Contemporary Intervention Research Articles

ARTISTIC INTERPRETATIONS OF WATER ISSUES IN THE CONTEXT OF URBANISM : THE YAMUNA RIVER IN DELHI

The present paper explores the reflection of water issues within urban spaces in contemporary art practices, specifically focusing on the Yamuna river in Delhi. The Yamuna holds historical and religious significance and plays a crucial role in meeting the water needs of Delhi's 31.2 million population. However, the rapid urbanization of Delhi has led to detrimental consequences for the river, including increased pollution levels, encroachment on river banks, water scarcity, reduced water flow and detachment from its surroundings. The paper examines contemporary artistic interventions that address these ecological concerns through new media, site-specific art projects and public art. The aim of this paper is to identify those artists and to discuss the various artistic modalities in which these ecological concerns are addressed in the form of aesthetical structures and to discover how art is functionalized as a social and collective agent to create awareness among the public. It also aims to explore how artists are incorporating the ecological aspect of Urbanity in their works. the methodology involves interviews with artists, where their creative insights are explored to discern the multifaceted relationship between the river's ecological challenges and urban development. The study employs an interdisciplinary approach that sheds light on the complex interplay between environmental concerns and artistic expression. the paper concludes how art functions as a social and collective agent, raising awareness among the public about the ecological urgency caused by rampant urbanization.

Assessing Conservation Conditions at La Fortaleza de Kuelap, Peru, Based on Integrated Close-Range Remote Sensing and Near-Surface Geophysics

We combined datasets from multiple research projects and remote sensing technologies to evaluate conservation conditions at La Fortaleza de Kuelap, a pre-Hispanic site in Peru that suffered significant damage under heavy seasonal rains in April 2022. To identify the causes of the collapse and where the monument is at further risk, we modeled surface hydrology using a DTM derived from drone LiDAR data, reconstructed a history of collapses, and calculated the volume of the most recent by fusing terrestrial LiDAR and photogrammetric datasets. In addition, we examined subsurface water accumulation with electrical resistivity, reconstructed the stratification of the monument with seismic refraction, and analyzed vegetation loss and ground moisture accumulation using satellite imagery. Our results point to rainwater infiltration as the most significant source of risk for La Fortaleza’s perimeter walls. Combined with other adverse natural conditions and contemporary conservation interventions, this led to the 2022 collapse. Specialists need to consider these factors when tasked with conserving monuments located in comparable high-altitude perhumid environments. This integration of analytical results demonstrates how multi-scalar and multi-instrumental approaches provide comprehensive and timely assessments of conservation needs.

Environmental Interventions for Preventing Atopic Diseases.

In this review, we detail the exposome (consisting of environmental factors such as diet, microbial colonization, allergens, pollutants, and stressors), mechanistic and clinical research supporting its influence on atopic disease, and potentiation from climate change. We highlight contemporary environmental interventions and available evidence substantiating their roles in atopic disease prevention, from observational cohorts to randomized controlled trials, when available. Early introduction to allergenic foods is an effective primary prevention strategy to reduce food allergy. Diverse dietary intake also appears to be a promising strategy for allergic disease prevention, but additional study is necessary. Air pollution and tobacco smoke are highly associated with allergic disease, among other medical comorbidities, paving the way for campaigns and legislation to reduce these exposures. There is no clear evidence that oral vitamin D supplementation, prebiotic or probiotic supplementation, daily emollient application, and antiviral prophylaxis are effective in preventing atopic disease, but these interventions require further study. While some environmental interventions have a well-defined role in the prevention of atopic disease, additional study of many remaining interventions is necessary to enhance our understanding of their role in disease prevention. Alignment of research findings from randomized controlled trials with public policy is essential to develop meaningful public health outcomes and prevent allergic disease on the population level.

