Contact Dermatitis Research Articles

Relationship between Personal Protective Equipment (PPE) Use Behavior and Working Period with Allergic Contact Dermatitis (ACD) Symptoms in Workers at Mabar Shrimp Factory

Background. Allergic contact dermatitis (ACD) is one of the most common occupational skin diseases after irritant contact dermatitis (ICD). One of the factors causing ACD is not using personal protective equipment (PPE) and a long working period. This study aimed to analyze the relationship between PPE use behavior and working period with ACD symptoms in workers at the Mabar shrimp factory, Medan. Method. Cross-sectional research with a consecutive sampling method. Assessment of PPE use behavior and working period used a questionnaire and ACD symptoms by a doctor. The analysis used was univariate and bivariate analysis with chi-square. Results. The total number of samples that met the inclusion and exclusion criteria of the study was 100 people, 28 people had symptoms of ACD, enough knowledge, good attitudes, and unfavorable actions with a working period of >2 years. Statistical analysis showed a relationship between PPE use behavior and working period with ACD symptoms. Conclusion. All behavioral factors (knowledge, attitude, and action) and working period have a significant relationship with ACD symptoms

Effect of Skin Barrier on Atopic Dermatitis.

The skin acts as the body's primary physical and immune barrier, maintaining the skin microbiome and providing a physical, chemical, and immune barrier. A disrupted skin barrier plays a critical role in the onset and advancement of inflammatory skin conditions such as atopic dermatitis (AD) and contact dermatitis. This narrative review outlines the relationship between AD and skin barrier function in preparation for the search for possible markers for the treatment of AD.

Health Profile of Workers at Gas Station X Maulafa District Kupang City

Gas stations are areas that operate in the petroleum sector where repeated exposure to the products produced (butane, pentane, isopentane, benzene, alkylbenzene, toluene, and xylene) can have an impact in the form of health problems. The individuals with the greatest exposure to gas station products are the workers. According to data, during the period from 2016 to 2018 there were 120 cases of work accidents around gas stations. The use of Personal Protective Equipment (PPE) and training regarding the prevention for the worker and management of accidents and illnesses resulting from working at gas stations are important in ensuring worker safety. According to research that has been conducted, it was found that the use of Personal Protective Equipment (PPE) is still very low among Gas Station X workers, Maulafa District, Kupang City. Training and equipment that support Occupational Safety and Health programs are also not available to the majority of workers. This is the cause of health problems among Gas Station X workers, Maulafa District, Kupang City. Method: This research is a quantitative study with a cross sectional approach and involved 12 respondents. This study data collection techniques by interview dan physical examination directly to the samples at Gas Station X Maulafa District, Kupang City. Result: Based on the research results, it was found that the majority of Gas Station The health problems found were Peripheral Vertigo (16%), Tension Type Headache (TTH) (8%), Allergic Rhinitis (8%) and Irritant Contact Dermatitis (8%). Conclusion: An occupational risk factor that can affect the occupational safety and health of employees at GAS STATION X is exposure to fuel oil which contains volatile substances. It was found that 4 out of 12 workers at the gas station in Maulafa District, Kupang City experienced health problems, the health problems they experienced were Peripheral Vertigo, Tension Type Headache, Allergic Rhinitis and Irritant ...........

Dyshidrotic eczema: clinical and epidemiological features and therapy tactics

Introduction. Dyshidrotic eczema is a clinical type of chronic eczema, the clinical picture of which is characterized by itchy vesicular or bullous rashes localized on the skin of the palms and/or soles, a tendency to long-term chronic and recurrent course, the development of complications and resistance to therapy. Despite its prevalence and impact on quality of life, treatment of dyshidrotic eczema may be ineffective due to its polyetiology, chronic and recurrent course, and the lack of well-organized randomized controlled studies on the pathogenetic therapy of dyshidrotic eczema.Aim. Conduct an analysis of available sources devoted to the study of dyshidrotic eczema. Provide a description of clinical cases of dyshidrotic eczema and experience with external therapy.Results. The proportion of dyshidrotic eczema among other types of eczema varies from 6 to 31.8%. More than 80% of patients note a negative impact of dyshidrotic eczema on the quality of life. Conducted studies demonstrate a variety of factors predisposing to the onset, among which genetic predisposition, atopy and contact allergy are the main ones. Possible triggers include medications, insolation, humidity, and mycotic sensitization. Dyshidrotic eczema is a long-term and recurrent process with a risk of developing infectious complications. Staphylococcus aureus, Corynebacterium, Streptococcus and Micrococcus are detected in dyshidrotic eczema foci, which must be taken into account in combination therapy. The article presents clinical examples of successful treatment of dyshidrotic eczema localized on the skin of the hands with an external preparation containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole.Conclusions. Dyshidrotic eczema is a common condition and affects quality of life. Proper diagnosis is essential for effective and efficient treatment. External therapy with the inclusion of a cream (ointment) containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole gives better results and increases satisfaction with the treatment of patients with dyshidrotic eczema.

