Contextual Modulation Research Articles

The moment of awareness influences the content of awareness in orientation repulsion

Through the neurally evolving process of dynamic contextual modulation of perceptual contents, it remains unclear how the content of awareness is determined. Here we quantified the visual illusion of orientation repulsion, wherein the target appears tilted against the surrounding’s orientation, and examined whether its extent changed when the target awareness was quickened by a preceding flanker. Independently of spatial cueing, repulsion was reduced when the flanker preceded the target by 100 ms compared with when they appeared simultaneously. We confirmed that the preceding flanker quickened the awareness of a nearby target relative to distant ones by 40 ms. Furthermore, the preceding flanker that was greater than 7 degrees away from the target still evoked such reduction of repulsion. These findings imply that the content of awareness is determined by the temporal interaction of two distinct processes: one controls the moment of awareness, and the other represents the perceptual content.

Contextual Modulation of Adult–Child Language Interaction: Semantic Network Connectivity and Children’s Vocabulary Development

Word learning encompasses the understanding of interconnected clusters of words, where the comprehension of one word aids in the learning of another. Semantic networks, which have a long history in cognitive science, are commonly employed to explore these semantic relationships. However, limited research has been conducted on adults’ use of semantically relevant conversations in the field of early childhood education, and there is insufficient information regarding contextual factors influencing the development of semantic networks. The present study investigated the extent to which the use and effectiveness of semantically relevant conversations vary across activity contexts. This study analyzed data from the Home-School Study of Language and Literacy Development (HSLLD) Corpus available in the CHILDES database, focusing on a subset of 62 children. This study utilized four statistical features to describe the structure of semantic networks: short path length, diameter, density, and clustering coefficient. The following findings emerged: (1) Book reading displayed a significantly greater diameter than toy play and mealtime, indicating that there exist specific pairs of concepts or words within its semantic networks that are notably more distant from each other than in the other two activity settings. (2) Toy play exhibited a significantly greater density in comparison to book reading and mealtime, suggesting a higher degree of overlap or interdependence among the concepts within its semantic networks. (3) Book reading demonstrated a significantly greater clustering coefficient compared to toy play and mealtime, signifying the existence of cohesive word communities or groups of words characterized by dense internal connections. (4) Adults’ use of semantically relevant conversations during book reading was positively associated with children’s lexical diversity.

Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.

Embodied theories of cognition consider many aspects of language and other cognitive domains as the result of sensory and motor processes. In this view, the appraisal and the use of concepts are based on mechanisms of simulation grounded on prior sensorimotor experiences. Even though these theories continue receiving attention and support, increasing evidence indicates the need to consider the flexible nature of the simulation process, and to accordingly refine embodied accounts. In this consensus paper, we discuss two potential sources of variability in experimental studies on embodiment of language: individual differences and context. Specifically, we show how factors contributing to individual differences may explain inconsistent findings in embodied language phenomena. These factors include sensorimotor or cultural experiences, imagery, context-related factors, and cognitive strategies. We also analyze the different contextual modulations, from single words to sentences and narratives, as well as the top-down and bottom-up influences. Similarly, we review recent efforts to include cultural and language diversity, aging, neurodegenerative diseases, and brain disorders, as well as bilingual evidence into the embodiment framework. We address the importance of considering individual differences and context in clinical studies to drive translational research more efficiently, and we indicate recommendations on how to correctly address these issues in future research. Systematically investigating individual differences and context may contribute to understanding the dynamic nature of simulation in language processes, refining embodied theories of cognition, and ultimately filling the gap between cognition in artificial experimental settings and cognition in the wild (i.e., in everyday life).

Contribution of dorsal versus ventral hippocampus to the hierarchical modulation of goal-directed actions in rats.

Adaptive behaviour often necessitates that animals learn about events in a manner that is specific to a particular context or environment. These hierarchical organisations allow the animal to decide which action is the most appropriate when faced with ambiguous or conflicting possibilities. This study examined the role of hippocampus in enabling animals to use the context to guide action selection. We used a hierarchical instrumental outcome devaluation task in which male rats learn that the context provides information about the unique action-outcome relations that are in effect. We first confirmed that rats encode and use hierarchical context-(action-outcome) relations. We then show that chemogenetic inhibition of ventral hippocampus impairs both the encoding and retrieval of these associations, while inhibition of dorsal hippocampus impairs only the retrieval. Importantly, neither dorsal nor ventral hippocampus was required for goal-directed behaviour per se as these impairments only emerged when rats were forced to use the context to identify the current action-outcome relationships. These findings are discussed with respect to the role of the hippocampus and its broader circuitry in the contextual modulation of goal-directed behaviour and the importance of hierarchical associations in flexible behaviour.