Abstract Spaces for Intervention in Libya and Nigeria

Abstract How is the space for contemporary interventions constructed? This article deepens our understanding of counterterrorism as a dialectical form of intervention by highlighting the importance of unifying rationalities in the creation of “ungoverned spaces” as abstract spaces for intervention purposes. We combine dialectical and decolonial thinking to track how unifying rationalities in Nigeria and Libya are deployed across cognitive, normative, and operational constructs. The article examines how interventions are cognitively tied to coloniality of knowing, being, and power, which exploit identity, religion, or societal divisions to justify ungovernance and normalize state and foreign violence. The simultaneous and reciprocal globalization of local security concerns and localization of global security predicaments facilitates the formation of abstract spaces for counterterrorism purposes. Empirically, our analysis shows how portraying Libya and Nigeria as ungoverned creates a void of meaning, putting external actors in charge of restoring governance and protecting human security, modernity, and civility. Interveners in Libya contributed to normalizing a broader spectrum of violence, frequently internalized by competing actors through their normative tropes. In Nigeria, state and foreign interventionism and counterinsurgency have been responsible for the widespread use of violence against entire communities.

A Framework for Effective Collaboration with Crisis-Affected Communities

In 2016, a localisation agenda was set across the international aid industry with the understanding that humanitarian interventions need to be led by local actors and local communities. Despite international agreements, the localisation efforts are largely failing. This paper demonstrates the challenges that prevent effective collaboration between international humanitarian agencies and crisis-affected communities. It draws on evaluation reports to highlight an inability to learn lessons or follow recommendations from previous crises. Based on the authors’ experiences, we present a novel framework for effectively collaborating with crisis-affected communities. The Communities Framework provides a pathway to establishing effective community collaboration and locally owned and led humanitarian interventions. The importance of local leadership, trust building, and local context are at the heart of the framework. In light of the need for a more localised and decolonial humanitarian response, this framework supports humanitarian actors and the affected communities in moving from a charity-led approach to one of mutual aid. The paper draws on alternative notions of compassion from the Global South of contemporary humanitarian interventions as a philosophical foundation for the framework. Caring for others and the world is central to implementing an appropriate and effective humanitarian response. There remains a largely unexplored scope regarding the outcome of resolving crises when both humanitarian actors and affected communities work as equal partners and how that will shape modern humanitarianism as we understand it today.

The HERVAT Method as a Neurolearning Strategy in Education

The pedagogical methodology has evolved in recent years, moving towards approaches that integrate advances in neuroscience with educational practices. In this context, the HERVAT method emerges, aiming to consolidate these advances and apply them in the educational sphere to enhance the learning experience. The main objective of this research was to implement the HERVAT method in various educational institutions in Ecuador. For this, a qualitative methodology was adopted, with an analysis based on the systematization of experiences and grounded in the profound interpretation of a specific phenomenon. Through a rigorous data collection and analysis process, which incorporated techniques such as observations and documentary analysis, the HERVAT method was applied to students in seven renowned educational institutions in the country. The findings of the study highlight those contemporary pedagogical interventions, supported by this method, emphasize the holistic development of the student. By integrating innovative techniques, such as gamification and multisensory stimulation, the aim is to align pedagogical practices with key discoveries in neuroscience. This alignment enhances brain plasticity, facilitating adaptability and depth in learning processes. The personalization of strategies and adherence to empirical evidence emerge as fundamental components to elevate educational quality in the contemporary era. It is concluded that the HERVAT method, rooted in neuroscientific principles, revitalizes learning by activating crucial neural circuits, optimizing aspects such as student attention and concentration. Strategies based on neurodidactics, backed by empirical evidence, highlight the relevance of natural environments and varied stimuli, enhancing sensory perception and the active commitment of the student in their educational process. This approach promotes comprehensive education, aiming to maximize each student's neurocognitive potential.
 
 Received: 22 September 2023 / Accepted: 27 January 2024 / Published: 5 March 2024

Revolutionizing Cardiac Anesthesia: A Comprehensive Review of Contemporary Approaches Outside the Operating Room.

