Consumption Of Beans Research Articles

Impact of COVID-19 Vaccination Status and Confidence on Dietary Practices among Chinese Residents.

Healthy diets promote immune functions and have been shown to reduce COVID-19 severity. In 2021, COVID-19 vaccines have become available to the general public. However, whether vaccination status could affect individual and populational health behaviors is unknown. This study aimed to investigate the impacts of vaccination status and confidence on dietary practices. An online survey was conducted in August 2021. We collected data on dietary intake, diversity and behaviors, vaccination status and confidence and socio-demographic characteristics. Among the 5107 responses received, a total of 4873 study participants were included in the final analysis. Most of our participants aged between 18 and 45 years and 82% of them were fully vaccinated against COVID-19. Household level dietary diversity was found to be higher among people who were fully vaccinated (β = 0.321, 95%CI: 0.024 to 0.618) or who were more confident in the protectiveness of the vaccine (β for tertile 3 comparing with lowest tertile = 0.544, 95%CI: 0.407, 0.682). Vaccination promoted the intake of seafood, but it was also positively associated with the consumption of sugar, preserved, fried and barbequed foods and reduced vegetable intake. Higher vaccination confidence was associated with increased consumption of seafood, bean, fruits and vegetables and reduced fat intake. Changes in dietary behaviors compared with early 2021 (when vaccination was not common) were observed and differed by vaccination status and confidence level. Conclusion: COVID-19 vaccination status and confidence had varied, and possibly negative, impacts on dietary intake and behaviors. Our results suggest that vaccination status and confidence might be significant influencing factors affecting people’s health behaviors and highlight that healthy eating should be consistently promoted to prevent poor dietary practices during global health crisis.

Factors Affecting Production and Consumption of African Yam Bean (SphenostylisstenocarpaHochst. Ex. A. Rich) Harms) in South-East Agro-ecological Zone of Nigeria

The study assessed factors affecting production and consumption of African yam bean, identified the socio-economic characteristics of the respondents, assessed factor affecting their production, and consumption of AYB and then identified factors affecting the adoption of African Yam Bean technologies in Imo and Enugu states. All the objectives were achieved using simple descriptive statistics such as percentages, frequencies and means. Mean score were determined using likert point scale measurement. The result revealed that African Yam Bean is cultivated majorly by women and middle aged farmers who are still within their productive age with high level of farming experience in the studied locations. Meanwhile, only a few of the farmers belonged to a cooperative societies of farmers organizations in Imo state while majority of the farmers belonged to farmers organization in Enugu state. Below revealed the factors affecting production of African Yam Bean to include high yielding ( = 4.7); early maturing (=4.2); resistant to disease (= 4.1); soil selection (=4.0); drought tolerant (=4.2); ability to maintain its colour over time (=4.0); high nutritious value (=5.0); accessibility (=3.8); affordability (=4.7); complexity (=3.6); and compatibility (=3.8). Also, factors influencing African Yam Bean technology in the studied area which include high nutrient content (=5.0); simple to process (=3.6); palatability (=4.6); less expensive (=4.5); high markatebility (=3.9); high economic value (=4.6); durability (=4.5); health benefits (=4.7); and it is demand driven (=4.3). Keywords : African Yam Bean, Effect, Production, Consumption DOI: 10.7176/JNSR/13-10-06 Publication date: May 31 st 2022

Influence of an Educational Intervention on Eating Habits in School-Aged Children.

A health promotion intervention directed at preventing unhealthy habits in relation to physical exercise, hygiene habits, diet and personal relationships can lead to a decrease in diseases during adulthood and obtaining a better quality of life. The intervention had a participative and multidisciplinary nature, and it was developed by health professionals, teachers and parents for school children. It promoted healthy lifestyle habits around food by working on four areas through video lessons, interactive talks, practical and theoretical–practical classes and an individual project on behalf of the student where they had to design healthy menus. We randomly selected, by stratified multistage sampling, three public primary education schools. A sample of 479 students registered during the 2014/2015 academic year aged between 6–12 years were included in the study. After the educational intervention, we found a significant reduction in the BMI of the students (p < 0.001). For breakfast, the overweight or obese children modified their usual food consumption after the intervention for a healthier breakfast based on fruit juice and bread instead of sugary snacks (p < 0.001). Regarding eating habits during the mid-morning break, there was a decrease in the consumption of sugary snacks (p < 0.001) and an increase in the consumption of fruits and sandwiches. We found that, after the intervention, the excessive consumption of pasta for the main meal reduced in favor of an increase in the consumption of proteins and different beans and pulses (p > 0.001). Educational interventions on healthy lifestyle habits carried out in children during their early years improve and correct unhealthy habits.

