Objective To explore the effect of multi-mode interactive continuous nursing on home rehabilitation and complications of patients after total hip arthroplasty (THA) . Methods From January 2017 to July 2018, patients undergoing THA in Zhejiang Provincial People's Hospital were selected by purposive sampling method. They were randomly divided into two groups according to visit numbers. There were 43 effective cases in the control group and 42 in the observation group. The control group adopted the traditional telephone follow-up mode, while the observation group adopted the multi-mode interactive continuous nursing intervention. The Modified Barthel Index (MBI) , Harris Hip Score (HHS) and 6-Minute Walking Test (6MWT) were used to compare the rehabilitation effects of the two groups at discharge, 1, 3 and 6 months after operation, and the complications, unplanned hospital visits and hospitalizations of the two groups were compared. Results There was no significant difference in each index between the two groups at discharge (P> 0.05) . The scores of MBI in the observation group were (78.57±7.43) , (90.36±7.76) , (94.41±7.51) respectively at 1, 3 and 6 months after operation, which were higher than those in the control group [ (70.35±7.60) , (82.40±7.82) , (91.86±8.80) ], and there were significant differences between the two groups at 1 and 3 months after operation (P<0.05) . The scores of HHS in the observation group were (82.05±7.40) , (87.52±6.94) , (91.17±7.40) respectively, higher than those in the control group (78.40±7.51) , (84.09±7.23) , (88.37±8.46) , there were significant differences between the two groups at 1 and 3 months after operation (P<0.05) . The distance of 6MWT in the observation group were (174.76±35.04) m, (241.55±40.67) m, (282.86±46.46) m, higher than those in the control group (151.61±42.52) m, (214.42±48.59) m, (260.35±48.05) m. There were significantly statistical differences in the 1, 3 and 6 months after operation (P<0.05) . In the observation group, there were 1 case of fracture, 9 cases of unplanned hospital visit or hospitalization, 2 cases of dislocation, 1 case of infection and 20 cases of unplanned hospital visit or hospitalization in the control group. Conclusions Continuous nursing with multi-mode interaction can improve the effect of home rehabilitation after THA, effectively improve the early and long-term hip function of patients, prevent and reduce complications, and improve the quality of life of patients. Key words: Anthroplasty, replacement, hip; Total hip arthroplasty; Complications; Continuous nursing; Home rehabilitation