Deriving a point of departure for assessing the skin sensitization risk of wearable device constituents with in vitro methods

Wearable devices are in contact with the skin for extended periods. As such, the device constituents should be evaluated for their skin sensitization potential, and a Point of Departure (PoD) should be derived to conduct a proper risk assessment. Without historical in vivo data, the PoD must be derived with New Approach Methods (NAMs). To accomplish this, regression models trained on LLNA data that use data inputs from OECD-validated in vitro tests were used to derive a predicted EC3 value, the LLNA value used to classify skin sensitization potency, for three adhesive monomers (Isobornyl acrylate (IBOA), N, N- Dimethylacrylamide (NNDMA), and Acryloylmorpholine (ACMO) and one dye (Solvent Orange 60 (SO60)). These chemicals can be used as constituents of wearable devices and have been associated with causing allergic contact dermatitis (ACD). Using kinetic DPRA and KeratinoSens™ data, the PoDs obtained with the regression model were 180, 215, 1535, and 8325 μg/cm2 for IBOA, SO60, ACMO, and NNDMA, respectively. The PoDs derived with the regression model using NAMs data will enable a proper skin sensitization risk assessment without using animals.

Contact allergy to the toothpastes ingredients: systematic literature review

A review of modern Russian and foreign, mainly English, literature on the topic of contact allergy to toothpaste ingredients is carried out. During the systematic review, literature data on the composition of toothpastes are analyzed, the most common allergens are identified, and the clinical picture of contact allergy to toothpaste ingredients is described. It is shown that the most common allergens in toothpastes are fragrances. In addition, potential allergens are cocamidopropyl betaine, propylene glycol, essential oils, parabens and propolis.

The role of the environment in allergic skin disease.

This paper explores how environmental factors influence allergic skin diseases, including atopic dermatitis (AD), contact dermatitis (CD), urticaria, angioedema, and reactions to drugs and insect bites. Research indicates a significant impact of environmental elements on allergic skin diseases. High air pollution levels exacerbate symptoms, while climate change contributes to increased skin barrier dysfunction, particularly affecting AD. Allergen prevalence is influenced by climate and pollution. Irritants, like those in detergents and cosmetics, play a major role in CD. Plants also contribute, causing various skin reactions. Understanding the interplay between environmental factors and allergic skin diseases is crucial for effective management. Physicians must address these factors to support patient well-being and promote skin health amidst environmental changes.

Contact Dermatitis Due to Hair Care Products: A Comprehensive Review

Hair cosmetics are in fashion. Numerous products are commonly used in combination. Frequent allergens are present in hair cosmetics, which, with almost daily use, increase the risk of sensitization. Familiarity with the clinical distribution of the eczematous rash is necessary to seriously consider patch testing. Not all the products on the market are haptens. It is necessary to know how to patch your own products. When avoidance of the allergen is not possible, new treatments are evaluated to combat allergic contact dermatitis, mainly of the occupational type. In this manuscript, a complete and practical review of the main allergens and contact sources of hair cosmetic origin has been carried out.