Relandscaping the Gut Microbiota with a Whole Food: Dose-Response Effects to Common Bean.

Underconsumption of dietary fiber and the milieu of chemicals with which it is associated is a health concern linked to the increasing global burden of chronic diseases. The benefits of fiber are partially attributed to modulation of the gut microbiota, whose composition and function depend on the amount and quality of microbiota-accessible substrates in the diet. However, not all types of fiber are equally accessible to the gut microbiota. Phaseolus vulgaris L., or common bean, is a food type rich in fiber as well as other prebiotics posing a great potential to positively impact diet-microbiota-host interactions. To elucidate the magnitude of bean’s effects on the gut microbiota, increasing doses of common bean were administered in macronutrient-matched diet formulations. The microbial communities in the ceca of female and male mice were evaluated via 16S rRNA gene sequencing. As the bean dose increased, the Bacillota:Bacteroidota ratio (formerly referred to as the Firmicutes:Bacteroidetes ratio) was reduced and α-diversity decreased, whereas the community composition was distinctly different between the diet groups according to β-diversity. These effects were more pronounced in female mice compared to male mice. Compositional analyses identified a dose-responsive bean-induced shift in microbial composition. With an increasing bean dose, Rikenellaceae, Bacteroides, and RF39, which are associated with health benefits, were enhanced. More taxa, however, were suppressed, among which were Allobaculum, Oscillospira, Dorea, and Ruminococcus, which are predominantly associated with chronic disease risk. Investigation of the origins of the dose dependent and biological sex differences in response to common bean consumption may provide insights into bean-gut microbiota-host interactions important to developing food-based precision approaches to chronic disease prevention and control.

Economic Assessment and Labour Utilization of Organic Kidney Beans and Black Gram

The present study examined the economics, production, and labour utilization of organic kidney beans and black gram crops. The study is based on 60 organic producers of kidney beans and black gram from the Chamba district of Himachal Pradesh. Three-stage random sampling was done to collect the data from the respondents. High utilization of human labour was noticed in the case of black gram (64 human days/ha) followed by kidney beans (61 human days/ha) on the overall farm category. The total cost of cultivation of organic kidney beans and black gram per hectare was worked out to be Rs. 39,494 and Rs. 34,676 per farm, respectively. The net income per hectare was Rs. 47,704 and Rs. 23,308 respectively. Organic farming is generally profi table in both pulse crops due to premium prices. The regression analysis has revealed that the coeffi cient of multiple determinations (R2) was 0.53 for organic Kidney beans and 0.55 for black gram were explained by the independent variables. Market surplus of organic kidney beans was 37.57 per cent and 45.11 per cent in black gram, while family consumption of kidney beans and black was 50.89 and 41.64 per cent on overall farms, respectively.

Socioeconomic inequalities in the consumption of minimally processed and ultra-processed foods in Brazilian adolescents.

In this study, we evaluated socioeconomic inequalities in the consumption of in natura/minimally processed and ultra-processed foods among adolescents. We used data from the Brazilian National Survey of School Health (PeNSE), 2015. According to the self-reported consumption of beans, vegetables and fruits, a score of in natura/minimally processed foods was generated (0-21 points). Sodas, sweets, instant noodles, and ultra-processed meat were used for the score of ultra-processed foods (0-21 points). Equality indicators were gender, maternal education, and socioeconomic level. Absolute difference, ratios, concentration index and slope index of inequality were calculated. Adolescents (n=101,689, 51% girls, 14.2 years) reported a mean score of 9.97 and 11.46 for ultra-processed foods and in natura/minimally processed foods, respectively. Absolute and relative differences between adolescents with the highest and lowest socioeconomic level, there were differences of 2.64 points and 33% for consumption of in natura/minimally processed foods; and 1.48 points and 15% for ultra-processed foods. Adolescents from higher socioeconomic level ate more in natura/minimally processed foods and ultra-processed foods.

