Negative bias temperature instability (NBTI) in a dual-gate-oxide complementary metal–oxide–semiconductor (CMOS) process induces threshold voltage (Vt) shift and has become a crucial challenge in designing advanced analog or mixed-signal circuits. In this paper, the impact of the stress from a contact etch stop layer (CESL) on the NBTI of dual-gate-oxide input/output (I/O) p-type MOS field effect transistors (P-MOSFETs) is investigated in detail. Experimental results show that applying tensile stress can suppress NBTI-induced Vt shift more significantly than applying compressive stress, thus becoming a simple and effective method of relieving NBTI.