Contextual Modulation of Sensory Encoding in the Tilt Illusion

Contextual Modulation of Sensory Encoding in the Tilt Illusion

NMDA-driven dendritic modulation enables multitask representation learning in hierarchical sensory processing pathways

While sensory representations in the brain depend on context, it remains unclear how such modulations are implemented at the biophysical level, and how processing layers further in the hierarchy can extract useful features for each possible contextual state. Here, we demonstrate that dendritic N-Methyl-D-Aspartate spikes can, within physiological constraints, implement contextual modulation of feedforward processing. Such neuron-specific modulations exploit prior knowledge, encoded in stable feedforward weights, to achieve transfer learning across contexts. In a network of biophysically realistic neuron models with context-independent feedforward weights, we show that modulatory inputs to dendritic branches can solve linearly nonseparable learning problems with a Hebbian, error-modulated learning rule. We also demonstrate that local prediction of whether representations originate either from different inputs, or from different contextual modulations of the same input, results in representation learning of hierarchical feedforward weights across processing layers that accommodate a multitude of contexts.

The Spatial Precision of Contextual Feedback Signals in Human V1.

Neurons in the primary visual cortex (V1) receive sensory inputs that describe small, local regions of the visual scene and cortical feedback inputs from higher visual areas processing the global scene context. Investigating the spatial precision of this visual contextual modulation will contribute to our understanding of the functional role of cortical feedback inputs in perceptual computations. We used human functional magnetic resonance imaging (fMRI) to test the spatial precision of contextual feedback inputs to V1 during natural scene processing. We measured brain activity patterns in the stimulated regions of V1 and in regions that we blocked from direct feedforward input, receiving information only from non-feedforward (i.e., feedback and lateral) inputs. We measured the spatial precision of contextual feedback signals by generalising brain activity patterns across parametrically spatially displaced versions of identical images using an MVPA cross-classification approach. We found that fMRI activity patterns in cortical feedback signals predicted our scene-specific features in V1 with a precision of approximately 4 degrees. The stimulated regions of V1 carried more precise scene information than non-stimulated regions; however, these regions also contained information patterns that generalised up to 4 degrees. This result shows that contextual signals relating to the global scene are similarly fed back to V1 when feedforward inputs are either present or absent. Our results are in line with contextual feedback signals from extrastriate areas to V1, describing global scene information and contributing to perceptual computations such as the hierarchical representation of feature boundaries within natural scenes.

A mechanistic account of visual discomfort.

Much of the neural machinery of the early visual cortex, from the extraction of local orientations to contextual modulations through lateral interactions, is thought to have developed to provide a sparse encoding of contour in natural scenes, allowing the brain to process efficiently most of the visual scenes we are exposed to. Certain visual stimuli, however, cause visual stress, a set of adverse effects ranging from simple discomfort to migraine attacks, and epileptic seizures in the extreme, all phenomena linked with an excessive metabolic demand. The theory of efficient coding suggests a link between excessive metabolic demand and images that deviate from natural statistics. Yet, the mechanisms linking energy demand and image spatial content in discomfort remain elusive. Here, we used theories of visual coding that link image spatial structure and brain activation to characterize the response to images observers reported as uncomfortable in a biologically based neurodynamic model of the early visual cortex that included excitatory and inhibitory layers to implement contextual influences. We found three clear markers of aversive images: a larger overall activation in the model, a less sparse response, and a more unbalanced distribution of activity across spatial orientations. When the ratio of excitation over inhibition was increased in the model, a phenomenon hypothesised to underlie interindividual differences in susceptibility to visual discomfort, the three markers of discomfort progressively shifted toward values typical of the response to uncomfortable stimuli. Overall, these findings propose a unifying mechanistic explanation for why there are differences between images and between observers, suggesting how visual input and idiosyncratic hyperexcitability give rise to abnormal brain responses that result in visual stress.

Electrophysiological signatures of temporal context in the bisection task.