Nutritional and Physiological Effects of Consuming Legume Seed Powders (Glycine Max, Phaseolus Lunatus, Vigna Unguiculata, Cajanus Cajan) in Combination with Kponan Yam Powder (Dioscorea Alata) in Young Rats (Rattus Norvegicus)

The aim of this study is to assess the effects of consumption of Lima beans, angole peas and cowpeas on nutritional and physiological characteristics in growing rats. To do this, twenty-four growing male rats in four batches of six were fed for 21 days, with four diets. For example, a control diet based on soy powder (SAI), a Lima bean powder diet (PLI), an Angole pea powder diet (PAI) and a commercially purchased cowpea powder (NEI) diet were put into experimentation. The protein level of these diets is set at 10 %. At the end of the experiment, the results reveal that rats fed Lima bean powder diets experienced a loss of body mass from the beginning to the end of the experiment, while those fed with the other three diets (SAI, PAI and NEI) caused growth in rats. This study shows that there is no significant difference (p&gt;0.05) between the values of triglycerides, HDL cholesterol and conjugated bilirubins of rats on the PLI, PAI and NEI diets compared to the control (SAI). Blood glucose levels in rats on the PAI and NEI diets are significantly higher (p≤0.05) than control rats (SAI). Similarly, the hemoglobin values of rats on PAI and NEI diets show no significant (p&gt;0.05) difference compard to those of controls. These results imply that soybeans, cowpeas and Angole Peas may contribute to the fight against children malnutrition unlike Lima beans.

Tooth loss severity and core and non-core food consumption among older Brazilian adults.

To investigate the association between tooth loss severity and core and non-core food consumption in the older Brazilian population. We analysed data from 20756 people aged 60years or older who participated in the 2019 Brazilian National Health Survey. The average consumption days a week of core (8-item) and non-core (4-item) foods were the outcomes, measured using a Food Frequency Questionnaire. Tooth loss severity was the main exposure, using a four-category ordinal variable: mild (1-12 teeth missing), moderate (13-22), severe (23-31) and edentulous (all 32). Sociodemographic, tobacco smoking, use of dental prosthesis, difficulty in chewing and systemic conditions were among the covariates. Linear regression models estimated the association between tooth loss and food consumption. Almost two-thirds of participants had moderate or worse levels of tooth loss. Older adults with more severe tooth loss reported an overall lower consumption of core and higher non-core foods than those with mild tooth loss. Worse tooth loss severity was associated with lower consumption of vegetables and/or legumes and fruits, and higher consumption of beans, artificial fruit juices and confectionery. Older Brazilian adults with more severe tooth loss are consuming lower core and higher non-core foods. Our findings reinforce the importance of the common risk factor approach to tackle the adverse effects of tooth loss on diet.

Pinto Beans and Green Beans Result in Comparable Glycemic Control in Adults with Type 2 Diabetes: A Randomized Pilot Trial

Aims: Glucose control is essential to slow disease progression in people with type 2 diabetes mellitus (T2DM). The acute effects of dry bean consumption on glucose control are well established, but their long-term effects in daily diets are less known. Methods: The effect of daily consumption of ½ cup pinto beans, compared to ½ cup green beans, on fasting glucose, postprandial glucose and hemoglobin A1c (HbA1c) in adults with T2DM was examined. After a 2-week wash-in period, 13 participants were randomized to two 12-week long treatments: pinto beans and green beans. Before and after each intervention period, a fasted venous blood sample for glucose and HbA1c analyses was drawn. On 28 non-consecutive days, including the washin, participants kept diet records and measured capillary glucose using a glucometer 1 hour after the meal during which the treatments were consumed. Results: Eight participants completed both treatment periods. There were no statistically significant changes (p&lt;0.05) in fasting glucose, HbA1c or average postprandial glucose values between the two interventions. Conclusions: Pinto beans and green beans result in comparable glycemic control when incorporated into the normal diet of adults with T2DM even though pinto beans have more available carbohydrate per serving.

