thickness with thinner films demonstrating lower mass transfer limitations. However, mass transfer limitations were observed in thicker films, prompting the development of alternative film designs, including enhanced macro-porous films and sandwich structures. These modifications successfully minimized diffusion limitations, achieving similar specific activity to the powder catalysts while maintaining the mechanical stability of the films. This work demonstrates the feasibility of using fibrillated films for continuous catalytic processes and highlights their potential for efficient catalyst reuse, avoiding filtration steps and enhancing process sustainability. Furthermore, while PTFE remains indispensable for producing such films due to its mechanical and thermal stability, ongoing research focuses on identifying more environmentally friendly alternatives without compromising performance.

Enhancing lead ion removal from simulated wastewater through continuous electrocoagulation process: investigating operating parameters and adsorption behavior

Enhancing lead ion removal from simulated wastewater through continuous electrocoagulation process: investigating operating parameters and adsorption behavior

Mechanical properties and energy evolution of outburst coal seams under different load regimes

AbstractCoal elasticity and gas expansion are important factors for coal and gas outburst. During the outburst process, the elastic strain energy of coal is mainly released from the stress region, and the gas expansion energy near the working face is larger, and it is not a continuous release process. To reveal the mechanical characteristics and energy evolution of outburst coal seam, uniaxial and triaxial compression tests were carried out on outburst coal seam samples under different loading methods. The experimental results show that the elastic characteristics become more obvious with the increase of loading rate, the peak strain increases, the elastic modulus is linearly related with the loading rate，and the overall degree of fragmentation increases with the increase of loading rate, which is consistent with the severity of macroscopic coal failure. The failure mode of coal under uniaxial compression conditions is often manifest as brittle failure. The strength characteristics of coal under different loading rates comply with the Mohr‐Coulomb criterion, and the peak strength is linearly related to the failure time and loading rate. With the increasing confining pressure causes the failure of coal samples to transition from ductile to brittle, and the failure mode develops from local shear to overall splitting. The elastic energy evolution curve is consistent with its stress‐strain curve. With the increase of confining pressure, the limiting elastic energy and peak total energy increase in a quasi‐linear manner. The accumulated limit elastic energy plays an important role in the failure of coal samples, and the macroscopic manifestation thereof is that the coal samples fail more severely under high confining pressure conditions than under low confining pressure conditions. The research results are of great significance for the comprehensive prevention and control of coal and gas outburst.

Time Scale Transformation in Bivariate Pearson Diffusions: A Shift from Light to Heavy Tails

Heavy-tailed Pearson diffusions provide a natural alternative to well-known Ornstein–Uhlenbeck and Cox–Ingersoll–Ross processes in applications that require addressing heavy-tailed behavior. In this paper, all three heavy-tailed Pearson diffusions, having inverse gamma, Fisher–Snedecor and Student stationary distributions, are constructed via an absolutely continuous time-change process employed in a specific functional transformation of CIR or OU. Moreover, time-change rates in stochastic clocks are continuous functionals of the CIR process.

Phenolics in soymilk manufactured from black and Proto soybeans by two continuous-ultrahigh-temperature-processing technologies inhibit DU145-prostate cancer cell proliferation through apoptosis.