This review article provides a comprehensive examination of the evolution of cardiac anesthesia, emphasizing contemporary approaches beyond the traditional operating room (OR) setting. Tracing the historical roots of cardiac anesthesia from its inception in the mid-20th century, the narrative explores the significant paradigm shift driven by technological advancements and changing procedural approaches. The review highlights the emergence of non-OR environments, such as hybrid operating rooms, catheterization laboratories, and electrophysiology labs, as integral spaces for cardiac interventions. Key findings underscore the importance of patient selection, preoperative assessment, and specialized anesthetic management in optimizing outcomes. Implications for the future of cardiac anesthesia include the potential for enhanced patient-centered care, reduced complications, and improved resource utilization through the integration of advanced technologies. The call to action involves encouraging ongoing research and fostering collaboration among healthcare professionals to refine protocols further, address challenges, and propel the field toward continued innovation in contemporary cardiac interventions.

Understanding employee reactions to union-busting in the US hospitality industry: An analysis based on union attitudes and cognitive frames

Union-busting, whose purpose is to weaken or eliminate labor unions within an organization, is particularly prevalent in the hospitality industry. This paper, which draws on data collected through semi-structured interviews with 38 US line-level hospitality workers, aims to analyze their reactions to union-busting. In doing so, it introduces an original analysis rooted in union attitudes, cognitive frames, and emotions, employing a lens that integrates framing theory and affective events theory. One of the most important contributions of this research lies in recognizing that employees’ responses to union-busting can deviate from the expected alignment with their union attitudes and cognitive frames. This research broadens their scope to encompass a previously unexplored phenomenon. It deepens our understanding of the complexities characterizing the employment relationship in hospitality, thereby offering insights that could inform contemporary HRM strategies and policy interventions.

Nutritional assessment and dietary intervention among survivors of childhood cancer: current landscape and a look to the future.

Over 85% of childhood cancer patients become long-term survivors. Still, cancer and its therapies are associated with a myriad of long-term complications such that childhood cancer survivors (CCS) endure excess disease burden, morbidity, and mortality throughout their lifetimes. Existing literature suggests that CCS maintain poor dietary intake and nutritional status. Thus, as childhood cancer cure rates continue to improve, the role of diet and nutrition in mitigating many of the most common adverse long-term health outcomes among CCS has gained significant interest. Herein we present an in-depth review of existing scientific literature evaluating dietary intake and nutrition status among CCS and its impact on treatment-related health complications; as well as contemporary intervention strategies aimed at overcoming distinctive barriers and improving deleterious lifestyle behaviors in this heterogeneous, at-risk population. Patient-specific, clinical, and systemic factors act as barriers to the timely conduct of comprehensive dietary/nutritional assessments and provision of tailored, risk-based recommendations. This Mini Review discusses the current state of the science, persisting research gaps, and opportunities for advancement of assessment and intervention strategies to address the unique needs of CCS. Search Strategy: We searched PubMed for peer-reviewed articles with the search terms "pediatric cancer," "pediatric malignancy," "pediatric oncology," "childhood cancer," "survivorship," "cancer late effects," "long-term follow-up," "body mass index," "nutritional status," "malnutrition," "body weight," "body weight changes," "body composition," "obesity," "overweight ", "Mediterranean diet," "DASH diet," "processed foods," "micronutrients," "antioxidants," "vitamin D," "calcium," "selenium," "zinc," "metabolic syndrome," "heart disease," "cardiovascular disease," "cardiometabolic disease," "hypertension," "hyperlipidemia," "HDL," "LDL," and "small dense LDL" from January 1, 1995, to July 21, 2023. We also selected relevant articles from our personal files and from reference lists of identified papers. We prioritized publications after 2013; however, commonly cited and highly regarded (defined by high citation count and journal impact factor) older publications were also included. Randomized controlled trials, observational studies, retrospective studies, meta-analysis, editorials, and review articles were included, whereas conference abstracts and case reports were excluded. We only searched for articles published in English, or those translated into English.

