Objective: To explore the effect of continuous nursing intervention on psychological status and medication compliance of patients with acute myocardial infarction after PCI operation. Methods: from February 2013 to September 2016, 102 patients with acute myocardial infarction treated by PCI were selected and divided into two groups, 51 cases in each group according to the different nursing methods. The observation group was added continuous nursing on the basis of routine nursing, while the control groupwas the usual nursing mode. The mental state of the two groups before and after treatment was evaluated, and the patients were followed up for 6 months after discharge. The compliance of the two groups at 1, 3 and June after discharge was statistically analyzed. Results: before nursing, there was no signifcant difference in the mental state evaluation between the two groups (P > 0.05). After nursing, the mental status of the two groups was improved, while the psychological state of the observation group was better than that of the control group (P < 0.05). After 6 months' follow-up, there was no signifcant difference in the compliance rate between the two groups at 1 months after discharge (P > 0.05). In 3 and June, the compliance of the patients in the observation group was better than that in the control group (P < 0.05). Conclusion: continuous nursing intervention for patients with acute myocardial infarction after PCI can effectively adjust the unhealthy psychological state of patients, improve medication compliance and promote early rehabilitation of patients.