Despite having relatively accurate timing, subjective time can be influenced by various contexts, such as stimulus spacing and sample frequency. Several electroencephalographic (EEG) components have been associated with timing, including the contingent negative variation (CNV), offset P2, and late positive component of timing (LPCt). However, the specific role of these components in the contextual modulation of perceived time remains unclear. In this study, we conducted two temporal bisection experiments to investigate this issue. Participants had to judge whether a test duration was close to a short or long standard. Unbeknownst to them, we manipulated the stimulus spacing (Experiment 1) and sample frequency (Experiment 2) to create short and long contexts while maintaining consistent test ranges and standards across different sessions. The results revealed that the bisection threshold shifted towards the ensemble mean, and both CNV and LPCt were sensitive to context modulation. In the short context, the CNV exhibited an increased climbing rate compared to the long context, whereas the LPCt displayed reduced amplitude and latency. These findings suggest that the CNV represents an expectancy wave preceding a temporal decision process, while the LPCt reflects the decision-making process itself, with both components influenced by the temporal context.

Contributions of low- and high-level contextual mechanisms to human face perception.

Contextual modulations at primary stages of visual processing depend on the strength of local input. Contextual modulations at high-level stages of (face) processing show a similar dependence to local input strength. Namely, the discriminability of a facial feature determines the amount of influence of the face context on that feature. How high-level contextual modulations emerge from primary mechanisms is unclear due to the scarcity of empirical research systematically addressing the functional link between the two. We tested (62) young adults' ability to process local input independent of the context using contrast detection and (upright and inverted) morphed facial feature matching tasks. We first investigated contextual modulation magnitudes across tasks to address their shared variance. A second analysis focused on the profile of performance across contextual conditions. In upright eye matching and contrast detection tasks, contextual modulations only correlated at the level of their profile (averaged Fisher-Z transformed r = 1.18, BF10 > 100), but not magnitude (r = .15, BF10 = .61), suggesting the functional independence but similar working principles of the mechanisms involved. Both the profile (averaged Fisher-Z transformed r = .32, BF10 = 9.7) and magnitude (r = .28, BF10 = 4.58) of the contextual modulations correlated between inverted eye matching and contrast detection tasks. Our results suggest that non-face-specialized high-level contextual mechanisms (inverted faces) work in connection to primary contextual mechanisms, but that the engagement of face-specialized mechanisms for upright faces obscures this connection. Such combined study of low- and high-level contextual modulations sheds new light on the functional relationship between different levels of the visual processing hierarchy, and thus on its functional organization.

Behavioral pattern separation is associated with neural and electrodermal correlates of context-dependent fear conditioning

Hippocampus-dependent pattern separation is considered as a relevant factor for context discrimination and might therefore impact the contextual modulation of conditioned fear. However, the association between pattern separation and context-dependent fear conditioning has not been investigated so far. In the current study, 72 healthy female students completed the Mnemonic Similarity Task, a measure of behavioral pattern separation, in addition to a context-dependent fear conditioning paradigm during functional magnetic resonance imaging. The paradigm included fear acquisition in context A and extinction training in context B on a first day, as well as retrieval testing of the fear and extinction memories in the safe context B (extinction recall) and a novel context C (fear renewal) one day later. Main outcome measures comprised skin conductance responses (SCRs) and blood oxygen level-dependent responses in brain regions of the fear and extinction circuit. Regarding retrieval testing, pattern separation did not correlate with extinction recall, but with stronger dorsal anterior cingulate cortex activation and conditioned SCRs (trend) during fear renewal, indicating a stronger retrieval of the fear memory trace. Our findings suggest that behavioral pattern separation ability seems to be important for context-dependent fear modulation, which is impaired in patients with posttraumatic stress disorder.

Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish.

Larval zebrafish that are exposed repeatedly to dark looming stimuli will quickly habituate to these aversive signals and cease to respond with their stereotypical escape swims. A dark looming stimulus can be separated into two independent components: one that is characterized by an overall spatial expansion, where overall luminance is maintained at the same level, and a second, that represents an overall dimming within the whole visual field in the absence of any motion energy. Using specific stimulation patterns that isolate these independent components, we first extracted the behavioral algorithms that dictate how these separate information channels interact with each other and across the two eyes during the habituation process. Concurrent brain wide imaging experiments then permitted the construction of circuit models that suggest the existence of two separate neural pathways. The first is a looming channel which responds specifically to expanding edges presented to the contralateral eye and relays that information to the brain stem escape network to generate directed escapes. The second is a dimming-specific channel that could be either monocular or binocularly responsive, and that appears to specifically inhibit escape response when activated. We propose that this second channel is under strong contextual modulation and that it is primarily responsible for the incremental silencing of successive dark looming-evoked escapes.