The post-hegemonic turn in humanitarian intervention: regional ownership and troubled great power management

Since the Great Recession in 2008, the academic debate has been flooded with literature that predicts the sunset of the liberal world order including the practice of humanitarian intervention as initiated at the United Nations (UN) in the early 1990s and regulated by the adoption of the Responsibility to Protect (R2P) in 2005. In contrast, this article argues that the practice of humanitarian intervention continues to operate under post-hegemonic and multipolar conditions, but in new ways. Based on a theorization of fundamental institutional change and exploratory case studies of the international reactions to the humanitarian crises in Libya, Côte d’Ivoire, Syria and Mali, and supportive evidence from Gambia and DR Congo, we show that contemporary humanitarian intervention is closely related to a normalization of the fundamental institution of great power management and a regionalization of international society. In this post-hegemonic world order, humanitarian intervention is shaped, facilitated or hampered by various practices of great power management including concert, soft balancing and hard balancing. The return of great-power competition means an inconsistent and sometimes counterproductive resort to humanitarian intervention far from the ideals of the R2P, but the growing importance of regional ownership affects the great powers, keeps this potential response to mass atrocity crimes on the table and adds to its legitimacy.

An in silico approach to identify potential downstream targets of miR-153 involved in Alzheimer's disease.

Background: In recent years, microRNAs (miRNAs) have emerged as key players in the pathophysiology of multiple diseases including Alzheimer's disease (AD). Messenger RNA (mRNA) targeting for regulation of gene expression by miRNAs has been implicated in the annotation of disease pathophysiology as well as in the explication of their starring role in contemporary therapeutic interventions. One such miRNA is miR-153 which mediates the survival of cortical neurons and inhibits plaque formation. However, the core mRNA targets of miR-153 have not been fully illustrated. Objective: The present study aimed to elucidate the potential involvement of miR-153 in AD pathogenesis and to reveal its downstream targets. Methods: miRanda was used to identify AD-associated targets of miR-153. TargetScan, PicTar, miRmap, and miRDB were further used to validate these targets. STRING 12 was employed to assess the protein-protein interaction network while Gene ontology (GO) analysis was carried out to identify the molecular functions exhibited by these gene targets. Results: In silico analysis using miRanda predicted five important AD-related targets of miR-153, including APP, SORL1, PICALM, USF1, and PSEN1. All five target genes are negatively regulated by miR-153 and are substantially involved in AD pathogenesis. A protein interaction network using STRING 12 uncovered 30 potential interacting partners for SORL1, PICALM, and USF1. GO analysis revealed that miR-153 target genes play a critical role in neuronal survival, differentiation, exon guidance, amyloid precursor protein processing, and synapse formation. Conclusion: These findings unravel the potential role of miR-153 in the pathogenesis of AD and provide the basis for forthcoming experimental studies.

The emerging role of osteoclasts in the treatment of bone metastases: rationale and recent clinical evidence.

The occurrence of bone metastasis is a grave medical concern that substantially impacts the quality of life in patients with cancer. The precise mechanisms underlying bone metastasis remain unclear despite extensive research efforts, and efficacious therapeutic interventions are currently lacking. The ability of osteoclasts to degrade the bone matrix makes them a crucial factor in the development of bone metastasis. Osteoclasts are implicated in several aspects of bone metastasis, encompassing the formation of premetastatic microenvironment, suppression of the immune system, and reactivation of quiescent tumor cells. Contemporary clinical interventions targeting osteoclasts have proven effective in mitigating bone-related symptoms in patients with cancer. This review comprehensively analyzes the mechanistic involvement of osteoclasts in bone metastasis, delineates potential therapeutic targets associated with osteoclasts, and explores clinical evidence regarding interventions targeting osteoclasts.

The emerging role of mechanical thrombectomy in acute DVT management.

Catheter directed thrombolysis (CDT) and pharmacomechanical thrombectomy in various technical combinations have been the main driver of acute deep venous interventions for over a decade. While the majority of high-level evidence was based on it, CDT requires longer procedural care and is associated to a small but not negligible bleeding risk. Contemporary DVT intervention, following the paradigm shift in myocardial infarction and stroke management, has steadily migrated towards minimizing or eliminating thrombolytics due to the introduction of mechanical/aspiration thrombectomy. Mechanical thrombectomy (MT) devices are undoubtedly improving our ability to remove thrombus more efficiently in a single session without the adverse events and complex logistics related to the use of thrombolytics.