Étude rétrospective (2007–2022) des causes de dermatites allergiques de contact en Algérie identifiées par la batterie standard européenne : à propos de 202 cas

The European Baseline Series (EBS) of patch tests is the essential tool for allergological exploration of patients suspected of allergic contact dermatitis. The main objective of our study was to define the epidemiological, clinical characteristics, and sensitization profile to contact allergens of the EBS among all patients who underwent contact allergological exploration in an allergology clinic in Algeria over a 15-year period (from 2007 to 2022). Our aim was to generate a map of allergic contact dermatitis in Eastern Algeria to support prevention efforts on a national scale. MethodsOur study was a retrospective descriptive monocentric study conducted in an allergology and contact allergen exploration medical office in Constantine, Algeria. It included all EBS performed between March 2007 and February 2022 on patients who were either first-time visitors or referred for patch testing. ResultsA total of 202 patients suspected of contact dermatitis were tested, with ages ranging from 3 to 75 years. Among them, 125 were female (61.9%) and 77 were male (38.1%). Of these, 138 patients (68.8%) (45 males, 93 females) tested positive for one or more allergens. Fifty-eight patients (42%) had a positive reaction to more than two contact allergens. The most common positive reactions were observed with nickel (30.2%), cobalt (28.2%), potassium dichromate (27.2%), myroxylon pereirae (9.9%), and fragrance mix I (8.4%). Sensitivity to nickel was more frequent among females (P < 0.0001), while sensitivity to potassium dichromate was more frequent among males (P = 0.01). ConclusionsThe distribution of different causes of contact allergy identified through EBS was similar to what is observed in Europe. It allowed us to define, based on the sensitization profile of the patients included in our study, the most frequent causes of allergic contact dermatitis within our population. However, the emergence of new contact allergens can only be identified if Algeria establishes an allergo-vigilance network, similar to that in Europe, enabling both the evolution of patch test compositions and the detection of new allergic risks within the population.

ALLERGIC CONTACT DERMATITIS AND ATOPIC DERMATITIS: HIGHLIGHTS OF THE OVERLAP SYNDROME

Introduction. The combination of atopic dermatitis (AD) with allergic contact dermatitis (ACD) or the occurrence of ACD on the background of atopic dermatitis is called the overlap syndrome. Studies have demonstrated several reasons why patients with AD have a similar or even increased risk of developing ACD compared to those without AD. Allergens and haptens are trigger factors in a group of patients with AD and ACD overlap syndrome. The aim of the study. To confirm the diagnosis of ACD in a group of patients with AD – diagnose the overlap syndrome and analyze which allergens and haptens were the trigger factors in this group. Materials and methods. To confirm IgE-dependent sensitization in atopic dermatitis, skin prick tests or determination of specific IgE in blood serum were performed. Skin patch tests (European series S-1000) were performed to determine the mechanisms of delayed-type hypersensitivity. Results. It was found that the highest specific weight of positive allergic reactions has been recorded in response to the following allergens: ticks, ticks/ambrosia, birch and mold. The absolute majority of patients demonstrated positive specific IgE-dependent sensitization to Dermatophagoides pteronyssinus and Dermatophagoides farinae – 24 (50%), in turn, on Ambrósia – 14 (29.2%), and on Alternaria alternata – 8 (16.7%). Also, the reaction was most often recorded to haptens: cobalt, nickel, formaldehyde, PPD, textile dyes. Deterioration of the clinical course and shortening of AD remission periods were observed due to the formation of ACD against the background of impaired skin barrier function and the presence of chronic immune inflammation. Conclusions. Patients with AD are more often diagnosed with ACD, which predictably worsens the course of AD. Patients with confirmed overlap syndrome "AD + ACD" most often show reactions to haptens: Cobalt, Nikel, Formaldehyde, PPD, Textile dye mix – and in the vast majority to 2 haptens or more in one patient.

Differential diagnosis of contact dermatitis: A practical-approach review by the EADV Task Force on contact dermatitis.

The diagnosis of eczema ('dermatitis') is mostly clinical and depends on the clinical history and exploratory objective findings (primary lesions, patterns). Contact dermatitis remains as an important condition in the group of eczematous disorders, with important socioeconomic and occupational relevance. Although irritant and allergic contact dermatitis have a different pathogenesis, both are characterized by a rather typical morphology, are triggered by external factors and tend to occur primarily in the area of contact with the exogenous agent. In addition, allergic and irritant dermatitis may also co-exist. The importance of diagnosing contact dermatitis, especially when allergic in nature, is both due to the possibility of avoiding the trigger, and due to its role in aggravating other skin conditions. Nevertheless, the heterogeneity of clinical presentations in daily practice may pose an important challenge for the suspicion and correct diagnosis of contact dermatitis. Furthermore, other conditions, with different pathogenesis and treatment, may clinically simulate contact dermatitis. The Task Force aims to conduct a review of the unifying clinical features of contact dermatitis and characterize its main clinical phenotypes, and its simulators, in order to contribute to an early suspicion or recognition of contact dermatitis and enable a correct differential diagnosis.