The time-course of contextual modulation for underspecified meaning

AbstractSentences like (1) “The singer began the album”are ambiguous between an agentive reading (The singer began recording/playing/etc. the album) and a constitutive reading (The singer’s song was the first track). The ambiguity is rooted in the meaning specification of the aspectual-verb class, which demands its complement be construed as a structured individual along a dimension (e.g., spatial, informational, eventive). In (1), the complement can be construed as a set of eventualities (eventive) or musical content (informational). Processing aspectual-verb sentences is shown to involve (a) exhaustive lexical-function retrieval and (b) construal of multiple dimension-specific structured individuals, leading to multiple compositions with agentive and constitutive readings. The ultimate interpretation depends on the biased dimensions in context. Our eye-tracking study comparing sentences in different contexts (agentive vs. constitutive-biasing) shows not only the aspectual-verb composition effect, previously reported for the agentive readings, but also a comparable processing profile for the constitutive readings, a novel finding supporting the unified linguistic analysis and processing implementation of the two readings. Regardless of reading, the composition effect is observable even after the complement has been retrieved, indicating that the fundamental lexico-semantic compositional processes must take place before context can serve as a constraining force.

The combinatorial patterns of twá 'to cut' in Asante-Twi (Akan):

Cross-linguistically, verbs have combinatorial patterns. When the semantics of a verb combines with the semantics of its internal arguments, different interpretations are derived. These interpretations can be literal or non-literal (Ameka 2019; Spalek 2015; Rappaport Hovav 2014; Bobuafor 2013, 2018; Levin and Rappaport Hovav 2013; Ameka and Essegbey 2007; Levin 1993). Using data collected from written texts, video-stimuli descriptions, spontaneous utterances and native-speaker intuitions, this paper explores the potential combinatorial patterns of twá ‘to cut’ in Asante-Twi (Akan, Kwa-Niger Congo). I show that the verb combines with different types of internal arguments, in different argument structure constructions to derive multiple interpretations. Taking into consideration the fact that “natural language tries to minimize polysemy” (Levin and Rappaport Hovav 2013: 2), I propose a univocal lexical semantics for twá ‘to cut’ and show that its basic semantics is kept constant even in non-prototypical contexts. I argue that the use of twá ‘to cut’ in non-prototypical contexts represent contextual modulations of the verb’s single meaning. Following Spalek (2015) and Ameka (2019), I suggest that such contextual interpretations should be analysed compositionally, paying attention to the verb’s internal arguments as well as the argument structure constructions in which it occurs.

The Grossberg Code: Universal Neural Network Signatures of Perceptual Experience

Two universal functional principles of Grossberg’s Adaptive Resonance Theory decipher the brain code of all biological learning and adaptive intelligence. Low-level representations of multisensory stimuli in their immediate environmental context are formed on the basis of bottom-up activation and under the control of top-down matching rules that integrate high-level, long-term traces of contextual configuration. These universal coding principles lead to the establishment of lasting brain signatures of perceptual experience in all living species, from aplysiae to primates. They are re-visited in this concept paper on the basis of examples drawn from the original code and from some of the most recent related empirical findings on contextual modulation in the brain, highlighting the potential of Grossberg’s pioneering insights and groundbreaking theoretical work for intelligent solutions in the domain of developmental and cognitive robotics.

Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat.

Ambiguous relationships between events may be established using interference procedures such as latent inhibition, extinction or counterconditioning. Under these conditions, the retrieval of individual associations between a stimulus and outcome is affected by contextual cues. To examine the roles of the dorsal (prelimbic) and ventral (infralimbic) medial prefrontal cortex in the contextual modulation of such associations, we investigated the context specificity of latent inhibition. Male Lister hooded rats were pre-exposed to two separate stimuli, one in each of two distinct contexts. Both stimuli were then paired with the delivery of mild foot-shock in the same one of these contexts. Finally, the strength of the resultant conditioned emotional response (CER) to each stimulus was assessed in each context. For the sham-operated control rats, the CER was attenuated for each stimulus when it was tested in the context in which it had been pre-exposed. Rats who had received lesions to the infralimbic cortex showed this effect only in the conditioning context, whereas rats with lesions to the prelimbic cortex showed the effect only in the context in which conditioning had not taken place. These findings indicate that infralimbic and prelimbic cortices play distinct, and competing, roles in the contextual modulation of initial and later learning.

Effect of stress on contextual pain sensitivity in the preoperative period- A proof of concept study.