Plant genotypes and processing technologies affect health properties of foods. How thermal processes with different sterilization values influence polyphenols in soymilk manufactured from different genotypes, particularly black soybean has not been well characterized. This study's aims were to investigate how one- and two-phase ultrahigh temperature (UHT) processing technologies, with wide differences of lethality (F0 158.5 and 6.35, respectively), affected anti-prostate cancer DU145-cell properties of black soymilk compared to light-yellow-Proto soymilk. Phenolics were extracted from soymilk and used for chemical, cell cycle and apoptosis analyses. Total isoflavones and genistein in black soymilk were significantly higher than Proto soymilk by either processing methods. Compared to one-phase processing, two-phase produced higher gallic acid in both soybeans, and higher oxygen radical absorbance capacity (ORAC) in black soymilk. Soymilk processed from both genotypes by both UHT methods inhibited DU145 cells. Two-phase-UHT processed black soymilk was more effective than one-phase UHT-processed soymilk. IC50 values (mg/mL) of black and yellow soy extracts against prostate cancer cells differed only by 11%-25%, which were lower than the differences of total isoflavone (29%-33%) or genistein (>50% between two beans). The mechanism by which soymilk inhibited DU145 cell proliferation was through apoptosis as evidenced by cell cycle analyses and expressions of caspase-3, Bcl-2, and PARP-1 proteins. Antioxidant properties, isoflavones, and phenolic acids were negatively correlated with prostate-cancer-cell inhibition IC50 (p<0.05) with ORAC having the highest coefficient (r=-0.98). Overall, two-phase-UHT processing of soybean would produce soymilk products with a higher health benefit than a one-phase UHT method. PRACTICAL APPLICATION: This study characterized the potential prostate cancer prevention effect of soymilk's phenolic extract in black soybean and compared with yellow soybean. The crude extract can be prepared much less costly than purified isoflavones and has potential to be developed into a dietary supplement. This study shows differences of soymilks made by continuous high-temperature processing of two soybean types and can serve as a scientific foundation for future clinical research and commercialization.

Onboard Sensors Reveal New Insights into Animal Decision-Making

The continuous process of decision-making in animals is crucial for their survival. For example, when deciding when, where, and with whom to forage, they need to consider their internal state, previous experience, and social information in addition to external factors such as food distribution and weather conditions. Studying animal decision-making in the wild is a complicated task due to the complexity of the process, which requires continuous monitoring of the examined individual and its environment. Here, we review the most advanced methods to examine decision-making from an individual point of view, namely tracking technologies to monitor the movement of an individual, the sensory information available to it, the presence and behavior of other animals around it, and its surrounding environment. We provide examples for studying decision-making during competition, examining the ontogeny of decision-making, and describing the importance of long-term monitoring and field manipulation for understanding decision processes throughout different life stages.

DEVELOPMENT OF AUTOMATED CONTROL SYSTEM AND REGISTRATION OF METAL IN CONTINUOUS CASTING

Context. Modern industrial enterprises face challenges that require introduction of latest technologies to improve efficiency and competitiveness. In metallurgy, one of key stages is continuous casting, where quality of products and economic performance of enterprise depend on accuracy and efficiency of process control. Products made using continuous casting technology are widely used in various industries due to their high mechanical properties, structural uniformity and cost-effectiveness. The development of automated metal management and registration system is becoming not only relevant, but also necessary to ensure stable and efficient production. The problem of improving quality of metal products has always been one of most important tasks in steel industry. Imperfect technological processes, human error and equipment malfunctions can lead to defects in finished metal products. This, in turn, affects final characteristics of products, their durability and reliability. To date, available sources have not yet found complete solution to this problem. Therefore, it is necessary to formulate problem and develop algorithm for operation of automated system for controlling and registering metal in continuous casting. Objective. The goal of work is to develop automated metal management and registration system to improve quality of metal products. Method. To achieve this goal, parametric model was proposed, which is formalized on basis of set theory. The model takes into account key parameters of continuous casting process: material characteristics, structural features of crystallizer, casting modes, metal level in crystallizer, and position of shot stopper. Results. The problem was formulated and key parameters were determined, which are taken into account in system’s algorithm, which made it possible to develop system for controlling parameters of continuous casting to solve problem of improving quality of metal products. Conclusions. To improve quality of metal products and stability of casting process, parametric model was created that is comprehensive, allows optimization of key parameters and ensures accuracy of process control by integrating not only modes of product formation, but also takes into account specific properties of source material (chemical composition of material grade, etc.) and design features of casting plant. Algorithm for automated control system has been developed that takes into account relationships between certain key parameters and ensures optimal control of casting process. Based on proposed complex parametric model and algorithm, automated control and metal registration system was created. The focus of work is on quality and efficiency of metal management and registration in continuous casting, based on modern methods of computer science and engineering. A comprehensive experimental comparison of developed system with commercial analogs in real production conditions was carried out, which allowed us to objectively assess its efficiency and reliability.

