The use of lightweight fabric structures as a substitute for traditional building materials, such as wood, concrete, masonry, and steel has become more commonplace. Attractive selection criteria include speed of construction as well as being an economically affordable alternative for many owners. However, lightweight fabric structures come with unique engineering considerations such as the increased vulnerability to environmental loading from wind and snow when compared to more traditional and massive (i.e., heavier) building systems. This paper examines the wind-induced response of an in-service 818 SM (8,800 sf) frame-supported fabric Large-Area Maintenance Structure monitored using a suite of structural and environmental instrumentation. Analysis of such structures is missing in the published literature. The study evaluates structural performance relative to the structural design parameters and assumptions using a combination of an in-situ monitoring study, numerical modeling, and targeted material and component-level testing that characterized accurate fundamental material properties and the behavior of key connections. The study finds a high degree of uncertainty in the longitudinal load path for the Main Wind Force Resisting System (MWFRS) due to the flexibility of the structure. Additionally, irregularly shaped structures that deviate significantly from rectangular, gable-roofed structures, wind tunnel testing or other means should be used to demonstrate that the maximum wind effects are adequately enveloped. This study also demonstrates a framework for fully remote structural monitoring systems that can provide near-continuous monitoring of the structural response of in-service structures.