Shape Context Research Articles

DIPG-08. THE LANDSCAPE OF TUMOR CELL STATES AND SPATIAL ORGANIZATION IN H3-K27M MUTANT DIFFUSE MIDLINE GLIOMA ACROSS AGE AND LOCATION

Abstract Histone 3 lysine27-to-methionine mutations (H3-K27M) frequently occur in childhood diffuse midline gliomas (DMGs) of the pons, thalamus, and spinal cord, presumed to be driven by the specific spatiotemporal context of these midline locations during postnatal development. While most common in the pons and at mid-childhood ages, the same oncohistone mutation is recurrently detected in adult DMGs and throughout different midline regions. The potential heterogeneity of tumors at different ages and in different anatomical locations of the midline are vastly understudied. Through dissecting the transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs - spanning the age range from 2-68 years and locations from spinal cord to thalamus - at single cell resolution, we delineate how age- and location-dependent contexts shape glioma cell-intrinsic and -extrinsic features in light of the shared driver mutation. We identify that oligodendrocyte precursor (OPC)-like cells constitute the stem-like compartment in H3-K27M DMGs across all clinico-anatomical groups, however, depending on location, display varying levels of maturity resembling less differentiated pre-OPCs or more mature OPCs further differentiated along the oligodendroglial lineage. We further demonstrate increased mesenchymal cell states in adult tumors, which we link to age-related differences in glioma-associated immune cell compartments, in particular an increase of macrophages in adult compared to pediatric tumors. Furthermore, we resolve the spatial organization of H3-K27M DMG cell types and states in intact patient tissues, identifying a local niche of the oligodendroglial lineage. Our study provides a powerful resource for rational modeling and therapeutic frameworks taking into account determinants of age and location in this lethal glioma group.

Discovery, discernment, and exploitation: Entrepreneurial mechanisms at the nexus of individual and opportunity

AbstractResearch SummaryExtending the opportunity‐discovery perspective on Kirznerian entrepreneurship, we propose a general framework in which new businesses emerge from three distinct mechanisms situated at the individual‐opportunity nexus: discovery, discernment, and exploitation. We propose observing opportunities in market exchanges and characterizing their profitability potential based on a component that is common to all observers and one that is specific to individual observers who vary in access to market information. Analysis of an online platform for freelance labor demonstrates our contributions in theory, measurement, and inference. In this context, discovery and exploitation mechanisms shape individuals' entrepreneurial transitions from freelancer to founder. We discuss applications of our framework across settings, extensions to other types of entrepreneurship, and the viability of opportunity as an orienting construct for entrepreneurship research.Managerial SummaryEntrepreneurial opportunities are present in all markets but there is no systematic way of observing or valuing such opportunities, much less predicting where and when they become the basis for new businesses. We propose doing this with data commonly collected and archived by online platforms. We acknowledge that new businesses are often founded if one is in the right place at the right time; if one can distinguish a great opportunity from a good (or bad) one; or if one is capable of making a market. Our framework makes each of these intuitions empirically distinct, thus offering insights on where, when, and by whom new businesses are likely to be founded.

Mental health among bereaved youth in the ALSPAC birth cohort: Consideration of early sociodemographic precursors, cognitive ability, and type of loss.

Bereaved youth are at greater risk for adverse mental health outcomes, yet less is known about how social context shapes health for bereaved children. Ecosocial theory is employed to conceptualize bereavement in the context of sociodemographic factors. This longitudinal study used data from the Avon Longitudinal Study of Parents and Children. Of the 15,454 pregnancies enrolled, 5050 youth were still enrolled at age 16.5 and completed self-report questionnaires on life events and emotional/behavioral symptoms. Sociodemographic precursors associated with parent, sibling, or close friend bereavement included maternal smoking, parental education levels, and financial difficulties. The significant yet small main effect of higher cognitive ability, assessed at age 8, on reduced emotional/behavioral symptoms at age 16.5 (β = -0.01, SE = 0.00, p < 0.001) did not interact with bereavement. Bereavement of a parent, sibling, or close friend was associated with a 0.19 point higher emotional/behavioral symptom log score compared to non-bereaved youth (95% CI: 0.10-0.28), across emotional, conduct, and hyperactivity subscales. Descriptive findings suggest sociodemographic precursors are associated with bereavement. While there was an association between the bereavement of a parent, sibling, or close friend and elevated emotional/behavioral symptoms, cognitive ability did not moderate that effect.

