The existence of a problem of conducting business by domestic enterprises due to russia’s military invasion of Ukraine and their reluctance to carry out effective management in the first days of the war is defined in the article. The amount of material damage caused to the national economy, consumer inflation, the level of decline of the national economy, the devaluation of the national currency, which led to the increase in the cost of goods, works and services, are indicated. Characteristic features of the crisis of the enterprise during the war are singled out. Such negative factors of influence on business development as an increase in the level of risk, the complexity of strategic planning and decision-making, the loss of labor force, a decrease in demand, restrictions on access to markets, and an increase in the cost of raw materials, energy, and labor are described. The complexity of the economic situation of agricultural, energy, metallurgical and logistics enterprises, caused by the territorial location and other features characteristic of each type of business, is proved. Despite the complexity of the existing conditions, the development of Ukrainian business, the creation of jobs, the support of the state economy, and the provision of financial assistance to the military were noted. The areas of state support for business are summarized, in particular, new legislative acts and programs for business adaptation to modern realities are indicated, changes in labor and tax legislation regarding the simplification of certain aspects of business activity are described. The government programs and business support initiatives created with the help of the Diya service are characterized, in particular those that help to find employment for a person internally displaced as a result of hostilities during the martial law in Ukraine and to receive compensation from the state for this, to submit an application for receiving free assistance in relocating one’s business to safe regions of the state or participating in a grant competition “is a job” to create, develop or restore one’s own business, or those that contain the necessary information for choosing a financing program, for Ukrainian exporters, and also help businesses communicate effectively with the state, to develop business development strategy and tactics. The main recommendations for overcoming the crisis and business management by applying the anti-crisis management mechanism have been developed. The importance of further legislative changes regarding conducting business with the aim of stabilizing and developing the economy of Ukraine was noted.