Objective To explore the effects of dual-track continuous health education based on universalization and individualization in patients post operation for endometrial cancer (EC) . Methods From June 2017 to June 2018, this prospective study selected 194 EC patients with surgery of Zhongnan Hospital of Wuhan University to carry out. All of patients were divided into observation group and control group with the method of random number table, 97 cases in each group. Observation group carried out the dual-track continuous health education based on universalization and individualization, while control group implemented the routine continuous nursing. This study compared the scores the Chinese Edition of Exercise of Self-Care Agency Rating Scale (ESCA) , Medical Coping Modes Questionnaire (MCMQ) , Zung Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) , Functional Assessment of Cancer Therapy-general (FACT-G) between two groups three after intervention. Results After intervention, the scores of health knowledge, self-conception, self-care responsibility, self-care agency and the total score of ESCA between two groups were higher than those before intervention, and those scores of observation group were higher than those of control group with statistical differences (P<0.05) . After intervention, the score of confrontation in MCMQ of two groups was higher than that before intervention, and scores of avoidance and submission were lower than those before intervention; the score of confrontation in MCMQ of observation group was higher than that of control group, and the scores of avoidance and submission of observation group were lower than those of control group with statistical differences (P<0.05) . The scores of SAS and SDS of two groups after intervention were higher than those before intervention, and the scores of SAS and SDS of observation group after intervention were higher than those of control group with statistical differences (P<0.05) . After intervention, the scores of family/society, physiology, emotion and function of FACT-G between two groups were higher than those before intervention, and those dimension scores of observation group were higher than those of control group with statistical differences (P<0.05) . Conclusions Dual-track continuous health education based on universalization and individualization for EC post operation can effectively lift patient's self-care ability and promote the positive coping style which helps patients improve their mental state, CRF and quality of life. Key words: Endometrial neoplasms; Continuing nursing; Dual-track health education; Universalization; Individualization