Changes in intestinal parameters and their association with dietary patterns in rotational shift workers

ABSTRACT Circadian rhythm disturbances induced by rotating shift work contribute to development of metabolic disorders. However, their effects on intestinal parameters such as epithelial permeability and fecal short chain fatty acid (SCFA) levels have not been established yet. This study was planned to investigate the changes in intestinal integrity, fecal SCFA levels, gut microbiota and nutritional intake of rotational shift workers. The study was conducted on ten male rotational shift workers, 25–40 years old. Circadian rhythm disruption was assumed to have occurred after 14 days in the night shift. Dietary data which was obtained by using 24 h record for 7 days, physical activity data, anthropometric measurements, fecal and blood samples were collected during day and night shift. Changes in dietary consumption, anthropometric measurements, blood chemistry and intestinal epithelial permeability indicator according to day and night shifts were not significant (p > .05). Additionally, acetic, propionic and total SCFA were associated with the intestinal permeability biomarker in night shift, but not in day shift (p < .05). Consumption of dark green vegetables and beans and peas was positively associated with fecal isobutyric acid and fecal total SCFA concentration (r = 0.685, p = .029; r = 0.695, p = .026, respectively). The proportions of the genus including Blautia, Bifidobacterium, Dialister, and Ruminococcus gnavus group increased when individuals shifted to the night shift. Gut microbiota changes responding to circadian rhythm disruption became more prominent when consumed high sugar diet. So, changes have been observed in the gut microbiota of rotational shift workers, especially in individuals with certain dietary pattern. Moreover, in individuals with the circadian rhythm disruption SCFAs levels have been demonstrated to be associated with intestinal barrier integrity. A better understanding of the relation among fecal SCFAs, gut microbiota, intestinal epithelial permeability and circadian rhythm disruption is necessary for the development of new dietary strategies for gut health.

Persistent Organic Pollutants in Human Milk: Exposure Levels and Determinants among Lactating Mothers in Lebanon

Exposure of newborns to persistent organic pollutants (POPs) is a public health concern. The objective of this study was to assess the prevalence of POPs in human milk collected from lactating mothers in Lebanon and to investigate the sociodemographic, nutritional, and other lifestyle determinants. Fifty-four breast milk samples were collected as per World Health Organization guidelines. A survey was used to assess the anthropometric and demographic characteristics of participants. Dietary habits were evaluated based on a semiquantitative food frequency questionnaire. Organochlorine pesticides and polychlorinated biphenyls were measured in milk samples with liquid-liquid extraction and gas chromatography. Among the screened POPs, dichlorodiphenyldichloroethylene (DDE) was the only POP detected in breast milk samples and was found in only 17.9% of the samples, with a mean (SD) of 11.6 (5.0) μg/L and a range of 5.7 to 21.4 μg/L. Prepregnancy body mass index and age were positively associated with DDE contamination in breast milk. Women who consumed cereals at least two times per week had detectable DDE contamination in their breast milk. Consumption of potatoes and beans at least once per week was also associated with DDE contamination. Our study is the first to assess the presence of POPs in breast milk in Lebanon. The benefits of breastfeeding compensate for the low prevalence of DDE in the breast milk. Our findings highlight the high need to implement monitoring policies, good agricultural practices, and education programs for breastfeeding mothers.

Effects of Whole Brown Bean and Its Isolated Fiber Fraction on Plasma Lipid Profile, Atherosclerosis, Gut Microbiota, and Microbiota-Dependent Metabolites in Apoe-/- Mice.