Suture-Induced Allergic Contact Dermatitis to Polypropylene.

Suture-Induced Allergic Contact Dermatitis to Polypropylene.

Peculiar Pattern of Irritant Contact Dermatitis to Semecarpus anacardium

Abstract Semecarpus anacardium (Family: Anacardiaceae), is a frequently used medicinal plant in alternative medicine. There has been few case reports suggesting the role of marking nut extract in allergic contact dermatitis. Case one presented with vesicles coalescing to form bullae with surrounding necrotic epidermis accompanied by itching and burning sensation over nape of neck. He developed recurrent urticarial episodes post treatment. Case two reported similar lesions over beard region after 2 weeks of our index case in addition to diffuse erythematous maculopapular pruritic rash over upper chest, face and anterior shoulder. Case three, four and five reported with similar kind of lesions over various body parts. Case six presented with targetoid lesion with central bullae over upper torso. Case seven reported with bizarre lesions like splattering of chemical which were morphologically similar as the other cases, over left popliteal fossa and calf area. Our cases were from the same geographic area and were in the same profession. On evaluation of the pattern and morphology of lesions and careful investigation, it was concluded that it was an irritant reaction to Semicarpus nut extract which was supported by histopathology findings. On further probing, it was observed that the individuals inflicted the injury in order to avoid some strenuous work. All were evaluated and none of them were found to be suffering from any psychiatric ailment. We reported this case series because of unique morphological presentation which has not yet been reported in the literature to the best of our knowledge.

Beyond Avoidance: Advanced Therapies for Contact Dermatitis

Contact dermatitis (CD) is a common and burdensome condition divided into irritant contact dermatitis and allergic contact dermatitis. Treatment relies on accurate diagnosis and identification of the trigger, because definitive treatment is irritant or allergen avoidance. However, avoidance is not always possible, such as when the patient is reacting to a necessary medical device, when the trigger is integral to the patient's occupation, and when avoidance is practically untenable. In these cases, treatment is particularly challenging, especially because the literature on treatments in this clinical scenario is limited. In addition, CD has a complex pathophysiology that varies according to the trigger type, leading to variable treatment efficacy. This article reviews the current literature on treatments for CD with a focus on treatments when trigger avoidance is not feasible.

Metal implant allergy: A retrospective cohort analysis at a university allergy practice.

Background: Concern of metal sensitization in pre- and postsurgical evaluation is growing, with the recent guidelines remaining the criterion standard for consideration of patch testing. Information remains scarce on surgical screening in the groups of patients who reported a history of metal sensitivity versus those with no reported history. Objective: The objective of this study was to assess the utility of patch testing in surgical candidates based on reported metal allergy history. The secondary objective was to evaluate the utility and outcomes in postsurgical patch testing. Methods: Nine hundred and thirty-one patient charts of patients with the diagnosis of "contact dermatitis" who underwent an evaluation at a single allergy clinic site between January 2013 and December 2022 were identified and reviewed as part of a retrospective chart review study. Patients were included in subgroups based on the time of patch testing and history of reported metal allergy. Results: In all, 67 patients underwent patch testing, 10 (14.9%) of whom were surgical candidates without a history of metal sensitivity, 31 (46.2%) of whom were surgical candidates with a history of metal sensitivity, and 26 (38.8%) of whom were postsurgical patients. Twenty-nine (43.3%) of patients had positive patch testing results, with only one (10%) in the presurgical group, 17 (54.8%) in the presurgical with a history of metal sensitivity, and 11 (42.3%) in the postsurgical group. Zero patients in our cohort without metal sensitivity who were undergoing the Nuss procedure had positive reactions on patch testing, whereas two of four (50%) with reported metal sensitivity who were undergoing the Nuss procedure had positive relevant metal reactions. Conclusion: Ambiguity in the utility of patch testing for surgical decision making remains, despite common utilization. Recent guidelines along with coordination of care among the surgeon, allergist, and patient remains the criterion standard of care.