COGNITIVE DESCRIPTION AND CLASSIFICATION OF LINGUISTIC UNITS OF DIFFERENT LEVELS

This article discusses the cognitive processes involved in the description and classification of linguistic units at different levels. It explores how language is processed and understood by the human brain, and how this understanding can be used to identify and categorize different types of linguistic units. The article also examines the role of context and cultural factors in shaping our perception and interpretation of language. By providing a comprehensive overview of the cognitive aspects of linguistic description and classification, this article offers insights into how we can better understand and analyze language at all levels.

Administrator Perceptions of Campus Sexual Assault Policy at an HBCU: A Composite Counterstory

Abstract: This article explores the campus climate of a Historically Black University in the Southeastern United States by providing an overview of the campus’ sexual assault policy and administrators’ perceptions of the climate surrounding sexual assault on the campus. The research question that guided this study is: How does institutional context shape the policy development and implementation of campus sexual assault policy at an HBCU? The research design consists of semi-structured interviews with six administrators that were analyzed using Counterstory. The significance of this study is to contribute to the body of research which exists about campus sexual assault policies at HBCUs. The findings of this study discuss how the institution views their stance on campus sexual assault policy. This study provides administrators with information that can assist in the development and implementation of campus sexual assault policy.

Social and structural determinants of injection drug use-associated bacterial and fungal infections: a qualitative systematic review and thematic synthesis.

Injection drug use-associated bacterial and fungal infections are increasingly common, and social contexts shape individuals' injecting practices and treatment experiences. We sought to synthesize qualitative studies of social-structural factors influencing incidence and treatment of injecting-related infections. We searched PubMed, EMBASE, Scopus, CINAHL, and PsycINFO from January 1, 2000, to February 18, 2021. Informed by Rhodes' "risk environment" framework, we performed thematic synthesis in three stages: (1) line-by-line coding; (2) organizing codes into descriptive themes, reflecting interpretations of study authors; (3) consolidating descriptive themes into conceptual categories to identify higher-order analytic themes. We screened 4,841 abstracts and included 26 qualitative studies on experiences of injecting-related bacterial and fungal infections. We identified six descriptive themes organized into two analytic themes. The first analytic theme, social production of risk, considered macro-environmental influences. Four descriptive themes highlighted pathways through which this occurs: (1) unregulated drug supply, leading to poor drug quality and solubility; (2) unsafe spaces, influenced by policing practices and insecure housing; (3) health care policies and practices, leading to negative experiences that discourage access to care; and (4) restrictions on harm reduction programs, including structural barriers to effective service provision. The second analytic theme, practices of care among people who use drugs, addressed protective strategies people employ within infection risk environments. Associated descriptive themes were: (5) mutual care, including assisted-injecting and sharing sterile equipment; and (6) self-care, including vein health and self-treatment. Within constraining risk environments, some protective strategies for bacterial infections precipitated other health risks (e.g., HIV transmission). Injecting-related bacterial and fungal infections are shaped by modifiable social-structural factors, including poor quality unregulated drugs, criminalization and policing enforcement, insufficient housing, limited harm reduction services, and harmful health care practices. People who inject drugs navigate these barriers while attempting to protect themselves and their community.

Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs

BackgroundMedications for opioid use disorder (MOUD; methadone, buprenorphine, naltrexone) are the most effective treatments for OUD, and MOUD is protective against fatal overdoses. However, continued illegal drug use can increase the risk of treatment discontinuation. Given the widespread presence of fentanyl in the drug supply, research is needed to understand who is at greatest risk for concurrent MOUD and drug use and the contexts shaping use and treatment discontinuation.MethodsFrom 2017 to 2020, Massachusetts residents with past-30-day illegal drug use completed surveys (N = 284) and interviews (N = 99) about MOUD and drug use. An age-adjusted multinomial logistic regression model tested associations between past-30-day drug use and MOUD use (current/past/never). Among those on methadone or buprenorphine (N = 108), multivariable logistic regression models examined the association between socio-demographics, MOUD type; and past-30-day use of heroin/fentanyl; crack; benzodiazepines; and pain medications. Qualitative interviews explored drivers of concurrent drug and MOUD use.ResultsMost (79.9%) participants had used MOUD (38.7% currently; 41.2% past), and past 30-day drug use was high: 74.4% heroin/fentanyl; 51.4% crack cocaine; 31.3% benzodiazepines, and 18% pain medications. In exploring drug use by MOUD history, multinomial regression analyses found that crack use was positively associated with past and current MOUD use (outcome referent: never used MOUD); whereas benzodiazepine use was not associated with past MOUD use but was positively associated with current use. Conversely, pain medication use was associated with reduced odds of past and current MOUD use. Among those on methadone or buprenorphine, separate multivariable logistic regression models found that benzodiazepine and methadone use were positively associated with heroin/fentanyl use; living in a medium-sized city and sex work were positively associated with crack use; heroin/fentanyl use was positively associated with benzodiazepine use; and witnessing an overdose was inversely associated with pain medication use. Many participants qualitatively reported reducing illegal opioid use while on MOUD, yet inadequate dosage, trauma, psychological cravings, and environmental triggers drove their continued drug use, which increased their risk of treatment discontinuation and overdose.ConclusionsFindings highlight variations in continued drug use by MOUD use history, reasons for concurrent use, and implications for MOUD treatment delivery and continuity.

Embedding Cognition: Judgment and Choice in an Interdependent and Dynamic World

Society is facing pressing interrelated, multilevel, and systemic challenges. Human consumption patterns are driving biodiversity loss and climate change, with unevenly distributed impacts that exacerbate preexisting inequalities. Structural or systems-level solutions to these challenges depend on group- and individual-level change, and vice versa. Although cognitive psychology has advanced our understanding of individual and group-level decision-making, it rarely links these microlevel processes and behaviors to network- and systems-level structures, resulting in a fragmented theory of how individual and collective action can drive broader social change. For example, psychology has established that physical, social, and historical contexts shape perception, reasoning, and decision-making but has largely ignored the dynamic and interdependent relationship between behavior and contexts. In this review, we urge researchers to move beyond a focus on static contexts and individual and group-level cognition to incorporate deeper theorizing about the temporal dynamics and feedbacks between individuals and the broader contexts in which they are embedded. We review literature emphasizing the role of context in shaping psychological processes as well as emerging research that considers individuals as embedded in complex adaptive systems. Complex adaptive systems frameworks are well suited to study the dynamic and interdependent relationship among individuals and the broader systems and structures they inhabit. The integration of research in psychology with these perspectives may thus offer traction in identifying solution pathways to complex, multilevel challenges by pointing to theories and methods that integrate across levels of analysis and account for coupled nature-society systems.

The genesis of staff-student partnerships: Institutional influences

As staff-student partnership activity becomes embedded into the infrastructure of higher education there is an increased institutional focus on systematising the staff-student partnership support processes. Drawing on data from a case study of a partnership conceived under the auspices of an institutional staff-student partnership programme, this article offers insight into how the institutional context shapes partnership aims, objectives, and composition. It finds that in the pre-partnership phase a gatekeeping role is performed by the institutional programme, which ultimately determines which partnerships proceed, and how they are evaluated. The study contributes to the broader critique of staff-student partnership practices, proposing a framework that integrates the various institutional influences and the pre and post-partnership phases.

Exploring the Professional Identity Formation of Racial/Ethnic Minoritized Physician Assistants.