Comparative study on machinability and surface integrity of γ-TiAl alloy in laser assisted milling

γ-TiAl alloy, as a typical difficult-to-cut material, is considered to have great potential in aero-engine manufacturing. However, it is difficult to achieve high-quality processing of γ-TiAl alloy using traditional cutting processes, due to the room temperature brittleness and high strength of theγ-TiAl alloy. This study proposes a fiber laser assisted machining (LAM) method to improve the cutting quality of γ-TiAl alloy, which attempts to address current challenges in applications of aero-engine manufacturing. The machinability and surface integrity of γ-TiAl specimens using LAM method and conventional milling are analyzed and discussed. Through cutting force testing, chip morphology research, surface hardness testing, and microstructure observation, it is found that the LAM method significantly improves the machinability and machined surface integrity of γ-TiAl specimens. Furthermore, the cooling strategies in LAM is discussed through comparative cutting experiments. During continuous LAM processing, it is found that the rapid heat accumulation effect induces tool adhesive wear, which leads to the decline of cutting quality and tool failure. The experimental results indicate that liquid cooling is an available strategy to reduce tool wear. However, it should be noted that periodic thermal shock by liquid cooling causes surface roughness to increase in continuous LAM processing. Through this work, it is proved that the LAM method can improve machinability and surface integrity of γ-TiAl specimens, which has great potential and worths further studies.

Real-Time Adaptive Inline Acidification Enhances Continuous pH Control for Viral Inactivation.

Existing low pH viral inactivation methods for continuous downstream processing of biologics typically rely on predictive models to estimate the necessary pH adjustments. However, these methods are of limited use during the process development stage due to the dynamic nature of capture chromatography, where batch variations can alter the eluted protein titer. This study introduces an inline viral inactivation system (IVIS) that utilizes real-time adaptive control and inline sensor readings to precisely regulate the pH manipulation for inline acidification and continuous viral inactivation. The IVIS, which includes a coiled flow inversion reactor (CFIR), is integrated with a multicolumn capture chromatography system to demonstrate a fully continuous process from protein capture chromatography to inline pH manipulation. The system achieved precise inline pH manipulation within ±0.15 and a narrow residence time distribution of 13.5min with a relative width of 0.7. The introduction of real-time inline pH manipulation with the IVIS signifies a notable advancement in managing critical process parameters (CPPs) and ensuring consistent product quality across varied production environments for continuous downstream bioprocessing.

Flowing Forward: Continuous Synthesis of and with Ionic Liquids

AbstractHerein, the developments in the field of continuous ionic liquid synthesis and continuous ionic liquid utilization from the last seven years are reviewed. Starting by discussing recent strategies for the preparation of ionic liquids themselves in different flow reactors, the review will further focus on various continuous strategies employing ionic liquids. The application of ionic liquids in continuous processes, particularly as supported catalytic layers, has drawn significant scientific interest in the last decades. These catalyst frameworks provide a versatile tool in many organic transformations, and their application became an attractive strategy in continuous catalytic approaches.

Ensuring Equity

The chief medical officer and other healthcare leaders are positioned to have a positive effect on both diversity and equity. While this has not often been a focus of the healthcare executive, it is important for CMOs to understand how they can influence diversity and equity. This article does not include an exclusive list of to-dos for the CMO; however, it does provide a framework so CMOs can build relationships to guarantee equity in the patient population and diversity within their workforce. It is paramount that CMOs view health equity as a top priority. It also is important to understand that equity is a continuous process. Pursuing equity should be part of everything that a CMO does.