Is the varying management of incontinence-associated dermatitis due to a lack of understanding of etiology?

Incontinence-associated dermatitis, previously and sometimes still referred to as moisture lesions or moisture damage, is a commonly seen contact dermatitis that is a reactive response of the skin to chronic contact to urine and faecal matter. Understanding the etiology is fundamental to creating a skin care plan and successfully prevention. Systemic reviews and studies have shown that the continued variability in management results from a combination of knowledge base, observation, diagnosis, and product selection. This article aims to improve clinicians' understanding of incontinence-associated dermatitis and its management.

Managing Contact Dermatitis Without Patch Testing

Allergic contact dermatitis (ACD) is a common skin condition caused by contact with an exogenous agent that elicits an inflammatory response. Patch testing (PT) is considered the gold standard for diagnosing ACD. Unfortunately, PT may not be available to some patients due to insurance and financial limitations, contributing to health care disparity and leaving patients with undiagnosed, incompletely managed dermatitis that can have further detrimental health and occupational effects. For other patients, PT is precluded by lack of availability of specialist/expert care, comorbid medications, or diffuse disease. This article will present a patient with ACD and will work through the differential diagnosis and share strategies for empiric avoidance of suspected/common triggers. The epidemiology of ACD with respect to race and ethnicity, considerations for affordability of hypoallergenic products, access to testing, and the need for future research are addressed in this article.

Triggered Skin Sensitivity: Understanding Contact Dermatitis.

Dermatitis, the incendiary reaction of the skin to various components, can manifest invarioustypes, including atopic dermatitis, contact dermatitis, nummular eczema, seborrhoea, and stasis dermatitis. Atopic dermatitis is the most common skin disease in children and has a growing prevalence in recent years.It is characterized by extreme tingling, eczemous skin injuries, dryness of the skin, and a family history of atopic illnesses.Contact dermatitis (CD) is a common, irritating skin disorder caused by allergens and aggravating elements in the environment. It is the most common cause of work-related dermatitis and plays a substantial role in hand and face dermatitis. A completerestorativehistory is essential for establishing CD and identifying the allergies that cause it. Fix testing, skin tests for fast contact reactions, serum allergen-specific IgE testing, subjective and quantitative evaluation of allergens inside probable items patientswere exposedto, and challenge testing are among the other diagnostic techniques. To avoid a breakdown and the continuation of the skin illness, early and suitable therapy is critical. Allergic dermatitis to contact (ACD) develops during thenormal, delayed incendiary reaction and has a perplexing etiology. Accurate identification of the allergenthat iscausing the reaction allows for adequate individual avoidance. Themajortreatment alternatives continue to be corticosteroids. Nickel-contact dermatitis is an allergic reaction that affects both children and adults. Adverse contact dermatitis (ACD) is a frequent skin reaction to a common allergen that can affectbothchildren and adults. Less than 10% of all diagnostic procedures in pediatric patients involve checking for ACD symptoms.To answer the clinical question,a thorough history is gathered based on appearance, age group, and dermatitis type.According to pediatricians in the US, metals, perfumes, topical antimicrobials, excessive chemicals, and fabric softeners are the most typical allergens.

Recognizing and Managing Allergic Contact Dermatitis: Focus on Major Allergens

Patch testing is the gold standard for the diagnosis of allergic contact dermatitis. The identification and avoidance of culprit allergen/s is essential in the treatment of this disease. Each year, new allergens are identified as emerging or important. The authors discuss allergens that are common, enduring, emergent, incompletely recognized and controversial for the practicing allergist and dermatologist. This Clinical Management Review will encompass a review of fragrances, preservatives, rubber, acrylates, metals, and medications, their common sources of exposure, controversies in diagnosis and patch testing, management and how to avoid those allergens. This review will also include practical aspects of diagnosis and management and will provide resources that can be used as guidance for physicians and patients on nickel, MCI/MI, fragrance, the most common allergens positive on patch testing.

Parthenium Induced Pigmented Contact Dermatitis.

Parthenium Induced Pigmented Contact Dermatitis.