The purpose of this article is to (1) describe how professional identity intersects with physician assistants' (PAs') and PA students' racial and ethnic identities and cultural backgrounds; (2) examine how sociohistorical contexts shape professional identity in racial/ethnic minoritized PAs and PA students; and (3) identify the role of PA program administrators and faculty to address the needs of racial/ethnic minoritized PAs and PA students. This study draws on elements of constructivist grounded theory to investigate the professional identity formation (PIF) experiences of 45 PA students and alumni from 3 institutions. Participants were recruited using a snowball method and identified as 23 Black/African American, 12 Hispanic/Latino, 6 mixed race, and 4 Native American/Indigenous. Interview data were analyzed using sociocultural theory as an analytic framework. The results suggest that participants felt that their racial/ethnic identity was an important part of their identity, yet many indicated they experienced frequent micro- and macroaggressions from fellow students, faculty, lecturers, administrators, preceptors, patients, and supervisors. Additionally, they indicated that they need more support from their programs than what is currently provided. The results of this study suggest that social experiences before, during, and after PA training strongly influence PIF development in racial/ethnic minoritized PAs. Administrators and professional PA organizations should evaluate methods to support those individuals who identify as a racial/ethnic minority throughout their careers.

Understanding Platform Mediated Work-Life: A Diary Study with Gig Economy Freelancers

Online freelancing platforms, such as Upwork, hold great promise in enabling flexible work opportunities where freelancers can combine their work with other life responsibilities, hereafter work-life. However, prior research suggests that platform features and self-managing demands of freelance work can jeopardise this apparent flexibility. In this paper, we report findings from a qualitative study, combining a 14-diary and semi-structured interview with 15 Upwork freelancers. We explored online freelancers' work practices, challenges, and the impact of platform features on their everyday lives. Our qualitative data suggest that platform features and individual context shape online freelancers' work-life practices. Freelancers develop strategies to mitigate platforms' constraints and balance their individual preferences and responsibilities. Further, our findings illustrate how platform features challenge freelancers' availability expectations, work autonomy, and work detachment. This paper contributes an empirical understanding of the factors influencing online freelancers' work-life practices by drawing upon Wanda J. Orlikowski's Structuration Model of Technology. This theoretical lens renders the interplay of freelancers, platforms, and instituted norms of freelance work.

Contexts shaping misdemeanor system interventions among people with mental illnesses: qualitative findings from a multi-site system mapping exercise

BackgroundPeople with mental illnesses are disproportionately entangled in the criminal legal system. Historically, this involvement has resulted from minor offending, often accompanied by misdemeanor charges. In recent years, policymakers have worked to reduce the footprint of the criminal legal system. This paper seeks to better understand how misdemeanor systems intervene in the lives of people with mental illnesses.MethodsSystem mapping exercises were conducted with misdemeanor system stakeholders from the jurisdictions of Atlanta, Chicago, Manhattan, and Philadelphia. Narrative detail on decision-making and case processing, both generally and in relation to specific types of behavior, including trespassing, retail theft/shoplifting, and simple assault, were coded and analyzed for thematic patterns. Based on the qualitative analysis, this paper offers a conceptual diagram of contexts shaping misdemeanor system interventions among people with mental illnesses.ResultsAll four sites have been engaged in efforts to reduce the use of misdemeanor charges both generally and in relation to people with mental illnesses. Decision-makers across all sites experience contexts that shape how, when, and where they intervene, which are: (1) law and policy environments; (2) location of the behavior; (3) expectations of stakeholders; (4) knowledge of mental illnesses; and (5) access to community resources. Law and policy environments expand or constrain opportunities for diversion. The location of offending is relevant to who has a stake in the behavior, and what demands they have. Clinical, experiential, and system-level knowledge of mental illnesses inform a chain of decisions about what to do. The capacity to address mental health needs is contingent on access to social services, including housing.ConclusionPeople making decisions along the criminal legal continuum are critical to illuminating the dynamic, inter-related contexts that facilitate and frustrate attempts to address defendants’ mental health needs while balancing considerations of public safety. Multi-sector, scenario-based or case study exercises could help identify concrete ways of improving each of the contexts that surround whole-of-system decisions.

Contexts shaping misdemeanor system interventions among people with mental illnesses: qualitative findings from a multi-site system mapping exercise

Contexts shaping misdemeanor system interventions among people with mental illnesses: qualitative findings from a multi-site system mapping exercise

Exposure Therapy with a First-Generation, Latino Transgender Man: A Dialectical Behavior and Feminist Therapy Framework

Transgender and Gender Expansive (TGE) individuals with multiple marginalized identities are at increased risk of minority stress and trauma because of intersecting systems of oppression, such as transphobia and racism. There is limited evidence-based guidance for TGE individuals experiencing trauma, especially TGE individuals of color. This case study describes the implementation of Prolonged Exposure and informal emotion exposure with a first-generation Latino transgender man using a Feminist Therapy and Dialectical Behavior Therapy lens. Seven clinical considerations drawing from the integration of these approaches are discussed, including recognition of the sociocultural context in shaping the client’s behaviors, balancing flexibility and accountability, and balancing exposure with validation of avoidance.