The health benefits of bean consumption are widely recognized and are largely attributed to the dietary fiber content. This study investigated and compared the effects of whole brown beans and an isolated bean dietary fiber fraction on the plasma lipid profile, atherosclerotic plaque amount, gut microbiota, and microbiota-dependent metabolites (cecal short-chain fatty acids (SCFAs) and plasma methylamines) in Apoe−/− mice fed high fat diets for 10.5 weeks. The results showed that both whole bean and the isolated fiber fraction had a tendency to lower atherosclerotic plaque amount, but not plasma lipid concentration. The whole bean diet led to a significantly higher diversity of gut microbiota compared with the high fat diet. Both bean diets resulted in a lower Firmicutes/Bacteroidetes ratio, higher relative abundance of unclassified S24-7, Prevotella, Bifidobacterium, and unclassified Clostridiales, and lower abundance of Lactobacillus. Both bean diets resulted in higher formation of all cecal SCFAs (higher proportion of propionic acid and lower proportion of acetic acid) and higher plasma trimethylamine N-oxide concentrations compared with the high fat diet. Whole beans and the isolated fiber fraction exerted similar positive effects on atherosclerotic plaque amount, gut microbiota, and cecal SCFAs in Apoe−/− mice compared with the control diets.

Predicting height growth in bean plants using non-linear and polynomial models

Brazil has stood out worldwide as one of the main producers and consumers of beans, which makes their cultivation important for the economic and social development of the country. As the bean plant has a short growth cycle, its modeling is essential for optimizing management plans for this crop. This modeling can be performed by linear and non-linear models, but the latter have stood out for providing more information to the researcher, mainly due to the practical interpretation of their parameters. In this sense, in the R statistical software, the third-degree linear polynomial model and the Logistic and Gompertz non-linear models were adjusted to height data, in centimeters, in relation to time, in days after emergence, totaling 11 observations. As criteria to assess the quality of the fit, the adjusted coefficient of determination, the corrected Akaike information criterion and the residual standard deviation were used. The logistic model best fitted the data.

MIND Diet Adherence Might be Associated with a Reduced Odds of Multiple Sclerosis: Results from a Case-Control Study.

IntroductionThe Mediterranean Dietary Approaches to the Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet has been shown to have beneficial neuroprotective effects. The purpose of this research was to evaluate the link between the MIND diet adherence and multiple sclerosis (MS), a degenerative neurological illness.MethodsIn a hospital-based case–control setting, 77 patients with relapsing–remitting multiple sclerosis (RRMS) and 148 healthy individuals were recruited. A validated 168-item semi-quantitative food frequency questionnaire was used to assess participants’ dietary intakes and the MIND diet score. A logistic regression model was used to evaluate the association between MIND diet adherence and MS.ResultsThere was significant difference between RRMS and control groups in the median (Q1-Q3) of age (years, P value < 0.001), body mass index (BMI) (kg/m2, P value < 0.001), and total intake of calories (kcal, P value = 0.032), carbohydrates (g, P value = 0.003), animal-based protein (g, P value = 0.009), and fiber (g, P value = 0.001). Adherence to the MIND diet was associated with a reduced odds of MS [adjusted odds ratio (aOR) = 0.10, 95 percent confidence interval (95% CI) = 0.01–0.88, P for trend = 0.001]. MS odds was significantly lower in the last tertile of green leafy vegetables (aOR = 0.02, 95% CI = 0.00–0.21, P value < 0.001), other vegetables (aOR = 0.17, 95% CI = 0.04–0.73, P value = 0.001), butter and stick margarine (aOR = 0.20, 95% CI = 0.06–0.65, P value = 0.008), and beans (aOR = 0.05, 95% CI = 0.01–0.28, P value < 0.001) consumption. While it was significantly higher in the last tertile of cheese (aOR = 4.45, 95% CI = 1.70–11.6, P value = 0.003), poultry (aOR = 3.95, 95% CI = 1.01–15.5, P value = 0.039), pastries and sweets (aOR = 13.9, 95% CI = 3.04–64.18, P value < 0.001), and fried/fast foods (aOR = 32.8, 95% CI = 5.39–199.3, P value < 0.001).ConclusionThe MIND diet and its components, including green leafy vegetables, other vegetables, and beans, seem to decrease the odds of MS; besides butter and stick margarine, the MIND diet's unhealthy components seem to have the same protective effects, while pastries and sweets, cheese, poultry, and fried/fast foods have an inverse effect.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40120-022-00325-z.

Adherence to the dietary approaches to stop hypertension diet and non-alcoholic fatty liver disease.

