Soil salinization is one of the most serious land-degrading threats globally, particularly in Asia, where there are 21 countries, e.g., Kazakhstan, China, Iran, and Indonesia, lack of accurate spatial information of salt-affected soils currently. Mapping the distribution of salt-affected soils and identifying their main driving factors is critical for sustainable development. Current studies for mapping the spatial distribution of salt-affected soils focused on recognizing the soil salinity by using the indicator of electrical conductivity of saturated soil paste extract (ECe), while cannot distinguish the soil sodicity. Meanwhile, the absence of uncertainty assessment is another problem for large-scale studies. To address these gaps, we developed an effective spatial prediction model that considered both soil salinity and sodicity using machine learning (ML) models and soil salinization data. This study used ECe, pH, and exchangeable sodium percent (ESP) as indicators, with sample sizes of 22,803, 30,821, and 12,961, respectively, to produce salt-affected soil maps with uncertainty assessments in Asia, and conducted the analysis of the drivers of soil salinization. The ML models involved cubist, random forest, quantile regression forest, quantile regression neural network, and a simple multiple linear regression model for comparison. The results showed that among these models, quantile regression forest exhibited the best performance, with mean absolute percentage error values of 2.54 %∼52.06 %, coefficient of determination values of 0.40 ∼ 0.74, and Nash-Sutcliffe efficiency values of 0.36 ∼ 0.71. The predicted maps, with 1 km resolution, demonstrated minimal uncertainty across over 60.4 % of the study area. Approximately 466.36 million hectares of topsoil (0–30 cm) and 377.68 million hectares of subsoil (30–100 cm) in Asia are salt-affected, mainly concentrated in arid, semi-arid, and coastal regions. Climatic factors (the annual precipitation and maximum temperature), topography (digital elevation model and slope), and salinity index V (SI5) were identified as the main drivers of soil salinization. Overall, this study provides important guidelines for soil salinization management and achieving ecological sustainability.