Study on pyrolysis process and mechanism of organic coating of waste polyesterimide enameled wire based on density functional theory

The pyrolysis treatment of waste polyesterimide enameled wire offers significant advantages such as continuous processing, non-hazardous nature, and high resource recovery rate. However, research on its pyrolysis process and mechanism remains insufficiently explored. In this study, techniques including thermogravimetry (TG), Fourier transform infrared spectroscopy(FT-IR), pyrolysis–gas chromatography-mass spectrometry(Py-GC/MS) were employed to investigate pyrolysis temperature, weight loss rate, pyrolysis and kinetic parameters, composition and distribution of pyrolysis products, and changes in functional groups under different temperatures and heating rates. The pyrolysis of polyesterimide enameled wire can be divided into three stages: volatilization of specific components (314.8 °C,1.6 %), rapid decomposition of polyesterimide (435.2 °C, 44.7 %), and generation of small organic molecules with the fixation of pyrolytic carbon (750 °C, 9.0 %). The main components of the pyrolysis gas products include aromatic compounds, ethers, aromatics, ketones, and carbon dioxide. At 400 °C, a substantial amount of pyrolysis gas products and free radicals are produced, with an increase in aromatic hydrocarbons. The carbon distribution in the pyrolysis products mainly focuses on C6-C10 and C11-C15, and many organic compounds such as benzoic acid, phenol, and aniline are generated. Based on density functional theory, the bond dissociation energies in the polyesterimide were calculated. This clarified the possible thermal decomposition pathways of the polyesterimide and provided the energy barrier values, elucidating the generation mechanism of pyrolysis products during thermal decomposition. The copper atom in specific location reduces the negative ESP of O and increases the positive ESP of H in EPI, which makes H more likely to attach to O. The presence of Cu increases the ESP range and promote the pyrolysis process. This study provides a theoretical basis for the high-value recycling of waste polyesterimide enamelled wire.

New route for fabricating low-carbon ductile martensite to optimize the stretch-flangeability of dual-phase steel

Traditional cold-rolling dual-phase steel (CR sheet), limited by poor stretch-flangeability as indicated by the hole expansion rate (HER), faces challenges in manufacturing complex automobile parts. To address this, a new type of hot-rolling dual-phase steel with an 800 MPa grade (manufactured by tyipical thin slab continuous casting and rolling process, TSCCR) was designed to replace the traditional one. The TSCCR sheet, with a lower carbon content of 0.047wt.%, compared to 0.093wt.% in the CR sheets, features 40.6% martensite significantly higher than 28.2% in the CR sheet. This increased martensite content, despite being softer and more ductile due to its low hardness, compensates for the tensile strength in the TSCCR sheet. Furthermore, the TSCCR sheet exhibits a unique heterostructure characterized by uneven carbon distribution from the ferrite/austenite interface to other boundaries/interfaces, estimated by the negligible partition local equilibrium (NPLE) model of ferrite transformation. This unique heterostructure diminishes the mechanical disparity between ferrite and martensite, resulting in a higher yield strength of 568 MPa, compared to 456 MPa in the CR sheet. During uniaxial tension, the ferrite and ductile martensite in the TSCCR sheet initiate cooperative plastic deformation earlier than in the CR sheet, despite initially having fewer favorable slip systems in the TSCCR martensite. The low working hardening rate of the TSCCR sheet facilitates the forming layered structure of ferrite and martensite during necking compared to the CR sheet. Consequently, the HER of the TSCCR sheet sharply increased by 144% compared to the CR sheet. This enhancement in HER can be attributed to the crack initiation area, longer crack propagation path, and higher crack propagation resistance facilitated by the ductile martensite, culminating in superior HER.

Model-based real-time optimization in continuous pharmaceutical manufacturing

In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating conditions by optimizing the considered objective functions while satisfying the specific constraints. Moreover, the RTO schemes can cope with intentional changes in the process and unintentional changes such as disturbances. Results from simulations and experiments are presented in this work. An advantageous performance is achieved when using the developed schemes.