The evidence of the relationship between dietary approaches to stop hypertension (DASH) and non-alcoholic fatty liver disease (NAFLD) is limited. Thus, we conducted a cohort-based case-control study to examine whether adherence to the DASH diet was associated with lower NAFLD risk in China. We included 11888 participants (2529 incident NAFLD and 9359 non-NAFLD) from the Kailuan cohort with no history of hepatitis B/C infection and alcohol drinking. DASH score was calculated based on the energy-adjusted consumption of vegetables, fruits, dairy, beans, grains, meats, fat, sodium and beverage, collected by a validated food frequency questionnaire. We used Logistic regression analysis to determine the NAFLD's risk according to the DASH score. Higher DASH score was associated with lower risk of NAFLD. Compared with the lowest quintile of DASH score, the highest DASH quintile had a lower risk of occurring NAFLD, with odds ratio (OR) of 0.82 (95% confidence interval [CI]: 0.70-0.96) in the multivariate model. Stratified analysis showed that the inverse association was only observed in women (OR=0.67, 95% CI: 0.48-0.94), and participants with overweight/obesity (OR=0.79, 95% CI: 0.66-0.94), fasting blood glucose <6.1mmol/L (OR=0.80, 95%: 0.67-0.96), low density lipoprotein ≥3.4mmol/L (OR=0.71, 95% CI: 0.53-0.96), high density lipoprotein ≥1.0mmol/L (OR=0.81, 95% CI: 0.69-0.96), ALT<40U/L (OR=0.79, 95% CI:0.67-0.93) and C-reactive protein ≥2.0mg/L (OR=0.56, 95% CI: 0.40-0.78). Adherence to the DASH diet was inversely associated with a lower risk of NAFLD in the Chinese population. DASH diet should be highly recommended, especially for women and people with overweight/obesity and a high CRP level.

Assessment of ochratoxin A exposure risk from the consumption of coffee beans in Phnom Penh, Cambodia

ABSTRACT This survey aimed to determine OTA contamination in roasted coffee samples commercialised in Phnom Penh, Cambodia and to assess the potential health risk from OTA exposure. Forty locally grown and imported coffee samples were collected and analysed. Analytical validation methods were fully performed. In 3 of 40 samples (7.5%), the results showed detectable levels of OTA, ranging from 0.19 to 1.12 µg kg−1, with an overall average of 0.26 µg kg−1 and an average over the LOQ (n = 3) at 0.81 µg kg−1. OTA estimated daily intake (EDI) of both values were 0.05 (overall average) and 0.17 ng/kg bw/day (the worst-case scenario) with the calculated risk of OTA exposure expressed as a Hazard Quotient at 0.003 and 0.01, respectively. This result could imply a low health risk to Cambodian coffee consumers.

Healthy nutritional status among Centenarians in Rugao, China, is associated with bean consumption, daily activity, and muscle mass retention.

Nutritional status is presumed essential for healthy longevity. The city of Rugao in Jiangsu province recognized as a long-lived area on the coastal plain of China, with a higher proportion of centenarians than Chinese elsewhere or in the world at large. The nutritional status and related factors of centenarians in Rugao, along with muscle mass and activities of daily living (ADL) have been documented with a view to improved nutritional and health approaches to healthy ageing. A cross-sectional study was conducted in Rugao from April 2020 to December 2020. 116 local centenarians agreed to participate in the study. Nutritional status was evaluated by the Mini Nutritional Assessment Short Form (MNA-SF), and ADL was assessed by the Barthel Index (BI). Anthropometric data (e.g., calf circumference) and body composition data (e.g., skeletal muscle mass) were collected as muscle mass variables. The age of centenarians ranged from 100 to 109 years. According to MNA-SF assessment, only 6 (5.2%) of 116 centenarians were malnourished, and 57 (49.1%) were at risk of malnutrition. Binary logistic regression results indicated that prealbumin, albumin, bean product consumption, and current exercise status were independent determinants of centenarians' nutritional status. Centenarians with poor nutritional status tended to have worse muscle mass and BI scores. Nearly half of the centenarians maintained normal nutritional status, insofar as muscle mass condition and function were concerned. Frequent bean product consumption and routine exercise were conducive to healthier centenarian nutritional status.

Association of a MIND Diet with Brain Structure and Dementia in a French Population.

Adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, which combines higher consumption of vegetables, berries, nuts, whole grains, olive oil, fish, beans and poultry, with lower consumption of meat, sugars and saturated fats, is a promising strategy to prevent dementia. However, evidence in populations with non-US food culture, especially from Europe, is limited. To evaluate the association of a French-adapted MIND diet score with gray matter volumes, white matter microstructure and incident dementia. This longitudinal study included participants from the population-based Three-City Bordeaux cohort (≥65 years), with a follow-up from June 2001 to February 2018. Dementia-free participants at dietary assessment, in 2001-2002, who underwent systematic detection of incident dementia (over up to 7 visits). A subset of the cohort was included in an ancillary MRI study in 2010-2011. A French-adapted MIND diet score (range, 0-15) was computed from a 148-item Food Frequency Questionnaire and a 24-hour recall administered at home. Incident dementia and its subtypes were adjudicated by an expert committee; and gray matter volumes and white matter microstructure were assessed by 3D-T1 MRI and diffusion-MRI. Among 1,412 participants (mean age, 75.8 [SD, 4.8]; 63% women), followed for a median of 9.7 years (maximum 16.3 years), 356 (25.2%) developed incident dementia. In multivariable-adjusted Cox model, a higher French MIND diet score was associated with lower risks of dementia and AD (hazard ratios for 1-point of score = 0.89 [95% confidence interval, 0.83-0.95] and 0.88 [0.81-0.96], respectively). In Tract-Based Spatial Statistics analysis of 175 participants included in the MRI sub-study, a higher MIND diet score was associated with lower diffusivity values in the splenium of the corpus callosum (P < .05 after Family-Wise Error-correction). In contrast, there was no significant association of the adapted MIND diet score with gray matter volumes in Voxel-Based Morphometry analysis. In this cohort of French older adults, higher adherence to the French MIND diet was associated with a lower dementia risk and with preserved white matter microstructure. These results provide further evidence for a role of the MIND diet in the prevention of dementia.

Faba beans with enhanced antioxidant activity ameliorate acetic acid-induced colitis in experimental rats.

Faba beans are among the legumes that are of the greatest importance due to their high nutritional value. In addition to the essential nutrients that faba beans contain, they also contain bioactive compounds such as phenolics and flavonoids that are considered as potent natural antioxidants. Ulcerative colitis (UC) is an inflammatory bowel disease in which oxidative stress plays an essential role in the pathophysiology. The aim of the current study was to evaluate the antioxidant activity of faba bean seeds harvested from plants grown from seeds pre-treated with selenium, garlic husk extract and/or lemon peel extract and to evaluate their in vivo effects in a rat model of UC. 54 female rats were divided randomly into nine groups (n = 9). All groups were given the different tested treatments 14 days prior to UC induction using acetic acid (intra-rectal injection of 2 ml, 4% v/v in saline). Our results revealed that the treatment of faba bean seeds with a mixture of selenium, garlic husk extract and lemon peel extract before planting led to a significant increase in selenium, nitrogen, potassium, total protein, phenolic and flavonoid content in the harvested faba bean seeds with a subsequent enhancement of their antioxidant capacity. Consumption of such faba beans showed potential protective and therapeutic effects during experimental colitis by reducing colonic oxidative stress and increasing colonic antioxidant defense mechanisms. Further research is required to understand the mechanisms by which faba beans influence colitis, their effects on various inflammatory biomarkers and their impact on the severity of colitis in humans.

Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica.

Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, glutathione S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play an important role in the metabolism of xenobiotics including As in humans. Using data from 375 typically developing children (2–8 years) in Jamaica, we investigated the environmental and sociodemographic factors, as well as their possible interactions with the children’s genotype for GST genes in relation to having a detectable level of blood As concentration (i.e., >1.3 μg/L). Using multivariable logistic regression, we have identified environmental factors significantly associated with blood As concentrations that include a child’s age, parental education levels, and the consumption of saltwater fish, cabbage, broad beans, and avocado (all p < 0.01). Based on the multivariable analysis including gene x environment interactions, we found that among children with the Ile/Ile genotype for GSTP1 Ile105Val, children who consumed avocado had higher odds of having a detectable blood As concentration compared to children who did not eat avocado.