Exercise for People with Parkinson's Disease: Updates and Future Considerations.

Parkinson's disease (PD) is now the world's fastest-growing neurological disorder with rapidly rising prevalence and increasing demand for effective health services. Recent research has focused on the importance of early diagnosis and proactive management of physical function. Accumulating evidence indicates that reduced physical activity levels and mild pre-clinical disability are present in many people prior to a clinical diagnosis, perhaps developing over years. Early referral to a physiotherapist at the time of diagnosis is now recommended in global guidelines. Multiple forms of exercise have been found to have benefits in early and mid-stage disease across a range of motor and non-motor symptoms. Evidence from longitudinal studies confirms that disability is delayed when regular exercise is sustained over long periods. Exercise is now recognized as an essential component of treatment, in combination with medical therapies. Contemporary physiotherapy interventions now combine health behavior change techniques with physical exercise to promote the development of long-term exercise adherence. Advances in technology and digital health have progressed quickly and now offer opportunities for remote assessment and monitoring, remote exercise supervision, and support adherence through feedback and motivational strategies. Recent biomedical discoveries forecast improved earlier and more accurate diagnosis of PD, allowing opportunities for earlier interventions. Current research in progress will provide important insights into the dose and intensity of aerobic exercise in PD. Physiotherapists have important roles in advocacy and education in conjunction with care delivery to support access to evidence-based care for all people with PD.

History and Stories through Jeremy Deller’s Performances

"I wanted to make a memorial that was alive, not an object or set of objects to make a pilgrimage to; a memorial that would come to you, that would appear in your city, town or shopping centre, intervening in your daily life". With these words Jeremy Deller introduces us to his We Are Here Because We Are Here, a true monument celebrating the centenary of the Battle of the Somme on 1st July 1916, in which almost twenty thousand British soldiers succumbed. In fact, with the help of Rufus Norris, director of the National Theatre, Deller organised a gigantic mass performance in which about 2000 volunteers worked, disguised as soldiers of the First World War who wandered around the main cities of the United Kingdom without anyone having warned the citizens of their presence.
 In my paper I will try to investigate, through Deller's work (and through the comparison with other artistic experiences), how some contemporary artistic interventions try to exploit the mechanisms of performance in order to reconstruct historical events not only relying on the strategies of re-enactment, but also resorting to an immersive and unexpected relationship able to produce an extreme involvement. We Are Here Because We Are Here thus contributes to the reconstruction of memory not through the description of historical facts, nor even through their celebration, but through a process that solicits the emotional states to which, in the harshest moments of the war, the community is subjected.

From Abiyala to Turtle Island

This hybrid article offers a glimpse into a plurality of Indigenous worldviews in the context of the contemporary art exhibition Arctic/ Amazon that took place at the Power Plant in Toronto, Canada in 2022. The article highlights the important connections between knowledge and culture in artworks by artists who translate practice, materiality, and knowledgeways into contemporary interventions.

Pulmonary hypertension secondary to valvular heart disease: a state-of-the-art review.

Pulmonary hypertension (PH) is a common disease affecting up to 1% of the population and at least 50% of patients diagnosed with heart failure (HF) (Hoeper et al. in Lancet Respir Med 4(4):306-322, 2016). It is estimated that PH is present in 15% to 60% of patients with valvular heart disease (VHD) which can result from an increase in pulmonary blood flow and subsequently in pulmonary venous congestion and pulmonary vascular resistance (PVR). It is important to identify the severity of PH in patients with VHD to appropriately risk stratify and manage these patients (Magne et al. in JACC Cardiovasc Imaging 8(1):83-99, 2015). In this review, we examine the diagnostic criteria for PH and its pathophysiology. We also focus on the growing evidence supporting the presence of PH secondary to VHD and describe the contemporary surgical and medical therapeutic interventions in this patient population (Fig.1).

Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions.

Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck, and lung cancer. Cisplatin is also used to treat tumors in children, such as neuroblastoma, osteosarcoma, and hepatoblastoma. However, its clinical use is limited by severe side effects, including ototoxicity, nephrotoxicity, neurotoxicity, hepatotoxicity, gastrointestinal toxicity, and retinal toxicity. Cisplatin-induced ototoxicity manifests as irreversible, bilateral, high-frequency sensorineural hearing loss in 40-60% of adults and in up to 60% of children. Hearing loss can lead to social isolation, depression, and cognitive decline in adults, and speech and language developmental delays in children. Cisplatin causes hair cell death by forming DNA adducts, mitochondrial dysfunction, oxidative stress, and inflammation, culminating in programmed cell death by apoptosis, necroptosis, pyroptosis, or ferroptosis. Contemporary medical interventions for cisplatin ototoxicity are limited to prosthetic devices, such as hearing aids, but these have significant limitations because the cochlea remains damaged. Recently, the U.S. Food and Drug Administration (FDA) approved the first therapy, sodium thiosulfate, to prevent cisplatin-induced hearing loss in pediatric patients with localized, non-metastatic solid tumors. Other pharmacological treatments for cisplatin ototoxicity are in various stages of preclinical and clinical development. This narrative review aims to highlight the molecular mechanisms involved in cisplatin-induced ototoxicity, focusing on cochlear inflammation, and shed light on potential antioxidant and anti-inflammatory therapeutic interventions to prevent or mitigate the ototoxic effects of cisplatin. We conducted a comprehensive literature search (Google Scholar, PubMed) focusing on publications in the last five years.

Contemporary Transformations of the Historic Urban Landscape of Sarajevo and Social Inclusion as a Traditional Value of a Multicultural Society

The main research question of this paper focuses on the impact of contemporary interventions on the protection of architectural heritage and the transformation of the unique historic urban landscape of Sarajevo, which symbolizes social tolerance. This study examines the tendencies that have been destroying the essence of such a landscape since the beginning of the 21st century. This research primarily relies on the method of direct observation to analyze the ongoing transformation of the urban landscape over the past 25 years. Additionally, previous research findings and relevant documentation regarding the ongoing urban metamorphosis were considered. The historical urban landscape of Sarajevo is the result of complex urban development that began in the mid-15th century. This urban form, still partially recognizable today, reflected prevailing social relationships, particularly the inclusion of different groups instead of their exclusion, which demonstrated tolerance. However, this research shows the incompatibility of today’s neoliberal concept with the preservation of an urban landscape that embodies tolerance and excludes social marginalization.

Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis.

Cytomegalovirus (CMV) infection is a significant health concern affecting numerous expectant mothers across the globe. CMV is the leading cause of health problems and developmental delays among infected infants. Notably, this study examines CMV infection in pregnancy, its management, prevention mechanisms, and treatment options. Specifically, information from the Cochrane Library, PUBMED, Wiley Online, Science Direct, and Taylor Francis databases were reviewed along with additional records identified through the register, the Google Scholar search engine. Based on the search, 21 articles were identified for systematic review. A total of six randomized controlled trials (RCTs) were utilized for a meta-analytic review. As heterogeneity was substantial, the random effects model was used for meta-analysis. Utilizing the random-effects model, the restricted maximum likelihood (REML) approach, the estimate of effect size (d = -0.479, 95% CI = -0.977 to 0.019, p = 0.060) suggests the results are not statistically significant, so it cannot be inferred that the prevention methods used were effective, despite an inverse relationship between treatment and number of infected cases. The findings indicated that several techniques are used to prevent, diagnose, and manage CMV infection during pregnancy, including proper hygiene, ultrasound examination (US), magnetic resonance imaging (MRI), amniocentesis, viremia, hyperimmunoglobulin (HIG), and valacyclovir (VACV). The current review has significant implications for addressing CMV infection in pregnancy. Specifically, it provides valuable findings on contemporary management interventions to prevent and treat CMV infection among expectant mothers. Therefore, it allows relevant stakeholders to address these critical health concerns and understand the effectiveness of the proposed prevention and treatment options.