The importance of non-noxious contextual inputs in the interplay of pain with neurophysiologic and behavioral factors is gaining recognition. Stress of impending surgery can act as a negative context, leading to a decrease in pain threshold in patients. This study was conducted to assess the influence of stress conferred by the imminent and other contextual inputs such as anxiety, socioeconomic status, prior painful experience, and the effect of gender on modulation of pain perception in patients undergoing elective surgery. In total, 120 patients aged between 18 and 60 years of either gender posted for elective gastrointestinal surgery under general anesthesia were recruited. Data were collected on preoperative anxiety level, socioeconomic status, education, and any prior painful experience. A pressure algometer was used to measure the pressure pain thresholds and pain tolerance on the day before surgery and on the morning of surgery in the preoperative suite. There was a statistically significant decrease in both pain threshold (P < 0.0001) and pain tolerance in the immediate preoperative period in comparison to the baseline readings taken the day before surgery (P = 0.048). The magnitude of change in pain scalars was greater in females (P < 0.001), those with a high anxiety score, and a history of severe painful experience in the past. Preoperative surgical stress lowers the pain threshold and pain tolerance. Contextual modulation of pain by factors such as anxiety and memory of prior painful experience, especially in the female gender, could influence postoperative patient outcomes and warrants further research.

Topographically Localized Modulation of Tectal Cell Spatial Tuning by Complex Natural Scenes.

The tuning properties of neurons in the visual system can be contextually modulated by the statistics of the area surrounding their receptive field (RF), particularly when the surround contains natural features. However, stimuli presented in specific egocentric locations may have greater behavioral relevance, raising the possibility that the extent of contextual modulation may vary with position in visual space. To explore this possibility, we utilized the small size and optical transparency of the larval zebrafish to describe the form and spatial arrangement of contextually modulated cells throughout an entire tectal hemisphere. We found that the spatial tuning of tectal neurons to a prey-like stimulus sharpens when the stimulus is presented against a background with the statistics of complex natural scenes, relative to a featureless background. These neurons are confined to a spatially restricted region of the tectum and have receptive fields centered within a region of visual space in which the presence of prey preferentially triggers hunting behavior. Our results suggest that contextual modulation of tectal neurons by complex backgrounds may facilitate prey-localization in cluttered visual environments.

Rapid, reliable mobile assessment of affect-related motor processing

Mobile technologies can be used for behavioral assessments to associate changes in behavior with environmental context and its influence on mental health and disease. Research on real-time motor control with a joystick, analyzed using a computational proportion-derivative (PD) modeling approach, has shown that model parameters can be estimated with high reliability and are related both to self-reported fear and to brain structures important for affective regulation, such as the anterior cingulate cortex. Here we introduce a mobile version of this paradigm, the rapid assessment of motor processing (RAMP) paradigm, and show that it provides robust, reliable, and accessible behavioral measurements relevant to mental health. A smartphone version of a previous joystick sensorimotor task was developed in which participants control a virtual car to a stop sign and stop. A sample of 89 adults performed the task, with 66 completing a second retest session. A PD modeling approach was applied to compute Kp (drive) and Kd (damping) parameters. Both Kp and Kd exhibited high test-retest reliabilities (ICC .81 and .78, respectively). Replicating a previous finding from a different sample with the joystick version of the task, both Kp and Kd were negatively associated with self-reported fear. The RAMP paradigm, a mobile sensorimotor assessment, can be used to assess drive and damping during motor control, which is robustly associated with subjective affect. This paradigm could be useful for examining dynamic contextual modulation of affect-related processing, which could improve assessment of the effects of interventions for psychiatric disorders in a real-world context.

Congruence-based contextual plausibility modulates cortical activity during vibrotactile perception in virtual multisensory environments

How congruence cues and congruence-based expectations may together shape perception in virtual reality (VR) still need to be unravelled. We linked the concept of plausibility used in VR research with congruence-based modulation by assessing brain responses while participants experienced vehicle riding experiences in VR scenarios. Perceptual plausibility was manipulated by sensory congruence, with multisensory stimulations confirming with common expectations of road scenes being plausible. We hypothesized that plausible scenarios would elicit greater cortical responses. The results showed that: (i) vibrotactile stimulations at expected intensities, given embedded audio-visual information, engaged greater cortical activities in frontal and sensorimotor regions; (ii) weaker plausible stimulations resulted in greater responses in the sensorimotor cortex than stronger but implausible stimulations; (iii) frontal activities under plausible scenarios negatively correlated with plausibility violation costs in the sensorimotor cortex. These results potentially indicate frontal regulation of sensory processing and extend previous evidence of contextual modulation to the tactile sense.