Can Environmental Assessment Protect Caribou? Analysis of EA in Nunavut, Canada, 1999-2019

Abstract This paper analyses the environmental assessment of every proposed mining project that has undergone full review through the Nunavut Impact Review Board from 1999 to 2019, with specific emphasis on how impacts to caribou were identified and assessed. Caribou are the most important terrestrial species in Nunavut from a food security, traditional culture, and harvesting perspective, and mining is known to have impacts on caribou habitat, migration and calving behaviour, predation and hunting patterns, and other effects. Close study of how caribou impacts are discerned and evaluated within environmental assessment (EA) can thus reveal broader trends about both EA and the broader resource governance process. Although some project proposals were initially rejected, every EA ultimately concluded that impacts to caribou were not significant, despite evidence presented to the contrary. We present three modes through which serious impacts are rendered insignificant within EA (mitigation, strategic use of scale, and strategic use of Inuit knowledge and consultation) and comment on the broader context shaping EA in Nunavut. We argue that EA cannot do what it is expected to do (come to rational, science-based decisions that balance ecological, social, and economic goals) and is an insufficient tool for ensuring the long-term well-being of caribou in Nunavut.

Cyber–physical system for fast prototyping of power electronic converters in EMI shaping context

Dynamic development of power systems, which utilize power electronic converters as interfaces between the renewable energy sources, as well as complex control and measuring arrangements, forces the cooperation of specialists representing various fields to assure electromagnetic compatibility (EMC) of the so-called smart industrial systems. Low voltage DC grid applications involving multiple power electronics devices may turn the grid susceptible to noise injection and impair the signal integrity and power quality due to the electromagnetic interference (EMI) emission and due to devices and grid interactions. The EMI propagation leads to misreading measurements and faulty conditions of equipments and in ICT (Information and Communications Technology) systems within the conducted emission frequency range, which impacts the hosting capacity of the grid. This paper proposes a cyber–physical system based on the NI-PXI platform for fast-prototyping and EMC assessment as pre-compliance tool of low-voltage DC grid in smart industrial systems. Thus, the LabVIEW-based design as well as the EMC-testbench system validation were performed with a DC/DC converter through the pulse-width modulation control algorithms. In addition, a case study has been investigated to evaluate the interferences between the converter and Power Line Communication. Hence, the theoretical control algorithms, hardware and software details, and experimental results are discussed, highlighting the paradigms of one flexible and collaborative cyber–physical system from the area of smart industrial systems.

Neighbourhood landscape context shapes local species richness patterns across continents

AbstractAimRecent studies highlight the importance of linking landscape ecology and macroecology for a better understanding of broad‐scale biodiversity patterns. The “landscape context effect” denotes that species responses and biodiversity in a focal area are shaped by neighbouring landscape composition and structure outside the focal area. Here, we test whether the landscape context effect could be pronounced at macroecological scales.LocationSub‐Saharan Africa and continental China.Time periodLate 20th to early 21st centuries.Taxa studiedTerrestrial mammals (≥2 kg).MethodsWe calculated species richness on the basis of grid cells of 50 km × 50 km and 100 km × 100 km. We used ordinary least square and random forest models to examine the relationships between species richness within grid cells and landscape context (defined as composition and structure of the neighbouring landscape outside the grid cells, with distances of 10–400 km to the boundary of a given grid cell). We used variation partitioning to quantify the independent and shared explanatory power of the landscape context variables, grouping species by body size and diet.ResultsLandscape context alone explained ≤20% of the variation in species richness, even when controlling for correlations with macroenvironmental variables (climate, productivity and topography) and correlations with landscape attributes within the grid cells. Importantly, the explanatory power of landscape context at the scales of 100–400 km ofen outweighed grid‐cell landscape attributes or macro‐environmental variables. The independent explanatory power of landscape context was lowest for small‐sized omnivores. Furthermore, we found higher independent explanatory power for large herbivores in sub‐Saharan Africa than in continental China.Main conclusionsLandscape context plays a substantial role in shaping local biodiversity patterns at regional and continental scales, with its strength varying with organism diet and movement needs and possibilities. These findings support that conservation efforts should include effective management of landscape structure, with attention to differing space requirements among organism groups. Our work also illustrates the scope for testing landscape ecological hypotheses at macroecological scales.

Stability and Change in Adolescents’ Sense of Agency: Contributions of Sex, Multiple Risk, Pandemic Stress, and Attachment to Parents

Although literature states that individual, relational, and contextual factors contribute to adolescents’ sense of agency, more research is needed to clarify and understand how adolescents develop this belief over time. The current study examined the stability/change trajectories of the sense of agency during adolescence, specifically across high school, analyzing whether attachment to parents over time, adolescents’ sex, cumulative risk in baseline, and pandemic-related stress explained these trajectories. The sample included 467 Portuguese adolescents (40.7% were males; Mage = 15.58 years, SD = 0.80), evaluated three times across 18 months. This work yielded three significant findings. First, adolescents’ sense of agency significantly increased over time, with significant between-subject variance at the initial levels but not at the growth rate. Second, attachment to parents consistently links to adolescents’ sense of agency across time, despite the differential contributions from attachment to mothers and fathers. Third, boys reported greater growth in the sense of agency than girls. Adolescents’ cumulative risk at T1 predicted lower initial levels of sense of agency, whereas higher pandemic-related stress predicted less growth of the sense of agency. These findings emphasize the contributions of individual and family characteristics and the role of the broader social context in shaping the development of adolescents’ sense of agency. The findings underline the need to consider further the differential influences of adolescents’ relationships with mothers and fathers to understand changes in adolescents’ sense of agency.

Semi-Supervised Semantic Segmentation Network for Point Clouds Based on 3D Shape

The semantic segmentation of point clouds has significant applications in fields such as autonomous driving, robot vision, and smart cities. As LiDAR technology continues to develop, point clouds have gradually become the main type of 3D data. However, due to the disordered and scattered nature of point cloud data, it is challenging to effectively segment them semantically. A three-dimensional (3D) shape provides an important means of studying the spatial relationships between different objects and their structures in point clouds. Thus, this paper proposes a semi-supervised semantic segmentation network for point clouds based on 3D shape, which we call SBSNet. This network groups and encodes the geometric information of 3D objects to form shape features. It utilizes an attention mechanism and local information fusion to capture shape context information and calculate the data features. The experimental results showed that the proposed method achieved an overall intersection ratio of 85.3% in the ShapeNet dataset and 90.6% accuracy in the ModelNet40 dataset. Empirically, it showed strong performance on par or even better than state-of-the-art models.

Does the Political Context Shape How “Due Impartiality” is Interpreted? An Analysis of BBC Reporting of the 2019 UK and 2020 US Election Campaigns

ABSTRACT Balance and impartiality are central principles in journalism, but this study argues their conceptual application in news reporting should be subject to more academic scrutiny. In the UK, the way “due impartiality” has been applied and regulated by broadcasters has raised concerns about promoting a ‘she-said-he-said’ style of reporting, which constructs balance but not scrutiny of competing claims. In this study, we analyse how the UK’s “due impartiality” was applied by journalists in different political contexts by assessing how the BBC dealt with competing party-political claims. We develop a nuanced quantitative analysis of BBC journalist interactions (N = 967) with claims made by the four main party leaders during the 2019 UK and 2020 US elections. Overall, we found BBC reporting robustly challenged claims by US politicians, whereas coverage of UK politicians often only conveyed claims and counterclaims with limited journalistic intervention, particularly on television news. We argue that impartiality should be viewed more as a fluid than fixed concept given that the context shapes how it is applied. As concerns about misinformation have grown over recent years, we conclude that more finely tuned studies are needed to understand how journalists apply concepts about balance and impartiality in political reporting.